Icariin, a major constituent of flavonoids from Epimedium brevicornum, protects against cognitive deficits induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats

Pharmacology Biochemistry and Behavior

Volumn 138, Issue , 2015, Pages 40-48

  Li, Wen Xian ^a   Deng, Yuan Yuan ^a   Li, Fei ^a   Liu, Bo ^a   Liu, Hui Yu ^a   Shi, Jing Shan ^a   Gong, Qi Hai ^a  

^a ZUNYI MEDICAL UNIVERSITY   (China)

Author keywords

Beta amyloid; Chronic cerebral hypoperfusion; Icariin; Permanent occlusion of bilateral common carotid arteries; Transforming growth factor 1< inf> signaling

Indexed keywords

ADAM10 ENDOPEPTIDASE; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; DISINTEGRIN; FLAVONOID; ICARIIN; INSULINASE; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; AMYLOID BETA PROTEIN; ASPARTIC PROTEINASE; BACE PROTEIN, RAT; SECRETASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; CAROTID ARTERY LIGATION; CHRONIC CEREBRAL HYPOPERFUSION; COGNITIVE DEFECT; COMMON CAROTID ARTERY; CONTROLLED STUDY; EPIMEDIUM; EPIMEDIUM BREVICORNUM; HIPPOCAMPUS; LEARNING; MALE; MEMORY DISORDER; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TREATMENT DURATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CAROTID ARTERY OBSTRUCTION; CEREBROVASCULAR DISEASE; CHEMISTRY; COGNITION DISORDERS; COMPLICATION; DRUG EFFECTS; MAZE TEST; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CAROTID ARTERY, COMMON; CAROTID STENOSIS; CEREBROVASCULAR DISORDERS; COGNITION DISORDERS; EPIMEDIUM; FLAVONOIDS; HIPPOCAMPUS; MALE; MAZE LEARNING; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84942103558     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2015.09.001     Document Type: Article

References (50)

