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Volumn 10, Issue , 2012, Pages

Preclinical Alzheimer disease: Identification of cases at risk among cognitively intact older individuals

Author keywords

Alzheimer disease; Asymptomatic; Cerebral Amyloidosis; Cognition; Compensatory Phenomena; Dementia

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E4; FLUORODEOXYGLUCOSE F 18; PITTSBURGH COMPOUND B; TAU PROTEIN;

EID: 84867745651     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/1741-7015-10-127     Document Type: Article
Times cited : (45)

References (177)
  • 2
    • 0030981585 scopus 로고    scopus 로고
    • Auguste D and Alzheimer's disease
    • 10.1016/S0140-6736(96)10203-8, 9167474
    • Maurer K, Volk S, Gerbaldo H. Auguste D and Alzheimer's disease. Lancet 1997, 349:1546-1549. 10.1016/S0140-6736(96)10203-8, 9167474.
    • (1997) Lancet , vol.349 , pp. 1546-1549
    • Maurer, K.1    Volk, S.2    Gerbaldo, H.3
  • 3
    • 33750510024 scopus 로고    scopus 로고
    • Alzheimer 100--highlights in the history of Alzheimer research
    • 10.1007/s00702-006-0578-3, 17039299
    • Jellinger KA. Alzheimer 100--highlights in the history of Alzheimer research. J Neural Transm 2006, 113:1603-1623. 10.1007/s00702-006-0578-3, 17039299.
    • (2006) J Neural Transm , vol.113 , pp. 1603-1623
    • Jellinger, K.A.1
  • 4
    • 33750600735 scopus 로고    scopus 로고
    • Alzheimer's centennial legacy: origins, landmarks and the current status of knowledge concerning cognitive aspects
    • 10.1093/brain/awl275, 17071920
    • Hodges JR. Alzheimer's centennial legacy: origins, landmarks and the current status of knowledge concerning cognitive aspects. Brain 2006, 129:2811-2822. 10.1093/brain/awl275, 17071920.
    • (2006) Brain , vol.129 , pp. 2811-2822
    • Hodges, J.R.1
  • 5
    • 33750705653 scopus 로고    scopus 로고
    • A century of Alzheimer's disease
    • 10.1126/science.1132814, 17082447
    • Goedert M, Spillantini MG. A century of Alzheimer's disease. Science 2006, 314:777-781. 10.1126/science.1132814, 17082447.
    • (2006) Science , vol.314 , pp. 777-781
    • Goedert, M.1    Spillantini, M.G.2
  • 6
    • 37049048544 scopus 로고
    • Paired helical filaments in electron microscopy of Alzheimer's disease
    • Kidd M. Paired helical filaments in electron microscopy of Alzheimer's disease. Nature 1963, 197:192-193.
    • (1963) Nature , vol.197 , pp. 192-193
    • Kidd, M.1
  • 7
    • 78651158156 scopus 로고
    • Ultrastructural studies in Alzheimer's presenile dementia
    • 1906996, 14119171
    • Terry RD, Gonatas NK, Weiss M. Ultrastructural studies in Alzheimer's presenile dementia. Am J Pathol 1964, 44:269-297. 1906996, 14119171.
    • (1964) Am J Pathol , vol.44 , pp. 269-297
    • Terry, R.D.1    Gonatas, N.K.2    Weiss, M.3
  • 8
    • 0013859362 scopus 로고
    • Correlation between scores for dementia and counts of 'senile plaques' in cerebral grey matter of elderly subjects
    • 10.1038/209109a0, 5927229
    • Roth M, Tomlinson BE, Blessed G. Correlation between scores for dementia and counts of 'senile plaques' in cerebral grey matter of elderly subjects. Nature 1966, 209:109-110. 10.1038/209109a0, 5927229.
    • (1966) Nature , vol.209 , pp. 109-110
    • Roth, M.1    Tomlinson, B.E.2    Blessed, G.3
  • 9
    • 33751245916 scopus 로고    scopus 로고
    • Assessing the cognitive impact of Alzheimer disease pathology and vascular burden in the aging brain: the Geneva experience
    • Giannakopoulos P, Gold G, Kövari E, von Gunten A, Imhof A, Bouras C, Hof PR. Assessing the cognitive impact of Alzheimer disease pathology and vascular burden in the aging brain: the Geneva experience. Acta Neuropathol 2007, 113:1-12.
