Cognitive decline in STZ-3V rats is largely due to dysfunctional insulin signalling through the dentate gyrus

Behavioural Brain Research

Volumn 229, Issue 2, 2012, Pages 378-383

  Shingo, Akiko Sheala ^a   Kanabayashi, Tomomichi ^b   Murase, Toshio ^a   Kito, Shozo ^c  

^a Okinaka Memorial Institute for Medical Research   (Japan)

^b Biopathology Institute   (Japan)

^c Doai kai Ozawa Hospital   (Japan)

Author keywords

Cognition; Dentate gyrus; Hippocampus; Insulin degrading enzyme; Morris water maze; Streptozotocin

Indexed keywords

AMYLOID BETA PROTEIN; CYCLIC AMP BINDING PROTEIN; INSULIN; INSULINASE; PHOSPHOPROTEIN; PROTEIN KINASE B; STREPTOZOCIN;

ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN DYSFUNCTION; COGNITIVE DEFECT; CONTROLLED STUDY; DENTATE GYRUS; DIABETES MELLITUS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LATENT PERIOD; MALE; MAZE TEST; MENTAL PERFORMANCE; MENTAL TASK; NEUROCHEMISTRY; NONHUMAN; PATH EFFICIENCY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; SWIMMING;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; COGNITION DISORDERS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DENTATE GYRUS; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; INJECTIONS, INTRAVENTRICULAR; INSULIN; INSULYSIN; MALE; MAZE LEARNING; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; STREPTOZOCIN;

EID: 84857783229     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.01.034     Document Type: Article

References (37)

