Anti-inflammatory effects of sargachromenol-rich ethanolic extract of Myagropsis myagroides on lipopolysaccharide-stimulated BV-2 cells

BMC Complementary and Alternative Medicine

Volumn 14, Issue , 2014, Pages

  Kim, Sunghee ^a   Lee, Min Sup ^a   Lee, Bonggi ^b   Gwon, Wi Gyeong ^a   Joung, Eun Ji ^a   Yoon, Na Young ^c   Kim, Hyeung Rak ^a  

^a Pukyong National University   (South Korea)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c National Fisheries Research and Development Institute (NFRDI)   (South Korea)

Author keywords

Microglia; Myagropsis myagroides; Neuroinflammation; Nuclear factor B; Pro inflammatory cytokine; Sargachromenol

Indexed keywords

ALCOHOL; CYCLOOXYGENASE 2; CYTOKINE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MYAGROPSIS MYAGROIDES ETHANOLIC EXTRACT; NITRIC OXIDE; PHLOROGLUCINOL; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; PROSTAGLANDIN E2; PROTEIN KINASE B; SARGACHROMENOL; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; BENZOPYRAN DERIVATIVE; ALGAL EXTRACT; MYAGROPSIS MYAGROIDES EXTRACT;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BROWN ALGA; CELL LINE; CELL STIMULATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DETERMINATION; DRUG INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GRIESS ASSAY; IMMUNOASSAY; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; MEDICINAL PLANT; MICROGLIA; MYAGROPSIS MYAGROIDES; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPORTER GENE; TRANSCRIPTION INITIATION; WESTERN BLOTTING; ANALYSIS OF VARIANCE; ANIMAL; CHEMISTRY; DRUG EFFECTS; METABOLISM; MOUSE; SIGNAL TRANSDUCTION; DRUG IDENTIFICATION; PROTEIN LOCALIZATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; EDEMA; ENZYME ASSAYS; ENZYME INHIBITORS; FEMALE; HUMANS; LIPOXYGENASE; MALE; PLANT EXTRACTS; POLYGONUM; RATS; RATS, WISTAR; ANALYSIS OF VARIANCE; BENZOPYRANS; CELL LINE; CYTOKINES; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHAEOPHYTA; SIGNAL TRANSDUCTION;

EID: 84903875785     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-231     Document Type: Article

References (40)