    • (2007) Acta Neuropathol , vol.113 , pp. 1-12
    • Giannakopoulos, P.1    Gold, G.2    Kövari, E.3    von Gunten, A.4    Imhof, A.5    Bouras, C.6    Hof, P.R.7
  • 12
    • 0014326852 scopus 로고
    • Observations on the brains of non-demented old people
    • 10.1016/0022-510X(68)90154-8, 5707082
    • Tomlinson BE, Blessed G, Roth M. Observations on the brains of non-demented old people. J Neurol Sci 1968, 7:331-356. 10.1016/0022-510X(68)90154-8, 5707082.
    • (1968) J Neurol Sci , vol.7 , pp. 331-356
    • Tomlinson, B.E.1    Blessed, G.2    Roth, M.3
  • 13
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • 10.1007/BF00308809, 1759558
    • Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991, 82:239-259. 10.1007/BF00308809, 1759558.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 14
    • 0029013727 scopus 로고
    • Staging of Alzheimer's disease-related neurofibrillary changes
    • 10.1016/0197-4580(95)00021-6, 7566337
    • Braak H, Braak E. Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging 1995, 16:271-278. 10.1016/0197-4580(95)00021-6, 7566337.
    • (1995) Neurobiol Aging , vol.16 , pp. 271-278
    • Braak, H.1    Braak, E.2
  • 15
    • 0021256895 scopus 로고
    • Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • 10.1016/S0006-291X(84)80190-4, 6375662
    • Glenner GG, Wong CW. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984, 120:885-890. 10.1016/S0006-291X(84)80190-4, 6375662.
    • (1984) Biochem Biophys Res Commun , vol.120 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 16
    • 0022550027 scopus 로고
    • Purification, ultrastructure, and chemical analysis of Alzheimer disease amyloid plaque core protein
    • 10.1073/pnas.83.8.2662, 323359, 3458224
    • Roher A, Wolfe D, Palutke M, KuKuruga D. Purification, ultrastructure, and chemical analysis of Alzheimer disease amyloid plaque core protein. Proc Natl Acad Sci USA 1986, 83:2662-2666. 10.1073/pnas.83.8.2662, 323359, 3458224.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 2662-2666
    • Roher, A.1    Wolfe, D.2    Palutke, M.3    KuKuruga, D.4
  • 18
    • 0024472693 scopus 로고
    • Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease
    • 10.1126/science.2474201, 2474201
    • Yankner BA, Dawes LR, Fisher S, Villa-Komaroff L, Oster-Granite ML, Neve RL. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 1989, 245:417-420. 10.1126/science.2474201, 2474201.
    • (1989) Science , vol.245 , pp. 417-420
    • Yankner, B.A.1    Dawes, L.R.2    Fisher, S.3    Villa-Komaroff, L.4    Oster-Granite, M.L.5    Neve, R.L.6
  • 19
    • 0015965912 scopus 로고
    • Human memory and the cholinergic system. A relationship to aging?
    • 10.1001/archneur.1974.00490320001001, 4359364
    • Drachman DA, Leavitt J. Human memory and the cholinergic system. A relationship to aging?. Arch Neurol 1974, 30:113-121. 10.1001/archneur.1974.00490320001001, 4359364.
    • (1974) Arch Neurol , vol.30 , pp. 113-121
    • Drachman, D.A.1    Leavitt, J.2
  • 20
    • 0017759674 scopus 로고
    • Chemical pathology of this organic dementias. II. Quantitative estimation of cellular changes in post-mortem brains
    • 10.1093/brain/100.3.427, 589427
    • Bowen DM, Smith CB, White P, Flack RH, Carrasco LH, Gedye JL, Davison AN. Chemical pathology of this organic dementias. II. Quantitative estimation of cellular changes in post-mortem brains. Brain 1977, 100:427-453. 10.1093/brain/100.3.427, 589427.
    • (1977) Brain , vol.100 , pp. 427-453
    • Bowen, D.M.1    Smith, C.B.2    White, P.3    Flack, R.H.4    Carrasco, L.H.5    Gedye, J.L.6    Davison, A.N.7
  • 21
    • 0017708253 scopus 로고
    • Chemical pathology of organic dementias. I. Validity of biochemical measurements on human post-mortem brain specimens
    • 10.1093/brain/100.3.397, 22388
    • Bowen DM, Smith CB, White P, Goodhardt MJ, Spillane JA, Flack RH, Davison AN. Chemical pathology of organic dementias. I. Validity of biochemical measurements on human post-mortem brain specimens. Brain 1977, 100:397-426. 10.1093/brain/100.3.397, 22388.
