메뉴 건너뛰기




Volumn 136, Issue 7, 2009, Pages

Depletion of the Colonic Epithelial Precursor Cell Compartment Upon Conditional Activation of the Hedgehog Pathway

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN;

EID: 66149103193     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.02.068     Document Type: Article
Times cited : (79)

References (40)
  • 1
    • 35648977027 scopus 로고    scopus 로고
    • Hedgehog signaling in development and homeostasis of the gastrointestinal tract
    • van den Brink G.R. Hedgehog signaling in development and homeostasis of the gastrointestinal tract. Physiol Rev 87 (2007) 1343-1375
    • (2007) Physiol Rev , vol.87 , pp. 1343-1375
    • van den Brink, G.R.1
  • 2
    • 10744233571 scopus 로고    scopus 로고
    • Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation
    • van den Brink G.R., Bleuming S.A., Hardwick J.C., et al. Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. Nat Genet 36 (2004) 277-282
    • (2004) Nat Genet , vol.36 , pp. 277-282
    • van den Brink, G.R.1    Bleuming, S.A.2    Hardwick, J.C.3
  • 3
    • 4143097168 scopus 로고    scopus 로고
    • Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia
    • Oniscu A., James R.M., Morris R.G., et al. Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia. J Pathol 203 (2004) 909-917
    • (2004) J Pathol , vol.203 , pp. 909-917
    • Oniscu, A.1    James, R.M.2    Morris, R.G.3
  • 4
    • 0347995025 scopus 로고    scopus 로고
    • Transcription of sonic hedgehog, a potential factor for gastric morphogenesis and gastric mucosa maintenance, is up-regulated in acidic conditions
    • Dimmler A., Brabletz T., Hlubek F., et al. Transcription of sonic hedgehog, a potential factor for gastric morphogenesis and gastric mucosa maintenance, is up-regulated in acidic conditions. Lab Invest 83 (2003) 1829-1837
    • (2003) Lab Invest , vol.83 , pp. 1829-1837
    • Dimmler, A.1    Brabletz, T.2    Hlubek, F.3
  • 5
    • 0034907949 scopus 로고    scopus 로고
    • Sonic hedgehog regulates gastric gland morphogenesis in man and mouse
    • van den Brink G.R., Hardwick J.C., Tytgat G.N., et al. Sonic hedgehog regulates gastric gland morphogenesis in man and mouse. Gastroenterology 121 (2001) 317-328
    • (2001) Gastroenterology , vol.121 , pp. 317-328
    • van den Brink, G.R.1    Hardwick, J.C.2    Tytgat, G.N.3
  • 6
    • 19944381545 scopus 로고    scopus 로고
    • Down-regulation of a morphogen (sonic hedgehog) gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils
    • Suzuki H., Minegishi Y., Nomoto Y., et al. Down-regulation of a morphogen (sonic hedgehog) gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils. J Pathol 206 (2005) 186-197
    • (2005) J Pathol , vol.206 , pp. 186-197
    • Suzuki, H.1    Minegishi, Y.2    Nomoto, Y.3
  • 7
    • 0036839405 scopus 로고    scopus 로고
    • Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract
    • van den Brink G.R., Hardwick J.C., Nielsen C., et al. Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. Gut 51 (2002) 628-633
    • (2002) Gut , vol.51 , pp. 628-633
    • van den Brink, G.R.1    Hardwick, J.C.2    Nielsen, C.3
  • 8
    • 0034721665 scopus 로고    scopus 로고
    • Transducing the hedgehog signal
    • Kalderon D. Transducing the hedgehog signal. Cell 103 (2000) 371-374
    • (2000) Cell , vol.103 , pp. 371-374
    • Kalderon, D.1
  • 9
    • 33746879125 scopus 로고    scopus 로고
    • Patched2 modulates tumorigenesis in patched1 heterozygous mice
    • Lee Y., Miller H.L., Russell H.R., et al. Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res 66 (2006) 6964-6971
    • (2006) Cancer Res , vol.66 , pp. 6964-6971
    • Lee, Y.1    Miller, H.L.2    Russell, H.R.3
  • 10
    • 12144288863 scopus 로고    scopus 로고
