-
1
-
-
79952574501
-
Epidemiology of Alzheimer disease
-
C. Reitz, C. Brayne, and R. Mayeux, "Epidemiology of Alzheimer disease, " Nature Reviews Neurology, vol. 7, no. 3, pp. 137-152, 2011.
-
(2011)
Nature Reviews Neurology
, vol.7
, Issue.3
, pp. 137-152
-
-
Reitz, C.1
Brayne, C.2
Mayeux, R.3
-
2
-
-
84863337843
-
Alzheimer mechanisms and therapeutic strategies
-
Y. Huang and L. Mucke, "Alzheimer mechanisms and therapeutic strategies, " Cell, vol. 148, no. 6, pp. 1204-1222, 2012.
-
(2012)
Cell
, vol.148
, Issue.6
, pp. 1204-1222
-
-
Huang, Y.1
Mucke, L.2
-
3
-
-
79952747862
-
Alzheimer's disease
-
C. Ballard, S. Gauthier, A. Corbett, C. Brayne, D. Aarsland, and E. Jones, "Alzheimer's disease, " The Lancet, vol. 377, no. 9770, pp. 1019-1031, 2011.
-
(2011)
The Lancet
, vol.377
, Issue.9770
, pp. 1019-1031
-
-
Ballard, C.1
Gauthier, S.2
Corbett, A.3
Brayne, C.4
Aarsland, D.5
Jones, E.6
-
4
-
-
80052266213
-
The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics
-
E. Karran, M. Mercken, and B. D. Strooper, "The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics, " Nature Reviews Drug Discovery, vol. 10, no. 9, pp. 698-712, 2011.
-
(2011)
Nature Reviews Drug Discovery
, vol.10
, Issue.9
, pp. 698-712
-
-
Karran, E.1
Mercken, M.2
Strooper, B.D.3
-
5
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
J. Hardy and D. J. Selkoe, "The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics, " Science, vol. 297, no. 5580, pp. 353-356, 2002.
-
(2002)
Science
, vol.297
, Issue.5580
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
6
-
-
84858046578
-
Neuropathological alterations in Alzheimer disease
-
Article ID
-
A. Serrano-Pozo, M. P. Frosch, E. Masliah, and B. T. Hyman, "Neuropathological alterations in Alzheimer disease, " Cold Spring Harbor Perspectives in Medicine, vol. 1, no. 1, Article ID a006189, 2011.
-
(2011)
Cold Spring Harbor Perspectives in Medicine
, vol.1
, Issue.1
-
-
Serrano-Pozo, A.1
Frosch, M.P.2
Masliah, E.3
Hyman, B.T.4
-
7
-
-
0033739282
-
Apoptosis and Alzheimer's disease
-
C. Behl, "Apoptosis and Alzheimer's disease, " Journal of Neural Transmission, vol. 107, no. 11, pp. 1325-1344, 2000.
-
(2000)
Journal of Neural Transmission
, vol.107
, Issue.11
, pp. 1325-1344
-
-
Behl, C.1
-
8
-
-
14044273642
-
Biomarkers for apoptosis in Alzheimer's disease
-
M. Ankarcrona and B. Winblad, "Biomarkers for apoptosis in Alzheimer's disease, " International Journal of Geriatric Psychiatry, vol. 20, no. 2, pp. 101-105, 2005.
-
(2005)
International Journal of Geriatric Psychiatry
, vol.20
, Issue.2
, pp. 101-105
-
-
Ankarcrona, M.1
Winblad, B.2
-
9
-
-
67650508325
-
Apoptosis and in vitro Alzheimer disease neuronal models
-
P. Calissano, C. Matrone, and G. Amadoro, "Apoptosis and in vitro Alzheimer disease neuronal models, " Communicative and Integrative Biology, vol. 2, no. 2, pp. 163-169, 2009.
