Effects of icariside II on corpus cavernosum and major pelvic ganglion neuropathy in streptozotocin-induced diabetic rats

International Journal of Molecular Sciences

Volumn 15, Issue 12, 2014, Pages 23294-23306

  Bai, Guang Yi ^a   Zhou, Feng ^a,b   Hui, Yu ^b   Xu, Yong De ^a   Lei, Hong En ^a   Pu, Jin Xian ^b   Xin, Zhong Cheng ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Diabetes; Erectile dysfunction; Icariside II; Major pelvic ganglion; Neuropathy; NGF; NNOS

Indexed keywords

ICARIIN; ICARISIDE II; NERVE GROWTH FACTOR; NEURONAL NITRIC OXIDE SYNTHASE; STREPTOZOCIN; UNCLASSIFIED DRUG; BAOHUOSIDE I; FLAVONOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DIABETES MELLITUS; ELECTROSTIMULATION; ERECTILE DYSFUNCTION; GANGLION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MAJOR PELVIC NERVE GANGLION; MALE; MEAN ARTERIAL PRESSURE; NERVE FIBER; NERVE STIMULATION; NEUROPATHY; NONHUMAN; PELVIC GANGLION NEUROPATHY; PROTEIN EXPRESSION; RAT; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL; DIABETIC NEUROPATHIES; DRUG EFFECTS; GENETICS; INNERVATION; METABOLISM; PELVIS; PENIS; SPINAL NERVE; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANIMALIA; RATTUS;

ANIMALS; DIABETIC NEUROPATHIES; FLAVONOIDS; MALE; NERVE GROWTH FACTOR; NITRIC OXIDE SYNTHASE TYPE I; PELVIS; PENIS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL NERVES;

EID: 84918506002     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms151223294     Document Type: Article

References (27)

