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Volumn 12, Issue 3, 2016, Pages 292-323

Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria

(35)  Dubois, Bruno a   Hampel, Harald a,b   Feldman, Howard H c   Scheltens, Philip d   Aisen, Paul e   Andrieu, Sandrine f   Bakardjian, Hovagim g   Benali, Habib a   Bertram, Lars h,i   Blennow, Kaj j   Broich, Karl k   Cavedo, Enrica b,l   Crutch, Sebastian m   Dartigues, Jean François n   Duyckaerts, Charles o   Epelbaum, Stéphane a   Frisoni, Giovanni B l,p   Gauthier, Serge q   Genthon, Remy a   Gouw, Alida A f,r   more..

b AXA   (France)

Author keywords

Alzheimer's disease; Amyloid PET; Asymptomatic; Biomarkers; Blood biomarkers; CSF biomarkers; Diagnostic criteria; Genetics; MRI; Pathophysiology; Preclinical; Tau PET

Indexed keywords

ACETYLSALICYLIC ACID; AMYLOID; AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E4; BIOLOGICAL MARKER; CELECOXIB; CRENEZUMAB; ESTROGEN; FATTY ACID; GANTENERUMAB; GEMFIBROZIL; GINKGO BILOBA EXTRACT; JNJ 54861911; NAPROXEN; OMEGA 2 FATTY ACID; OMEGA 3 FATTY ACID; PIOGLITAZONE; SIMVASTATIN; SOLANEZUMAB; TAU PROTEIN; THIOCTIC ACID; UNCLASSIFIED DRUG;

EID: 84962325429     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2016.02.002     Document Type: Review
Times cited : (1416)

References (298)
  • 1
    • 0025240790 scopus 로고
    • A quantitative histological study of early clinical and preclinical Alzheimer's disease
    • B.M. Hubbard, G.W. Fenton, and J.M. Anderson A quantitative histological study of early clinical and preclinical Alzheimer's disease Neuropathol Appl Neurobiol 16 1990 111 121
    • (1990) Neuropathol Appl Neurobiol , vol.16 , pp. 111-121
    • Hubbard, B.M.1    Fenton, G.W.2    Anderson, J.M.3
  • 2
    • 77954239263 scopus 로고    scopus 로고
    • Biomarkers for Alzheimer's disease: Academic, industry and regulatory perspectives
    • H. Hampel, R. Frank, K. Broich, S.J. Teipel, R.G. Katz, J. Hardy, and et al. Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives Nat Rev Drug Discov 9 2010 560 574
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 560-574
    • Hampel, H.1    Frank, R.2    Broich, K.3    Teipel, S.J.4    Katz, R.G.5    Hardy, J.6
  • 3
  • 5
    • 84855304100 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of beta-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia
    • P. Buchhave, L. Minthon, H. Zetterberg, A.K. Wallin, K. Blennow, and O. Hansson Cerebrospinal fluid levels of beta-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia Arch Gen Psychiatry 69 2012 98 106
    • (2012) Arch Gen Psychiatry , vol.69 , pp. 98-106
    • Buchhave, P.1    Minthon, L.2    Zetterberg, H.3    Wallin, A.K.4    Blennow, K.5    Hansson, O.6
  • 6
    • 0030862438 scopus 로고    scopus 로고
    • Side-effects of rinsing fluids on the rat femoral artery. A histological and electron microscopic study
    • O. Delaere, U. Mennen, W. Van Heerden, E. Raubenheimer, A.M. Wiese, and D. Boomker Side-effects of rinsing fluids on the rat femoral artery. A histological and electron microscopic study J Hand Surg Br 22 1997 568 573
    • (1997) J Hand Surg Br , vol.22 , pp. 568-573
    • Delaere, O.1    Mennen, U.2    Van Heerden, W.3    Raubenheimer, E.4    Wiese, A.M.5    Boomker, D.6
  • 9
    • 72049130805 scopus 로고    scopus 로고
    • Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
    • C.R. Jack Jr., D.S. Knopman, W.J. Jagust, L.M. Shaw, P.S. Aisen, M.W. Weiner, and et al. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade Lancet Neurol 9 2010 119 128
    • (2010) Lancet Neurol , vol.9 , pp. 119-128
    • Jack, C.R.1    Knopman, D.S.2    Jagust, W.J.3    Shaw, L.M.4    Aisen, P.S.5    Weiner, M.W.6
  • 10
    • 79956098248 scopus 로고    scopus 로고
    • Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • R.A. Sperling, P.S. Aisen, L.A. Beckett, D.A. Bennett, S. Craft, A.M. Fagan, and et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Alzheimers Dement 7 2011 280 292
    • (2011) Alzheimers Dement , vol.7 , pp. 280-292
    • Sperling, R.A.1    Aisen, P.S.2    Beckett, L.A.3    Bennett, D.A.4    Craft, S.5    Fagan, A.M.6
  • 11
    • 84900988440 scopus 로고    scopus 로고
    • Advancing research diagnostic criteria for Alzheimer's disease: The IWG-2 criteria
    • B. Dubois, H.H. Feldman, C. Jacova, H. Hampel, J.L. Molinuevo, K. Blennow, and et al. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria Lancet Neurol 13 2014 614 629
    • (2014) Lancet Neurol , vol.13 , pp. 614-629
    • Dubois, B.1    Feldman, H.H.2    Jacova, C.3    Hampel, H.4    Molinuevo, J.L.5    Blennow, K.6
  • 12
    • 84890528022 scopus 로고    scopus 로고
    • Biomarker modeling of Alzheimer's disease
    • C.R. Jack Jr., and D.M. Holtzman Biomarker modeling of Alzheimer's disease Neuron 80 2013 1347 1358
    • (2013) Neuron , vol.80 , pp. 1347-1358
    • Jack, C.R.1    Holtzman, D.M.2
  • 13
    • 84888228877 scopus 로고    scopus 로고
    • Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity
    • C.R. Jack Jr., H.J. Wiste, S.D. Weigand, D.S. Knopman, V. Lowe, P. Vemuri, and et al. Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity Neurology 81 2013 1732 1740
    • (2013) Neurology , vol.81 , pp. 1732-1740
    • Jack, C.R.1    Wiste, H.J.2    Weigand, S.D.3    Knopman, D.S.4    Lowe, V.5    Vemuri, P.6
  • 14
    • 84926513913 scopus 로고    scopus 로고
    • Spreading of pathology in neurodegenerative diseases: A focus on human studies
    • J. Brettschneider, K. Del Tredici, V.M. Lee, and J.Q. Trojanowski Spreading of pathology in neurodegenerative diseases: a focus on human studies Nat Rev Neurosci 16 2015 109 120
    • (2015) Nat Rev Neurosci , vol.16 , pp. 109-120
    • Brettschneider, J.1    Del Tredici, K.2    Lee, V.M.3    Trojanowski, J.Q.4
  • 15
  • 16
    • 79958116172 scopus 로고    scopus 로고
    • Alzheimer's disease is not "brain aging": Neuropathological, genetic, and epidemiological human studies
    • P.T. Nelson, E. Head, F.A. Schmitt, P.R. Davis, J.H. Neltner, G.A. Jicha, and et al. Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies Acta Neuropathol 121 2011 571 587
    • (2011) Acta Neuropathol , vol.121 , pp. 571-587
    • Nelson, P.T.1    Head, E.2    Schmitt, F.A.3    Davis, P.R.4    Neltner, J.H.5    Jicha, G.A.6
  • 18
    • 78649573450 scopus 로고    scopus 로고
    • Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease
    • L. Jones, P.A. Holmans, M.L. Hamshere, D. Harold, V. Moskvina, D. Ivanov, and et al. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease PLoS One 5 2010 e13950
    • (2010) PLoS One , vol.5
    • Jones, L.1    Holmans, P.A.2    Hamshere, M.L.3    Harold, D.4    Moskvina, V.5    Ivanov, D.6
  • 19
    • 84931560814 scopus 로고    scopus 로고
    • Convergent genetic and expression data implicate immunity in Alzheimer's disease
    • International Genomics of Alzheimer's Disease Consortium Convergent genetic and expression data implicate immunity in Alzheimer's disease Alzheimers Dement 11 2015 658 671
    • (2015) Alzheimers Dement , vol.11 , pp. 658-671
  • 20
    • 84904264999 scopus 로고    scopus 로고
    • Potential for primary prevention of Alzheimer's disease: An analysis of population-based data
    • S. Norton, F.E. Matthews, D.E. Barnes, K. Yaffe, and C. Brayne Potential for primary prevention of Alzheimer's disease: An analysis of population-based data Lancet Neurol 13 2014 788 794
    • (2014) Lancet Neurol , vol.13 , pp. 788-794
    • Norton, S.1    Matthews, F.E.2    Barnes, D.E.3    Yaffe, K.4    Brayne, C.5
  • 23
    • 79956076567 scopus 로고    scopus 로고
    • Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • C.R. Jack Jr., M.S. Albert, D.S. Knopman, G.M. McKhann, R.A. Sperling, M.C. Carrillo, and et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Alzheimers Dement 7 2011 257 262
    • (2011) Alzheimers Dement , vol.7 , pp. 257-262
    • Jack, C.R.1    Albert, M.S.2    Knopman, D.S.3    McKhann, G.M.4    Sperling, R.A.5    Carrillo, M.C.6
  • 24
    • 84872379077 scopus 로고    scopus 로고
    • Tracking pathophysiological processes in Alzheimer's disease: An updated hypothetical model of dynamic biomarkers
    • C.R. Jack Jr., D.S. Knopman, W.J. Jagust, R.C. Petersen, M.W. Weiner, P.S. Aisen, and et al. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers Lancet Neurol 12 2013 207 216
    • (2013) Lancet Neurol , vol.12 , pp. 207-216
    • Jack, C.R.1    Knopman, D.S.2    Jagust, W.J.3    Petersen, R.C.4    Weiner, M.W.5    Aisen, P.S.6
  • 25
    • 0027410176 scopus 로고
    • Beta A4 deposits are constant in the brain of the oldest old: An immunocytochemical study of 20 French centenarians
    • P. Delaere, Y. He, G. Fayet, C. Duyckaerts, and J.J. Hauw Beta A4 deposits are constant in the brain of the oldest old: An immunocytochemical study of 20 French centenarians Neurobiol Aging 14 1993 191 194
    • (1993) Neurobiol Aging , vol.14 , pp. 191-194
    • Delaere, P.1    He, Y.2    Fayet, G.3    Duyckaerts, C.4    Hauw, J.J.5
  • 28
    • 79451471618 scopus 로고    scopus 로고
    • The pathological process underlying Alzheimer's disease in individuals under thirty
    • H. Braak, and K. Del Tredici The pathological process underlying Alzheimer's disease in individuals under thirty Acta Neuropathol 121 2011 171 181
    • (2011) Acta Neuropathol , vol.121 , pp. 171-181
    • Braak, H.1    Del Tredici, K.2
  • 29
    • 79451470073 scopus 로고    scopus 로고
    • Tau pathology in children and young adults: Can you still be unconditionally baptist?
    • C. Duyckaerts Tau pathology in children and young adults: can you still be unconditionally baptist? Acta Neuropathol 121 2011 145 147
    • (2011) Acta Neuropathol , vol.121 , pp. 145-147
    • Duyckaerts, C.1
  • 34
    • 0030805991 scopus 로고    scopus 로고
    • Frequency of stages of Alzheimer-related lesions in different age categories
    • H. Braak, and E. Braak Frequency of stages of Alzheimer-related lesions in different age categories Neurobiol Aging 18 1997 351 357
    • (1997) Neurobiol Aging , vol.18 , pp. 351-357
    • Braak, H.1    Braak, E.2
  • 35
    • 0022414054 scopus 로고
    • Diagnosis of Alzheimer's disease
    • Z.S. Khachaturian Diagnosis of Alzheimer's disease Arch Neurol 42 1985 1097 1105
    • (1985) Arch Neurol , vol.42 , pp. 1097-1105
    • Khachaturian, Z.S.1
  • 36
    • 0025908356 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
    • S.S. Mirra, A. Heyman, D. McKeel, S.M. Sumi, B.J. Crain, L.M. Brownlee, and et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease Neurology 41 1991 479 486
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6
  • 37
    • 77957927865 scopus 로고    scopus 로고
    • The genetics of Alzheimer disease: Back to the future
    • L. Bertram, C.M. Lill, and R.E. Tanzi The genetics of Alzheimer disease: back to the future Neuron 68 2010 270 281
    • (2010) Neuron , vol.68 , pp. 270-281
    • Bertram, L.1    Lill, C.M.2    Tanzi, R.E.3
  • 38
    • 0036163714 scopus 로고    scopus 로고
    • The clinical phenotype of familial and sporadic late onset Alzheimer's disease
    • C. Holmes, and S. Lovestone The clinical phenotype of familial and sporadic late onset Alzheimer's disease Int J Geriatr Psychiatry 17 2002 146 149
    • (2002) Int J Geriatr Psychiatry , vol.17 , pp. 146-149
    • Holmes, C.1    Lovestone, S.2
  • 39
    • 84905868699 scopus 로고    scopus 로고
    • Symptom onset in autosomal dominant Alzheimer disease: A systematic review and meta-analysis
    • D.C. Ryman, N. Acosta-Baena, P.S. Aisen, T. Bird, A. Danek, N.C. Fox, and et al. Symptom onset in autosomal dominant Alzheimer disease: A systematic review and meta-analysis Neurology 83 2014 253 260
    • (2014) Neurology , vol.83 , pp. 253-260
    • Ryman, D.C.1    Acosta-Baena, N.2    Aisen, P.S.3    Bird, T.4    Danek, A.5    Fox, N.C.6
  • 40
    • 0026572346 scopus 로고
    • Alzheimer's disease: Identical phenotype of familial and non-familial cases
    • M. Haupt, A. Kurz, S. Pollmann, and B. Romero Alzheimer's disease: Identical phenotype of familial and non-familial cases J Neurol 239 1992 248 250
    • (1992) J Neurol , vol.239 , pp. 248-250
    • Haupt, M.1    Kurz, A.2    Pollmann, S.3    Romero, B.4
  • 41
    • 0038488364 scopus 로고    scopus 로고
    • Familial forms of Alzheimer's disease
    • L. Marechal, D. Campion, and D. Hannequin Familial forms of Alzheimer's disease Presse Med 32 2003 756 763
    • (2003) Presse Med , vol.32 , pp. 756-763
    • Marechal, L.1    Campion, D.2    Hannequin, D.3
  • 42
    • 0027438964 scopus 로고
    • Comparison of the severity of neuropathologic changes in familial and sporadic Alzheimer's disease
    • D. Nochlin, G. van Belle, T.D. Bird, and S.M. Sumi Comparison of the severity of neuropathologic changes in familial and sporadic Alzheimer's disease Alzheimer Dis Assoc Disord 7 1993 212 222
    • (1993) Alzheimer Dis Assoc Disord , vol.7 , pp. 212-222
    • Nochlin, D.1    Van Belle, G.2    Bird, T.D.3    Sumi, S.M.4
  • 43
    • 84855364400 scopus 로고    scopus 로고
    • Effectiveness and safety of 18F-FDG PET in the evaluation of dementia: A review of the recent literature
    • N.I. Bohnen, D.S. Djang, K. Herholz, Y. Anzai, and S. Minoshima Effectiveness and safety of 18F-FDG PET in the evaluation of dementia: a review of the recent literature J Nucl Med 53 2012 59 71
    • (2012) J Nucl Med , vol.53 , pp. 59-71
    • Bohnen, N.I.1    Djang, D.S.2    Herholz, K.3    Anzai, Y.4    Minoshima, S.5
  • 44
    • 60849136325 scopus 로고    scopus 로고
    • Cortical hubs revealed by intrinsic functional connectivity: Mapping, assessment of stability, and relation to Alzheimer's disease
    • R.L. Buckner, J. Sepulcre, T. Talukdar, F.M. Krienen, H. Liu, T. Hedden, and et al. Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease J Neurosci 29 2009 1860 1873
    • (2009) J Neurosci , vol.29 , pp. 1860-1873
    • Buckner, R.L.1    Sepulcre, J.2    Talukdar, T.3    Krienen, F.M.4    Liu, H.5    Hedden, T.6
  • 45
    • 67650908100 scopus 로고    scopus 로고
    • Amyloid + activation = Alzheimer's?
