Icariside II, a novel phosphodiesterase-5 inhibitor, attenuates streptozotocin-induced cognitive deficits in rats

Neuroscience

Volumn 328, Issue , 2016, Pages 69-79

  Yin, Caixia ^a   Deng, Yuanyuan ^a   Gao, Jianmei ^a   Li, Xiaohui ^a   Liu, Yuangui ^a   Gong, Qihai ^a  

^a ZUNYI MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Beta amyloid; Icariside II; Neuroinflammation; Phosphodiesterase 5; Streptozotocin

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; CYCLOOXYGENASE 2; I KAPPA B ALPHA; ICARISIDE II; INTERLEUKIN 1BETA; MEMBRANE METALLOENDOPEPTIDASE; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; BAOHUOSIDE I; FLAVONOID; NEUROPROTECTIVE AGENT; NOOTROPIC AGENT; STREPTOZOCIN;

ADULT; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; EPIMEDIUM; EPIMEDIUM BREVICORNUM; HIPPOCAMPUS; LEARNING DISORDER; LOW DRUG DOSE; MALE; MEMORY DISORDER; NERVE CELL NECROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; COGNITION DISORDERS; DISEASE MODEL; DRUG EFFECTS; IMMUNOLOGY; MAZE TEST; NERVE CELL; PATHOLOGY; PHYSIOLOGY; PRECLINICAL STUDY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALS; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; FLAVONOIDS; HIPPOCAMPUS; MALE; MAZE LEARNING; NEURONS; NEUROPROTECTIVE AGENTS; NOOTROPIC AGENTS; PHOSPHODIESTERASE 5 INHIBITORS; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; STREPTOZOCIN;

EID: 84966372687     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2016.04.022     Document Type: Article

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