1. J. Ai, L.-H. Sun, H. Che, R. Zhang, T.Z. Zhang, W.C. Wu, and et al. MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats J. Neurosci. 33 2013 3989 4001
2. A. Baskys, and J.X. Cheng Pharmacological prevention and treatment of vascular dementia: approaches and perspectives Exp. Gerontol. 47 2012 887 891
3. D. Burdick, B. Soreghan, M. Kwon, J. Kosmoski, M. Knauer, A. Henschen, and et al. Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs J. Biol. Chem. 267 1992 546 554
4. O. Butovsky, M.P. Jedrychowski, C.S. Moore, R. Cialic, A.J. Lanser, G. Gabriely, and et al. Identification of a unique TGF-[beta]-dependent molecular and functional signature in microglia Nat. Neurosci. 17 2014 131 143
5. F. Cechetti, A.S. Pagnussat, P.V. Worm, V.R. Elsner, J. Ben, M.S. da Costa, and et al. Chronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment Brain Res. Bull. 87 2012 109 116
6. K.M. Chen, B.F. Ge, H.P. Ma, X.Y. Liu, M.H. Bai, and Y. Wang Icariin, a flavonoid from the herb Epimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells Pharmazie 60 2005 939 942
7. M. Chen, J. Hao, Q. Yang, and G. Li Effects of icariin on reproductive functions in male rats Molecules 19 2014 9502 9514
8. M. Citron Strategies for disease modification in Alzheimer's disease Nat. Rev. Neurosci. 5 2004 677 685
9. S.L. Cole, and R. Vassar Linking vascular disorders and Alzheimer's disease: potential involvement of BACE1 Neurobiol. Aging 30 2009 1535 1544
10. J.C. de la Torre Cerebral hemodynamics and vascular risk factors: setting the stage for Alzheimer's disease J. Alzheimers Dis. 32 2012 553 567
11. D. Del Turco, J. Schlaudraff, M. Bonin, and T. Deller Upregulation of APP, ADAM10 and ADAM17 in the denervated mouse dentate gyrus PLoS One 9 2014 e84962
12. E. Farkas, P.G. Luiten, and F. Bari Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases Brain Res. Rev. 54 2007 162 180
13. W. Farris, S. Mansourian, Y. Chang, L. Lindsley, E.A. Eckman, M.P. Frosch, and et al. Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo Proc. Natl. Acad. Sci. U. S. A. 100 2003 4162 4167
14. D.S. Gelinas, K. DaSilva, D. Fenili, P.S. George-Hyslop, and J. McLaurin Immunotherapy for Alzheimer's disease Proc. Natl. Acad. Sci. U. S. A. 101 2004 14657 14662
15. J. Guo, F. Li, Q. Wu, Q. Gong, Y. Lu, and J. Shi Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats Phytomedicine 17 2010 950 955
16. H. Hanyu, T. Sato, K. Hirao, H. Kanetaka, T. Iwamoto, and K. Koizumi The progression of cognitive deterioration and regional cerebral blood flow patterns in Alzheimer's disease: a longitudinal SPECT study J. Neurol. Sci. 290 2010 96 101
17. L. Kukreja, G.C. Kujoth, T.A. Prolla, F. Van Leuven, and R. Vassar Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease Mol. Neurodegener. 9 2014 16
18. K. Kume, H. Hanyu, T. Sato, K. Hirao, S. Shimizu, H. Kanetaka, and et al. Vascular risk factors are associated with faster decline of Alzheimer disease: a longitudinal SPECT study J. Neurol. 258 2011 1295 1303
19. D.A. Levine, and K.M. Langa Vascular cognitive impairment: disease mechanisms and therapeutic implications Neurotherapeutics 8 2011 361 373
20. E. Li, D.H. Kim, M. Cai, S. Lee, Y. Kim, E. Lim, and et al. Hippocampus-dependent spatial learning and memory are impaired in growth hormone-deficient spontaneous dwarf rats Endocr. J. 58 2010 257 267
21. J. Meunier, V. Villard, L. Givalois, and T. Maurice The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer's disease Eur. J. Pharmacol. 698 2013 193 199
22. J.S. Miners, N. Barua, P.G. Kehoe, S. Gill, and S. Love Aβ-degrading enzymes: potential for treatment of Alzheimer disease J. Neuropathol. Exp. Neurol. 70 2011 944 959
23. R. Morris Developments of a water-maze procedure for studying spatial learning in the rat J. Neurosci. Methods 11 1984 47 60
24. S. Patil, J. Melrose, and C. Chan Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons Eur. J. Neurosci. 26 2007 2131 2141
25. S.P. Patil, S. Maki, S.A. Khedkar, A.C. Rigby, and C. Chan Withanolide A and Asiatic acid modulate multiple targets associated with amyloid-β precursor protein processing and amyloid-β protein clearance J. Nat. Prod. 73 2010 1196 1202
26. Y. Peng, S. Xu, G. Chen, L. Wang, Y. Feng, and X. Wang l-3-n-Butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats J. Pharmacol. Exp. Ther. 321 2007 902 910
27. R. Postina, A. Schroeder, I. Dewachter, J. Bohl, U. Schmitt, E. Kojro, and et al. A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model J. Clin. Invest. 113 2004 1456 1464
28. L.J. Ritchie, M. De Butte, and B.A. Pappas Chronic mild stress exacerbates the effects of permanent bilateral common carotid artery occlusion on CA1 neurons Brain Res. 1014 2004 228 235
