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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 7, 2015, Pages 1431-1435

8-(3-Chloro-4-methoxybenzyl)-8H-pyrido[2,3-d]pyrimidin-7-one derivatives as potent and selective phosphodiesterase 5 inhibitors

(11) Sakamoto, Toshiaki a Koga, Yuichi a Hikota, Masataka a Matsuki, Kenji a Mochida, Hideki a Kikkawa, Kohei a Fujishige, Kotomi a Kotera, Jun a Omori, Kenji a,b Morimoto, Hiroshi a Yamada, Koichiro a

a MITSUBISHI TANABE PHARMA CORPORATION (Japan)

b NAGOYA UNIVERSITY (Japan)

Author keywords

Erectile dysfunction; PDE5; PDE6

Indexed keywords

8 (3 CHLORO 4 METHOXYBENZYL) 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE DERIVATIVE; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; PHOSPHODIESTERASE VI; PYRIMIDINE DERIVATIVE; SILDENAFIL; UNCLASSIFIED DRUG; PYRIDONE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; CYCLIZATION; DRUG POTENCY; DRUG SYNTHESIS; HORNER WADSWORTH EMMONS REACTION; LIPOPHILICITY; MALE; NONHUMAN; OXIDATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; RABBIT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ORYCTOLAGUS CUNICULUS;

ANIMALS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; DOSE-RESPONSE RELATIONSHIP, DRUG; MOLECULAR STRUCTURE; PHOSPHODIESTERASE 5 INHIBITORS; PYRIDONES; PYRIMIDINES; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84925068438 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.02.041 Document Type: Article

Times cited : (14)

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