1. Hoyer S. Oxidative energy metabolism in Alzheimer brain. Studies in early-onset and late-onset cases. Mol Chem Neuropathol 1992, 16:207-224.
2. Meier-Ruge W., Bertoni-Freddari C., Iwangoff P. Changes in brain glucose metabolism as a key to the pathogenesis of Alzheimer's disease. Gerontology 1994, 40:246-252.
3. Plata-Salaman C.R. Insulin in the cerebrospinal fluid. Neurosci Biobehav Rev 1991, 15:243-258.
4. Schechter R., Whitmire J., Holtzclaw L., George M., Harlow R., Devaskar S.U. Developmental regulation of insulin in the mammalian central nervous system. Brain Res 1992, 582:27-37.
5. Schechter R., Beju D., Gaffney T., Schaefer F., Whetsell L. Preproinsulin I and II mRNAs and insulin electron microscopic immunoreaction are present within the rat foetal nervous system. Brain Res 1996, 736:16-27.
6. Schechter R., Abboud M. Neuronal synthesized insulin roles on neural differentiation within foetal rat neuron cell cultures. Brain Res Dev Brain Res 2001, 127:41-49.
7. Devaskar S.U., Giddings S.J., Rajakumar P.A., Carnaghi L.R., Menon R.K., Zahm D.S. Insulin gene expression and insulin synthesis in mammalian neuronal cells. J Biol Chem 1994, 269:8445-8454.
8. Gerozissis K. Brain insulin: regulation, mechanisms of action and functions. Cell Mol Neurobiol 2003, 23:1-25.
9. Gerozissis K. Function (and dysfunctions) of insulin in the brain. J Japan Diab Soc 2009, 52:333-339.
10. Banks W.A. The source of cerebral insulin. Eur J Pharmacol 2004, 490:5-12.
11. Santos M.S., Pereira E.M., Carvaho A.P. Stimulation of immunoreactive insulin release by glucose in rat brain synaptosomes. Neurochem Res 1999, 24:33-36.
12. Bolzán A.D., Bianchi M.S. Genotoxicity of streptozotocin. Mutat Res 2002, 512:121-134.
13. Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 2001, 50:537-546.
14. de la Monte S.M., Wands J.R. Alzheimer's disease is type 3 diabetes-evidence reviewed. J Diabetes Sci Technol 2008, 2:1101-1113.
15. Arluison M., Quignon M., Nguyen P., Thorens B., Leloup C., Penicaud L. Distribution and anatomical localization of the glucose transporter 2 (GLUT2) in the adult rat brain-an immunohistochemical study. J Chem Neuroanat 2004, 28:117-136.
16. Brant A.M., Jess T.J., Milligan G., Brown C.M., Gould G.W. Immunological analysis of glucose transporters expressed in different regions of the rat brain and central nervous system. BBRC 1993, 192:1297-1302.
17. Leloup C., Arluison M., Lepetit N., Cartier N., Marfaing-Jallat P., Ferré P., et al. Glucose transporter 2 (GLUT 2): expression in specific brain nuclei. Brain Res 1994, 638:221-226.
18. Ngarmukos C., Baur E.L., Kumagai A.K. Co-localization of GLUT1 and GLUT4 in the blood-brain barrier of the rat ventromedial hypothalamus. Brain Res 2001, 900:1-8.
19. Nitsch R., Hoyer S. Local action of the diabetogenic drug, streptozotocin, on glucose and energy metabolism in rat brain cortex. Neurosci Lett 1991, 128:199-202.
20. Hoyer S., Nitsch R., Oesterreich K. Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: a cross-sectional comparison against advanced late-onset and incipient early-onset cases. J Neural Transm Park Dis Dement Sect 1991, 3:1-14.
21. Blokland A., Jolles J. Spatial learning deficit and reduced hippocampal ChAT activity in rats after an ICV injection of streptozotocin. Pharmacol Biochem Behav 1993, 44:491-494.
22. Barbaccia M.L., Chuang D.M., Costa E. Is insulin a neuromodulator?. Adv Biochem Psychopharmacol 1982, 33:511-518.
23. Boyd F.T., Clarke D.W., Raizada M.K. Insulin inhibits specific norepinephrine uptake in neuronal cultures from rat brain. Brain Res 1986, 398:1-5.
24. Gispen W.H., Biessels G.J. Cognition and synaptic plasticity in diabetes mellitus. Trend Neurosci 2000, 23:542-549.
25. Jonas E.A., Knox R.J., Smith T.C., Wayne N.L., Connor J.A., Kaczmarek L.K. Regulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretion. Nature 1997, 385:343-346.
26. Wan Q., Xiong Z.G., Man H.Y., Ackerley C.A., Braunton J., Lu W.Y., et al. Recruitment of functional GABA(A) receptors to postsynaptic domains by insulin. Nature 1997, 388:686-690.
27. Agrawal R., Tyagi E., Shukla R., Nath C. Insulin receptor signaling in rat hippocampus: a study in STZ (ICV) induced memory deficit model. Eur Neuropsychopharmacol 2011, 21:261-273.
28. Hawkins B.T., Ocheltree S.M., Norwood K.M., Egleton R.D. Decreased blood-brain barrier permeability to fluorescein in streptozotocin-treated rats. Neurosci Lett 2007, 411:1-5.
29. Barco A., Pittenger C., Kandel E.R. CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospects. Expert Opin Ther Targets 2003, 7:101-114.
30. Yamamoto-Sasaki M., Ozawa H., Saito T., Rösler M., Riederer P. Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type. Brain Res 1999, 824:300-303.
31. Dineley K.T., Westerman M., Bui D., Bell K., Ashe K.H., Sweatt J.D. Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: in vitro and in vivo mechanisms related to Alzheimer's disease. J Neurosci 2001, 21:4125-4133.
32. Grünblatt E., Salkovic-Petrisic M., Osmanovic J., Riederer P., Hoyer S. Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein. J Neurochem 2007, 101:757-770.
33. Liang Z., Liu F., Grundke-Iqbal I., Iqbal K., Gong C.-X. Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain. J Neurochem 2007, 103:2462-2470.
34. Grillo C.A., Piroli G.G., Hendry R.M., Reagan L.P. Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent. Brain Res 2009, 1296:35-45.
35. Duckworth W.C. Insulin degradation: mechanisms, products, and significance. Endocr Rev 1988, 9:319-345.
36. Bernstein H.-G., Lendeckel U., Bukowska A., Ansorge S., Ernst T., Stauch R., et al. Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary. J Chemical Neuroanat 2008, 35:216-224.
37. Kurochkin I.V., Goto S. Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett 1994, 345:33-37.