29. C.V. Romanini, A.P. Schiavon, E.D.F. Ferreira, R.M.W. de Oliveira, and H. Milani Sildenafil prevents mortality and reduces hippocampal damage after permanent, stepwise, 4-vessel occlusion in rats Brain Res. Bull. 81 2010 631 640
30. A. Ruitenberg, T. den Heijer, S.L. Bakker, J.C. van Swieten, P.J. Koudstaal, A. Hofman, and et al. Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study Ann. Neurol. 57 2005 789 794
31. C. Sarti, L. Pantoni, L. Bartolini, and D. Inzitari Cognitive impairment and chronic cerebral hypoperfusion: what can be learned from experimental models J. Neurol. Sci. 203 2002 263 266
32. C. Sarti, L. Pantoni, L. Bartolini, and D. Inzitari Persistent impairment of gait performances and working memory after bilateral common carotid artery occlusion in the adult Wistar rat Behav. Brain Res. 136 2002 13 20
33. B. Schmierer, and C.S. Hill TGFβ-SMAD signal transduction: molecular specificity and functional flexibility Nat. Rev. Mol. Cell Biol. 8 2007 970 982
34. S. Singh, A. Kushwah, R. Singh, M. Farswan, and R. Kaur Current therapeutic strategy in Alzheimer's disease Eur. Rev. Med. Pharmacol. Sci. 16 2012 1651 1664
35. Y.H. Song, H. Cai, N. Gu, C.F. Qian, S.P. Cao, and Z.M. Zhao Icariin attenuates cardiac remodelling through down-regulating myocardial apoptosis and matrix metalloproteinase activity in rats with congestive heart failure J. Pharm. Pharmacol. 63 2011 541 549
36. W. Staffen, U. Schönauer, H. Zauner, I. Spindler, A. Mair, B. Iglseder, and et al. Brain perfusion SPECT in patients with mild cognitive impairment and Alzheimer's disease: comparison of a semiquantitative and a visual evaluation J. Neural Transm. 113 2006 195 203
37. M. Tanaka, H. Fukuyama, H. Yamauchi, M. Narita, H. Nabatame, M. Yokode, and et al. Regional cerebral blood flow abnormalities in nondemented patients with memory impairment J. Neuroimaging 12 2002 112 118
38. I. Tesseur, K. Zou, L. Esposito, F. Bard, E. Berber, J. Van Can, and et al. Deficiency in neuronal TGF-β signaling promotes neurodegeneration and Alzheimer's pathology J. Clin. Invest. 116 2006 3060 3069
39. É. Vicente, D. Degerone, L. Bohn, F. Scornavaca, A. Pimentel, M.C. Leite, and et al. Astroglial and cognitive effects of chronic cerebral hypoperfusion in the rat Brain Res. 1251 2009 204 212
40. Y. Xi, M. Wang, W. Zhang, M. Bai, Y. Du, Z. Zhang, and et al. Neuronal damage, central cholinergic dysfunction and oxidative damage correlate with cognitive deficits in rats with chronic cerebral hypoperfusion Neurobiol. Learn. Mem. 109 2014 7 19
41. C.Q. Xu, B.J. Liu, J.F. Wu, Y.C. Xu, X.H. Duan, Y.X. Cao, and et al. Icariin attenuates LPS-induced acute inflammatory responses: Involvement of PI3K/Akt and NF-κB signaling pathway Eur. J. Pharmacol. 642 2010 146 153
42. R.X. Xu, Q. Wu, Y. Luo, Q.H. Gong, L.M. Yu, X.N. Huang, and et al. Protective effects of icariin on cognitive deficits induced by chronic cerebral hypoperfusion in rats Clin. Exp. Pharmacol. Physiol. 36 2009 810 815
43. H. Zhang, B. Liu, J. Wu, C. Xu, J. Tao, X. Duan, and et al. Icariin inhibits corticosterone-induced apoptosis in hypothalamic neurons via the PI3-K/Akt signaling pathway Mol. Med. Rep. 6 2012 967 972
44. H.A. Zhang, M. Gao, B. Chen, L. Shi, Q. Wang, X. Yu, and et al. Evaluation of hippocampal injury and cognitive function induced by embolization in the rat brain Anat. Rec. (Hoboken) 296 2013 1207 1214
45. L. Zhang, C. Shen, J. Chu, R. Zhang, Y. Li, and L. Li Icariin decreases the expression of APP and BACE-1 and reduces the beta-amyloid burden in an APP transgenic mouse model of Alzheimer's disease Int. J. Biol. Sci. 10 2014 181 191
46. S.Q. Zhang, D. Sawmiller, S. Li, K. Rezai-Zadeh, H. Hou, S. Zhou, and et al. Octyl gallate markedly promotes anti-amyloidogenic processing of APP through estrogen receptor-mediated ADAM10 activation PLoS One 8 2013 e71913
47. J. Zhou, J. Wu, X. Chen, N. Fortenbery, E. Eksioglu, K.N. Kodumudi, and et al. Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions Int. Immunopharmacol. 11 2011 890 898
48. Z.D. Zhou, C.H. Chan, Q.H. Ma, X.H. Xu, Z.C. Xiao, and E.K. Tan The roles of amyloid precursor protein (APP) in neurogenesis: implications to pathogenesis and therapy of Alzheimer disease Cell Adhes. Migr. 5 2011 280 292
49. H.R. Zhu, Z.Y. Wang, X.L. Zhu, X.X. Wu, E.G. Li, and Y. Xu Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1α Expression in experimental stroke Neuropharmacology 59 2010 70 76
50. Z. Zhu, J. Yan, W. Jiang, X.G. Yao, J. Chen, L. Chen, and et al. Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance J. Neurosci. 33 2013 13138 13149