-
1
-
-
35548974423
-
Identification of stem cells in small intestine and colon by marker gene Lgr5
-
Barker, N., J.H. van Es, J. Kuipers, P. Kujala, M. van den Born, M. Cozijnsen, A. Haegebarth, J. Korving, H. Begthel, P.J. Peters, and H. Clevers. 2007. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 449:1003-1007.
-
(2007)
Nature
, vol.449
, pp. 1003-1007
-
-
Barker, N.1
van Es, J.H.2
Kuipers, J.3
Kujala, P.4
van den Born, M.5
Cozijnsen, M.6
Haegebarth, A.7
Korving, J.8
Begthel, H.9
Peters, P.J.10
Clevers, H.11
-
2
-
-
59049106578
-
Crypt stem cells as the cells-of-origin of intestinal cancer
-
Barker, N., R.A. Ridgway, J.H. van Es, M. van de Wetering, H. Begthel, M. van den Born, E. Danenberg, A.R. Clarke, O.J. Sansom, and H. Clevers. 2009. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature. 457:608-611.
-
(2009)
Nature
, vol.457
, pp. 608-611
-
-
Barker, N.1
Ridgway, R.A.2
van Es, J.H.3
van de Wetering, M.4
Begthel, H.5
van den Born, M.6
Danenberg, E.7
Clarke, A.R.8
Sansom, O.J.9
Clevers, H.10
-
3
-
-
73049116186
-
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro
-
Barker, N., M. Huch, P. Kujala, M. van de Wetering, H.J. Snippert, J.H. van Es, T. Sato, D.E. Stange, H. Begthel, M. van den Born, et al. 2010. Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell. 6:25-36.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 25-36
-
-
Barker, N.1
Huch, M.2
Kujala, P.3
van de Wetering, M.4
Snippert, H.J.5
van Es, J.H.6
Sato, T.7
Stange, D.E.8
Begthel, H.9
van den Born, M.10
-
4
-
-
12444313589
-
Variation in gene expression patterns in human gastric cancers
-
Chen, X., S.Y. Leung, S.T. Yuen, K.M. Chu, J. Ji, R. Li, A.S. Chan, S. Law, O.G. Troyanskaya, J. Wong, et al. 2003. Variation in gene expression patterns in human gastric cancers. Mol. Biol. Cell. 14:3208-3215.
-
(2003)
Mol. Biol. Cell.
, vol.14
, pp. 3208-3215
-
-
Chen, X.1
Leung, S.Y.2
Yuen, S.T.3
Chu, K.M.4
Ji, J.5
Li, R.6
Chan, A.S.7
Law, S.8
Troyanskaya, O.G.9
Wong, J.10
-
5
-
-
33746808398
-
Wnt/beta-catenin signaling in development and disease
-
Clevers, H. 2006. Wnt/beta-catenin signaling in development and disease. Cell. 127:469-480.
-
(2006)
Cell
, vol.127
, pp. 469-480
-
-
Clevers, H.1
-
6
-
-
20544447734
-
Notch signals control the fate of immature progenitor cells in the intestine
-
Fre, S., M. Huyghe, P. Mourikis, S. Robine, D. Louvard, and S. Artavanis-Tsakonas. 2005. Notch signals control the fate of immature progenitor cells in the intestine. Nature. 435:964-968.
-
(2005)
Nature
, vol.435
, pp. 964-968
-
-
Fre, S.1
Huyghe, M.2
Mourikis, P.3
Robine, S.4
Louvard, D.5
Artavanis-Tsakonas, S.6
-
7
-
-
65549086537
-
Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine
-
Fre, S., S.K. Pallavi, M. Huyghe, M. Laé, K.P. Janssen, S. Robine, S. Artavanis-Tsakonas, and D. Louvard. 2009. Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc. Natl. Acad. Sci. USA. 106:6309-6314.
-
(2009)
Proc. Natl. Acad. Sci. USA.
, vol.106
, pp. 6309-6314
-
-
Fre, S.1
Pallavi, S.K.2
Huyghe, M.3
Laé, M.4
Janssen, K.P.5
Robine, S.6
Artavanis-Tsakonas, S.7
Louvard, D.8
-
8
-
-
0026720075
-
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
-
Gossen, M., and H. Bujard. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA. 89:5547-5551.