-
(2009)
Communicative and Integrative Biology
, vol.2
, Issue.2
, pp. 163-169
-
-
Calissano, P.1
Matrone, C.2
Amadoro, G.3
-
10
-
-
40849135716
-
Apoptotic mechanisms involved in neurodegenerative diseases: Experimental and therapeutic approaches
-
A. Camins, M. Pallas, and J. S. Silvestre, "Apoptotic mechanisms involved in neurodegenerative diseases: experimental and therapeutic approaches, " Methods and Findings in Experimental and Clinical Pharmacology, vol. 30, no. 1, pp. 43-65, 2008.
-
(2008)
Methods and Findings in Experimental and Clinical Pharmacology
, vol.30
, Issue.1
, pp. 43-65
-
-
Camins, A.1
Pallas, M.2
Silvestre, J.S.3
-
11
-
-
0038205745
-
Targeting programmed cell death in neurodegenerative diseases
-
M. Vila and S. Przedborski, "Targeting programmed cell death in neurodegenerative diseases, " Nature Reviews Neuroscience, vol. 4, no. 5, pp. 365-375, 2003.
-
(2003)
Nature Reviews Neuroscience
, vol.4
, Issue.5
, pp. 365-375
-
-
Vila, M.1
Przedborski, S.2
-
12
-
-
17144395975
-
The activation of Akt/PKB signaling pathway and cell survival
-
G. Song, G. Ouyang, and S. Bao, "The activation of Akt/PKB signaling pathway and cell survival, " Journal of Cellular and Molecular Medicine, vol. 9, no. 1, pp. 59-71, 2005.
-
(2005)
Journal of Cellular and Molecular Medicine
, vol.9
, Issue.1
, pp. 59-71
-
-
Song, G.1
Ouyang, G.2
Bao, S.3
-
13
-
-
0034641936
-
Apoptosis in the nervous system
-
J. Yuan and B. A. Yankner, "Apoptosis in the nervous system, " Nature, vol. 407, no. 6805, pp. 802-809, 2000.
-
(2000)
Nature
, vol.407
, Issue.6805
, pp. 802-809
-
-
Yuan, J.1
Yankner, B.A.2
-
14
-
-
78649472934
-
Herba Epimedii: Anti-oxidative properties and its medical implications
-
S. C. Wing Sze, Y. Tong, T. B. Ng, C. L. Yin Cheng, and H. P. Cheung, "Herba Epimedii: anti-oxidative properties and its medical implications, " Molecules, vol. 15, no. 11, pp. 7861-7870, 2010.
-
(2010)
Molecules
, vol.15
, Issue.11
, pp. 7861-7870
-
-
Wing Sze, S.C.1
Tong, Y.2
Ng, T.B.3
Yin Cheng, C.L.4
Cheung, H.P.5
-
15
-
-
77956616914
-
Protective Effects of icariin on brain dysfunction induced by lipopolysaccharide in rats
-
J. Guo, F. Li, Q. Wu, Q. Gong, Y. Lu, and J. Shi, "Protective Effects of icariin on brain dysfunction induced by lipopolysaccharide in rats, " Phytomedicine, vol. 17, no. 12, pp. 950-955, 2010.
-
(2010)
Phytomedicine
, vol.17
, Issue.12
, pp. 950-955
-
-
Guo, J.1
Li, F.2
Wu, Q.3
Gong, Q.4
Lu, Y.5
Shi, J.6
-
16
-
-
77957932118
-
Icariin, a natural favonol glycoside, induces apoptosis in human hepatoma SMMC-7721 cells via a ROS/JNK-dependent mitochondrial pathway
-
S. Li, P. Dong, J. Wang et al., "Icariin, a natural favonol glycoside, induces apoptosis in human hepatoma SMMC-7721 cells via a ROS/JNK-dependent mitochondrial pathway, " Cancer Letters, vol. 298, no. 2, pp. 222-230, 2010.