    • (1977) Brain , vol.100 , pp. 397-426
    • Bowen, D.M.1    Smith, C.B.2    White, P.3    Goodhardt, M.J.4    Spillane, J.A.5    Flack, R.H.6    Davison, A.N.7
  • 22
    • 0021145680 scopus 로고
    • Alzheimer's disease: cell-specific pathology isolates the hippocampal formation
    • 10.1126/science.6474172, 6474172
    • Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science 1984, 225:1168-1170. 10.1126/science.6474172, 6474172.
    • (1984) Science , vol.225 , pp. 1168-1170
    • Hyman, B.T.1    Van Hoesen, G.W.2    Damasio, A.R.3    Barnes, C.L.4
  • 23
    • 0020523717 scopus 로고
    • The effect of verbal mediators on the pictorial memory of brain-damaged patients
    • 10.1016/0028-3932(83)90018-0, 6225962
    • Butters N, Albert MS, Sax DS, Miliotis P, Nagode J, Sterste A. The effect of verbal mediators on the pictorial memory of brain-damaged patients. Neuropsychologia 1983, 21:307-323. 10.1016/0028-3932(83)90018-0, 6225962.
    • (1983) Neuropsychologia , vol.21 , pp. 307-323
    • Butters, N.1    Albert, M.S.2    Sax, D.S.3    Miliotis, P.4    Nagode, J.5    Sterste, A.6
  • 24
    • 0021854982 scopus 로고
    • Rates of forgetting in Alzheimer-type dementia and Korsakoff's syndrome
    • 10.1016/0028-3932(85)90064-8, 4058708
    • Kopelman MD. Rates of forgetting in Alzheimer-type dementia and Korsakoff's syndrome. Neuropsychologia 1985, 23:623-638. 10.1016/0028-3932(85)90064-8, 4058708.
    • (1985) Neuropsychologia , vol.23 , pp. 623-638
    • Kopelman, M.D.1
  • 25
    • 0022652187 scopus 로고
    • Differential patterns of memory loss among patients with Alzheimer's disease, Huntington's disease, and alcoholic Korsakoff's syndrome
    • 10.1001/archneur.1986.00520030031008, 2936323
    • Moss MB, Albert MS, Butters N, Payne M. Differential patterns of memory loss among patients with Alzheimer's disease, Huntington's disease, and alcoholic Korsakoff's syndrome. Arch Neurol 1986, 43:239-246. 10.1001/archneur.1986.00520030031008, 2936323.
    • (1986) Arch Neurol , vol.43 , pp. 239-246
    • Moss, M.B.1    Albert, M.S.2    Butters, N.3    Payne, M.4
  • 35
    • 79952592605 scopus 로고    scopus 로고
    • Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals
    • 10.1001/archneurol.2010.292, 3268783, 21059989
    • Lee JH, Cheng R, Barral S, Reitz C, Medrano M, Lantigua R, Jiménez-Velazquez IZ, Rogaeva E, St George-Hyslop PH, Mayeux R. Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals. Arch Neurol 2011, 68:320-328. 10.1001/archneurol.2010.292, 3268783, 21059989.
    • (2011) Arch Neurol , vol.68 , pp. 320-328
    • Lee, J.H.1    Cheng, R.2    Barral, S.3    Reitz, C.4    Medrano, M.5    Lantigua, R.6    Jiménez-Velazquez, I.Z.7    Rogaeva, E.8    St George-Hyslop, P.H.9    Mayeux, R.10
  • 40
    • 84862831893 scopus 로고    scopus 로고
    • SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in a Northern Han Chinese population
    • Wang HF, Yu JT, Zhang W, Wang W, Liu QY, Ma XY, Ding HM, Tan L. SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in a Northern Han Chinese population. Brain Res 2012, 1448:111-116.