-
(1992)
Proc. Natl. Acad. Sci. USA.
, vol.89
, pp. 5547-5551
-
-
Gossen, M.1
Bujard, H.2
-
9
-
-
39549096683
-
A Cre transgene active in developing endodermal organs, heart, limb, and extra-ocular muscle
-
Grieshammer, U., P. Agarwal, and G.R. Martin. 2008. A Cre transgene active in developing endodermal organs, heart, limb, and extra-ocular muscle. Genesis. 46:69-73.
-
(2008)
Genesis
, vol.46
, pp. 69-73
-
-
Grieshammer, U.1
Agarwal, P.2
Martin, G.R.3
-
10
-
-
0035988246
-
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision
-
Han, H., K. Tanigaki, N. Yamamoto, K. Kuroda, M. Yoshimoto, T. Nakahata, K. Ikuta, and T. Honjo. 2002. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int. Immunol. 14:637-645.
-
(2002)
Int. Immunol.
, vol.14
, pp. 637-645
-
-
Han, H.1
Tanigaki, K.2
Yamamoto, N.3
Kuroda, K.4
Yoshimoto, M.5
Nakahata, T.6
Ikuta, K.7
Honjo, T.8
-
11
-
-
0017135358
-
Tritiated thymidine autoradiographic study of cell migration and renewal in the pyloric mucosa of golden hamsters
-
Hattori, T., and S. Fujita. 1976. Tritiated thymidine autoradiographic study of cell migration and renewal in the pyloric mucosa of golden hamsters. Cell Tissue Res. 175:49-57.
-
(1976)
Cell Tissue Res
, vol.175
, pp. 49-57
-
-
Hattori, T.1
Fujita, S.2
-
12
-
-
0037363922
-
HES and HERP families: multiple effectors of the Notch signaling pathway
-
Iso, T., L. Kedes, and Y. Hamamori. 2003. HES and HERP families: multiple effectors of the Notch signaling pathway. J. Cell. Physiol. 194:237-255.
-
(2003)
J. Cell. Physiol.
, vol.194
, pp. 237
-
-
Iso, T.1
Kedes, L.2
Hamamori, Y.3
-
13
-
-
18544404101
-
Control of endodermal endocrine development by Hes-1
-
Jensen, J., E.E. Pedersen, P. Galante, J. Hald, R.S. Heller, M. Ishibashi, R. Kageyama, F. Guillemot, P. Serup, and O.D. Madsen. 2000. Control of endodermal endocrine development by Hes-1. Nat. Genet. 24:36-44.
-
(2000)
Nat. Genet.
, vol.24
, pp. 36-44
-
-
Jensen, J.1
Pedersen, E.E.2
Galante, P.3
Hald, J.4
Heller, R.S.5
Ishibashi, M.6
Kageyama, R.7
Guillemot, F.8
Serup, P.9
Madsen, O.D.10
-
14
-
-
0027253264
-
Dynamics of epithelial cells in the corpus of the mouse stomach. I. Identification of proliferative cell types and pinpointing of the stem cell
-
Karam, S.M., and C.P. Leblond. 1993. Dynamics of epithelial cells in the corpus of the mouse stomach. I. Identification of proliferative cell types and pinpointing of the stem cell. Anat. Rec. 236:259-279.
-
(1993)
Anat. Rec.
, vol.236
, pp. 259-279
-
-
Karam, S.M.1
Leblond, C.P.2
-
15
-
-
77956144348
-
Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells
-
e1-e6
-
Kazanjian, A., T. Noah, D. Brown, J. Burkart, and N.F. Shroyer. 2010. Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells. Gastroenterology. 139:918-928: 928: e1-e6.
-
(2010)
Gastroenterology
, vol.139
, pp. 918-928
-
-
Kazanjian, A.1
Noah, T.2
Brown, D.3
Burkart, J.4
Shroyer, N.F.5
-
16
-
-
79953176341
-
Genetic evidence that instestinal notch functions vary regionally and operate through a common mechanism of math1 repression
-
Kim, T.H., and R.A. Shivdasani. 2011. Genetic evidence that instestinal notch functions vary regionally and operate through a common mechanism of math1 repression. J. Biol. Chem.