1. Shamloul, R.; Ghanem, H. Erectile dysfunction. Lancet2013, 381, 153–165.
2. Andersen, M.L.; Guindalini, C.; Tufik, S. Genetics of erectile dysfunction: A review of the interface between sex and molecular biomarkers. J. Sex. Med. 2011, 8, 3030–3039.
3. Lopushnyan, N.A.; Chitaley, K. Genetics of erectile dysfunction. J. Urol. 2012, 188, 1676–1683.
4. Fedele, D. Therapy Insight: Sexual and bladder dysfunction associated with diabetes mellitus. Nat. Clin. Pract. Urol. 2005, 2, 282–290.
5. Adeniyi, A.F.; Adeleye, J.O.; Adeniyi, C.Y. Diabetes, sexual dysfunction and therapeutic exercise: A 20 year review. Curr. Diabetes Rev. 2010, 6, 201–206.
6. Zhao, Y.; Zhang, L.; Qiao, Y.; Zhou, X.; Wu, G.; Wang, L.; Peng, Y.; Dong, X.; Huang, H.; Si, L.; et al. Heme oxygenase-1 prevents cardiac dysfunction in streptozotocin-diabetic mice by reducing inflammation, oxidative stress, apoptosis and enhancing autophagy. PLoS One2013, 8, e75927.
7. Angulo, J.; Wright, H.M.; Cuevas, P.; Gonzalez-Corrochano, R.; Fernandez, A.; Cuevas, B.; La Fuente, J.M.; Gupta, S.; Saenz de Tejada, I. Nebivolol dilates human penile arteries and reverses erectile dysfunction in diabetic rats through enhancement of nitric oxide signaling. J. Sex. Med. 2010, 7, 2681–2697.
8. Vickers, M.A.; Satyanarayana, R. Phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction in patients with diabetes mellitus. Int. J. Impot. Res. 2002, 14, 466–471.
9. Harraz, A.; Shindel, A.W.; Lue, T.F. Emerging gene and stem cell therapies for the treatment of erectile dysfunction. Nat. Rev. Urol. 2010, 7, 143–152.
10. Wong, M.S.; Hawthorne, W.J.; Manolios, N. Gene therapy in diabetes. Self Nonself2010, 1, 165–175.
11. Albersen, M.; Lin, G.; Fandel, T.M.; Zhang, H.; Qiu, X.; Lin, C.S.; Lue, T.F. Functional, Metabolic, and Morphologic Characteristics of a Novel Rat Model of Type 2 Diabetes-associated Erectile Dysfunction. Urology2011, 78, 476.e1–476.e8.
12. Lau, D.H.; Kommu, S.S.; Siddiqui, E.J.; Thompson, C.S.; Morgan, R.J.; Mikhailidis, D.P.; Mumtaz, F.H. Gene therapy and erectile dysfunction: The current status. Asian J. Androl. 2007, 9, 8–15.
13. Bahk, J.Y.; Jung, J.H.; Han, H.; Min, S.K.; Lee, Y.S. Treatment of diabetic impotence with umbilical cord blood stem cell intracavernosal transplant: preliminary report of 7 cases. Exp. Clin. Transplant. 2010, 8, 150–160.
14. Jin, H.R.; Kim, W.J.; Song, J.S.; Piao, S.; Choi, M.J.; Tumurbaatar, M.; Shin, S.H.; Yin, G.N.; Koh, G.Y.; Ryu, J.K.; et al. Intracavernous delivery of a designed angiopoietin-1 variant rescues erectile function by enhancing endothelial regeneration in the streptozotocin-induced diabetic mouse. Diabetes2011, 60, 969–980.
15. Xin, Z.C.; Kim, E.K.; Lin, C.S.; Liu, W.J.; Tian, L.; Yuan, Y.M.; Fu, J. Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian J. Androl. 2003, 5, 15–18.
16. Liu, T.; Xin, H.; Li, W.R.; Zhou, F.; Li, G.Y.; Gong, Y.Q.; Gao, Z.Z.; Qin, X.C.; Cui, W.S.; Shindel, A.W.; et al. Effects of icariin on improving erectile function in streptozotocin-induced diabetic rats. J. Sex. Med. 2011, 8, 2761–2772.
17. Zhou, F.; Xin, H.; Liu, T.; Li, G.Y.; Gao, Z.Z.; Liu, J.; Li, W.R.; Cui, W.S.; Bai, G.Y.; Park, N.C.; et al. Effects of icariside II on improving erectile function in rats with streptozotocin-induced diabetes. J. Androl. 2012, 33, 832–844.
18. Musicki, B.; Ross, A.E.; Champion, H.C.; Burnett, A.L.; Bivalacqua, T.J. Posttranslational modification of constitutive nitric oxide synthase in the penis. J. Androl. 2009, 30, 352–362.
19. Shindel, A.W.; Xin, Z.C.; Lin, G.; Fandel, T.M.; Huang, Y.C.; Banie, L.; Breyer, B.N.; Garcia, M.M.; Lin, C.S.; Lue, T.F. Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo. J. Sex. Med. 2010, 7, 1518–1528.
20. Miner, M.; Seftel, A.D.; Nehra, A.; Ganz, P.; Kloner, R.A.; Montorsi, P.; Vlachopoulos, C.; Ramsey, M.; Sigman, M.; Tilkemeier, P.; et al. Prognostic utility of erectile dysfunction for cardiovascular disease in younger men and those with diabetes. Am. Heart J. 2012, 164, 21–28.
21. Nehra, A.; Jackson, G.; Miner, M.; Billups, K.L.; Burnett, A.L.; Buvat, J.; Carson, C.C.; Cunningham, G.R.; Goldstein, I.; Guay, A.T.; et al. Diagnosis and treatment of erectile dysfunction for reduction of cardiovascular risk. J. Urol. 2013, 189, 2031–2038.
22. Ning, H.; Xin, Z.C.; Lin, G.; Banie, L.; Lue, T.F.; Lin, C.S. Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology2006, 68, 1350–1354.
23. Dell’Agli, M.; Galli, G.V.; dal Cero, E.; Belluti, F.; Matera, R.; Zironi, E.; Pagliuca, G.; Bosisio, E. Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J. Nat. Prod. 2008, 71, 1513–1517.
24. Zhang, J.; Wang, Y.B.; Ma, C.G.; Liu, T.; Li, W.R.; Gong, Y.Q.; Xin, Z.C. Icarisid II, a PDE5 inhibitor from Epimedium wanshanense, increases cellular cGMP by enhancing NOS in diabetic ED rats corpus cavernosum tissue. Andrologia2012, 44, 87–93.
25. Lin, G.; Chen, K.C.; Hsieh, P.S.; Yeh, C.H.; Lue, T.F.; Lin, C.S. Neurotrophic effects of vascular endothelial growth factor and neurotrophins on cultured major pelvic ganglia. BJU Int. 2003, 92, 631–635.
26. Lin, G.; Bella, A.J.; Lue, T.F.; Lin, C.S. Brain-derived neurotrophic factor (BDNF) acts primarily via the JAK/STAT pathway to promote neurite growth in the major pelvic ganglion of the rat: Part 2. J. Sex. Med. 2006, 3, 821–827.
27. Xia, Q.; Xu, D.; Huang, Z.; Liu, J.; Wang, X.; Liu, S. Preparation of icariside II from icariin by enzymatic hydrolysis method. Fitoterapia2010, 81, 437–442.