-
(2010)
Cancer Letters
, vol.298
, Issue.2
, pp. 222-230
-
-
Li, S.1
Dong, P.2
Wang, J.3
-
17
-
-
79958061935
-
Icariin and its derivative, ICT, exert anti-infammatory, anti-tumor Effects, and modulate myeloid derived suppressive cells (MDSCs) functions
-
J. Zhou, J. Wu, X. Chen et al., "Icariin and its derivative, ICT, exert anti-infammatory, anti-tumor Effects, and modulate myeloid derived suppressive cells (MDSCs) functions, " International Immunopharmacology, vol. 11, no. 7, pp. 890-898, 2011.
-
(2011)
International Immunopharmacology
, vol.11
, Issue.7
, pp. 890-898
-
-
Zhou, J.1
Wu, J.2
Chen, X.3
-
18
-
-
33947319498
-
Neuropro-tective Effects of icaritin against beta amyloid-induced neuro-toxicity in primary cultured rat neuronal cells via estrogen-dependent pathway
-
Z. Wang, X. Zhang, H. Wang, L. Qi, and Y. Lou, "Neuropro-tective Effects of icaritin against beta amyloid-induced neuro-toxicity in primary cultured rat neuronal cells via estrogen-dependent pathway, " Neuroscience, vol. 145, no. 3, pp. 911-922, 2007.
-
(2007)
Neuroscience
, vol.145
, Issue.3
, pp. 911-922
-
-
Wang, Z.1
Zhang, X.2
Wang, H.3
Qi, L.4
Lou, Y.5
-
19
-
-
84872936076
-
Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)
-
L. Yang, D. Lu, J. Guo, X. Meng, G. Zhang, and F. Wang, "Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19), " Journal of Ethnopharmacology, vol. 145, no. 3, pp. 715-721, 2013.
-
(2013)
Journal of Ethnopharmacology
, vol.145
, Issue.3
, pp. 715-721
-
-
Yang, L.1
Lu, D.2
Guo, J.3
Meng, X.4
Zhang, G.5
Wang, F.6
-
20
-
-
70849136305
-
Icariin inhibits beta-amyloid peptide segment 25-35 induced expression of beta-secretase in rat hippocampus
-
J. Nie, Y. Luo, X.-N. Huang, Q.-H. Gong, Q. Wu, and J.-S. Shi, "Icariin inhibits beta-amyloid peptide segment 25-35 induced expression of beta-secretase in rat hippocampus, " European Journal of Pharmacology, vol. 626, no. 2-3, pp. 213-218, 2010.
-
(2010)
European Journal of Pharmacology
, vol.626
, Issue.2-3
, pp. 213-218
-
-
Nie, J.1
Luo, Y.2
Huang, X.-N.3
Gong, Q.-H.4
Wu, Q.5
Shi, J.-S.6
-
21
-
-
78049443933
-
Icariin improves memory impairment in Alzheimer's disease model mice (5xFAD) and attenuates amyloid induced neurite atrophy
-
T. Urano and C. Tohda, "Icariin improves memory impairment in Alzheimer's disease model mice (5xFAD) and attenuates amyloid induced neurite atrophy, " Phytotherapy Research, vol. 24, no. 11, pp. 1658-1663, 2010.
-
(2010)
Phytotherapy Research
, vol.24
, Issue.11
, pp. 1658-1663
-
-
Urano, T.1
Tohda, C.2
-
22
-
-
77952104760
-
Neuroprotec-tive Effects of icariin on memory impairment and neurochem-ical defcits in senescence-accelerated mouse prone 8 (SAMP8) mice
-
X.-L. He, W.-Q. Zhou, M.-G. Bi, and G.-H. Du, "Neuroprotec-tive Effects of icariin on memory impairment and neurochem-ical defcits in senescence-accelerated mouse prone 8 (SAMP8) mice, " Brain Research, vol. 1334, pp. 73-83, 2010.
