Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice

Neurobiology of Aging

Volumn 35, Issue 3, 2014, Pages 520-531

  Puzzo, Daniela ^a   Loreto, Carla ^a   Giunta, Salvatore ^a   Musumeci, Giuseppe ^a   Frasca, Giuseppina ^a   Podda, Maria Vittoria ^b   Arancio, Ottavio ^c   Palmeri, Agostino ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c NewYork Presbyterian Hospital   (United States)

Author keywords

Aging; Apoptosis; APP processing; Bax Bcl 2 ratio; BDNF; Beta amyloid; Caspase 3; Sildenafil

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE 3; DEOXYURIDINE PHOSPHATE; PROTEIN BAK; PROTEIN BCL 2; SILDENAFIL;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG INHIBITION; ENZYME SYNTHESIS; FEMALE; HIPPOCAMPAL CA1 REGION; MALE; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION;

AGING; APOPTOSIS; APP PROCESSING; BAX/BCL-2 RATIO; BDNF; BETA-AMYLOID; CASPASE-3; SILDENAFIL;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CA1 REGION, HIPPOCAMPAL; CASPASE 3; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; DEOXYURACIL NUCLEOTIDES; DISEASE MODELS, ANIMAL; HUMANS; INJECTIONS, INTRAPERITONEAL; MICE; MICE, INBRED C57BL; MOLECULAR TARGETED THERAPY; NEURONAL PLASTICITY; PHOSPHODIESTERASE 5 INHIBITORS; PHOSPHORYLATION; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-BCL-2; PURINES; SULFONES;

EID: 84889560709     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2013.09.002     Document Type: Article

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