    • W. Jagust Amyloid + activation = Alzheimer's? Neuron 63 2009 141 143
    • (2009) Neuron , vol.63 , pp. 141-143
    • Jagust, W.1
  • 46
    • 84937529452 scopus 로고    scopus 로고
    • Prevalence of cerebral amyloid pathology in persons without dementia: A meta-analysis
    • W.J. Jansen, R. Ossenkoppele, D.L. Knol, B.M. Tijms, P. Scheltens, F.R. Verhey, and et al. Prevalence of cerebral amyloid pathology in persons without dementia: A meta-analysis JAMA 313 2015 1924 1938
    • (2015) JAMA , vol.313 , pp. 1924-1938
    • Jansen, W.J.1    Ossenkoppele, R.2    Knol, D.L.3    Tijms, B.M.4    Scheltens, P.5    Verhey, F.R.6
  • 48
    • 33947223454 scopus 로고    scopus 로고
    • Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults
    • A.M. Fagan, C.M. Roe, C. Xiong, M.A. Mintun, J.C. Morris, and D.M. Holtzman Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults Arch Neurol 64 2007 343 349
    • (2007) Arch Neurol , vol.64 , pp. 343-349
    • Fagan, A.M.1    Roe, C.M.2    Xiong, C.3    Mintun, M.A.4    Morris, J.C.5    Holtzman, D.M.6
  • 49
    • 34447634667 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly
    • E. Stomrud, O. Hansson, K. Blennow, L. Minthon, and E. Londos Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly Dement Geriatr Cogn Disord 24 2007 118 124
    • (2007) Dement Geriatr Cogn Disord , vol.24 , pp. 118-124
    • Stomrud, E.1    Hansson, O.2    Blennow, K.3    Minthon, L.4    Londos, E.5
  • 50
    • 79955813252 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers in Alzheimer's disease families with PSEN1 mutations
    • J. Fortea, A. Llado, B. Bosch, A. Antonell, R. Oliva, J.L. Molinuevo, and et al. Cerebrospinal fluid biomarkers in Alzheimer's disease families with PSEN1 mutations Neurodegener Dis 8 2011 202 207
    • (2011) Neurodegener Dis , vol.8 , pp. 202-207
    • Fortea, J.1    Llado, A.2    Bosch, B.3    Antonell, A.4    Oliva, R.5    Molinuevo, J.L.6
  • 52
    • 79959733052 scopus 로고    scopus 로고
    • Cognitively preserved subjects with transitional cerebrospinal fluid ss-amyloid 1-42 values have thicker cortex in Alzheimer's disease vulnerable areas
    • J. Fortea, R. Sala-Llonch, D. Bartres-Faz, A. Llado, C. Sole-Padulles, B. Bosch, and et al. Cognitively preserved subjects with transitional cerebrospinal fluid ss-amyloid 1-42 values have thicker cortex in Alzheimer's disease vulnerable areas Biol Psychiatry 70 2011 183 190
    • (2011) Biol Psychiatry , vol.70 , pp. 183-190
    • Fortea, J.1    Sala-Llonch, R.2    Bartres-Faz, D.3    Llado, A.4    Sole-Padulles, C.5    Bosch, B.6
  • 53
    • 84865580405 scopus 로고    scopus 로고
    • Distinct functional activity of the precuneus and posterior cingulate cortex during encoding in the preclinical stage of Alzheimer's disease
    • L. Rami, R. Sala-Llonch, C. Sole-Padulles, J. Fortea, J. Olives, A. Llado, and et al. Distinct functional activity of the precuneus and posterior cingulate cortex during encoding in the preclinical stage of Alzheimer's disease J Alzheimers Dis 31 2012 517 526
    • (2012) J Alzheimers Dis , vol.31 , pp. 517-526
    • Rami, L.1    Sala-Llonch, R.2    Sole-Padulles, C.3    Fortea, J.4    Olives, J.5    Llado, A.6
  • 54
  • 55
    • 84865507195 scopus 로고    scopus 로고
    • Injury markers predict time to dementia in subjects with MCI and amyloid pathology
    • I.A. van Rossum, S.J. Vos, L. Burns, D.L. Knol, P. Scheltens, H. Soininen, and et al. Injury markers predict time to dementia in subjects with MCI and amyloid pathology Neurology 79 2012 1809 1816
    • (2012) Neurology , vol.79 , pp. 1809-1816
    • Van Rossum, I.A.1    Vos, S.J.2    Burns, L.3    Knol, D.L.4    Scheltens, P.5    Soininen, H.6
  • 56
    • 84859399418 scopus 로고    scopus 로고
    • Injury markers but not amyloid markers are associated with rapid progression from mild cognitive impairment to dementia in Alzheimer's disease
    • I.A. van Rossum, P.J. Visser, D.L. Knol, W.M. van der Flier, C.E. Teunissen, F. Barkhof, and et al. Injury markers but not amyloid markers are associated with rapid progression from mild cognitive impairment to dementia in Alzheimer's disease J Alzheimers Dis 29 2012 319 327
    • (2012) J Alzheimers Dis , vol.29 , pp. 319-327
    • Van Rossum, I.A.1    Visser, P.J.2    Knol, D.L.3    Van Der Flier, W.M.4    Teunissen, C.E.5    Barkhof, F.6
  • 57
    • 84888205849 scopus 로고    scopus 로고
    • Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-beta changes occur before increases of tau in cerebrospinal fluid
    • H. Braak, H. Zetterberg, K. Del Tredici, and K. Blennow Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-beta changes occur before increases of tau in cerebrospinal fluid Acta Neuropathol 126 2013 631 641
    • (2013) Acta Neuropathol , vol.126 , pp. 631-641
    • Braak, H.1    Zetterberg, H.2    Del Tredici, K.3    Blennow, K.4
  • 58
    • 0026740795 scopus 로고
    • Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
    • P.V. Arriagada, J.H. Growdon, E.T. Hedley-Whyte, and B.T. Hyman Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease Neurology 42 1992 631 639
    • (1992) Neurology , vol.42 , pp. 631-639
    • Arriagada, P.V.1    Growdon, J.H.2    Hedley-Whyte, E.T.3    Hyman, B.T.4
  • 59
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • H. Braak, and E. Braak Neuropathological stageing of Alzheimer-related changes Acta Neuropathol 82 1991 239 259
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 61
    • 33750589818 scopus 로고    scopus 로고
    • CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease
    • K. Buerger, M. Ewers, T. Pirttila, R. Zinkowski, I. Alafuzoff, S.J. Teipel, and et al. CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease Brain 129 2006 3035 3041
    • (2006) Brain , vol.129 , pp. 3035-3041
    • Buerger, K.1    Ewers, M.2    Pirttila, T.3    Zinkowski, R.4    Alafuzoff, I.5    Teipel, S.J.6
  • 62
    • 62449262536 scopus 로고    scopus 로고
    • Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain
    • T. Tapiola, I. Alafuzoff, S.K. Herukka, L. Parkkinen, P. Hartikainen, H. Soininen, and et al. Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain Arch Neurol 66 2009 382 389
    • (2009) Arch Neurol , vol.66 , pp. 382-389
    • Tapiola, T.1    Alafuzoff, I.2    Herukka, S.K.3    Parkkinen, L.4    Hartikainen, P.5    Soininen, H.6
  • 64
    • 84947866840 scopus 로고    scopus 로고
    • CSF biomarkers for the differential diagnosis of Alzheimer's disease: A large-scale international multicenter study
    • M. Ewers, N. Mattsson, L. Minthon, J.L. Molinuevo, A. Antonell, J. Popp, and et al. CSF biomarkers for the differential diagnosis of Alzheimer's disease: A large-scale international multicenter study Alzheimers Dement 11 2015 1306 1315
    • (2015) Alzheimers Dement , vol.11 , pp. 1306-1315
    • Ewers, M.1    Mattsson, N.2    Minthon, L.3    Molinuevo, J.L.4    Antonell, A.5    Popp, J.6
  • 65
    • 84936797429 scopus 로고    scopus 로고
    • Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: Statistical and pathological evaluation
    • S. Villeneuve, G.D. Rabinovici, B.I. Cohn-Sheehy, C. Madison, N. Ayakta, P.M. Ghosh, and et al. Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: Statistical and pathological evaluation Brain 138 2015 2020 2033
    • (2015) Brain , vol.138 , pp. 2020-2033
    • Villeneuve, S.1    Rabinovici, G.D.2    Cohn-Sheehy, B.I.3    Madison, C.4    Ayakta, N.5    Ghosh, P.M.6
  • 66
    • 84929657432 scopus 로고    scopus 로고
    • Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer's disease spectrum
    • M.E. Murray, V.J. Lowe, N.R. Graff-Radford, A.M. Liesinger, A. Cannon, S.A. Przybelski, and et al. Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer's disease spectrum Brain 138 2015 1370 1381
    • (2015) Brain , vol.138 , pp. 1370-1381
    • Murray, M.E.1    Lowe, V.J.2    Graff-Radford, N.R.3    Liesinger, A.M.4    Cannon, A.5    Przybelski, S.A.6
  • 67
    • 84863869296 scopus 로고    scopus 로고
    • Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-beta plaques: A prospective cohort study
    • C.M. Clark, M.J. Pontecorvo, T.G. Beach, B.J. Bedell, R.E. Coleman, P.M. Doraiswamy, and et al. Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-beta plaques: A prospective cohort study Lancet Neurol 11 2012 669 678
    • (2012) Lancet Neurol , vol.11 , pp. 669-678
    • Clark, C.M.1    Pontecorvo, M.J.2    Beach, T.G.3    Bedell, B.J.4    Coleman, R.E.5    Doraiswamy, P.M.6
  • 68
    • 84926359799 scopus 로고    scopus 로고
    • Phase 3 trial of flutemetamol labeled with radioactive fluorine 18 imaging and neuritic plaque density
    • C. Curtis, J.E. Gamez, U. Singh, C.H. Sadowsky, T. Villena, M.N. Sabbagh, and et al. Phase 3 trial of flutemetamol labeled with radioactive fluorine 18 imaging and neuritic plaque density JAMA Neurol 72 2015 287 294
    • (2015) JAMA Neurol , vol.72 , pp. 287-294
    • Curtis, C.1    Gamez, J.E.2    Singh, U.3    Sadowsky, C.H.4    Villena, T.5    Sabbagh, M.N.6
  • 69
    • 84939264152 scopus 로고    scopus 로고
    • Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: Phase 3 study
    • O. Sabri, M.N. Sabbagh, J. Seibyl, H. Barthel, H. Akatsu, Y. Ouchi, and et al. Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: Phase 3 study Alzheimers Dement 11 2015 964 974
    • (2015) Alzheimers Dement , vol.11 , pp. 964-974
    • Sabri, O.1    Sabbagh, M.N.2    Seibyl, J.3    Barthel, H.4    Akatsu, H.5    Ouchi, Y.6
  • 70
    • 84939171626 scopus 로고    scopus 로고
    • [(18)F]flutemetamol amyloid positron emission tomography in preclinical and symptomatic Alzheimer's disease: Specific detection of advanced phases of amyloid-beta pathology
    • D.R. Thal, T.G. Beach, M. Zanette, K. Heurling, A. Chakrabarty, A. Ismail, and et al. [(18)F]flutemetamol amyloid positron emission tomography in preclinical and symptomatic Alzheimer's disease: specific detection of advanced phases of amyloid-beta pathology Alzheimers Dement 11 2015 975 985
    • (2015) Alzheimers Dement , vol.11 , pp. 975-985
    • Thal, D.R.1    Beach, T.G.2    Zanette, M.3    Heurling, K.4    Chakrabarty, A.5    Ismail, A.6
  • 74
    • 84907502637 scopus 로고    scopus 로고
    • Automated quantification of 18F-flutemetamol PET activity for categorizing scans as negative or positive for brain amyloid: Concordance with visual image reads
    • L. Thurfjell, J. Lilja, R. Lundqvist, C. Buckley, A. Smith, R. Vandenberghe, and et al. Automated quantification of 18F-flutemetamol PET activity for categorizing scans as negative or positive for brain amyloid: Concordance with visual image reads J Nucl Med 55 2014 1623 1628
    • (2014) J Nucl Med , vol.55 , pp. 1623-1628
    • Thurfjell, L.1    Lilja, J.2    Lundqvist, R.3    Buckley, C.4    Smith, A.5    Vandenberghe, R.6
  • 75
    • 84873688351 scopus 로고    scopus 로고
    • Classification of amyloid-positivity in controls: Comparison of visual read and quantitative approaches
    • A.D. Cohen, W. Mowrey, L.A. Weissfeld, H.J. Aizenstein, E. McDade, J.M. Mountz, and et al. Classification of amyloid-positivity in controls: Comparison of visual read and quantitative approaches Neuroimage 71 2013 207 215
    • (2013) Neuroimage , vol.71 , pp. 207-215
    • Cohen, A.D.1    Mowrey, W.2    Weissfeld, L.A.3    Aizenstein, H.J.4    McDade, E.5    Mountz, J.M.6
  • 76
    • 84944104375 scopus 로고    scopus 로고
    • Comparison of visual and quantitative Florbetapir F 18 positron emission tomography analysis in predicting mild cognitive impairment outcomes
    • S. Schreiber, S.M. Landau, A. Fero, F. Schreiber, W.J. Jagust Alzheimer's Disease Neuroimaging Initiative Comparison of visual and quantitative Florbetapir F 18 positron emission tomography analysis in predicting mild cognitive impairment outcomes JAMA Neurol 72 2015 1183 1190
    • (2015) JAMA Neurol , vol.72 , pp. 1183-1190
    • Schreiber, S.1    Landau, S.M.2    Fero, A.3    Schreiber, F.4    Jagust, W.J.5
  • 78
    • 84907978955 scopus 로고    scopus 로고
    • Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid beta-amyloid 42: A cross-validation study against amyloid positron emission tomography
    • S. Palmqvist, H. Zetterberg, K. Blennow, S. Vestberg, U. Andreasson, D.J. Brooks, and et al. Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid beta-amyloid 42: a cross-validation study against amyloid positron emission tomography JAMA Neurol 71 2014 1282 1289