-
(2010)
Brain Research
, vol.1334
, pp. 73-83
-
-
He, X.-L.1
Zhou, W.-Q.2
Bi, M.-G.3
Du, G.-H.4
-
23
-
-
77956920667
-
Icariin attenuates amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells
-
K.-W. Zeng, H. Ko, H. O. Yang, and X.-M. Wang, "Icariin attenuates amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells, " Neuropharma-cology, vol. 59, no. 6, pp. 542-550, 2010.
-
(2010)
Neuropharma-cology
, vol.59
, Issue.6
, pp. 542-550
-
-
Zeng, K.-W.1
Ko, H.2
Yang, H.O.3
Wang, X.-M.4
-
24
-
-
84866455174
-
Icariin inhibits corticosterone-induced apoptosis in hypothalamic neurons via the PI3-K/Akt signaling pathway
-
H. Zhang, B. Liu, J. Wu et al., "Icariin inhibits corticosterone-induced apoptosis in hypothalamic neurons via the PI3-K/Akt signaling pathway, " Molecular Medicine Reports, vol. 6, no. 5, pp. 967-972, 2012.
-
(2012)
Molecular Medicine Reports
, vol.6
, Issue.5
, pp. 967-972
-
-
Zhang, H.1
Liu, B.2
Wu, J.3
-
25
-
-
84872485542
-
Evidence of early involvement of apoptosis inducing factor-induced neuronal death in Alzheimer brain
-
J.-H. Lee, Y.-H. Cheon, R.-S. Woo, D.-Y. Song, C. Moon, and T.-K. Baik, "Evidence of early involvement of apoptosis inducing factor-induced neuronal death in Alzheimer brain, " Anatomy & Cell Biology, vol. 45, no. 1, pp. 26-37, 2012.
-
(2012)
Anatomy & Cell Biology
, vol.45
, Issue.1
, pp. 26-37
-
-
Lee, J.-H.1
Cheon, Y.-H.2
Woo, R.-S.3
Song, D.-Y.4
Moon, C.5
Baik, T.-K.6
-
26
-
-
77952048948
-
Evidence for the involvement of apoptosis-inducing factor-mediated caspase-independent neuronal death in Alzheimer disease
-
W. Yu, N. Mechawar, S. Krantic, and R. Quirion, "Evidence for the involvement of apoptosis-inducing factor-mediated caspase-independent neuronal death in Alzheimer disease, " The American Journal of Pathology, vol. 176, no. 5, pp. 2209-2218, 2010.
-
(2010)
The American Journal of Pathology
, vol.176
, Issue.5
, pp. 2209-2218
-
-
Yu, W.1
Mechawar, N.2
Krantic, S.3
Quirion, R.4
-
27
-
-
1342326749
-
Increased apoptotic cell death in sporadic and genetic Alzheimer's disease
-
A. Eckert, C. A. Marques, U. Keil, K. Schüssel, and W. E. Müller, "Increased apoptotic cell death in sporadic and genetic Alzheimer's disease, " Annals of the New York Academy of Sciences, vol. 1010, pp. 604-609, 2003.
-
(2003)
Annals of the New York Academy of Sciences
, vol.1010
, pp. 604-609
-
-
Eckert, A.1
Marques, C.A.2
Keil, U.3
Schüssel, K.4
Müller, W.E.5
-
28
-
-
0029120647
-
Evidence for apoptotic cell death in Alzheimer's disease
-
G. Smale, N. R. Nichols, D. R. Brady, C. E. Finch, and W. E. Horton Jr., "Evidence for apoptotic cell death in Alzheimer's disease, " Experimental Neurology, vol. 133, no. 2, pp. 225-230, 1995.
-
(1995)
Experimental Neurology
, vol.133
, Issue.2
, pp. 225-230
-
-
Smale, G.1
Nichols, N.R.2
Brady, D.R.3
Finch, C.E.4
Horton, W.E.5
-
29
-
-
77951150250
-
Neuronal death in Alzheimer's disease and therapeutic opportunities
-
R. Donev, M. Kolev, B. Millet, and J. Tome, "Neuronal death in Alzheimer's disease and therapeutic opportunities, " Journal of Cellular and Molecular Medicine, vol. 13, no. 11-12, pp. 4329-4348, 2009.