    • (2012) Brain Res , vol.1448 , pp. 111-116
    • Wang, H.F.1    Yu, J.T.2    Zhang, W.3    Wang, W.4    Liu, Q.Y.5    Ma, X.Y.6    Ding, H.M.7    Tan, L.8
  • 42
    • 0034633632 scopus 로고    scopus 로고
    • Immunization against Alzheimer's beta -amyloid plaques via EFRH phage administration
    • 10.1073/pnas.97.21.11455, 17221, 11027345
    • Frenkel D, Katz O, Solomon B. Immunization against Alzheimer's beta -amyloid plaques via EFRH phage administration. Proc Natl Acad Sci USA 2000, 97:11455-11459. 10.1073/pnas.97.21.11455, 17221, 11027345.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11455-11459
    • Frenkel, D.1    Katz, O.2    Solomon, B.3
  • 46
    • 11444267243 scopus 로고    scopus 로고
    • Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD
    • 10.1212/01.WNL.0000148604.77591.67, 15642910
    • Bayer AJ, Bullock R, Jones RW, Wilkinson D, Paterson KR, Jenkins L, Millais SB, Donoghue S. Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD. Neurology 2005, 64:94-101. 10.1212/01.WNL.0000148604.77591.67, 15642910.
    • (2005) Neurology , vol.64 , pp. 94-101
    • Bayer, A.J.1    Bullock, R.2    Jones, R.W.3    Wilkinson, D.4    Paterson, K.R.5    Jenkins, L.6    Millais, S.B.7    Donoghue, S.8
  • 49
    • 18144415471 scopus 로고    scopus 로고
    • Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
    • 10.1212/01.WNL.0000159743.08996.99, 15883317
    • Fox NC, Black RS, Gilman S, Rossor MN, Griffith SG, Jenkins L, Koller M. Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease. Neurology 2005, 64:1563-1572. 10.1212/01.WNL.0000159743.08996.99, 15883317.
    • (2005) Neurology , vol.64 , pp. 1563-1572
    • Fox, N.C.1    Black, R.S.2    Gilman, S.3    Rossor, M.N.4    Griffith, S.G.5    Jenkins, L.6    Koller, M.7
  • 50
    • 0026432318 scopus 로고
    • Beta-Amyloid and the pathogenesis of Alzheimer's disease
    • 10.1056/NEJM199112263252605, 1961223
    • Yankner BA, Mesulam MM. beta-Amyloid and the pathogenesis of Alzheimer's disease. N Engl J Med 1991, 325:1849-1857. 10.1056/NEJM199112263252605, 1961223.
    • (1991) N Engl J Med , vol.325 , pp. 1849-1857
    • Yankner, B.A.1    Mesulam, M.M.2
  • 51
    • 0023514236 scopus 로고
    • Alzheimer's disease as a presumptive threshold phenomenon
    • 10.1016/0197-4580(87)90131-X, 3323928
    • Arendt T, Bigl V. Alzheimer's disease as a presumptive threshold phenomenon. Neurobiol Aging 1987, 8:552-554. 10.1016/0197-4580(87)90131-X, 3323928.
    • (1987) Neurobiol Aging , vol.8 , pp. 552-554
    • Arendt, T.1    Bigl, V.2
  • 52
    • 0024406110 scopus 로고
    • The pathogenesis and progression of the pathological changes of Alzheimer's disease
    • 10.3109/07853898909149200, 2669845
    • Mann DM. The pathogenesis and progression of the pathological changes of Alzheimer's disease. Ann Med 1989, 21:133-136. 10.3109/07853898909149200, 2669845.
    • (1989) Ann Med , vol.21 , pp. 133-136
    • Mann, D.M.1
  • 53
    • 78751692575 scopus 로고    scopus 로고
    • Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift
    • 10.1016/j.neuron.2011.01.002, 3058906, 21262461
    • Golde TE, Schneider LS, Koo EH. Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift. Neuron 2011, 69:203-213. 10.1016/j.neuron.2011.01.002, 3058906, 21262461.
    • (2011) Neuron , vol.69 , pp. 203-213
    • Golde, T.E.1    Schneider, L.S.2    Koo, E.H.3
  • 54
    • 0034746897 scopus 로고    scopus 로고
    • Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition
    • 10.1016/S0197-4580(01)00245-7, 11705631
    • Das P, Murphy MP, Younkin LH, Younkin SG, Golde TE. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition. Neurobiol Aging 2001, 22:721-727. 10.1016/S0197-4580(01)00245-7, 11705631.