    • (2014) JAMA Neurol , vol.71 , pp. 1282-1289
    • Palmqvist, S.1    Zetterberg, H.2    Blennow, K.3    Vestberg, S.4    Andreasson, U.5    Brooks, D.J.6
  • 79
    • 84892918273 scopus 로고    scopus 로고
    • Comparing positron emission tomography imaging and cerebrospinal fluid measurements of beta-amyloid
    • S.M. Landau, M. Lu, A.D. Joshi, M. Pontecorvo, M.A. Mintun, J.Q. Trojanowski, and et al. Comparing positron emission tomography imaging and cerebrospinal fluid measurements of beta-amyloid Ann Neurol 74 2013 826 836
    • (2013) Ann Neurol , vol.74 , pp. 826-836
    • Landau, S.M.1    Lu, M.2    Joshi, A.D.3    Pontecorvo, M.4    Mintun, M.A.5    Trojanowski, J.Q.6
  • 80
    • 84927957367 scopus 로고    scopus 로고
    • Independent information from cerebrospinal fluid amyloid-beta and florbetapir imaging in Alzheimer's disease
    • N. Mattsson, P.S. Insel, M. Donohue, S. Landau, W.J. Jagust, L.M. Shaw, and et al. Independent information from cerebrospinal fluid amyloid-beta and florbetapir imaging in Alzheimer's disease Brain 138 2015 772 783
    • (2015) Brain , vol.138 , pp. 772-783
    • Mattsson, N.1    Insel, P.S.2    Donohue, M.3    Landau, S.4    Jagust, W.J.5    Shaw, L.M.6
  • 81
    • 84887416188 scopus 로고    scopus 로고
    • [(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease
    • C.F. Xia, J. Arteaga, G. Chen, U. Gangadharmath, L.F. Gomez, D. Kasi, and et al. [(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease Alzheimers Dement 9 2013 666 676
    • (2013) Alzheimers Dement , vol.9 , pp. 666-676
    • Xia, C.F.1    Arteaga, J.2    Chen, G.3    Gangadharmath, U.4    Gomez, L.F.5    Kasi, D.6
  • 82
    • 84881451115 scopus 로고    scopus 로고
    • Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease
    • N. Okamura, S. Furumoto, R. Harada, T. Tago, T. Yoshikawa, M. Fodero-Tavoletti, and et al. Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease J Nucl Med 54 2013 1420 1427
    • (2013) J Nucl Med , vol.54 , pp. 1420-1427
    • Okamura, N.1    Furumoto, S.2    Harada, R.3    Tago, T.4    Yoshikawa, T.5    Fodero-Tavoletti, M.6
  • 83
    • 84874288678 scopus 로고    scopus 로고
    • Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807
    • D.T. Chien, S. Bahri, A.K. Szardenings, J.C. Walsh, F. Mu, M.Y. Su, and et al. Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807 J Alzheimers Dis 34 2013 457 468
    • (2013) J Alzheimers Dis , vol.34 , pp. 457-468
    • Chien, D.T.1    Bahri, S.2    Szardenings, A.K.3    Walsh, J.C.4    Mu, F.5    Su, M.Y.6
  • 84
    • 84884273839 scopus 로고    scopus 로고
    • Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls
    • M. Maruyama, H. Shimada, T. Suhara, H. Shinotoh, B. Ji, J. Maeda, and et al. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 79 2013 1094 1108
    • (2013) Neuron , vol.79 , pp. 1094-1108
    • Maruyama, M.1    Shimada, H.2    Suhara, T.3    Shinotoh, H.4    Ji, B.5    Maeda, J.6
  • 85
    • 84901391350 scopus 로고    scopus 로고
    • Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET
    • N. Okamura, S. Furumoto, M.T. Fodero-Tavoletti, R.S. Mulligan, R. Harada, P. Yates, and et al. Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET Brain 137 2014 1762 1771
    • (2014) Brain , vol.137 , pp. 1762-1771
    • Okamura, N.1    Furumoto, S.2    Fodero-Tavoletti, M.T.3    Mulligan, R.S.4    Harada, R.5    Yates, P.6
  • 87
    • 84856002055 scopus 로고    scopus 로고
    • National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease
    • B.T. Hyman, C.H. Phelps, T.G. Beach, E.H. Bigio, N.J. Cairns, M.C. Carrillo, and et al. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease Alzheimers Dement 8 2012 1 13
    • (2012) Alzheimers Dement , vol.8 , pp. 1-13
    • Hyman, B.T.1    Phelps, C.H.2    Beach, T.G.3    Bigio, E.H.4    Cairns, N.J.5    Carrillo, M.C.6
  • 91
    • 84875366315 scopus 로고    scopus 로고
    • Global standardization measurement of cerebral spinal fluid for Alzheimer's disease: An update from the Alzheimer's Association Global Biomarkers Consortium
    • M.C. Carrillo, K. Blennow, H. Soares, P. Lewczuk, N. Mattsson, P. Oberoi, and et al. Global standardization measurement of cerebral spinal fluid for Alzheimer's disease: an update from the Alzheimer's Association Global Biomarkers Consortium Alzheimers Dement 9 2013 137 140
    • (2013) Alzheimers Dement , vol.9 , pp. 137-140
    • Carrillo, M.C.1    Blennow, K.2    Soares, H.3    Lewczuk, P.4    Mattsson, N.5    Oberoi, P.6
  • 92
    • 78349265011 scopus 로고    scopus 로고
    • Standardization of Assay Procedures for Analysis of the CSF Biomarkers Amyloid beta((1-42)), Tau, and Phosphorylated Tau in Alzheimer's Disease: Report of an International Workshop
    • C.E. Teunissen, N.A. Verwey, M.I. Kester, K. van Uffelen, and M.A. Blankenstein Standardization of Assay Procedures for Analysis of the CSF Biomarkers Amyloid beta((1-42)), Tau, and Phosphorylated Tau in Alzheimer's Disease: Report of an International Workshop Int J Alzheimers Dis 2010 2010
    • (2010) Int J Alzheimers Dis , vol.2010
    • Teunissen, C.E.1    Verwey, N.A.2    Kester, M.I.3    Van Uffelen, K.4    Blankenstein, M.A.5
  • 93
    • 84856008210 scopus 로고    scopus 로고
    • Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's Biomarkers Standardization Initiative
    • H. Vanderstichele, M. Bibl, S. Engelborghs, N. Le Bastard, P. Lewczuk, J.L. Molinuevo, and et al. Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: a consensus paper from the Alzheimer's Biomarkers Standardization Initiative Alzheimers Dement 8 2012 65 73
    • (2012) Alzheimers Dement , vol.8 , pp. 65-73
    • Vanderstichele, H.1    Bibl, M.2    Engelborghs, S.3    Le Bastard, N.4    Lewczuk, P.5    Molinuevo, J.L.6
  • 94
    • 77949423619 scopus 로고    scopus 로고
    • Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
    • K. Blennow, H. Hampel, M. Weiner, and H. Zetterberg Cerebrospinal fluid and plasma biomarkers in Alzheimer disease Nat Rev Neurol 6 2010 131 144
    • (2010) Nat Rev Neurol , vol.6 , pp. 131-144
    • Blennow, K.1    Hampel, H.2    Weiner, M.3    Zetterberg, H.4
  • 95
    • 84865517103 scopus 로고    scopus 로고
    • What is a certified reference material?
    • N. Mattsson, and H. Zetterberg What is a certified reference material? Biomark Med 6 2012 369 370
    • (2012) Biomark Med , vol.6 , pp. 369-370
    • Mattsson, N.1    Zetterberg, H.2
  • 96
    • 84865452551 scopus 로고    scopus 로고
    • Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: Definitions and approaches with focus on amyloid beta42
    • N. Mattsson, I. Zegers, U. Andreasson, M. Bjerke, M.A. Blankenstein, R. Bowser, and et al. Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid beta42 Biomark Med 6 2012 409 417
    • (2012) Biomark Med , vol.6 , pp. 409-417
    • Mattsson, N.1    Zegers, I.2    Andreasson, U.3    Bjerke, M.4    Blankenstein, M.A.5    Bowser, R.6
  • 97
    • 84903703012 scopus 로고    scopus 로고
    • Mass spectrometry-based candidate reference measurement procedure for quantification of amyloid-beta in cerebrospinal fluid
    • A. Leinenbach, J. Pannee, T. Dulffer, A. Huber, T. Bittner, U. Andreasson, and et al. Mass spectrometry-based candidate reference measurement procedure for quantification of amyloid-beta in cerebrospinal fluid Clin Chem 60 2014 987 994
    • (2014) Clin Chem , vol.60 , pp. 987-994
    • Leinenbach, A.1    Pannee, J.2    Dulffer, T.3    Huber, A.4    Bittner, T.5    Andreasson, U.6
  • 98
    • 84965138012 scopus 로고    scopus 로고
    • Technical performance of a novel, fully automated electrochemiluminescence immunoassay for the quantitation of beta-amyloid (1-42) in human cerebrospinal fluid
    • T. Bittner, H. Zetterberg, C.E. Teunissen, R.E. Ostlund Jr., M. Militello, U. Andreasson, and et al. Technical performance of a novel, fully automated electrochemiluminescence immunoassay for the quantitation of beta-amyloid (1-42) in human cerebrospinal fluid Alzheimers Dement 2015
    • (2015) Alzheimers Dement
    • Bittner, T.1    Zetterberg, H.2    Teunissen, C.E.3    Ostlund, R.E.4    Militello, M.5    Andreasson, U.6
  • 99
    • 35648932901 scopus 로고    scopus 로고
    • Beta-amyloid imaging and memory in non-demented individuals: Evidence for preclinical Alzheimer's disease
    • K.E. Pike, G. Savage, V.L. Villemagne, S. Ng, S.A. Moss, P. Maruff, and et al. Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease Brain 130 2007 2837 2844
    • (2007) Brain , vol.130 , pp. 2837-2844
    • Pike, K.E.1    Savage, G.2    Villemagne, V.L.3    Ng, S.4    Moss, S.A.5    Maruff, P.6
  • 100
    • 84887471492 scopus 로고    scopus 로고
    • The effect of amyloid beta on cognitive decline is modulated by neural integrity in cognitively normal elderly
    • M. Wirth, H. Oh, E.C. Mormino, C. Markley, S.M. Landau, and W.J. Jagust The effect of amyloid beta on cognitive decline is modulated by neural integrity in cognitively normal elderly Alzheimers Dement 9 2013 687 698.e1
    • (2013) Alzheimers Dement , vol.9 , pp. 687.e1-698.e1
    • Wirth, M.1    Oh, H.2    Mormino, E.C.3    Markley, C.4    Landau, S.M.5    Jagust, W.J.6
  • 101
    • 84912064760 scopus 로고    scopus 로고
    • Synergistic effect of beta-amyloid and neurodegeneration on cognitive decline in clinically normal individuals
    • E.C. Mormino, R.A. Betensky, T. Hedden, A.P. Schultz, R.E. Amariglio, D.M. Rentz, and et al. Synergistic effect of beta-amyloid and neurodegeneration on cognitive decline in clinically normal individuals JAMA Neurol 71 2014 1379 1385
    • (2014) JAMA Neurol , vol.71 , pp. 1379-1385
    • Mormino, E.C.1    Betensky, R.A.2    Hedden, T.3    Schultz, A.P.4    Amariglio, R.E.5    Rentz, D.M.6
  • 102
    • 84892765470 scopus 로고    scopus 로고
    • Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease
    • Y.Y. Lim, P. Maruff, R.H. Pietrzak, D. Ames, K.A. Ellis, K. Harrington, and et al. Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease Brain 137 2014 221 231
    • (2014) Brain , vol.137 , pp. 221-231
    • Lim, Y.Y.1    Maruff, P.2    Pietrzak, R.H.3    Ames, D.4    Ellis, K.A.5    Harrington, K.6
  • 104
    • 73549106106 scopus 로고    scopus 로고
    • Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: Cognitive decline associated with Abeta deposition
    • M. Storandt, M.A. Mintun, D. Head, and J.C. Morris Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition Arch Neurol 66 2009 1476 1481
    • (2009) Arch Neurol , vol.66 , pp. 1476-1481
    • Storandt, M.1    Mintun, M.A.2    Head, D.3    Morris, J.C.4
  • 105
    • 84923612196 scopus 로고    scopus 로고
    • Trajectories of memory decline in preclinical Alzheimer's disease: Results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of ageing
    • R.H. Pietrzak, Y.Y. Lim, D. Ames, K. Harrington, C. Restrepo, R.N. Martins, and et al. Trajectories of memory decline in preclinical Alzheimer's disease: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of ageing Neurobiol Aging 36 2015 1231 1238
    • (2015) Neurobiol Aging , vol.36 , pp. 1231-1238
    • Pietrzak, R.H.1    Lim, Y.Y.2    Ames, D.3    Harrington, K.4    Restrepo, C.5    Martins, R.N.6
  • 106
    • 84863185648 scopus 로고    scopus 로고
    • Short-term clinical outcomes for stages of NIA-AA preclinical Alzheimer disease
    • D.S. Knopman, C.R. Jack Jr., H.J. Wiste, S.D. Weigand, P. Vemuri, V. Lowe, and et al. Short-term clinical outcomes for stages of NIA-AA preclinical Alzheimer disease Neurology 78 2012 1576 1582
    • (2012) Neurology , vol.78 , pp. 1576-1582
    • Knopman, D.S.1    Jack, C.R.2    Wiste, H.J.3    Weigand, S.D.4    Vemuri, P.5    Lowe, V.6
  • 108
    • 84923540976 scopus 로고    scopus 로고
    • APOE epsilon4 moderates amyloid-related memory decline in preclinical Alzheimer's disease
    • Y.Y. Lim, V.L. Villemagne, R.H. Pietrzak, D. Ames, K.A. Ellis, K. Harrington, and et al. APOE epsilon4 moderates amyloid-related memory decline in preclinical Alzheimer's disease Neurobiol Aging 36 2015 1239 1244
    • (2015) Neurobiol Aging , vol.36 , pp. 1239-1244
    • Lim, Y.Y.1    Villemagne, V.L.2    Pietrzak, R.H.3    Ames, D.4    Ellis, K.A.5    Harrington, K.6
  • 109
    • 84875250937 scopus 로고    scopus 로고
    • Amyloid beta deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: A prospective cohort study
