Ketamine reduces amyloid β-protein degradation by suppressing neprilysin expression in primary cultured astrocytes

Neuroscience Letters

Volumn 545, Issue , 2013, Pages 54-58

  Yamamoto, Naoki ^a   Arima, Hajime ^b   Naruse, Kaori ^a   Kasahara, Rika ^a   Taniura, Hideo ^a   Hirate, Hiroyuki ^b   Sugiura, Takeshi ^b   Suzuki, Kenji ^a   Sobue, Kazuya ^b  

^a RITSUMEIKAN UNIVERSITY   (Japan)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

Alzheimer's disease; Amyloid protein; Ketamine; Neprilysin; Non competitive N methyl d aspartate receptor

Indexed keywords

AMYLOID BETA PROTEIN; DIZOCILPINE; INSULINASE; KETAMINE; MEMBRANE METALLOENDOPEPTIDASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; EMBRYO; ENZYME PHOSPHORYLATION; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AMYLOID BETA-PEPTIDES; ANALGESICS; ANIMALS; ASTROCYTES; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; KETAMINE; NEPRILYSIN; PROTEIN DENATURATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84878576310     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.04.016     Document Type: Article

References (17)

1. Apelt J., Ach K., Schliebs R. Aging-related down-regulation of neprilysin, a putative beta-amyloid-degrading enzyme, in transgenic Tg2576 Alzheimer-like mouse brain is accompanied by an astroglial upregulation in the vicinity of beta-amyloid plaques. Neurosci. Lett. 2003, 339:183-186.
2. Farris W., Mansourian S., Chang Y., Lindsley L., Eckman E.A., Frosch M.P., Eckman C.B., Tanzi R.E., Selkoe D.J., Guenette S. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:4162-4167.
3. Harper S.J., LoGrasso P. Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38. Cell Signal. 2001, 13:299-310.
4. Hetman M., Gozdz A. Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. Eur. J. Biochem. 2004, 271:2050-2055.
5. Higuchi M., Iwata N., Saido T.C. Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventions. Biochim. Biophys. Acta 2005, 1751:60-67.
6. Hudetz J.A., Pagel P.S. Neuroprotection by ketamine: a review of the experimental and clinical evidence. J. Cardiothorac. Vasc. Anesth. 2010, 1:131-142.
7. Ikonomidou C., Bosch F., Miksa M., Bittigau P., Vöckler J., Dikranian K., Tenkova T.I., Stefovska V., Turski L., Olney J.W. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 1999, 283:70-74.
8. Iwata N., Tsubuki S., Takaki Y., Shirotani K., Lu B., Gerard N.P., Gerard C., Hama E., Lee H.J., Saido T.C. Metabolic regulation of brain Aβ by neprilysin. Science 2001, 292:1550-1552.
9. Kalia L.V., Kalia S.K., Salter M.W. NMDA receptors in clinical neurology: excitatory times ahead. Lancet Neurol. 2008, 7:742-755.
10. Krystal J.H., Bennett A., Abi-Saab D., Belger A., Karper L.P., D'Souza D.C., Lipschitz D., Abi-Dargham A., Charney D.S. Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functions. Biol. Psychiatry 2000, 47:137-143.
11. Leal M.C., Dorfman V.B., Gamba A.F., Frangione B., Wisniewski T., Castaño E.M., Sigurdsson E.M., Morelli L. Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology. J. Neuropathol. Exp. Neurol. 2006, 65:976-987.
12. Monaghan D.T., Jane D.E. Pharmacology of NMDA receptors. Biology of the NMDA Receptor. 2009, CRC Press, Boca Raton, FL, (Chapter 12). A.M. Van Dongen (Ed.).
13. Okon T. Ketamine: an introduction for the pain and palliative medicine physician. Pain Physician 2007, 10:493-500.
14. Saito T., Takaki Y., Iwata N., Trojanowski J., Saido T.C. Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-beta peptide metabolism. Sci. Aging Knowledge Environ. 2003, PE1.
15. Turner A.J., Nalivaeva N.N. New insights into the roles of metalloproteinases in neurodegeneration and neuroprotection. Int. Rev. Neurobiol. 2007, 82:113-135.
16. Yamamoto N., Sobue K., Fujita M., Katsuya H., Asai K. Differential regulation of aquaporin-5 and -9 expression in astrocytes by protein kinase A. Mol. Brain Res. 2002, 104:96-102.
17. Yong V.W., Kim S.U., Kim M.W., Shin D.H. Growth factors for human glial cells in culture. Glia 1988, 1:113-123.