-
(2011)
J. Biol. Chem.
-
-
Kim, T.H.1
Shivdasani, R.A.2
-
17
-
-
64249172203
-
The canonical Notch signaling pathway: unfolding the activation mechanism
-
Kopan, R., and M.X. Ilagan. 2009. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 137:216-233.
-
(2009)
Cell
, vol.137
, pp. 216-233
-
-
Kopan R1
Ilagan, M.X.2
-
18
-
-
34548462062
-
Presenilins regulate alphabeta T cell development by modulating TCR signaling
-
Laky, K., and B.J. Fowlkes. 2007. Presenilins regulate alphabeta T cell development by modulating TCR signaling. J. Exp. Med. 204:2115-2129.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2115-2129
-
-
Laky, K.1
Fowlkes, B.J.2
-
19
-
-
0021957288
-
Dynamic histology of the antral epithelium in the mouse stomach: II. Ultrastructure and renewal of isthmal cells
-
Lee, E.R., and C.P. Leblond. 1985. Dynamic histology of the antral epithelium in the mouse stomach: II. Ultrastructure and renewal of isthmal cells. Am. J. Anat. 172:205-224.
-
(1985)
Am. J. Anat.
, vol.172
, pp. 205-224
-
-
Lee, E.R.1
Leblond, C.P.2
-
20
-
-
0020071305
-
Division of the mouse gastric mucosa into zymogenic and mucous regions on the basis of gland features
-
Lee, E.R., J. Trasler, S. Dwivedi, and C.P. Leblond. 1982. Division of the mouse gastric mucosa into zymogenic and mucous regions on the basis of gland features. Am. J. Anat. 164:187-207.
-
(1982)
Am. J. Anat.
, vol.164
, pp. 187-207
-
-
Lee, E.R.1
Trasler, J.2
Dwivedi, S.3
Leblond, C.P.4
-
21
-
-
8444247084
-
Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation
-
Milano, J., J. McKay, C. Dagenais, L. Foster-Brown, F. Pognan, R. Gadient, R.T. Jacobs, A. Zacco, B. Greenberg, and P.J. Ciaccio. 2004. Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation. Toxicol. Sci. 82:341-358.
-
(2004)
Toxicol. Sci.
, vol.82
, pp. 341-358
-
-
Milano, J.1
McKay, J.2
Dagenais, C.3
Foster-Brown, L.4
Pognan, F.5
Gadient, R.6
Jacobs, R.T.7
Zacco, A.8
Greenberg, B.9
Ciaccio, P.J.10
-
22
-
-
0344736673
-
Notch signaling controls multiple steps of pancreatic differentiation
-
Murtaugh, L.C., B.Z. Stanger, K.M. Kwan, and D.A. Melton. 2003. Notch signaling controls multiple steps of pancreatic differentiation. Proc. Natl. Acad. Sci. USA. 100:14920-14925.
-
(2003)
Proc. Natl. Acad. Sci. USA.
, vol.100
, pp. 14920-14925
-
-
Murtaugh, L.C.1
Stanger, B.Z.2
Kwan, K.M.3
Melton, D.A.4
-
24
-
-
0033561365
-
Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation
-
Ohtsuka, T., M. Ishibashi, G. Gradwohl, S. Nakanishi, F. Guillemot, and R. Kageyama. 1999. Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J. 18:2196-2207.
-
(1999)
EMBO J
, vol.18
, pp. 2196-2207
-
-
Ohtsuka, T.1
Ishibashi, M.2
Gradwohl, G.3
Nakanishi, S.4
Guillemot, F.5
Kageyama, R.6
-
25
-
-
34249880066
-
Generation of germline-competent induced pluripotent stem cells
-
Okita, K., T. Ichisaka, and S. Yamanaka. 2007. Generation of germline-competent induced pluripotent stem cells. Nature. 448:313-317.