1. Bonaiuto C, McDonald PP, Rossi F, Cassatella MA. Activation of nuclear factor-κB by β-amyloid peptides and interferon-γ in murine microglia. J Neuroimmunol 1997, 77:51-56. 10.1016/S0165-5728(97)00054-4, 9209268.
2. Qin L, Li G, Qian X, Liu Y, Wu X, Liu B, Hong JS, Block ML. Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation. Glia 2005, 52:78-84. 10.1002/glia.20225, 15920727.
3. Bianchi R, Giambanco I, Donato R. S100B/RAGE-dependent activation of microglia via NF- κB and AP-1 Co-regulation of COX-2 expression by S100B, IL-1β and TNF-α. Neurobiol Aging 2010, 31:665-677. 10.1016/j.neurobiolaging.2008.05.017, 18599158.
4. Dheen ST, Kaur C, Ling EA. Microglial activation and its implications in the brain diseases. Curr Med Chem 2007, 14:1189-1197. 10.2174/092986707780597961, 17504139.
5. Gonzalez-Scarano F, Baltuch G. Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci 1999, 22:219-240. 10.1146/annurev.neuro.22.1.219, 10202538.
6. Teismann P, Tieu K, Cohen O, Choi DK, Wu DC, Marks D, Vila M, Jackson-Lewis V, Przedborski S. Pathogenic role of glial cells in Parkinson's disease. MovDisord 2003, 18:121-129.
7. D'Acquisto F, Iuvone T, Rombola L, Sautebin L, Di Rosa M, Carnuccio R. Involvement of NF-κB in the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages. FEBS Lett 1997, 418:175-178. 10.1016/S0014-5793(97)01377-X, 9414121.
8. Marks-Konczalik J, Chu SC, Moss J. Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor κB-binding sites. J Biol Chem 1998, 273:22201-22208. 10.1074/jbc.273.35.22201, 9712833.
9. Kim AR, Lee MS, Shin TS, Hua H, Jang BC, Choi JS, Byun DS, Utsuki T, Ingram D, Kim HR. Phlorofucofuroeckol A inhibits the LPS-stimulated iNOS and COX-2 expressions in macrophages via inhibition of NF-κB, Akt, and p38 MAPK. Toxicol In Vitro 2011, 25:1789-1795. 10.1016/j.tiv.2011.09.012, 21963823.
10. Makarov SS. NF-κB in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction. Arthritis Res 2001, 3:200-206. 10.1186/ar300, 128895, 11438035.
11. Janssen-Heininger YM, Poynter ME, Baeuerle PA. Recent advances towards understanding redox mechanisms in the activation of nuclear factor κB. Free Radic Biol Med 2000, 28:1317-1327. 10.1016/S0891-5849(00)00218-5, 10924851.
12. Zeng KW, Wang S, Dong X, Jiang Y, Tu PF. Sesquiterpene dimer (DSF-52) from Artemisia argyi inhibits microglia-mediated neuroinflammation via suppression of NF-κB, JNK/p38 MAPKs and Jak2/Stat3 signaling pathways. Phytomedicine 2014, 21:298-306. 10.1016/j.phymed.2013.08.016, 24055519.
13. Herlaar E, Brown Z. p38 MAPK signalling cascades in inflammatory disease. Mol Med Today 1999, 5:439-447. 10.1016/S1357-4310(99)01544-0, 10498912.
14. Kim AR, Shin TS, Lee MS, Park JY, Park KE, Yoon NY, Kim JS, Choi JS, Jang BC, Byun DS, Park NK, Kim HR. Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and anti-inflammatory properties. J Agric Food Chem 2009, 57:3483-3489. 10.1021/jf900820x, 19338274.
15. Lee MS, Kwon MS, Choi JW, Shin T, No HK, Choi JS, Byun DS, Kim JI, Kim HR. Anti-inflammatory activities of an ethanol extract of Ecklonia stolonifera in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. J Agric Food Chem 2012, 60:9120-9129. 10.1021/jf3022018, 22897701.
16. Lee MS, Shin T, Utsuki T, Choi JS, Byun DS, Kim HR. Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and hepatoprotective properties in tacrine-treated HepG2 cells. J Agric Food Chem 2012, 60:5340-5349. 10.1021/jf300157w, 22587607.
17. Kang JY, Khan MN, Park NH, Cho JY, Lee MC, Fujii H, Hong YK. Antipyretic, analgesic, and anti-inflammatory activities of the seaweed Sargassum fulvellum and Sargassum thunbergii in mice. J Ethnopharmacol 2008, 116:187-190. 10.1016/j.jep.2007.10.032, 18079077.
18. Khan MN, Lee MC, Kang JY, Park NG, Fujii H, Hong YK. Effects of the brown seaweed Undaria pinnatifida on erythematous inflammation assessed using digital photo analysis. Phytother Res 2008, 22:634-639. 10.1002/ptr.2349, 18384198.
19. Lee HS, Ryu DS, Lee GS, Lee DS. Anti-inflammatory effects of dichloromethane fraction from Orostachysjaponicus in RAW 264.7 cells: suppression of NF-κB activation and MAPK signaling. J Ethnopharmacol 2012, 140:271-276. 10.1016/j.jep.2012.01.016, 22285522.
20. Lee JY, Lee MS, Choi HJ, Choi JW, Shin T, Woo HC, Kim JI, Kim HR. Hexane fraction from Laminaria japonica exerts anti-inflammatory effects on lipopolysaccharide-stimulated RAW 264.7 macrophages via inhibiting NF-kappaB pathway. Eur J Nutr 2013, 52:409-421. 10.1007/s00394-012-0345-1, 22476925.
21. Joung EJ, Lee MS, Choi JW, Kim JS, Shin T, Jung BM, Kim JI, Kim HR. Anti-inflammatory effects of phlorofucofuroeckol B-rich ethyl acetate fraction obtained from Myagropsis myagroides on lipopolysaccharide-stimulated RAW 264.7 cells and mouse edema. Int Immunopharmacol 2012, 14:471-480. 10.1016/j.intimp.2012.08.021, 22974580.