-
(2009)
Journal of Cellular and Molecular Medicine
, vol.13
, Issue.11-12
, pp. 4329-4348
-
-
Donev, R.1
Kolev, M.2
Millet, B.3
Tome, J.4
-
30
-
-
58149175555
-
The life of a cell: Apoptosis regulation by the PI3K/PKB pathway
-
V. Duronio, "The life of a cell: apoptosis regulation by the PI3K/PKB pathway, " Biochemical Journal, vol. 415, no. 3, pp. 333-344, 2008.
-
(2008)
Biochemical Journal
, vol.415
, Issue.3
, pp. 333-344
-
-
Duronio, V.1
-
31
-
-
0031053360
-
Akt signaling: Linking membrane events to life and death decisions
-
B. A. Hemmings, "Akt signaling: linking membrane events to life and death decisions, " Science, vol. 275, no. 5300, pp. 628-630, 1997.
-
(1997)
Science
, vol.275
, Issue.5300
, pp. 628-630
-
-
Hemmings, B.A.1
-
32
-
-
65249113325
-
The insulin/Akt signaling pathway is targeted by intracellular amyloid
-
H.-K. Lee, P. Kumar, Q. Fu, K. M. Rosen, and H. W. Querfurth, "The insulin/Akt signaling pathway is targeted by intracellular amyloid, " Molecular Biology of the Cell, vol. 20, no. 5, pp. 1533-1544, 2009.
-
(2009)
Molecular Biology of the Cell
, vol.20
, Issue.5
, pp. 1533-1544
-
-
Lee, H.-K.1
Kumar, P.2
Fu, Q.3
Rosen, K.M.4
Querfurth, H.W.5
-
33
-
-
2342558065
-
Akt activity in Alzheimer's disease and other neurodegenerative disorders
-
A.Rickle, N.Bogdanovic, I.Volkman, B.Winblad, R.Ravid, and R. F. Cowburn, "Akt activity in Alzheimer's disease and other neurodegenerative disorders, " NeuroReport, vol. 15, no. 6, pp. 955-959, 2004.
-
(2004)
NeuroReport
, vol.15
, Issue.6
, pp. 955-959
-
-
Rickle, A.1
Bogdanovic, N.2
Volkman, I.3
Winblad, B.4
Ravid, R.5
Cowburn, R.F.6
-
34
-
-
77954624419
-
Icariin attenuates LPS-induced acute infammatory responses: Involvement of PI3K/Akt and NFκB signaling pathway
-
C.-Q. Xu, B.-J. Liu, J.-F. Wu et al., "Icariin attenuates LPS-induced acute infammatory responses: involvement of PI3K/Akt and NFκB signaling pathway, " European Journal of Pharmacology, vol. 642, no. 1-3, pp. 146-153, 2010.
-
(2010)
European Journal of Pharmacology
, vol.642
, Issue.1-3
, pp. 146-153
-
-
Xu, C.-Q.1
Liu, B.-J.2
Wu, J.-F.3
-
35
-
-
83755186160
-
Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. Elegans
-
Article ID
-
W.-J. Cai, J.-H. Huang, S.-Q. Zhang et al., "Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans, " PLoS ONE, vol. 6, no. 12, Article ID e28835, 2011.
-
(2011)
PLoS ONE
, vol.6
, Issue.12
-
-
Cai, W.-J.1
Huang, J.-H.2
Zhang, S.-Q.3
-
36
-
-
84857406235
-
PI3K signalling: The path to discovery and understanding
-
B. Vanhaesebroeck, L. Stephens, and P. Hawkins, "PI3K signalling: the path to discovery and understanding, " Nature Reviews Molecular Cell Biology, vol. 13, no. 3, pp. 195-203, 2012.
