Intracerebroventricular streptozotocin exacerbates alzheimer-like changes of 3xTg-AD mice

Molecular Neurobiology

Volumn 49, Issue 1, 2014, Pages 547-562

  Chen, Yanxing ^a,b,c   Liang, Zhihou ^c   Tian, Zhu ^a,d   Blanchard, Julie ^a   Dai, Chun Ling ^a   Chalbot, Sonia ^a   Iqbal, Khalid ^a   Liu, Fei ^a   Gong, Cheng Xin ^a  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^b ZHEJIANG UNIVERSITY   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d TIANJIN FIRST CENTRAL HOSPITAL   (China)

Author keywords

3xTg AD mice; Amyloid ; Cognitive deficits; Insulin signaling; Neuroinflammation; Streptozotocin; Synaptic proteins; Tau phosphorylation

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; CALCIUM BINDING PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 2; GLUTAMATE RECEPTOR 3; GLYCOGEN SYNTHASE KINASE 3; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; IONIZED CALCIUM BINDING ADAPTOR MOLECULE 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN KINASE; PROTEIN KINASE B; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; STREPTOZOCIN; SYNAPTOPHYSIN; TAU PROTEIN; UNCLASSIFIED DRUG;

3XTG MOUSE; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; APOPTOSIS; ASTROCYTE; BRAIN METABOLISM; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOSKELETON; DISEASE EXACERBATION; ENCEPHALITIS; FEMALE; GENE EXPRESSION; GLUCOSE METABOLISM; HIPPOCAMPUS; INTRACELLULAR SIGNALING; LATERAL BRAIN VENTRICLE; MAZE TEST; MICROGLIA; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; OPEN FIELD TEST; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; REFERENCE MEMORY; REVIEW; ROTAROD TEST; SHORT TERM MEMORY; SPATIAL LEARNING;

ALZHEIMER DISEASE; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; FEMALE; INJECTIONS, INTRAVENTRICULAR; MAZE LEARNING; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, TRANSGENIC; STREPTOZOCIN;

EID: 84894306171     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-013-8539-y     Document Type: Review

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