    • (2001) Neurobiol Aging , vol.22 , pp. 721-727
    • Das, P.1    Murphy, M.P.2    Younkin, L.H.3    Younkin, S.G.4    Golde, T.E.5
  • 55
    • 69149106814 scopus 로고    scopus 로고
    • Treatment of mild cognitive impairment (MCI)
    • 10.2174/156720509788929282, 19689235
    • Farlow MR. Treatment of mild cognitive impairment (MCI). Curr Alzheimer Res 2009, 6:362-367. 10.2174/156720509788929282, 19689235.
    • (2009) Curr Alzheimer Res , vol.6 , pp. 362-367
    • Farlow, M.R.1
  • 56
    • 80053385646 scopus 로고    scopus 로고
    • Pharmacological treatment of dementia and mild cognitive impairment due to Alzheimer's disease
    • Popp J, Arlt S. Pharmacological treatment of dementia and mild cognitive impairment due to Alzheimer's disease. Curr Opin Psychiatry 2011, 24:556-561.
    • (2011) Curr Opin Psychiatry , vol.24 , pp. 556-561
    • Popp, J.1    Arlt, S.2
  • 57
    • 0035099984 scopus 로고    scopus 로고
    • Mild cognitive impairment represents early-stage Alzheimer disease
    • 10.1001/archneur.58.3.397, 11255443
    • Morris JC, Storandt M, Miller JP, McKeel DW, Price JL, Rubin EH, Berg L. Mild cognitive impairment represents early-stage Alzheimer disease. Arch Neurol 2001, 58:397-405. 10.1001/archneur.58.3.397, 11255443.
    • (2001) Arch Neurol , vol.58 , pp. 397-405
    • Morris, J.C.1    Storandt, M.2    Miller, J.P.3    McKeel, D.W.4    Price, J.L.5    Rubin, E.H.6    Berg, L.7
  • 59
    • 33846906502 scopus 로고    scopus 로고
    • Mild cognitive impairment: current research and clinical implications
    • 10.1055/s-2006-956752, 17226738
    • Petersen RC. Mild cognitive impairment: current research and clinical implications. Semin Neurol 2007, 27:22-31. 10.1055/s-2006-956752, 17226738.
    • (2007) Semin Neurol , vol.27 , pp. 22-31
    • Petersen, R.C.1
  • 61
    • 22844444303 scopus 로고    scopus 로고
    • Mild cognitive impairment as a clinical entity and treatment target
    • 10.1001/archneur.62.7.1160, 16009779
    • Petersen RC, Morris JC. Mild cognitive impairment as a clinical entity and treatment target. Arch Neurol 2005, 62:1160-1163. 10.1001/archneur.62.7.1160, 16009779.
    • (2005) Arch Neurol , vol.62 , pp. 1160-1163
    • Petersen, R.C.1    Morris, J.C.2
  • 62
    • 0033863654 scopus 로고    scopus 로고
    • 'Prodromal Alzheimer's disease': a more useful concept than mild cognitive impairment?
    • 10.1097/00019052-200008000-00001, 10970051
    • Dubois B. 'Prodromal Alzheimer's disease': a more useful concept than mild cognitive impairment?. Curr Opin Neurol 2000, 13:367-369. 10.1097/00019052-200008000-00001, 10970051.
    • (2000) Curr Opin Neurol , vol.13 , pp. 367-369
    • Dubois, B.1
  • 63
    • 0023939251 scopus 로고
    • Normal ageing, impaired cognitive function, and senile dementia of the Alzheimer's type: a continuum?
    • Brayne C, Calloway P. Normal ageing, impaired cognitive function, and senile dementia of the Alzheimer's type: a continuum?. Lancet 1988, 1:1265-1267.
    • (1988) Lancet , vol.1 , pp. 1265-1267
    • Brayne, C.1    Calloway, P.2
  • 65
    • 0028122463 scopus 로고
    • Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
    • 10.1016/S0140-6736(94)92338-8, 7916070
    • West MJ, Coleman PD, Flood DG, Troncoso JC. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 1994, 344:769-772. 10.1016/S0140-6736(94)92338-8, 7916070.
    • (1994) Lancet , vol.344 , pp. 769-772
    • West, M.J.1    Coleman, P.D.2    Flood, D.G.3    Troncoso, J.C.4
  • 66
    • 0027164617 scopus 로고
    • Regionally specific loss of neurons in the aging human hippocampus
    • 10.1016/0197-4580(93)90113-P, 8367010
    • West MJ. Regionally specific loss of neurons in the aging human hippocampus. Neurobiol Aging 1993, 14:287-293. 10.1016/0197-4580(93)90113-P, 8367010.