    • V.L. Villemagne, S. Burnham, P. Bourgeat, B. Brown, K.A. Ellis, O. Salvado, and et al. Amyloid beta deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: A prospective cohort study Lancet Neurol 12 2013 357 367
    • (2013) Lancet Neurol , vol.12 , pp. 357-367
    • Villemagne, V.L.1    Burnham, S.2    Bourgeat, P.3    Brown, B.4    Ellis, K.A.5    Salvado, O.6
  • 110
    • 84862907684 scopus 로고    scopus 로고
    • Preclinical AD Workgroup staging: Pathological correlates and potential challenges
    • G.A. Jicha, E.L. Abner, F.A. Schmitt, R.J. Kryscio, K.P. Riley, G.E. Cooper, and et al. Preclinical AD Workgroup staging: pathological correlates and potential challenges Neurobiol Aging 33 2012 622.e1 622.e16
    • (2012) Neurobiol Aging , vol.33 , pp. 622.e1-622.e16
    • Jicha, G.A.1    Abner, E.L.2    Schmitt, F.A.3    Kryscio, R.J.4    Riley, K.P.5    Cooper, G.E.6
  • 112
    • 66549127860 scopus 로고    scopus 로고
    • Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects
    • E.C. Mormino, J.T. Kluth, C.M. Madison, G.D. Rabinovici, S.L. Baker, B.L. Miller, and et al. Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects Brain 132 2009 1310 1323
    • (2009) Brain , vol.132 , pp. 1310-1323
    • Mormino, E.C.1    Kluth, J.T.2    Madison, C.M.3    Rabinovici, G.D.4    Baker, S.L.5    Miller, B.L.6
  • 113
    • 84902162274 scopus 로고    scopus 로고
    • Amyloid and APOE epsilon4 interact to influence short-term decline in preclinical Alzheimer disease
    • E.C. Mormino, R.A. Betensky, T. Hedden, A.P. Schultz, A. Ward, W. Huijbers, and et al. Amyloid and APOE epsilon4 interact to influence short-term decline in preclinical Alzheimer disease Neurology 82 2014 1760 1767
    • (2014) Neurology , vol.82 , pp. 1760-1767
    • Mormino, E.C.1    Betensky, R.A.2    Hedden, T.3    Schultz, A.P.4    Ward, A.5    Huijbers, W.6
  • 115
  • 116
    • 84859482874 scopus 로고    scopus 로고
    • Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition
    • D. Head, J.M. Bugg, A.M. Goate, A.M. Fagan, M.A. Mintun, T. Benzinger, and et al. Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition Arch Neurol 69 2012 636 643
    • (2012) Arch Neurol , vol.69 , pp. 636-643
    • Head, D.1    Bugg, J.M.2    Goate, A.M.3    Fagan, A.M.4    Mintun, M.A.5    Benzinger, T.6
  • 117
    • 77956363424 scopus 로고    scopus 로고
    • Exercise and Alzheimer's disease biomarkers in cognitively normal older adults
    • K.Y. Liang, M.A. Mintun, A.M. Fagan, A.M. Goate, J.M. Bugg, D.M. Holtzman, and et al. Exercise and Alzheimer's disease biomarkers in cognitively normal older adults Ann Neurol 68 2010 311 318
    • (2010) Ann Neurol , vol.68 , pp. 311-318
    • Liang, K.Y.1    Mintun, M.A.2    Fagan, A.M.3    Goate, A.M.4    Bugg, J.M.5    Holtzman, D.M.6
  • 118
    • 84899917989 scopus 로고    scopus 로고
    • Neuroprotective pathways: Lifestyle activity, brain pathology, and cognition in cognitively normal older adults
    • M. Wirth, C.M. Haase, S. Villeneuve, J. Vogel, and W.J. Jagust Neuroprotective pathways: lifestyle activity, brain pathology, and cognition in cognitively normal older adults Neurobiol Aging 35 2014 1873 1882
    • (2014) Neurobiol Aging , vol.35 , pp. 1873-1882
    • Wirth, M.1    Haase, C.M.2    Villeneuve, S.3    Vogel, J.4    Jagust, W.J.5
  • 120
    • 84981225490 scopus 로고    scopus 로고
    • Age, Sex, and APOE epsilon4 Effects on Memory, Brain Structure, and beta-Amyloid Across the Adult Life Span
    • C.R. Jack Jr., H.J. Wiste, S.D. Weigand, D.S. Knopman, P. Vemuri, M.M. Mielke, and et al. Age, Sex, and APOE epsilon4 Effects on Memory, Brain Structure, and beta-Amyloid Across the Adult Life Span JAMA Neurol 72 2015 511 519
    • (2015) JAMA Neurol , vol.72 , pp. 511-519
    • Jack, C.R.1    Wiste, H.J.2    Weigand, S.D.3    Knopman, D.S.4    Vemuri, P.5    Mielke, M.M.6
  • 121
    • 77954033257 scopus 로고    scopus 로고
    • Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging
    • C.C. Rowe, K.A. Ellis, M. Rimajova, P. Bourgeat, K.E. Pike, G. Jones, and et al. Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging Neurobiol Aging 31 2010 1275 1283
    • (2010) Neurobiol Aging , vol.31 , pp. 1275-1283
    • Rowe, C.C.1    Ellis, K.A.2    Rimajova, M.3    Bourgeat, P.4    Pike, K.E.5    Jones, G.6
  • 122
    • 0035168927 scopus 로고    scopus 로고
    • Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease
    • J.C. Morris, and J.L. Price Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease J Mol Neurosci 17 2001 101 118
    • (2001) J Mol Neurosci , vol.17 , pp. 101-118
    • Morris, J.C.1    Price, J.L.2
  • 123
    • 77649314191 scopus 로고    scopus 로고
    • APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging
    • J.C. Morris, C.M. Roe, C. Xiong, A.M. Fagan, A.M. Goate, D.M. Holtzman, and et al. APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging Ann Neurol 67 2010 122 131
    • (2010) Ann Neurol , vol.67 , pp. 122-131
    • Morris, J.C.1    Roe, C.M.2    Xiong, C.3    Fagan, A.M.4    Goate, A.M.5    Holtzman, D.M.6
  • 124
    • 84908009018 scopus 로고    scopus 로고
    • Age-specific population frequencies of cerebral beta-amyloidosis and neurodegeneration among people with normal cognitive function aged 50-89 years: A cross-sectional study
    • C.R. Jack Jr., H.J. Wiste, S.D. Weigand, W.A. Rocca, D.S. Knopman, M.M. Mielke, and et al. Age-specific population frequencies of cerebral beta-amyloidosis and neurodegeneration among people with normal cognitive function aged 50-89 years: a cross-sectional study Lancet Neurol 13 2014 997 1005
    • (2014) Lancet Neurol , vol.13 , pp. 997-1005
    • Jack, C.R.1    Wiste, H.J.2    Weigand, S.D.3    Rocca, W.A.4    Knopman, D.S.5    Mielke, M.M.6
  • 126
    • 65249101314 scopus 로고    scopus 로고
    • MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers
    • N. Schuff, N. Woerner, L. Boreta, T. Kornfield, L.M. Shaw, J.Q. Trojanowski, and et al. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers Brain 132 2009 1067 1077
    • (2009) Brain , vol.132 , pp. 1067-1077
    • Schuff, N.1    Woerner, N.2    Boreta, L.3    Kornfield, T.4    Shaw, L.M.5    Trojanowski, J.Q.6
  • 127
    • 84867897154 scopus 로고    scopus 로고
    • Cerebrospinal fluid markers for Alzheimer's disease in a cognitively healthy cohort of young and old adults
    • D. Paternico, S. Galluzzi, V. Drago, L. Bocchio-Chiavetto, R. Zanardini, L. Pedrini, and et al. Cerebrospinal fluid markers for Alzheimer's disease in a cognitively healthy cohort of young and old adults Alzheimers Dement 8 2012 520 527
    • (2012) Alzheimers Dement , vol.8 , pp. 520-527
    • Paternico, D.1    Galluzzi, S.2    Drago, V.3    Bocchio-Chiavetto, L.4    Zanardini, R.5    Pedrini, L.6
  • 128
    • 84904678185 scopus 로고    scopus 로고
    • Apolipoprotein E in Alzheimer's disease: An update
    • J.T. Yu, L. Tan, and J. Hardy Apolipoprotein E in Alzheimer's disease: an update Annu Rev Neurosci 37 2014 79 100
    • (2014) Annu Rev Neurosci , vol.37 , pp. 79-100
    • Yu, J.T.1    Tan, L.2    Hardy, J.3
  • 129
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • E.H. Corder, A.M. Saunders, W.J. Strittmatter, D.E. Schmechel, P.C. Gaskell, G.W. Small, and et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families Science 261 1993 921 923
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3    Schmechel, D.E.4    Gaskell, P.C.5    Small, G.W.6
  • 131
    • 0030823158 scopus 로고    scopus 로고
    • Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
    • L.A. Farrer, L.A. Cupples, J.L. Haines, B. Hyman, W.A. Kukull, R. Mayeux, and et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium JAMA 278 1997 1349 1356
    • (1997) JAMA , vol.278 , pp. 1349-1356
    • Farrer, L.A.1    Cupples, L.A.2    Haines, J.L.3    Hyman, B.4    Kukull, W.A.5    Mayeux, R.6
  • 132
    • 0027374047 scopus 로고
    • Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
    • G.W. Rebeck, J.S. Reiter, D.K. Strickland, and B.T. Hyman Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions Neuron 11 1993 575 580
    • (1993) Neuron , vol.11 , pp. 575-580
    • Rebeck, G.W.1    Reiter, J.S.2    Strickland, D.K.3    Hyman, B.T.4
  • 133
    • 84884985250 scopus 로고    scopus 로고
    • Neuroimaging biomarkers for Alzheimer's disease in asymptomatic APOE4 carriers
    • G. Chetelat, and M. Fouquet Neuroimaging biomarkers for Alzheimer's disease in asymptomatic APOE4 carriers Rev Neurol (Paris) 169 2013 729 736
    • (2013) Rev Neurol (Paris) , vol.169 , pp. 729-736
    • Chetelat, G.1    Fouquet, M.2
  • 134
    • 79952812955 scopus 로고    scopus 로고
    • The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease
    • V. Leoni The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease Clin Chem Lab Med 49 2011 375 383
    • (2011) Clin Chem Lab Med , vol.49 , pp. 375-383
    • Leoni, V.1
  • 135
    • 58149462475 scopus 로고    scopus 로고
    • Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: A population-based study
    • M. Kivipelto, S. Rovio, T. Ngandu, I. Kareholt, M. Eskelinen, B. Winblad, and et al. Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study J Cell Mol Med 12 2008 2762 2771
    • (2008) J Cell Mol Med , vol.12 , pp. 2762-2771
    • Kivipelto, M.1    Rovio, S.2    Ngandu, T.3    Kareholt, I.4    Eskelinen, M.5    Winblad, B.6
  • 136
    • 70349558522 scopus 로고    scopus 로고
    • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    • D. Harold, R. Abraham, P. Hollingworth, R. Sims, A. Gerrish, M.L. Hamshere, and et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease Nat Genet 41 2009 1088 1093
    • (2009) Nat Genet , vol.41 , pp. 1088-1093
    • Harold, D.1    Abraham, R.2    Hollingworth, P.3    Sims, R.4    Gerrish, A.5    Hamshere, M.L.6
  • 137
    • 67349270965 scopus 로고    scopus 로고
    • Apolipoprotein E and its receptors in Alzheimer's disease: Pathways, pathogenesis and therapy
    • G. Bu Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy Nat Rev Neurosci 10 2009 333 344
    • (2009) Nat Rev Neurosci , vol.10 , pp. 333-344
    • Bu, G.1
  • 138
    • 79954605836 scopus 로고    scopus 로고
    • Apolipoprotein E: Implications for AD neurobiology, epidemiology and risk assessment
    • H.M. Schipper Apolipoprotein E: implications for AD neurobiology, epidemiology and risk assessment Neurobiol Aging 32 2011 778 790
    • (2011) Neurobiol Aging , vol.32 , pp. 778-790
    • Schipper, H.M.1
  • 139
    • 43549116348 scopus 로고    scopus 로고
    • APOE epsilon 4 lowers age at onset and is a high risk factor for Alzheimer's disease; A case control study from central Norway
    • S.B. Sando, S. Melquist, A. Cannon, M.L. Hutton, O. Sletvold, I. Saltvedt, and et al. APOE epsilon 4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case control study from central Norway BMC Neurol 8 2008 9
    • (2008) BMC Neurol , vol.8 , pp. 9
    • Sando, S.B.1    Melquist, S.2    Cannon, A.3    Hutton, M.L.4    Sletvold, O.5    Saltvedt, I.6
  • 140
    • 84888317489 scopus 로고    scopus 로고
    • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
    • J.C. Lambert, C.A. Ibrahim-Verbaas, D. Harold, A.C. Naj, R. Sims, C. Bellenguez, and et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease Nat Genet 45 2013 1452 1458
    • (2013) Nat Genet , vol.45 , pp. 1452-1458
    • Lambert, J.C.1    Ibrahim-Verbaas, C.A.2    Harold, D.3    Naj, A.C.4    Sims, R.5    Bellenguez, C.6
  • 141
    • 84897954480 scopus 로고    scopus 로고
    • Future directions in Alzheimer's disease from risk factors to prevention
    • B. Imtiaz, A.M. Tolppanen, M. Kivipelto, and H. Soininen Future directions in Alzheimer's disease from risk factors to prevention Biochem Pharmacol 88 2014 661 670
    • (2014) Biochem Pharmacol , vol.88 , pp. 661-670
    • Imtiaz, B.1    Tolppanen, A.M.2    Kivipelto, M.3    Soininen, H.4
  • 142
    • 84921849274 scopus 로고    scopus 로고
    • Target risk factors for dementia prevention: A systematic review and Delphi consensus study on the evidence from observational studies
    • K. Deckers, M.P. van Boxtel, O.J. Schiepers, M. de Vugt, J.L. Munoz Sanchez, K.J. Anstey, and et al. Target risk factors for dementia prevention: a systematic review and Delphi consensus study on the evidence from observational studies Int J Geriatr Psychiatry 30 2015 234 246