22. Joung EJ, Lee MS, Choi JW, Kim JS, Shin T, Jung BM, Yoon NY, Lim CW, Kim JI, Kim HR. Anti-inflammatory effect of ethanolic extract from Myagropsis myagroides on murine macrophages and mouse ear edema. BMC Complement Altern Med 2012, 12:171. 10.1186/1472-6882-12-171, 3517429, 23031211.
23. Kim JA, Ahn BN, Kong CS, Kim SK. Protective effect of chromene isolated from Sargassum horneri against UV-A-induced damage in skin dermal fibroblasts. Exp Dermatol 2012, 21:630-631. 10.1111/j.1600-0625.2012.01535.x, 22775999.
24. Choi BW, Ryu G, Park SH, Kim ES, Shin J, Roh SS, Shin HC, Lee BH. Anticholinesterase activity of plastoquinones from Sargassum sagamianum: lead compounds for Alzheimer's disease therapy. Phytother Res 2007, 21:423-426. 10.1002/ptr.2090, 17236179.
25. Tsang CK, Ina A, Goto T, Kamei Y. Sargachromenol, a novel nerve growth factor-potentiating substance isolated from Sargassum macrocarpum, promotes neurite outgrowth and survival via distinct signaling pathways in PC12D cells. Neuroscience 2005, 132:633-643. 10.1016/j.neuroscience.2005.01.028, 15837125.
26. Henn A, Lund S, Hedtjarn M, Schrattenholz A, Porzgen P, Leist M. The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation. ALTEX 2009, 26:83-94.
27. Jayasooriya RG, Lee KT, Lee HJ, Choi YH, Jeong JW, Kim GY. Anti-inflammatory effects of beta-hydroxyisovalerylshikonin in BV2 microglia are mediated through suppression of the PI3K/Akt/NF-κB pathway and activation of the Nrf2/HO-1 pathway. Food Chem Toxicol 2014, 65:82-89.
28. Koivikko R, Loponen J, Honkanen T, Jormalainen V. Contents of soluble, cell-wall-bound and exuded phlorotannins in the brown alga Fucus vesiculosus, with implications on their ecological functions. J Chem Ecol 2005, 31:195-212. 10.1007/s10886-005-0984-2, 15839490.
29. Wang T, Jónsdóttir R, Ólafsdóttir G. Total phenolic compounds, radical scavenging and metal chelation of extracts from Icelandic seaweeds. Food Chem 2009, 116:240-248.
30. Conner EM, Grisham MB. Inflammation, free radicals, and antioxidants. Nutrition 1996, 12:274-277. 10.1016/S0899-9007(96)00000-8, 8862535.
31. Haslam E. Natural polyphenols (vegetable tannins) as drugs: possible modes of action. J Nat Prod 1996, 59:205-215. 10.1021/np960040+, 8991956.
32. Heo SJ, Yoon WJ, Kim KN, Ahn GN, Kang SM, Kang DH, Affan A, Oh C, Jung WK, Jeon YJ. Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages. Food Chem Toxicol 2010, 48:2045-2051. 10.1016/j.fct.2010.05.003, 20457205.
33. Kim S, Kim JI, Choi JW, Kim M, Yoon NY, Choi CG, Choi JS, Kim HR. Anti-inflammatory effect of hexane fraction from Myagropsis myagroides ethanolic extract in lipopolysaccharide-stimulated BV-2 microglial cells. J Pharm Pharmacol 2013, 65:895-906. 10.1111/jphp.12049, 23647683.
34. Meda L, Cassatella MA, Szendrei GI, Otvos L, Baron P, Villalba M, Ferrari D, Rossi F. Activation of microglial cells by β-amyloid protein and interferon-γ. Nature 1995, 374:647-650. 10.1038/374647a0, 7715705.
35. Oh YT, Lee JY, Lee J, Kim H, Yoon KS, Choe W, Kang I. Oleic acid reduces lipopolysaccharide-induced expression of iNOS and COX-2 in BV2 murine microglial cells: possible involvement of reactive oxygen species, p38 MAPK, and IKK/NF-κB signaling pathways. Neurosci Lett 2009, 464:93-97. 10.1016/j.neulet.2009.08.040, 19699266.
36. Raivich G, Bohatschek M, Kloss CU, Werner A, Jones LL, Kreutzberg GW. Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function. Brain Res Brain Res Rev 1999, 30:77-105. 10.1016/S0165-0173(99)00007-7, 10407127.
37. Pahan K, Sheikh FG, Liu X, Hilger S, McKinney M, Petro TM. Induction of nitric- oxide synthase and activation of NF-κB by interleukin-12 p40 in microglial cells. J Biol Chem 2001, 276:7899-7905. 10.1074/jbc.M008262200, 2041874, 11110796.
38. Kim AR, Lee MS, Choi JW, Utsuki T, Kim JI, Jang BC, Kim HR. Phlorofucofuroeckol A suppresses expression of inducible nitric oxide synthase, cyclooxygenase-2, and pro-inflammatory cytokines via inhibition of nuclear factor-κB, c-Jun NH2-terminal kinases, and Akt in microglial cells. Inflammation 2013, 36:259-271. 10.1007/s10753-012-9542-6, 22993079.
39. Gwon WG, Lee MS, Kim JS, Kim JI, Lim CW, Kim NG, Kim HR. Hexane fraction from Sargassum fulvellum inhibits lipopolysaccharide-induced inducible nitric oxide synthase expression in RAW 264.7 cells via NF-κB pathways. Am J Chin Med 2013, 41:565-584. 10.1142/S0192415X13500407, 23711142.
40. Chen Z, Hagler J, Palombella VJ, Melandri F, Scherer D, Ballard D, Maniatis T. Signal-induced site-specific phosphorylation targets IkBα to the ubiquitin-proteasome pathway. Genes Dev 1995, 9:1586-1597. 10.1101/gad.9.13.1586, 7628694.