    • (1993) Neurobiol Aging , vol.14 , pp. 287-293
    • West, M.J.1
  • 67
    • 0025770134 scopus 로고
    • The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease
    • 10.1016/0197-4580(91)90006-6, 1961359
    • Price JL, Davis PB, Morris JC, White DL. The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease. Neurobiol Aging 1991, 12:295-312. 10.1016/0197-4580(91)90006-6, 1961359.
    • (1991) Neurobiol Aging , vol.12 , pp. 295-312
    • Price, J.L.1    Davis, P.B.2    Morris, J.C.3    White, D.L.4
  • 71
    • 32544435900 scopus 로고    scopus 로고
    • Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study
    • 10.1016/S1474-4422(06)70355-6, 16488378
    • Hansson O, Zetterberg H, Buchhave P, Londos E, Blennow K, Minthon L. Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol 2006, 5:228-234. 10.1016/S1474-4422(06)70355-6, 16488378.
    • (2006) Lancet Neurol , vol.5 , pp. 228-234
    • Hansson, O.1    Zetterberg, H.2    Buchhave, P.3    Londos, E.4    Blennow, K.5    Minthon, L.6
  • 74
    • 84855304100 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of b-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia
    • 10.1001/archgenpsychiatry.2011.155, 22213792
    • Buchhave P, Minthon L, Zetterberg H, Wallin AK, Blennow K, Hansson O. Cerebrospinal fluid levels of b-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia. Arch Gen Psychiatry 2012, 69:98-106. 10.1001/archgenpsychiatry.2011.155, 22213792.
    • (2012) Arch Gen Psychiatry , vol.69 , pp. 98-106
    • Buchhave, P.1    Minthon, L.2    Zetterberg, H.3    Wallin, A.K.4    Blennow, K.5    Hansson, O.6
  • 75
    • 77949425172 scopus 로고    scopus 로고
    • Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease
    • 10.1002/emmm.200900048, 2806678,2806678, 20049742
    • Fagan AM, Mintun MA, Shah AR, Aldea P, Roe CM, Mach RH, Marcus D, Morris JC, Holtzman DM. Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease. EMBO Mol Med 2009, 1:371-380. 10.1002/emmm.200900048, 2806678,2806678, 20049742.
    • (2009) EMBO Mol Med , vol.1 , pp. 371-380
    • Fagan, A.M.1    Mintun, M.A.2    Shah, A.R.3    Aldea, P.4    Roe, C.M.5    Mach, R.H.6    Marcus, D.7    Morris, J.C.8    Holtzman, D.M.9
  • 76
    • 62549122091 scopus 로고    scopus 로고
    • Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly
    • 10.1002/ana.21559, 2763631, 19260027
    • Fagan AM, Head D, Shah AR, Marcus D, Mintun M, Morris JC, Holtzman DM. Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly. Ann Neurol 2009, 65:176-183. 10.1002/ana.21559, 2763631, 19260027.
    • (2009) Ann Neurol , vol.65 , pp. 176-183
    • Fagan, A.M.1    Head, D.2    Shah, A.R.3    Marcus, D.4    Mintun, M.5    Morris, J.C.6    Holtzman, D.M.7
  • 77
    • 33947223454 scopus 로고    scopus 로고
    • Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults
    • 10.1001/archneur.64.3.noc60123, 17210801
    • Fagan AM, Roe CM, Xiong C, Mintun MA, Morris JC, Holtzman DM. Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults. Arch Neurol 2007, 64:343-349. 10.1001/archneur.64.3.noc60123, 17210801.
    • (2007) Arch Neurol , vol.64 , pp. 343-349
    • Fagan, A.M.1    Roe, C.M.2    Xiong, C.3    Mintun, M.A.4    Morris, J.C.5    Holtzman, D.M.6
  • 78
    • 78650906323 scopus 로고    scopus 로고
    • Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42
    • 10.1002/ana.22315, 21181717
    • Schott JM, Bartlett JW, Fox NC, Barnes J. Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42. Ann Neurol 2010, 68:825-834. 10.1002/ana.22315, 21181717.