    • (2015) Int J Geriatr Psychiatry , vol.30 , pp. 234-246
    • Deckers, K.1    Van Boxtel, M.P.2    Schiepers, O.J.3    De Vugt, M.4    Munoz Sanchez, J.L.5    Anstey, K.J.6
  • 143
    • 84927979900 scopus 로고    scopus 로고
    • Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly
    • P. Vemuri, T.G. Lesnick, S.A. Przybelski, D.S. Knopman, G.M. Preboske, K. Kantarci, and et al. Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly Brain 138 2015 761 771
    • (2015) Brain , vol.138 , pp. 761-771
    • Vemuri, P.1    Lesnick, T.G.2    Przybelski, S.A.3    Knopman, D.S.4    Preboske, G.M.5    Kantarci, K.6
  • 144
    • 84886240569 scopus 로고    scopus 로고
    • A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: Results of the Cognitive Function and Ageing Study I and II
    • F.E. Matthews, A. Arthur, L.E. Barnes, J. Bond, C. Jagger, L. Robinson, and et al. A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II Lancet 382 2013 1405 1412
    • (2013) Lancet , vol.382 , pp. 1405-1412
    • Matthews, F.E.1    Arthur, A.2    Barnes, L.E.3    Bond, J.4    Jagger, C.5    Robinson, L.6
  • 145
    • 84879076246 scopus 로고    scopus 로고
    • Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden
    • C. Qiu, E. von Strauss, L. Backman, B. Winblad, and L. Fratiglioni Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden Neurology 80 2013 1888 1894
    • (2013) Neurology , vol.80 , pp. 1888-1894
    • Qiu, C.1    Von Strauss, E.2    Backman, L.3    Winblad, B.4    Fratiglioni, L.5
  • 148
    • 84934294678 scopus 로고    scopus 로고
    • A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): A randomised controlled trial
    • T. Ngandu, J. Lehtisalo, A. Solomon, E. Levalahti, S. Ahtiluoto, R. Antikainen, and et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial Lancet 385 2015 2255 2263
    • (2015) Lancet , vol.385 , pp. 2255-2263
    • Ngandu, T.1    Lehtisalo, J.2    Solomon, A.3    Levalahti, E.4    Ahtiluoto, S.5    Antikainen, R.6
  • 149
    • 84941279892 scopus 로고    scopus 로고
    • Physical Activity, Mediterranean Diet and Biomarkers-Assessed Risk of Alzheimer's: A Multi-Modality Brain Imaging Study
    • D.C. Matthews, M. Davies, J. Murray, S. Williams, W.H. Tsui, Y. Li, and et al. Physical Activity, Mediterranean Diet and Biomarkers-Assessed Risk of Alzheimer's: A Multi-Modality Brain Imaging Study Adv J Mol Imaging 4 2014 43 57
    • (2014) Adv J Mol Imaging , vol.4 , pp. 43-57
    • Matthews, D.C.1    Davies, M.2    Murray, J.3    Williams, S.4    Tsui, W.H.5    Li, Y.6
  • 151
    • 84917700026 scopus 로고    scopus 로고
    • Physical activity attenuates age-related biomarker alterations in preclinical AD
    • O.C. Okonkwo, S.A. Schultz, J.M. Oh, J. Larson, D. Edwards, D. Cook, and et al. Physical activity attenuates age-related biomarker alterations in preclinical AD Neurology 83 2014 1753 1760
    • (2014) Neurology , vol.83 , pp. 1753-1760
    • Okonkwo, O.C.1    Schultz, S.A.2    Oh, J.M.3    Larson, J.4    Edwards, D.5    Cook, D.6
  • 152
    • 84924801639 scopus 로고    scopus 로고
    • Mediterranean Diet and Magnetic Resonance Imaging-Assessed Brain Atrophy in Cognitively Normal Individuals at Risk for Alzheimer's Disease
    • L. Mosconi, J. Murray, W.H. Tsui, Y. Li, M. Davies, S. Williams, and et al. Mediterranean Diet and Magnetic Resonance Imaging-Assessed Brain Atrophy in Cognitively Normal Individuals at Risk for Alzheimer's Disease J Prev Alzheimers Dis 1 2014 23 32
    • (2014) J Prev Alzheimers Dis , vol.1 , pp. 23-32
    • Mosconi, L.1    Murray, J.2    Tsui, W.H.3    Li, Y.4    Davies, M.5    Williams, S.6
  • 154
    • 84867603343 scopus 로고    scopus 로고
    • Cognitive reserve in ageing and Alzheimer's disease
    • Y. Stern Cognitive reserve in ageing and Alzheimer's disease Lancet Neurol 11 2012 1006 1012
    • (2012) Lancet Neurol , vol.11 , pp. 1006-1012
    • Stern, Y.1
  • 155
    • 0035956486 scopus 로고    scopus 로고
    • Influence of leisure activity on the incidence of Alzheimer's disease
    • N. Scarmeas, G. Levy, M.X. Tang, J. Manly, and Y. Stern Influence of leisure activity on the incidence of Alzheimer's disease Neurology 57 2001 2236 2242
    • (2001) Neurology , vol.57 , pp. 2236-2242
    • Scarmeas, N.1    Levy, G.2    Tang, M.X.3    Manly, J.4    Stern, Y.5
  • 156
    • 67449143126 scopus 로고    scopus 로고
    • Elderly women with larger social networks are less likely to develop dementia
    • R.S. Wilson Elderly women with larger social networks are less likely to develop dementia Evid Based Ment Health 12 2009 22
    • (2009) Evid Based Ment Health , vol.12 , pp. 22
    • Wilson, R.S.1
  • 157
    • 33644919176 scopus 로고    scopus 로고
    • Brain reserve and dementia: A systematic review
    • M.J. Valenzuela, and P. Sachdev Brain reserve and dementia: a systematic review Psychol Med 36 2006 441 454
    • (2006) Psychol Med , vol.36 , pp. 441-454
    • Valenzuela, M.J.1    Sachdev, P.2
  • 158
    • 78651307767 scopus 로고    scopus 로고
    • Instrumental activities of daily living among community-dwelling older adults: Discrepancies between self-report and performance are mediated by cognitive reserve
    • Y. Suchy, M.L. Kraybill, and E. Franchow Instrumental activities of daily living among community-dwelling older adults: discrepancies between self-report and performance are mediated by cognitive reserve J Clin Exp Neuropsychol 33 2011 92 100
    • (2011) J Clin Exp Neuropsychol , vol.33 , pp. 92-100
    • Suchy, Y.1    Kraybill, M.L.2    Franchow, E.3
  • 159
    • 84888133625 scopus 로고    scopus 로고
    • Effect of cognitive reserve markers on Alzheimer pathologic progression
    • R.Y. Lo, W.J. Jagust Alzheimer's Disease Neuroimaging Initiative Effect of cognitive reserve markers on Alzheimer pathologic progression Alzheimer Dis Assoc Disord 27 2013 343 350
    • (2013) Alzheimer Dis Assoc Disord , vol.27 , pp. 343-350
    • Lo, R.Y.1    Jagust, W.J.2
  • 160
    • 84864471159 scopus 로고    scopus 로고
    • A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
    • T. Jonsson, J.K. Atwal, S. Steinberg, J. Snaedal, P.V. Jonsson, S. Bjornsson, and et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline Nature 488 2012 96 99
    • (2012) Nature , vol.488 , pp. 96-99
    • Jonsson, T.1    Atwal, J.K.2    Steinberg, S.3    Snaedal, J.4    Jonsson, P.V.5    Bjornsson, S.6
  • 161
    • 33645001561 scopus 로고    scopus 로고
    • The P300 component in patients with Alzheimer's disease and their biological children
    • B.A. Ally, G.E. Jones, J.A. Cole, and A.E. Budson The P300 component in patients with Alzheimer's disease and their biological children Biol Psychol 72 2006 180 187
    • (2006) Biol Psychol , vol.72 , pp. 180-187
    • Ally, B.A.1    Jones, G.E.2    Cole, J.A.3    Budson, A.E.4
  • 162
    • 84862777153 scopus 로고    scopus 로고
    • Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: A retrospective analysis
    • R. Sperling, S. Salloway, D.J. Brooks, D. Tampieri, J. Barakos, N.C. Fox, and et al. Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis Lancet Neurol 11 2012 241 249
    • (2012) Lancet Neurol , vol.11 , pp. 241-249
    • Sperling, R.1    Salloway, S.2    Brooks, D.J.3    Tampieri, D.4    Barakos, J.5    Fox, N.C.6
  • 163
  • 164
    • 84928159328 scopus 로고    scopus 로고
    • Tracking early decline in cognitive function in older individuals at risk for Alzheimer disease dementia: The Alzheimer's Disease Cooperative Study Cognitive Function Instrument
    • R.E. Amariglio, M.C. Donohue, G.A. Marshall, D.M. Rentz, D.P. Salmon, S.H. Ferris, and et al. Tracking early decline in cognitive function in older individuals at risk for Alzheimer disease dementia: the Alzheimer's Disease Cooperative Study Cognitive Function Instrument JAMA Neurol 72 2015 446 454
    • (2015) JAMA Neurol , vol.72 , pp. 446-454
    • Amariglio, R.E.1    Donohue, M.C.2    Marshall, G.A.3    Rentz, D.M.4    Salmon, D.P.5    Ferris, S.H.6
  • 167
    • 77952877416 scopus 로고    scopus 로고
    • Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment
    • S.B. Martin, C.D. Smith, H.R. Collins, F.A. Schmitt, and B.T. Gold Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment Neurobiol Aging 31 2010 1099 1106
    • (2010) Neurobiol Aging , vol.31 , pp. 1099-1106
    • Martin, S.B.1    Smith, C.D.2    Collins, H.R.3    Schmitt, F.A.4    Gold, B.T.5
  • 169
    • 84880272466 scopus 로고    scopus 로고
    • Cross-sectional and longitudinal analysis of the relationship between Abeta deposition, cortical thickness, and memory in cognitively unimpaired individuals and in Alzheimer disease
    • V. Dore, V.L. Villemagne, P. Bourgeat, J. Fripp, O. Acosta, G. Chetelat, and et al. Cross-sectional and longitudinal analysis of the relationship between Abeta deposition, cortical thickness, and memory in cognitively unimpaired individuals and in Alzheimer disease JAMA Neurol 70 2013 903 911
    • (2013) JAMA Neurol , vol.70 , pp. 903-911
    • Dore, V.1    Villemagne, V.L.2    Bourgeat, P.3    Fripp, J.4    Acosta, O.5    Chetelat, G.6
  • 173
    • 84867745651 scopus 로고    scopus 로고
    • Preclinical Alzheimer disease: Identification of cases at risk among cognitively intact older individuals
    • M.J. Lazarczyk, P.R. Hof, C. Bouras, and P. Giannakopoulos Preclinical Alzheimer disease: identification of cases at risk among cognitively intact older individuals BMC Med 10 2012 127
    • (2012) BMC Med , vol.10 , pp. 127
    • Lazarczyk, M.J.1    Hof, P.R.2    Bouras, C.3    Giannakopoulos, P.4
  • 174
    • 84883619455 scopus 로고    scopus 로고
    • Early indications of future cognitive decline: Stable versus declining controls
    • A. Rizk-Jackson, P. Insel, R. Petersen, P. Aisen, C. Jack, and M. Weiner Early indications of future cognitive decline: stable versus declining controls PLoS One 8 2013 e74062
    • (2013) PLoS One , vol.8
    • Rizk-Jackson, A.1    Insel, P.2    Petersen, R.3    Aisen, P.4    Jack, C.5    Weiner, M.6
  • 175
    • 84888606928 scopus 로고    scopus 로고
    • Reduced FDG-PET brain metabolism and executive function predict clinical progression in elderly healthy subjects
    • M. Ewers, M. Brendel, A. Rizk-Jackson, A. Rominger, P. Bartenstein, N. Schuff, and et al. Reduced FDG-PET brain metabolism and executive function predict clinical progression in elderly healthy subjects Neuroimage Clin 4 2014 45 52
    • (2014) Neuroimage Clin , vol.4 , pp. 45-52
    • Ewers, M.1    Brendel, M.2    Rizk-Jackson, A.3    Rominger, A.4    Bartenstein, P.5    Schuff, N.6
  • 177
    • 1842427969 scopus 로고    scopus 로고
    • Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI
    • M.D. Greicius, G. Srivastava, A.L. Reiss, and V. Menon Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI Proc Natl Acad Sci U S A 101 2004 4637 4642
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4637-4642
    • Greicius, M.D.1    Srivastava, G.2    Reiss, A.L.3    Menon, V.4
  • 178
    • 36749045805 scopus 로고    scopus 로고
    • Selective changes of resting-state networks in individuals at risk for Alzheimer's disease
    • C. Sorg, V. Riedl, M. Muhlau, V.D. Calhoun, T. Eichele, L. Laer, and et al. Selective changes of resting-state networks in individuals at risk for Alzheimer's disease Proc Natl Acad Sci U S A 104 2007 18760 18765
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 18760-18765
    • Sorg, C.1    Riedl, V.2    Muhlau, M.3    Calhoun, V.D.4    Eichele, T.5    Laer, L.6
  • 179
    • 79952073234 scopus 로고    scopus 로고
    • Multimodal classification of Alzheimer's disease and mild cognitive impairment
    • D. Zhang, Y. Wang, L. Zhou, H. Yuan, D. Shen Alzheimer's Disease Neuroimaging Initiative Multimodal classification of Alzheimer's disease and mild cognitive impairment Neuroimage 55 2011 856 867
    • (2011) Neuroimage , vol.55 , pp. 856-867
    • Zhang, D.1    Wang, Y.2    Zhou, L.3    Yuan, H.4    Shen, D.5
  • 180
    • 41149168614 scopus 로고    scopus 로고
    • Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation
    • S.L. Miller, K. Celone, K. DePeau, E. Diamond, B.C. Dickerson, D. Rentz, and et al. Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation Proc Natl Acad Sci U S A 105 2008 2181 2186
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 2181-2186