-
(2007)
Nature
, vol.448
, pp. 313-317
-
-
Okita, K.1
Ichisaka, T.2
Yamanaka, S.3
-
26
-
-
48749089743
-
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2
-
Riccio, O., M.E. van Gijn, A.C. Bezdek, L. Pellegrinet, J.H. van Es, U. Zimber-Strobl, L.J. Strobl, T. Honjo, H. Clevers, and F. Radtke. 2008. Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep. 9:377-383.
-
(2008)
EMBO Rep
, vol.9
, pp. 377-383
-
-
Riccio, O.1
van Gijn, M.E.2
Bezdek, A.C.3
Pellegrinet, L.4
van Es, J.H.5
Zimber-Strobl, U.6
Strobl, L.J.7
Honjo, T.8
Clevers, H.9
Radtke, F.10
-
27
-
-
65549140672
-
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer
-
Rodilla, V., A. Villanueva, A. Obrador-Hevia, A. Robert-Moreno, V. Fernández-Majada, A. Grilli, N. López-Bigas, N. Bellora, M.M. Albà, F. Torres, et al. 2009. Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc. Natl. Acad. Sci. USA. 106:6315-6320.
-
(2009)
Proc. Natl. Acad. Sci. USA.
, vol.106
, pp. 6315-6320
-
-
Rodilla, V.1
Villanueva, A.2
Obrador-Hevia, A.3
Robert-Moreno, A.4
Fernández-Majada, V.5
Grilli, A.6
López-Bigas, N.7
Bellora, N.8
Albà, M.M.9
Torres, F.10
-
28
-
-
0036947013
-
Expression of Notch pathway components in fetal and adult mouse small intestine
-
Schröder, N., and A. Gossler. 2002. Expression of Notch pathway components in fetal and adult mouse small intestine. Gene Expr. Patterns. 2:247-250.
-
(2002)
Gene Expr. Patterns.
, vol.2
, pp. 247-250
-
-
Schröder, N.1
Gossler, A.2
-
29
-
-
0032923739
-
Generalized lacZ expression with the ROSA26 Cre reporter strain
-
Soriano, P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21:70-71.
-
(1999)
Nat. Genet.
, vol.21
, pp. 70-71
-
-
Soriano, P.1
-
30
-
-
75549089019
-
PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification
-
Spandidos, A., X. Wang, H. Wang, and B. Seed. 2010. PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification. Nucleic Acids Res. 38:D792-D799.
-
(2010)
Nucleic Acids Res
, vol.38
-
-
Spandidos, A.1
Wang, X.2
Wang, H.3
Seed, B.4
-
31
-
-
3042856262
-
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
-
Srinivas, S., T. Watanabe, C.S. Lin, C.M. William, Y. Tanabe, T.M. Jessell, and F. Costantini. 2001. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1:4.
-
(2001)
BMC Dev. Biol.
, vol.1
, pp. 4
-
-
Srinivas, S.1
Watanabe, T.2
Lin, C.S.3
William, C.M.4
Tanabe, Y.5
Jessell, T.M.6
Costantini, F.7
-
32
-
-
24644494243
-
Direct regulation of intestinal fate by Notch
-
Stanger, B.Z., R. Datar, L.C. Murtaugh, and D.A. Melton. 2005. Direct regulation of intestinal fate by Notch. Proc. Natl. Acad. Sci. USA. 102:12443-12448.
-
(2005)
Proc. Natl. Acad. Sci. USA.
, vol.102
, pp. 12443-12448
-
-
Stanger, B.Z.1
Datar, R.2
Murtaugh, L.C.3
Melton, D.A.4
-
33
-
-
1842585627
-
A transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotype
-
Syder, A.J., S.M. Karam, J.C. Mills, J.E. Ippolito, H.R. Ansari, V. Farook, and J.I. Gordon. 2004. A transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotype. Proc. Natl. Acad. Sci. USA. 101:4471-4476.
-
(2004)
Proc. Natl. Acad. Sci. USA.
, vol.101
, pp. 4471-4476
-
-
Syder, A.J.1
Karam, S.M.2
Mills, J.C.3
Ippolito, J.E.4
Ansari, H.R.5
Farook, V.6
Gordon, J.I.7
-
34
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
Takahashi, K., and S. Yamanaka. 2006. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 126:663-676.