    • Distinct roles of PTCH2 splice variants in Hedgehog signalling
    • Rahnama F., Toftgard R., and Zaphiropoulos P.G. Distinct roles of PTCH2 splice variants in Hedgehog signalling. Biochem J 378 (2004) 325-334
    • (2004) Biochem J , vol.378 , pp. 325-334
    • Rahnama, F.1    Toftgard, R.2    Zaphiropoulos, P.G.3
  • 11
    • 34548834154 scopus 로고    scopus 로고
    • The Hedgehog receptor Patched controls lymphoid lineage commitment
    • Uhmann A., Dittmann K., Nitzki F., et al. The Hedgehog receptor Patched controls lymphoid lineage commitment. Blood 110 (2007) 1814-1823
    • (2007) Blood , vol.110 , pp. 1814-1823
    • Uhmann, A.1    Dittmann, K.2    Nitzki, F.3
  • 12
    • 34548817270 scopus 로고    scopus 로고
    • Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues
    • Hameyer D., Loonstra A., Eshkind L., et al. Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues. Physiol Genomics 31 (2007) 32-41
    • (2007) Physiol Genomics , vol.31 , pp. 32-41
    • Hameyer, D.1    Loonstra, A.2    Eshkind, L.3
  • 13
    • 23044514938 scopus 로고    scopus 로고
    • Hedgehog signaling in mouse ovary: Indian hedgehog and desert hedgehog from granulosa cells induce target gene expression in developing theca cells
    • Wijgerde M., Ooms M., Hoogerbrugge J.W., et al. Hedgehog signaling in mouse ovary: Indian hedgehog and desert hedgehog from granulosa cells induce target gene expression in developing theca cells. Endocrinology 146 (2005) 3558-3566
    • (2005) Endocrinology , vol.146 , pp. 3558-3566
    • Wijgerde, M.1    Ooms, M.2    Hoogerbrugge, J.W.3
  • 14
    • 58149464866 scopus 로고    scopus 로고
    • Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways
    • Lees C.W., Zacharias W.J., Tremelling M., et al. Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways. PLoS Med 5 (2008) e239
    • (2008) PLoS Med , vol.5
    • Lees, C.W.1    Zacharias, W.J.2    Tremelling, M.3
  • 15
    • 0033558504 scopus 로고    scopus 로고
    • Lineage commitment and maturation of epithelial cells in the gut
    • Karam S.M. Lineage commitment and maturation of epithelial cells in the gut. Front Biosci 4 (1999) D286-D298
    • (1999) Front Biosci , vol.4
    • Karam, S.M.1
  • 16
    • 13944259054 scopus 로고    scopus 로고
    • Epithelial hedgehog signals pattern the intestinal crypt-villus axis
    • Madison B.B., Braunstein K., Kuizon E., et al. Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development 132 (2005) 279-289
    • (2005) Development , vol.132 , pp. 279-289
    • Madison, B.B.1    Braunstein, K.2    Kuizon, E.3
  • 17
    • 0037829660 scopus 로고    scopus 로고
    • Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
    • Pinto D., Gregorieff A., Begthel H., et al. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev 17 (2003) 1709-1713
    • (2003) Genes Dev , vol.17 , pp. 1709-1713
    • Pinto, D.1    Gregorieff, A.2    Begthel, H.3
  • 18
    • 18644373146 scopus 로고    scopus 로고
    • The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
    • van de Wetering M., Sancho E., Verweij C., et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111 (2002) 241-250
    • (2002) Cell , vol.111 , pp. 241-250
    • van de Wetering, M.1    Sancho, E.2    Verweij, C.3
  • 19
    • 18644376279 scopus 로고    scopus 로고
    • Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB
    • Batlle E., Henderson J.T., Beghtel H., et al. Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell 111 (2002) 251-263
    • (2002) Cell , vol.111 , pp. 251-263
    • Batlle, E.1    Henderson, J.T.2    Beghtel, H.3
  • 20
    • 0032912720 scopus 로고    scopus 로고
    • Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway
    • Wielenga V.J., Smits R., Korinek V., et al. Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am J Pathol 154 (1999) 515-523