    • Miller, S.L.1    Celone, K.2    DePeau, K.3    Diamond, E.4    Dickerson, B.C.5    Rentz, D.6
  • 181
    • 64149093013 scopus 로고    scopus 로고
    • Neurodegenerative diseases target large-scale human brain networks
    • W.W. Seeley, R.K. Crawford, J. Zhou, B.L. Miller, and M.D. Greicius Neurodegenerative diseases target large-scale human brain networks Neuron 62 2009 42 52
    • (2009) Neuron , vol.62 , pp. 42-52
    • Seeley, W.W.1    Crawford, R.K.2    Zhou, J.3    Miller, B.L.4    Greicius, M.D.5
  • 182
    • 84907058022 scopus 로고    scopus 로고
    • Characteristics of the default mode functional connectivity in normal ageing and Alzheimer's disease using resting state fMRI with a combined approach of entropy-based and graph theoretical measurements
    • P.J. Toussaint, S. Maiz, D. Coynel, J. Doyon, A. Messe, L.C. de Souza, and et al. Characteristics of the default mode functional connectivity in normal ageing and Alzheimer's disease using resting state fMRI with a combined approach of entropy-based and graph theoretical measurements Neuroimage 101 2014 778 786
    • (2014) Neuroimage , vol.101 , pp. 778-786
    • Toussaint, P.J.1    Maiz, S.2    Coynel, D.3    Doyon, J.4    Messe, A.5    De Souza, L.C.6
  • 183
    • 23944444806 scopus 로고    scopus 로고
    • Molecular, structural, and functional characterization of Alzheimer's disease: Evidence for a relationship between default activity, amyloid, and memory
    • R.L. Buckner, A.Z. Snyder, B.J. Shannon, G. LaRossa, R. Sachs, A.F. Fotenos, and et al. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory J Neurosci 25 2005 7709 7717
    • (2005) J Neurosci , vol.25 , pp. 7709-7717
    • Buckner, R.L.1    Snyder, A.Z.2    Shannon, B.J.3    LaRossa, G.4    Sachs, R.5    Fotenos, A.F.6
  • 184
    • 70350331591 scopus 로고    scopus 로고
    • Functional MRI assessment of task-induced deactivation of the default mode network in Alzheimer's disease and at-risk older individuals
    • M. Pihlajamaki, and R.A. Sperling Functional MRI assessment of task-induced deactivation of the default mode network in Alzheimer's disease and at-risk older individuals Behav Neurol 21 2009 77 91
    • (2009) Behav Neurol , vol.21 , pp. 77-91
    • Pihlajamaki, M.1    Sperling, R.A.2
  • 185
    • 84927945410 scopus 로고    scopus 로고
    • Eyes-closed task-free electroencephalography in clinical trials for Alzheimer's disease: An emerging method based upon brain dynamics
    • E.C. van Straaten, P. Scheltens, A.A. Gouw, and C.J. Stam Eyes-closed task-free electroencephalography in clinical trials for Alzheimer's disease: an emerging method based upon brain dynamics Alzheimers Res Ther 6 2014 86
    • (2014) Alzheimers Res Ther , vol.6 , pp. 86
    • Van Straaten, E.C.1    Scheltens, P.2    Gouw, A.A.3    Stam, C.J.4
  • 186
  • 187
    • 80051511249 scopus 로고    scopus 로고
    • Event-related potential markers of brain changes in preclinical familial Alzheimer disease
    • Y.T. Quiroz, B.A. Ally, K. Celone, J. McKeever, A.L. Ruiz-Rizzo, F. Lopera, and et al. Event-related potential markers of brain changes in preclinical familial Alzheimer disease Neurology 77 2011 469 475
    • (2011) Neurology , vol.77 , pp. 469-475
    • Quiroz, Y.T.1    Ally, B.A.2    Celone, K.3    McKeever, J.4    Ruiz-Rizzo, A.L.5    Lopera, F.6
  • 188
    • 78650915565 scopus 로고    scopus 로고
    • MEG connectivity analysis in patients with Alzheimer's disease using cross mutual information and spectral coherence
    • J.F. Alonso, J. Poza, M.A. Mananas, S. Romero, A. Fernandez, and R. Hornero MEG connectivity analysis in patients with Alzheimer's disease using cross mutual information and spectral coherence Ann Biomed Eng 39 2011 524 536
    • (2011) Ann Biomed Eng , vol.39 , pp. 524-536
    • Alonso, J.F.1    Poza, J.2    Mananas, M.A.3    Romero, S.4    Fernandez, A.5    Hornero, R.6
  • 189
    • 78650638896 scopus 로고    scopus 로고
    • Functional connectivity in mild cognitive impairment during a memory task: Implications for the disconnection hypothesis
    • R. Bajo, F. Maestu, A. Nevado, M. Sancho, R. Gutierrez, P. Campo, and et al. Functional connectivity in mild cognitive impairment during a memory task: implications for the disconnection hypothesis J Alzheimers Dis 22 2010 183 193
    • (2010) J Alzheimers Dis , vol.22 , pp. 183-193
    • Bajo, R.1    Maestu, F.2    Nevado, A.3    Sancho, M.4    Gutierrez, R.5    Campo, P.6
  • 190
    • 84880058381 scopus 로고    scopus 로고
    • Altered oscillation and synchronization of default-mode network activity in mild Alzheimer's disease compared to mild cognitive impairment: An electrophysiological study
    • F.J. Hsiao, Y.J. Wang, S.H. Yan, W.T. Chen, and Y.Y. Lin Altered oscillation and synchronization of default-mode network activity in mild Alzheimer's disease compared to mild cognitive impairment: an electrophysiological study PLoS One 8 2013 e68792
    • (2013) PLoS One , vol.8
    • Hsiao, F.J.1    Wang, Y.J.2    Yan, S.H.3    Chen, W.T.4    Lin, Y.Y.5
  • 191
    • 84979149636 scopus 로고    scopus 로고
    • Brain neural synchronization and functional coupling in Alzheimer's disease as revealed by resting state EEG rhythms
    • C. Babiloni, R. Lizio, N. Marzano, P. Capotosto, A. Soricelli, A.I. Triggiani, and et al. Brain neural synchronization and functional coupling in Alzheimer's disease as revealed by resting state EEG rhythms Int J Psychophysiol 2015
    • (2015) Int J Psychophysiol
    • Babiloni, C.1    Lizio, R.2    Marzano, N.3    Capotosto, P.4    Soricelli, A.5    Triggiani, A.I.6
  • 194
    • 84897910461 scopus 로고    scopus 로고
    • Compensatory mechanisms in higher-educated subjects with Alzheimer's disease: A study of 20 years of cognitive decline
    • H. Amieva, H. Mokri, M. Le Goff, C. Meillon, H. Jacqmin-Gadda, A. Foubert-Samier, and et al. Compensatory mechanisms in higher-educated subjects with Alzheimer's disease: a study of 20 years of cognitive decline Brain 137 2014 1167 1175
    • (2014) Brain , vol.137 , pp. 1167-1175
    • Amieva, H.1    Mokri, H.2    Le Goff, M.3    Meillon, C.4    Jacqmin-Gadda, H.5    Foubert-Samier, A.6
  • 195
    • 15044349446 scopus 로고    scopus 로고
    • A meta-analytic review of verbal fluency deficits in depression
    • J. Henry, and J.R. Crawford A meta-analytic review of verbal fluency deficits in depression J Clin Exp Neuropsychol 27 2005 78 101
    • (2005) J Clin Exp Neuropsychol , vol.27 , pp. 78-101
    • Henry, J.1    Crawford, J.R.2
  • 197
    • 79954514830 scopus 로고    scopus 로고
    • Drug-related decrease in neuropsychological functions of abstinent drug users
    • R.J. van Holst, and T. Schilt Drug-related decrease in neuropsychological functions of abstinent drug users Curr Drug Abuse Rev 4 2011 42 56
    • (2011) Curr Drug Abuse Rev , vol.4 , pp. 42-56
    • Van Holst, R.J.1    Schilt, T.2
  • 199
    • 80052851449 scopus 로고    scopus 로고
    • Prediction of preclinical Alzheimer's disease: Longitudinal rates of change in cognition
    • K.P. Riley, G.A. Jicha, D. Davis, E.L. Abner, G.E. Cooper, N. Stiles, and et al. Prediction of preclinical Alzheimer's disease: longitudinal rates of change in cognition J Alzheimers Dis 25 2011 707 717
    • (2011) J Alzheimers Dis , vol.25 , pp. 707-717
    • Riley, K.P.1    Jicha, G.A.2    Davis, D.3    Abner, E.L.4    Cooper, G.E.5    Stiles, N.6
  • 200
    • 84876385490 scopus 로고    scopus 로고
    • Meta-analysis of amyloid-cognition relations in cognitively normal older adults
    • T. Hedden, H. Oh, A.P. Younger, and T.A. Patel Meta-analysis of amyloid-cognition relations in cognitively normal older adults Neurology 80 2013 1341 1348
    • (2013) Neurology , vol.80 , pp. 1341-1348
    • Hedden, T.1    Oh, H.2    Younger, A.P.3    Patel, T.A.4
  • 202
    • 84934434661 scopus 로고    scopus 로고
    • Phenomenological characterization of memory complaints in preclinical and prodromal Alzheimer's disease
    • R.F. Buckley, K.A. Ellis, D. Ames, C.C. Rowe, N.T. Lautenschlager, P. Maruff, and et al. Phenomenological characterization of memory complaints in preclinical and prodromal Alzheimer's disease Neuropsychology 29 2015 571 581
    • (2015) Neuropsychology , vol.29 , pp. 571-581
    • Buckley, R.F.1    Ellis, K.A.2    Ames, D.3    Rowe, C.C.4    Lautenschlager, N.T.5    Maruff, P.6
  • 203
    • 84929094484 scopus 로고    scopus 로고
    • Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network
    • J.M. Ringman, L.J. Liang, Y. Zhou, S. Vangala, E. Teng, S. Kremen, and et al. Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network Brain 138 2015 1036 1045
    • (2015) Brain , vol.138 , pp. 1036-1045
    • Ringman, J.M.1    Liang, L.J.2    Zhou, Y.3    Vangala, S.4    Teng, E.5    Kremen, S.6
  • 204
    • 84927175617 scopus 로고    scopus 로고
    • An empirically derived composite cognitive test score with improved power to track and evaluate treatments for preclinical Alzheimer's disease
    • J.B. Langbaum, S.B. Hendrix, N. Ayutyanont, K. Chen, A.S. Fleisher, R.C. Shah, and et al. An empirically derived composite cognitive test score with improved power to track and evaluate treatments for preclinical Alzheimer's disease Alzheimers Dement 10 2014 666 674
    • (2014) Alzheimers Dement , vol.10 , pp. 666-674
    • Langbaum, J.B.1    Hendrix, S.B.2    Ayutyanont, N.3    Chen, K.4    Fleisher, A.S.5    Shah, R.C.6
  • 205
    • 84888350571 scopus 로고    scopus 로고
    • Promising developments in neuropsychological approaches for the detection of preclinical Alzheimer's disease: A selective review
    • D.M. Rentz, M.A. Parra Rodriguez, R. Amariglio, Y. Stern, R. Sperling, and S. Ferris Promising developments in neuropsychological approaches for the detection of preclinical Alzheimer's disease: a selective review Alzheimers Res Ther 5 2013 58
    • (2013) Alzheimers Res Ther , vol.5 , pp. 58
    • Rentz, D.M.1    Parra Rodriguez, M.A.2    Amariglio, R.3    Stern, Y.4    Sperling, R.5    Ferris, S.6
  • 206
    • 84876364640 scopus 로고    scopus 로고
    • Screening for predementia AD: Time-dependent operating characteristics of episodic memory tests
    • C.A. Derby, L.C. Burns, C. Wang, M.J. Katz, M.E. Zimmerman, G. L'Italien, and et al. Screening for predementia AD: time-dependent operating characteristics of episodic memory tests Neurology 80 2013 1307 1314
    • (2013) Neurology , vol.80 , pp. 1307-1314
    • Derby, C.A.1    Burns, L.C.2    Wang, C.3    Katz, M.J.4    Zimmerman, M.E.5    L'Italien, G.6
  • 208
    • 35948993429 scopus 로고    scopus 로고
    • Amnestic syndrome of the medial temporal type identifies prodromal AD: A longitudinal study
    • M. Sarazin, C. Berr, J. De Rotrou, C. Fabrigoule, F. Pasquier, S. Legrain, and et al. Amnestic syndrome of the medial temporal type identifies prodromal AD: a longitudinal study Neurology 69 2007 1859 1867
    • (2007) Neurology , vol.69 , pp. 1859-1867
    • Sarazin, M.1    Berr, C.2    De Rotrou, J.3    Fabrigoule, C.4    Pasquier, F.5    Legrain, S.6
  • 209
    • 77956377310 scopus 로고    scopus 로고
    • Visual short-term memory binding deficits in familial Alzheimer's disease
    • M.A. Parra, S. Abrahams, R.H. Logie, L.G. Mendez, F. Lopera, and S. Della Sala Visual short-term memory binding deficits in familial Alzheimer's disease Brain 133 2010 2702 2713
    • (2010) Brain , vol.133 , pp. 2702-2713
    • Parra, M.A.1    Abrahams, S.2    Logie, R.H.3    Mendez, L.G.4    Lopera, F.5    Della Sala, S.6
  • 211
    • 77950535797 scopus 로고    scopus 로고
    • Relationship between atrophy and beta-amyloid deposition in Alzheimer disease
    • G. Chetelat, V.L. Villemagne, P. Bourgeat, K.E. Pike, G. Jones, D. Ames, and et al. Relationship between atrophy and beta-amyloid deposition in Alzheimer disease Ann Neurol 67 2010 317 324
    • (2010) Ann Neurol , vol.67 , pp. 317-324
    • Chetelat, G.1    Villemagne, V.L.2    Bourgeat, P.3    Pike, K.E.4    Jones, G.5    Ames, D.6
  • 212
    • 84927176303 scopus 로고    scopus 로고
    • A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease
    • F. Jessen, R.E. Amariglio, M. van Boxtel, M. Breteler, M. Ceccaldi, G. Chetelat, and et al. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease Alzheimers Dement 10 2014 844 852
    • (2014) Alzheimers Dement , vol.10 , pp. 844-852
    • Jessen, F.1    Amariglio, R.E.2    Van Boxtel, M.3    Breteler, M.4    Ceccaldi, M.5    Chetelat, G.6