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
35
-
-
66149175569
-
Identification of gastric cancer stem cells using the cell surface marker CD44
-
Takaishi, S., T. Okumura, S. Tu, S.S. Wang, W. Shibata, R. Vigneshwaran, S.A. Gordon, Y. Shimada, and T.C. Wang. 2009. Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells. 27:1006-1020.
-
(2009)
Stem Cells
, vol.27
, pp. 1006-1020
-
-
Takaishi, S.1
Okumura, T.2
Tu, S.3
Wang, S.S.4
Shibata, W.5
Vigneshwaran, R.6
Gordon, S.A.7
Shimada, Y.8
Wang., T.C.9
-
36
-
-
34249317261
-
Development of gastric tumors in Apc(Min/+) mice by the activation of the beta-catenin/Tcf signaling pathway
-
Tomita, H., Y. Yamada, T. Oyama, K. Hata, Y. Hirose, A. Hara, T. Kunisada, Y. Sugiyama, Y. Adachi, H. Linhart, and H. Mori. 2007. Development of gastric tumors in Apc(Min/+) mice by the activation of the beta-catenin/Tcf signaling pathway. Cancer Res. 67:4079-4087.
-
(2007)
Cancer Res
, vol.67
, pp. 4079-4087
-
-
Tomita, H.1
Yamada, Y.2
Oyama, T.3
Hata, K.4
Hirose, Y.5
Hara, A.6
Kunisada, T.7
Sugiyama, Y.8
Adachi, Y.9
Linhart, H.10
Mori., H.11
-
37
-
-
67651159312
-
Stem cells, self-renewal, and differentiation in the intestinal epithelium
-
van der Flier, L.G., and H. Clevers. 2009. Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu. Rev. Physiol. 71:241-260.
-
(2009)
Annu. Rev. Physiol.
, vol.71
, pp. 241-260
-
-
van der Flier, L.G.1
Clevers, H.2
-
38
-
-
33847214547
-
The Intestinal Wnt/TCF Signature
-
Van der Flier, L.G., J. Sabates-Bellver, I. Oving, A. Haegebarth, M. De Palo, M. Anti, M.E. Van Gijn, S. Suijkerbuijk, M. Van de Wetering, G. Marra, and H. Clevers. 2007. The Intestinal Wnt/TCF Signature. Gastroenterology. 132:628-632.
-
(2007)
Gastroenterology
, vol.132
, pp. 628-632
-
-
Van der Flier, L.G.1
Sabates-Bellver, J.2
Oving, I.3
Haegebarth, A.4
De Palo, M.5
Anti, M.6
Van Gijn, M.E.7
Suijkerbuijk, S.8
Van de Wetering, M.9
Marra, G.10
Clevers, H.11
-
39
-
-
20544460148
-
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
-
van Es, J.H., M.E. van Gijn, O. Riccio, M. van den Born, M. Vooijs, H. Begthel, M. Cozijnsen, S. Robine, D.J. Winton, F. Radtke, and H. Clevers. 2005. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature. 435:959-963.
-
(2005)
Nature
, vol.435
, pp. 959-963
-
-
van Es, J.H.1
van Gijn, M.E.2
Riccio, O.3
van den Born, M.4
Vooijs, M.5
Begthel, H.6
Cozijnsen, M.7
Robine, S.8
Winton, D.J.9
Radtke, F.10
Clevers, H.11
-
40
-
-
79959187704
-
Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors
-
van Es, J.H., N. de Geest, M. van de Born, H. Clevers, and B.A. Hassan. 2010. Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors. Nat. Commun. 1:1-5.
-
(2010)
Nat. Commun.
, vol.1
, pp. 1-5
-
-
van Es, J.H.1
de Geest, N.2
van de Born, M.3
Clevers, H.4
Hassan, B.A.5
-
41
-
-
0035824487
-
Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
-
Yang, Q., N.A. Bermingham, M.J. Finegold, and H.Y. Zoghbi. 2001. Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science. 294:2155-2158.
-
(2001)
Science
, vol.294
, pp. 2155-2158
-
-
Yang, Q.1
Bermingham, N.A.2
Finegold, M.J.3
Zoghbi, H.Y.4
|