Icarisid II, a PDE5 inhibitor from Epimedium wanshanense, increases cellular cGMP by enhancing NOS in diabetic ED rats corpus cavernosum tissue

Andrologia

Volumn 44, Issue SUPPL.1, 2012, Pages 87-93

  Zhang, J ^a,c   Wang, Y B ^b   Ma, C G ^a   Liu, T ^c   Li, W R ^c   Gong, Y Q ^c   Xin, Z C ^c  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY SCHOOL AND HOSPITAL OF STOMATOLOGY   (China)

^c PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

CGMP; Erectile dysfunction; Icarisid II; NOS; PDE5 inhibitor

Indexed keywords

APOMORPHINE; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ICARIIN; ICARISID II; INDUCIBLE NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME IMMUNOASSAY; ENZYME INHIBITION; EPIMEDIUM; EPIMEDIUM WANSHANENSE; EXPERIMENTAL DIABETES MELLITUS; IN VITRO STUDY; IN VIVO STUDY; MALE; MEDICINAL PLANT; NONHUMAN; PENIS ERECTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; RAT CORPUS CAVERNOSUM TISSUE; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; TISSUE CULTURE; WESTERN BLOTTING;

ANIMALS; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; DIABETES COMPLICATIONS; EPIMEDIUM; ERECTILE DYSFUNCTION; FLAVONOIDS; MALE; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, WISTAR;

EID: 84861515076     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/j.1439-0272.2010.01144.x     Document Type: Article

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