  • 214
    • 84867528523 scopus 로고    scopus 로고
    • Indicators of amyloid burden in a population-based study of cognitively normal elderly
    • M.M. Mielke, H.J. Wiste, S.D. Weigand, D.S. Knopman, V.J. Lowe, R.O. Roberts, and et al. Indicators of amyloid burden in a population-based study of cognitively normal elderly Neurology 79 2012 1570 1577
    • (2012) Neurology , vol.79 , pp. 1570-1577
    • Mielke, M.M.1    Wiste, H.J.2    Weigand, S.D.3    Knopman, D.S.4    Lowe, V.J.5    Roberts, R.O.6
  • 215
    • 84909980100 scopus 로고    scopus 로고
    • Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: Meta-analysis
    • A.J. Mitchell, H. Beaumont, D. Ferguson, M. Yadegarfar, and B. Stubbs Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis Acta Psychiatr Scand 130 2014 439 451
    • (2014) Acta Psychiatr Scand , vol.130 , pp. 439-451
    • Mitchell, A.J.1    Beaumont, H.2    Ferguson, D.3    Yadegarfar, M.4    Stubbs, B.5
  • 216
    • 79960199327 scopus 로고    scopus 로고
    • Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study
    • K.E. Pike, K.A. Ellis, V.L. Villemagne, N. Good, G. Chetelat, D. Ames, and et al. Cognition and beta-amyloid in preclinical Alzheimer's disease: data from the AIBL study Neuropsychologia 49 2011 2384 2390
    • (2011) Neuropsychologia , vol.49 , pp. 2384-2390
    • Pike, K.E.1    Ellis, K.A.2    Villemagne, V.L.3    Good, N.4    Chetelat, G.5    Ames, D.6
  • 219
    • 84866106602 scopus 로고    scopus 로고
    • Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
    • W.T. Hu, D.M. Holtzman, A.M. Fagan, L.M. Shaw, R. Perrin, S.E. Arnold, and et al. Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease Neurology 79 2012 897 905
    • (2012) Neurology , vol.79 , pp. 897-905
    • Hu, W.T.1    Holtzman, D.M.2    Fagan, A.M.3    Shaw, L.M.4    Perrin, R.5    Arnold, S.E.6
  • 220
    • 77957066281 scopus 로고    scopus 로고
    • A serum protein-based algorithm for the detection of Alzheimer disease
    • S.E. O'Bryant, G. Xiao, R. Barber, J. Reisch, R. Doody, T. Fairchild, and et al. A serum protein-based algorithm for the detection of Alzheimer disease Arch Neurol 67 2010 1077 1081
    • (2010) Arch Neurol , vol.67 , pp. 1077-1081
    • O'Bryant, S.E.1    Xiao, G.2    Barber, R.3    Reisch, J.4    Doody, R.5    Fairchild, T.6
  • 221
    • 84867339786 scopus 로고    scopus 로고
    • Blood-based protein biomarkers for the diagnosis of Alzheimer's disease
    • J. Doecke, S.M. Laws, N.G. Faux, W. Wilson, S.C. Burnham, C.P. Lam, and et al. Blood-based protein biomarkers for the diagnosis of Alzheimer's disease Arch Neurol 69 2012 1318 1325
    • (2012) Arch Neurol , vol.69 , pp. 1318-1325
    • Doecke, J.1    Laws, S.M.2    Faux, N.G.3    Wilson, W.4    Burnham, S.C.5    Lam, C.P.6
  • 223
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group Biomarkers and surrogate endpoints: preferred definitions and conceptual framework Clin Pharmacol Ther 69 2001 89 95
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89-95
  • 224
    • 82855163989 scopus 로고    scopus 로고
    • A Blood-Based Screening Tool for Alzheimer's Disease That Spans Serum and Plasma: Findings from TARC and ADNI
    • S.E. O'Bryant, G. Xiao, R. Barber, R. Huebinger, K. Wilhelmsen, M. Edwards, and et al. A Blood-Based Screening Tool for Alzheimer's Disease That Spans Serum and Plasma: Findings from TARC and ADNI PLoS One 6 2011 e28092
    • (2011) PLoS One , vol.6
    • O'Bryant, S.E.1    Xiao, G.2    Barber, R.3    Huebinger, R.4    Wilhelmsen, K.5    Edwards, M.6
  • 225
    • 84907968763 scopus 로고    scopus 로고
    • Validation of a serum screen for alzheimer's disease across assay platforms, species, and tissues
    • S.E. O'Bryant, G. Xiao, F. Zhang, M. Edwards, D.C. German, X. Yin, and et al. Validation of a serum screen for alzheimer's disease across assay platforms, species, and tissues J Alzheimers Dis 42 2014 1325 1335
    • (2014) J Alzheimers Dis , vol.42 , pp. 1325-1335
    • O'Bryant, S.E.1    Xiao, G.2    Zhang, F.3    Edwards, M.4    German, D.C.5    Yin, X.6
  • 226
    • 84889664846 scopus 로고    scopus 로고
    • Candidate blood proteome markers of Alzheimer's disease onset and progression: A systematic review and replication study
    • S.J. Kiddle, M. Sattlecker, P. Proitsi, A. Simmons, E. Westman, C. Bazenet, and et al. Candidate blood proteome markers of Alzheimer's disease onset and progression: A systematic review and replication study J Alzheimers Dis 38 2014 515 531
    • (2014) J Alzheimers Dis , vol.38 , pp. 515-531
    • Kiddle, S.J.1    Sattlecker, M.2    Proitsi, P.3    Simmons, A.4    Westman, E.5    Bazenet, C.6
  • 229
    • 33947282076 scopus 로고    scopus 로고
    • Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease
    • N.R. Graff-Radford, J.E. Crook, J. Lucas, B.F. Boeve, D.S. Knopman, R.J. Ivnik, and et al. Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease Arch Neurol 64 2007 354 362
    • (2007) Arch Neurol , vol.64 , pp. 354-362
    • Graff-Radford, N.R.1    Crook, J.E.2    Lucas, J.3    Boeve, B.F.4    Knopman, D.S.5    Ivnik, R.J.6
  • 230
    • 34548650273 scopus 로고    scopus 로고
    • Sep
    • [erratum appears in Arch Neurol. 2007 Sep;64(9):1246]
    • (2007) Arch Neurol. , vol.64 , Issue.9 , pp. 1246
  • 231
    • 84897108729 scopus 로고    scopus 로고
    • A blood-based predictor for neocortical Aβ burden in Alzheimer's disease: Results from the AIBL study
    • S.C. Burnham, N.G. Faux, W. Wilson, S.M. Laws, D. Ames, J. Bedo, and et al. A blood-based predictor for neocortical Aβ burden in Alzheimer's disease: Results from the AIBL study Mol Psychiatry 19 2014 519 526
    • (2014) Mol Psychiatry , vol.19 , pp. 519-526
    • Burnham, S.C.1    Faux, N.G.2    Wilson, W.3    Laws, S.M.4    Ames, D.5    Bedo, J.6
  • 232
    • 84923217304 scopus 로고    scopus 로고
    • Brain amyloidosis ascertainment from cognitive, imaging, and peripheral blood protein measures
    • L.G. Apostolova, K.S. Hwang, D. Avila, D. Elashoff, O. Kohannim, E. Teng, and et al. Brain amyloidosis ascertainment from cognitive, imaging, and peripheral blood protein measures Neurology 84 2015 729 737
    • (2015) Neurology , vol.84 , pp. 729-737
    • Apostolova, L.G.1    Hwang, K.S.2    Avila, D.3    Elashoff, D.4    Kohannim, O.5    Teng, E.6
  • 233
    • 84929264851 scopus 로고    scopus 로고
    • Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research
    • S.E. O'Bryant, V. Gupta, K. Henriksen, M. Edwards, A. Jeromin, S. Lista, and et al. Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research Alzheimers Dement 11 2015 549 560
    • (2015) Alzheimers Dement , vol.11 , pp. 549-560
    • O'Bryant, S.E.1    Gupta, V.2    Henriksen, K.3    Edwards, M.4    Jeromin, A.5    Lista, S.6
  • 234
    • 0032030921 scopus 로고    scopus 로고
    • Evaluation and use of diagnostic tests in Alzheimer's disease
    • R. Mayeux Evaluation and use of diagnostic tests in Alzheimer's disease Neurobiol Aging 19 1998 139 143
    • (1998) Neurobiol Aging , vol.19 , pp. 139-143
    • Mayeux, R.1
  • 235
    • 78751532097 scopus 로고    scopus 로고
    • Mapping out biomarkers for Alzheimer's disease
    • M. Breteler Mapping out biomarkers for Alzheimer's disease JAMA 305 2011 304 305
    • (2011) JAMA , vol.305 , pp. 304-305
    • Breteler, M.1
  • 236
    • 70349515367 scopus 로고    scopus 로고
    • Approaching clinical proteomics: Current state and future fields of application in cellular proteomics
    • R. Apweiler, C. Aslanidis, T. Deufel, A. Gerstner, J. Hansen, D. Hochstrasser, and et al. Approaching clinical proteomics: current state and future fields of application in cellular proteomics Cytometry A 75 2009 816 832
    • (2009) Cytometry A , vol.75 , pp. 816-832
    • Apweiler, R.1    Aslanidis, C.2    Deufel, T.3    Gerstner, A.4    Hansen, J.5    Hochstrasser, D.6
  • 240
    • 84875514732 scopus 로고    scopus 로고
    • Regulatory innovation and drug development for early-stage Alzheimer's disease
    • N. Kozauer, and R. Katz Regulatory innovation and drug development for early-stage Alzheimer's disease N Engl J Med 368 2013 1169 1171
    • (2013) N Engl J Med , vol.368 , pp. 1169-1171
    • Kozauer, N.1    Katz, R.2
  • 242
    • 84905963790 scopus 로고    scopus 로고
    • Secondary prevention trials in Alzheimer disease: The challenge of identifying a meaningful end point
    • R.J. Kryscio Secondary prevention trials in Alzheimer disease: the challenge of identifying a meaningful end point JAMA Neurol 71 2014 947 949
    • (2014) JAMA Neurol , vol.71 , pp. 947-949
    • Kryscio, R.J.1
  • 246
    • 80055034288 scopus 로고    scopus 로고
    • Alzheimer's Prevention Initiative: A plan to accelerate the evaluation of presymptomatic treatments
    • E.M. Reiman, J.B. Langbaum, A.S. Fleisher, R.J. Caselli, K. Chen, N. Ayutyanont, and et al. Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments J Alzheimers Dis 26 Suppl 3 2011 321 329
    • (2011) J Alzheimers Dis , vol.26 , pp. 321-329
    • Reiman, E.M.1    Langbaum, J.B.2    Fleisher, A.S.3    Caselli, R.J.4    Chen, K.5    Ayutyanont, N.6
  • 248
    • 84902649164 scopus 로고    scopus 로고
    • Toward onset prevention of cognitive decline in adults with Down syndrome (the TOP-COG study): Study protocol for a randomized controlled trial
    • S.A. Cooper, M. Caslake, J. Evans, A. Hassiotis, A. Jahoda, A. McConnachie, and et al. Toward onset prevention of cognitive decline in adults with Down syndrome (the TOP-COG study): study protocol for a randomized controlled trial Trials 15 2014 202
    • (2014) Trials , vol.15 , pp. 202
    • Cooper, S.A.1    Caslake, M.2    Evans, J.3    Hassiotis, A.4    Jahoda, A.5    McConnachie, A.6
  • 249
    • 59349103299 scopus 로고    scopus 로고
    • A multi-center, randomized, double blind placebo-controlled trial of estrogens to prevent Alzheimer's disease and loss of memory in women: Design and baseline characteristics
    • M. Sano, D. Jacobs, H. Andrews, K. Bell, N. Graff-Radford, J. Lucas, and et al. A multi-center, randomized, double blind placebo-controlled trial of estrogens to prevent Alzheimer's disease and loss of memory in women: design and baseline characteristics Clin Trials 5 2008 523 533
    • (2008) Clin Trials , vol.5 , pp. 523-533
    • Sano, M.1    Jacobs, D.2    Andrews, H.3    Bell, K.4    Graff-Radford, N.5    Lucas, J.6
  • 250
    • 33847373072 scopus 로고    scopus 로고
    • Cardiovascular and cerebrovascular events in the randomized, controlled Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT)
    • Group AR Cardiovascular and cerebrovascular events in the randomized, controlled Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT) PLoS Clin Trials 1 2006 e33
    • (2006) PLoS Clin Trials , vol.1 , pp. e33
  • 251
    • 84866445630 scopus 로고    scopus 로고
    • Long-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): A randomised placebo-controlled trial
    • B. Vellas, N. Coley, P.J. Ousset, G. Berrut, J.F. Dartigues, B. Dubois, and et al. Long-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial Lancet Neurol 11 2012 851 859
    • (2012) Lancet Neurol , vol.11 , pp. 851-859
    • Vellas, B.1    Coley, N.2    Ousset, P.J.3    Berrut, G.4    Dartigues, J.F.5    Dubois, B.6
  • 253
    • 62849118735 scopus 로고    scopus 로고
    • Commentary on "a roadmap for the prevention of dementia II. Leon Thal Symposium 2008." the Multidomain Alzheimer Preventive Trial (MAPT): A new approach to the prevention of Alzheimer's disease
    • S. Gillette-Guyonnet, S. Andrieu, T. Dantoine, J.F. Dartigues, J. Touchon, B. Vellas, and et al. Commentary on "A roadmap for the prevention of dementia II. Leon Thal Symposium 2008." The Multidomain Alzheimer Preventive Trial (MAPT): a new approach to the prevention of Alzheimer's disease Alzheimers Dement 5 2009 114 121
    • (2009) Alzheimers Dement , vol.5 , pp. 114-121
    • Gillette-Guyonnet, S.1    Andrieu, S.2    Dantoine, T.3    Dartigues, J.F.4    Touchon, J.5    Vellas, B.6
  • 254
    • 84921931130 scopus 로고    scopus 로고
    • Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: A 6-month randomised controlled trial
    • L.F. ten Brinke, N. Bolandzadeh, L.S. Nagamatsu, C.L. Hsu, J.C. Davis, K. Miran-Khan, and et al. Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial Br J Sports Med 49 2015 248 254
    • (2015) Br J Sports Med , vol.49 , pp. 248-254