-
(2012)
Nature Reviews Molecular Cell Biology
, vol.13
, Issue.3
, pp. 195-203
-
-
Vanhaesebroeck, B.1
Stephens, L.2
Hawkins, P.3
-
37
-
-
0032575688
-
The Bcl-2 protein family: Arbiters of cell survival
-
J. M. Adams and S. Cory, "The Bcl-2 protein family: arbiters of cell survival, " Science, vol. 281, no. 5381, pp. 1322-1326, 1998.
-
(1998)
Science
, vol.281
, Issue.5381
, pp. 1322-1326
-
-
Adams, J.M.1
Cory, S.2
-
38
-
-
84860580628
-
Caspase-3 activation as a bifurcation point between plasticity and cell death
-
S. Snigdha, E. D. Smith, G. A. Prieto, and C. W. Cotman, "Caspase-3 activation as a bifurcation point between plasticity and cell death, " Neuroscience Bulletin, vol. 28, no. 1, pp. 14-24, 2012.
-
(2012)
Neuroscience Bulletin
, vol.28
, Issue.1
, pp. 14-24
-
-
Snigdha, S.1
Smith, E.D.2
Prieto, G.A.3
Cotman, C.W.4
-
39
-
-
84867903332
-
Caspase-3 in the central nervous system: Beyond apoptosis
-
M. D'Amelio, M. Sheng, and F. Cecconi, "Caspase-3 in the central nervous system: beyond apoptosis, " Trends in Neurosciences, vol. 35, no. 11, pp. 700-709, 2012.
-
(2012)
Trends in Neurosciences
, vol.35
, Issue.11
, pp. 700-709
-
-
D'Amelio, M.1
Sheng, M.2
Cecconi, F.3
-
40
-
-
73649089980
-
ERK and cell death: Mechanisms of ERK-induced cell death-apoptosis, autophagy and senescence
-
S. Cagnol and J. C. Chambard, "ERK and cell death: mechanisms of ERK-induced cell death-apoptosis, autophagy and senescence, " FEBS Journal, vol. 277, no. 1, pp. 2-21, 2010.
-
(2010)
FEBS Journal
, vol.277
, Issue.1
, pp. 2-21
-
-
Cagnol, S.1
Chambard, J.C.2
-
41
-
-
84892447748
-
Icariin stimulates the proliferation of rat Sertoli cells in an ERK1/2-dependent manner in vitro
-
Y. Nan, X. Zhang, G. Yang et al., "Icariin stimulates the proliferation of rat Sertoli cells in an ERK1/2-dependent manner in vitro, " Andrologia, vol. 46, no. 1, pp. 9-16, 2014.
-
(2014)
Andrologia
, vol.46
, Issue.1
, pp. 9-16
-
-
Nan, Y.1
Zhang, X.2
Yang, G.3
-
42
-
-
53149148455
-
Icariin stimulates angiogenesis by activating the MEK/ERK-and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells
-
B. H. Chung, J. D. Kim, C. K. Kim et al., "Icariin stimulates angiogenesis by activating the MEK/ERK-and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells, " Biochemical and Biophysical Research Communications, vol. 376, no. 2, pp. 404-408, 2008.
-
(2008)
Biochemical and Biophysical Research Communications
, vol.376
, Issue.2
, pp. 404-408
-
-
Chung, B.H.1
Kim, J.D.2
Kim, C.K.3
-
43
-
-
79651470943
-
Neuroprotective Effects of icariin on corticosterone-induced apoptosis in primary cultured rat hippocampal neurons
-
B. Liu, H. Zhang, C. Xu et al., "Neuroprotective Effects of icariin on corticosterone-induced apoptosis in primary cultured rat hippocampal neurons, " Brain Research, vol. 1375, pp. 59-67, 2011.
-
(2011)
Brain Research
, vol.1375
, pp. 59-67
-
-
Liu, B.1
Zhang, H.2
Xu, C.3
|