    • (1999) Am J Pathol , vol.154 , pp. 515-523
    • Wielenga, V.J.1    Smits, R.2    Korinek, V.3
  • 21
    • 0028837742 scopus 로고
    • Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo
    • Bitgood M.J., and McMahon A.P. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol 172 (1995) 126-138
    • (1995) Dev Biol , vol.172 , pp. 126-138
    • Bitgood, M.J.1    McMahon, A.P.2
  • 22
    • 0028875032 scopus 로고
    • Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut
    • Roberts D.J., Johnson R.L., Burke A.C., et al. Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut. Development 121 (1995) 3163-3174
    • (1995) Development , vol.121 , pp. 3163-3174
    • Roberts, D.J.1    Johnson, R.L.2    Burke, A.C.3
  • 23
    • 0031661708 scopus 로고    scopus 로고
    • Epithelial-mesenchymal signaling during the regionalization of the chick gut
    • Roberts D.J., Smith D.M., Goff D.J., et al. Epithelial-mesenchymal signaling during the regionalization of the chick gut. Development 125 (1998) 2791-2801
    • (1998) Development , vol.125 , pp. 2791-2801
    • Roberts, D.J.1    Smith, D.M.2    Goff, D.J.3
  • 24
    • 34548478312 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling is essential for terminal differentiation of the intestinal secretory cell lineage
    • Auclair B.A., Benoit Y.D., Rivard N., et al. Bone morphogenetic protein signaling is essential for terminal differentiation of the intestinal secretory cell lineage. Gastroenterology 133 (2007) 887-896
    • (2007) Gastroenterology , vol.133 , pp. 887-896
    • Auclair, B.A.1    Benoit, Y.D.2    Rivard, N.3
  • 25
    • 0034972978 scopus 로고    scopus 로고
    • Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis
    • Howe J.R., Bair J.L., Sayed M.G., et al. Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat Genet 28 (2001) 184-187
    • (2001) Nat Genet , vol.28 , pp. 184-187
    • Howe, J.R.1    Bair, J.L.2    Sayed, M.G.3
  • 26
    • 39149088615 scopus 로고    scopus 로고
    • Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation
    • Beppu H., Mwizerwa O.N., Beppu Y., et al. Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation. Oncogene 27 (2008) 1063-1070
    • (2008) Oncogene , vol.27 , pp. 1063-1070
    • Beppu, H.1    Mwizerwa, O.N.2    Beppu, Y.3
  • 27
    • 1542618115 scopus 로고    scopus 로고
    • De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine
    • Haramis A.P., Begthel H., van den B.M., et al. De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science 303 (2004) 1684-1686
    • (2004) Science , vol.303 , pp. 1684-1686
    • Haramis, A.P.1    Begthel, H.2    van den, B.M.3
  • 28
    • 0346100581 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon
    • Hardwick J.C., van den Brink G.R., Bleuming S.A., et al. Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon. Gastroenterology 126 (2004) 111-121
    • (2004) Gastroenterology , vol.126 , pp. 111-121
    • Hardwick, J.C.1    van den Brink, G.R.2    Bleuming, S.A.3
  • 29
    • 6944224156 scopus 로고    scopus 로고
    • BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling
    • He X.C., Zhang J., Tong W.G., et al. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet 36 (2004) 1117-1121
    • (2004) Nat Genet , vol.36 , pp. 1117-1121
    • He, X.C.1    Zhang, J.2    Tong, W.G.3
  • 30
    • 34848868159 scopus 로고    scopus 로고
    • Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors
    • Kosinski C., Li V.S., Chan A.S., et al. Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. Proc Natl Acad Sci U S A 104 (2007) 15418-15423
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 15418-15423
    • Kosinski, C.1    Li, V.S.2    Chan, A.S.3
  • 31
    • 4644223417 scopus 로고    scopus 로고
    • Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation
    • Samanta J., and Kessler J.A. Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation. Development 131 (2004) 4131-4142
    • (2004) Development , vol.131 , pp. 4131-4142
    • Samanta, J.1    Kessler, J.A.2
  • 32
    • 0033916281 scopus 로고    scopus 로고
    • Hedgehog signals regulate multiple aspects of gastrointestinal development
    • Ramalho-Santos M., Melton D.A., and McMahon A.P. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127 (2000) 2763-2772
    • (2000) Development , vol.127 , pp. 2763-2772
    • Ramalho-Santos, M.1    Melton, D.A.2    McMahon, A.P.3
  • 33
    • 0036165339 scopus 로고    scopus 로고
    • Disruption of hedgehog signaling reveals a novel role in intestinal morphogenesis and intestinal-specific lipid metabolism in mice
    • Wang L.C., Nassir F., Liu Z.Y., et al. Disruption of hedgehog signaling reveals a novel role in intestinal morphogenesis and intestinal-specific lipid metabolism in mice. Gastroenterology 122 (2002) 469-482
    • (2002) Gastroenterology , vol.122 , pp. 469-482
    • Wang, L.C.1    Nassir, F.2    Liu, Z.Y.3
  • 34
    • 32044442728 scopus 로고    scopus 로고
    • Expression of hedgehog pathway components in the adult colon
    • van den Brink G.R., and Peppelenbosch M.P. Expression of hedgehog pathway components in the adult colon. Gastroenterology 130 (2006) 619
    • (2006) Gastroenterology , vol.130 , pp. 619
    • van den Brink, G.R.1    Peppelenbosch, M.P.2
  • 35
    • 0242268525 scopus 로고    scopus 로고
    • Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    • Berman D.M., Karhadkar S.S., Maitra A., et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425 (2003) 846-851
    • (2003) Nature , vol.425 , pp. 846-851
    • Berman, D.M.1    Karhadkar, S.S.2    Maitra, A.3
  • 36
    • 33745634379 scopus 로고    scopus 로고
    • Activation of the hedgehog pathway in human hepatocellular carcinomas
    • Huang S., He J., Zhang X., et al. Activation of the hedgehog pathway in human hepatocellular carcinomas. Carcinogenesis 27 (2006) 1334-1340
    • (2006) Carcinogenesis , vol.27 , pp. 1334-1340
    • Huang, S.1    He, J.2    Zhang, X.3
  • 37
    • 0242270878 scopus 로고    scopus 로고
    • Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
    • Thayer S.P., di Magliano M.P., Heiser P.W., et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425 (2003) 851-856
    • (2003) Nature , vol.425 , pp. 851-856
    • Thayer, S.P.1    di Magliano, M.P.2    Heiser, P.W.3
  • 38
    • 33746682493 scopus 로고    scopus 로고
    • PPARbeta/delta regulates paneth cell differentiation via controlling the hedgehog signaling pathway
    • Varnat F., Heggeler B.B., Grisel P., et al. PPARbeta/delta regulates paneth cell differentiation via controlling the hedgehog signaling pathway. Gastroenterology 131 (2006) 538-553
    • (2006) Gastroenterology , vol.131 , pp. 538-553
    • Varnat, F.1    Heggeler, B.B.2    Grisel, P.3
  • 39
    • 52149119128 scopus 로고    scopus 로고
    • A paracrine requirement for hedgehog signalling in cancer
    • Yauch R.L., Gould S.E., Scales S.J., et al. A paracrine requirement for hedgehog signalling in cancer. Nature 455 (2008) 406-410
    • (2008) Nature , vol.455 , pp. 406-410
    • Yauch, R.L.1    Gould, S.E.2    Scales, S.J.3
  • 40
    • 48349135915 scopus 로고    scopus 로고
    • The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling
    • Takashima S., Mkrtchyan M., Younossi-Hartenstein A., et al. The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling. Nature 454 (2008) 651-655
    • (2008) Nature , vol.454 , pp. 651-655
    • Takashima, S.1    Mkrtchyan, M.2    Younossi-Hartenstein, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.