    • Ten Brinke, L.F.1    Bolandzadeh, N.2    Nagamatsu, L.S.3    Hsu, C.L.4    Davis, J.C.5    Miran-Khan, K.6
  • 255
    • 84887370094 scopus 로고    scopus 로고
    • Study design of ASPirin in Reducing Events in the Elderly (ASPREE): A randomized, controlled trial
    • Group AI Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial Contemp Clin Trials 36 2013 555 564
    • (2013) Contemp Clin Trials , vol.36 , pp. 555-564
  • 257
    • 33646205347 scopus 로고    scopus 로고
    • The Ginkgo Evaluation of Memory (GEM) study: Design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia
    • S.T. DeKosky, A. Fitzpatrick, D.G. Ives, J. Saxton, J. Williamson, O.L. Lopez, and et al. The Ginkgo Evaluation of Memory (GEM) study: design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia Contemp Clin Trials 27 2006 238 253
    • (2006) Contemp Clin Trials , vol.27 , pp. 238-253
    • DeKosky, S.T.1    Fitzpatrick, A.2    Ives, D.G.3    Saxton, J.4    Williamson, J.5    Lopez, O.L.6
  • 260
    • 84882308754 scopus 로고    scopus 로고
    • Designing drug trials for Alzheimer's disease: What we have learned from the release of the phase III antibody trials: A report from the EU/US/CTAD Task Force
    • B. Vellas, M.C. Carrillo, C. Sampaio, H.R. Brashear, E. Siemers, H. Hampel, and et al. Designing drug trials for Alzheimer's disease: what we have learned from the release of the phase III antibody trials: a report from the EU/US/CTAD Task Force Alzheimers Dement 9 2013 438 444
    • (2013) Alzheimers Dement , vol.9 , pp. 438-444
    • Vellas, B.1    Carrillo, M.C.2    Sampaio, C.3    Brashear, H.R.4    Siemers, E.5    Hampel, H.6
  • 261
    • 84957440529 scopus 로고    scopus 로고
    • Development of interventions for the secondary prevention of Alzheimer's dementia: The European Prevention of Alzheimer's Dementia (EPAD) project
    • C.W. Ritchie, J.L. Molinuevo, L. Truyen, A. Satlin, S. Van der Geyten, S. Lovestone, and et al. Development of interventions for the secondary prevention of Alzheimer's dementia: the European Prevention of Alzheimer's Dementia (EPAD) project Lancet Psychiatry 3 2016 179 186
    • (2016) Lancet Psychiatry , vol.3 , pp. 179-186
    • Ritchie, C.W.1    Molinuevo, J.L.2    Truyen, L.3    Satlin, A.4    Van Der Geyten, S.5    Lovestone, S.6
  • 262
    • 84863211664 scopus 로고    scopus 로고
    • Alzheimer's disease therapeutic trials: EU/US Task Force report on recruitment, retention, and methodology
    • B. Vellas, H. Hampel, M.E. Rouge-Bugat, M. Grundman, S. Andrieu, S. Abu-Shakra, and et al. Alzheimer's disease therapeutic trials: EU/US Task Force report on recruitment, retention, and methodology J Nutr Health Aging 16 2012 339 345
    • (2012) J Nutr Health Aging , vol.16 , pp. 339-345
    • Vellas, B.1    Hampel, H.2    Rouge-Bugat, M.E.3    Grundman, M.4    Andrieu, S.5    Abu-Shakra, S.6
  • 264
    • 84897954102 scopus 로고    scopus 로고
    • Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: A long-range point of view beyond 2020
    • H. Hampel, S. Lista, S.J. Teipel, F. Garaci, R. Nistico, K. Blennow, and et al. Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: a long-range point of view beyond 2020 Biochem Pharmacol 88 2014 426 449
    • (2014) Biochem Pharmacol , vol.88 , pp. 426-449
    • Hampel, H.1    Lista, S.2    Teipel, S.J.3    Garaci, F.4    Nistico, R.5    Blennow, K.6
  • 266
    • 84895729886 scopus 로고    scopus 로고
    • Clinical trials and late-stage drug development for Alzheimer's disease: An appraisal from 1984 to 2014
    • L.S. Schneider, F. Mangialasche, N. Andreasen, H. Feldman, E. Giacobini, R. Jones, and et al. Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014 J Intern Med 275 2014 251 283
    • (2014) J Intern Med , vol.275 , pp. 251-283
    • Schneider, L.S.1    Mangialasche, F.2    Andreasen, N.3    Feldman, H.4    Giacobini, E.5    Jones, R.6
  • 267
    • 84886747917 scopus 로고    scopus 로고
    • A conceptual framework and ethics analysis for prevention trials of Alzheimer Disease
    • K.R. Peters, B. Lynn Beattie, H.H. Feldman, and J. Illes A conceptual framework and ethics analysis for prevention trials of Alzheimer Disease Prog Neurobiol 110 2013 114 123
    • (2013) Prog Neurobiol , vol.110 , pp. 114-123
    • Peters, K.R.1    Lynn Beattie, B.2    Feldman, H.H.3    Illes, J.4
  • 269
    • 84867658978 scopus 로고    scopus 로고
    • Enrichment and stratification for predementia Alzheimer disease clinical trials
    • D. Holland, L.K. McEvoy, R.S. Desikan, A.M. Dale Alzheimer's Disease Neuroimaging Initiative Enrichment and stratification for predementia Alzheimer disease clinical trials PLoS One 7 2012 e47739
    • (2012) PLoS One , vol.7
    • Holland, D.1    McEvoy, L.K.2    Desikan, R.S.3    Dale, A.M.4
  • 270
    • 84867579437 scopus 로고    scopus 로고
    • Methodological challenges in designing dementia prevention trials - The European Dementia Prevention Initiative (EDPI)
    • E. Richard, S. Andrieu, A. Solomon, F. Mangialasche, S. Ahtiluoto, E.P. Moll van Charante, and et al. Methodological challenges in designing dementia prevention trials - the European Dementia Prevention Initiative (EDPI) J Neurol Sci 322 2012 64 70
    • (2012) J Neurol Sci , vol.322 , pp. 64-70
    • Richard, E.1    Andrieu, S.2    Solomon, A.3    Mangialasche, F.4    Ahtiluoto, S.5    Moll Van Charante, E.P.6
  • 272
    • 84886726315 scopus 로고    scopus 로고
    • Diagnosis and management of Alzheimer's disease: Past, present and future ethical issues
    • S. Gauthier, A. Leuzy, E. Racine, and P. Rosa-Neto Diagnosis and management of Alzheimer's disease: past, present and future ethical issues Prog Neurobiol 110 2013 102 113
    • (2013) Prog Neurobiol , vol.110 , pp. 102-113
    • Gauthier, S.1    Leuzy, A.2    Racine, E.3    Rosa-Neto, P.4
  • 273
    • 84876942135 scopus 로고    scopus 로고
    • Risk disclosure and preclinical Alzheimer's disease clinical trial enrollment
    • J.D. Grill, J. Karlawish, D. Elashoff, and B.G. Vickrey Risk disclosure and preclinical Alzheimer's disease clinical trial enrollment Alzheimers Dement 9 2013 356 359.e1
    • (2013) Alzheimers Dement , vol.9 , pp. 356.e1-359.e1
    • Grill, J.D.1    Karlawish, J.2    Elashoff, D.3    Vickrey, B.G.4
  • 276
    • 79960845369 scopus 로고    scopus 로고
    • Presymptomatic apolipoprotein E genotyping for Alzheimer's disease risk assessment and prevention
    • H.M. Schipper Presymptomatic apolipoprotein E genotyping for Alzheimer's disease risk assessment and prevention Alzheimers Dement 7 2011 e118 e123
    • (2011) Alzheimers Dement , vol.7 , pp. e118-e123
    • Schipper, H.M.1
  • 278
    • 82955235703 scopus 로고    scopus 로고
    • Addressing the ethical, policy, and social challenges of preclinical Alzheimer disease
    • J. Karlawish Addressing the ethical, policy, and social challenges of preclinical Alzheimer disease Neurology 77 2011 1487 1493
    • (2011) Neurology , vol.77 , pp. 1487-1493
    • Karlawish, J.1
  • 283
    • 84872464390 scopus 로고    scopus 로고
    • Use of biomarkers and imaging to assess pathophysiology, mechanisms of action and target engagement
    • H. Hampel, and S. Lista Use of biomarkers and imaging to assess pathophysiology, mechanisms of action and target engagement J Nutr Health Aging 17 2013 54 63
    • (2013) J Nutr Health Aging , vol.17 , pp. 54-63
    • Hampel, H.1    Lista, S.2
  • 284
    • 84863224067 scopus 로고    scopus 로고
    • Development of biomarkers to chart all Alzheimer's disease stages: The royal road to cutting the therapeutic Gordian Knot
    • H. Hampel, S. Lista, and Z.S. Khachaturian Development of biomarkers to chart all Alzheimer's disease stages: the royal road to cutting the therapeutic Gordian Knot Alzheimers Dement 8 2012 312 336
    • (2012) Alzheimers Dement , vol.8 , pp. 312-336
    • Hampel, H.1    Lista, S.2    Khachaturian, Z.S.3
  • 285
    • 84868582421 scopus 로고    scopus 로고
    • Alzheimer disease: From inherited to sporadic AD-crossing the biomarker bridge
    • H. Hampel, and S. Lista Alzheimer disease: from inherited to sporadic AD-crossing the biomarker bridge Nat Rev Neurol 8 2012 598 600
    • (2012) Nat Rev Neurol , vol.8 , pp. 598-600
    • Hampel, H.1    Lista, S.2
  • 286
    • 82755197084 scopus 로고    scopus 로고
    • The role of genetics for biomarker development in neurodegeneration
    • L. Bertram, and H. Hampel The role of genetics for biomarker development in neurodegeneration Prog Neurobiol 95 2011 501 504
    • (2011) Prog Neurobiol , vol.95 , pp. 501-504
    • Bertram, L.1    Hampel, H.2
  • 287
    • 77954724831 scopus 로고    scopus 로고
    • Advances and perspectives from genetic research: Development of biological markers in Alzheimer's disease
    • T. Zetzsche, D. Rujescu, J. Hardy, and H. Hampel Advances and perspectives from genetic research: development of biological markers in Alzheimer's disease Expert Rev Mol Diagn 10 2010 667 690
    • (2010) Expert Rev Mol Diagn , vol.10 , pp. 667-690
    • Zetzsche, T.1    Rujescu, D.2    Hardy, J.3    Hampel, H.4
  • 288
    • 84877074899 scopus 로고    scopus 로고
    • Relevance of magnetic resonance imaging for early detection and diagnosis of Alzheimer disease
    • S.J. Teipel, M. Grothe, S. Lista, N. Toschi, F.G. Garaci, and H. Hampel Relevance of magnetic resonance imaging for early detection and diagnosis of Alzheimer disease Med Clin North Am 97 2013 399 424
    • (2013) Med Clin North Am , vol.97 , pp. 399-424
    • Teipel, S.J.1    Grothe, M.2    Lista, S.3    Toschi, N.4    Garaci, F.G.5    Hampel, H.6
  • 289
    • 79960942624 scopus 로고    scopus 로고
    • Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia
    • M. Ewers, R.A. Sperling, W.E. Klunk, M.W. Weiner, and H. Hampel Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia Trends Neurosci 34 2011 430 442
    • (2011) Trends Neurosci , vol.34 , pp. 430-442
    • Ewers, M.1    Sperling, R.A.2    Klunk, W.E.3    Weiner, M.W.4    Hampel, H.5
  • 293
    • 77952542382 scopus 로고    scopus 로고
    • Biological markers of amyloid beta-related mechanisms in Alzheimer's disease
    • H. Hampel, Y. Shen, D.M. Walsh, P. Aisen, L.M. Shaw, H. Zetterberg, and et al. Biological markers of amyloid beta-related mechanisms in Alzheimer's disease Exp Neurol 223 2010 334 346
    • (2010) Exp Neurol , vol.223 , pp. 334-346
    • Hampel, H.1    Shen, Y.2    Walsh, D.M.3    Aisen, P.4    Shaw, L.M.5    Zetterberg, H.6
  • 295
    • 84916940971 scopus 로고    scopus 로고
    • Combining select neuropsychological assessment with blood-based biomarkers to detect mild Alzheimer's disease: A molecular neuropsychology approach
    • M. Edwards, V.H. Balldin, J. Hall, and S. O'Bryant Combining select neuropsychological assessment with blood-based biomarkers to detect mild Alzheimer's disease: a molecular neuropsychology approach J Alzheimers Dis 42 2014 635 640
    • (2014) J Alzheimers Dis , vol.42 , pp. 635-640
    • Edwards, M.1    Balldin, V.H.2    Hall, J.3    O'Bryant, S.4
  • 296
    • 84899495209 scopus 로고    scopus 로고
    • CSF Abeta1-42 combined with neuroimaging biomarkers in the early detection, diagnosis and prediction of Alzheimer's disease
    • S. Lista, F.G. Garaci, M. Ewers, S. Teipel, H. Zetterberg, K. Blennow, and et al. CSF Abeta1-42 combined with neuroimaging biomarkers in the early detection, diagnosis and prediction of Alzheimer's disease Alzheimers Dement 10 2014 381 392
    • (2014) Alzheimers Dement , vol.10 , pp. 381-392
    • Lista, S.1    Garaci, F.G.2    Ewers, M.3    Teipel, S.4    Zetterberg, H.5    Blennow, K.6
  • 297
    • 82755197628 scopus 로고    scopus 로고
    • Biomarkers in clinical trials for neurodegenerative diseases: Regulatory perspectives and requirements
    • K. Broich, M. Weiergraber, and H. Hampel Biomarkers in clinical trials for neurodegenerative diseases: regulatory perspectives and requirements Prog Neurobiol 95 2011 498 500
    • (2011) Prog Neurobiol , vol.95 , pp. 498-500
    • Broich, K.1    Weiergraber, M.2    Hampel, H.3
  • 298
    • 84959349986 scopus 로고    scopus 로고
    • The rising global tide of cognitive impairment
    • H. Hampel, and S. Lista The rising global tide of cognitive impairment Nat Rev Neurol 2016 10.1038/nrneurol.2015.250
    • (2016) Nat Rev Neurol
    • Hampel, H.1    Lista, S.2


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