    • (2010) Ann Neurol , vol.68 , pp. 825-834
    • Schott, J.M.1    Bartlett, J.W.2    Fox, N.C.3    Barnes, J.4
  • 79
    • 66249116626 scopus 로고    scopus 로고
    • Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findings
    • 10.1001/archneurol.2009.59, 2718788, 19433663
    • Petrie EC, Cross DJ, Galasko D, Schellenberg GD, Raskind MA, Peskind ER, Minoshima S. Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findings. Arch Neurol 2009, 66:632-637. 10.1001/archneurol.2009.59, 2718788, 19433663.
    • (2009) Arch Neurol , vol.66 , pp. 632-637
    • Petrie, E.C.1    Cross, D.J.2    Galasko, D.3    Schellenberg, G.D.4    Raskind, M.A.5    Peskind, E.R.6    Minoshima, S.7
  • 81
    • 12244283089 scopus 로고    scopus 로고
    • Cerebrospinal fluid beta-amyloid 42 is reduced before the onset of sporadic dementia: a population-based study in 85-year-olds
    • 10.1159/000068478, 12584433
    • Skoog I, Davidsson P, Aevarsson O, Vanderstichele H, Vanmechelen E, Blennow K. Cerebrospinal fluid beta-amyloid 42 is reduced before the onset of sporadic dementia: a population-based study in 85-year-olds. Dement Geriatr Cogn Disord 2003, 15:169-176. 10.1159/000068478, 12584433.
    • (2003) Dement Geriatr Cogn Disord , vol.15 , pp. 169-176
    • Skoog, I.1    Davidsson, P.2    Aevarsson, O.3    Vanderstichele, H.4    Vanmechelen, E.5    Blennow, K.6
  • 82
    • 34247219169 scopus 로고    scopus 로고
    • Cerebrospinal fluid beta-amyloid 1-42 concentration may predict cognitive decline in older women
    • 2117838, 17098843
    • Gustafson DR, Skoog I, Rosengren L, Zetterberg H, Blennow K. Cerebrospinal fluid beta-amyloid 1-42 concentration may predict cognitive decline in older women. J Neurol Neurosurg Psychiatry 2007, 78:461-464. 2117838, 17098843.
    • (2007) J Neurol Neurosurg Psychiatry , vol.78 , pp. 461-464
    • Gustafson, D.R.1    Skoog, I.2    Rosengren, L.3    Zetterberg, H.4    Blennow, K.5
  • 84
    • 81055146931 scopus 로고    scopus 로고
    • The association of APOE genotype with cognitive function in persons aged 35 years or older
    • 10.1371/journal.pone.0027415, 3215744, 22110642
    • Izaks GJ, Gansevoort RT, van der Knaap AM, Navis G, Dullaart RP, Slaets JP. The association of APOE genotype with cognitive function in persons aged 35 years or older. PLoS One 2011, 6:e27415. 10.1371/journal.pone.0027415, 3215744, 22110642.
    • (2011) PLoS One , vol.6
    • Izaks, G.J.1    Gansevoort, R.T.2    van der Knaap, A.M.3    Navis, G.4    Dullaart, R.P.5    Slaets, J.P.6
  • 86
    • 84865824004 scopus 로고    scopus 로고
    • White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machines
    • 10.1371/journal.pone.0036024, 3338494, 22558310
    • O'Dwyer L, Lamberton F, Matura S, Scheibe M, Miller J, Rujescu D, Prvulovic D, Hampel H. White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machines. PLoS One 2012, 7:e36024. 10.1371/journal.pone.0036024, 3338494, 22558310.
    • (2012) PLoS One , vol.7
    • O'Dwyer, L.1    Lamberton, F.2    Matura, S.3    Scheibe, M.4    Miller, J.5    Rujescu, D.6    Prvulovic, D.7    Hampel, H.8
  • 87
    • 34447634667 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly
    • 10.1159/000105017, 17622715
    • Stomrud E, Hansson O, Blennow K, Minthon L, Londos E. Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly. Dement Geriatr Cogn Disord 2007, 24:118-124. 10.1159/000105017, 17622715.
    • (2007) Dement Geriatr Cogn Disord , vol.24 , pp. 118-124
    • Stomrud, E.1    Hansson, O.2    Blennow, K.3    Minthon, L.4    Londos, E.5
  • 90
    • 85026136018 scopus 로고    scopus 로고
    • Familial Alzheimer disease: decreases in CSF Abeta42 levels precede cognitive decline
    • 10.1212/01.wnl.0000171397.32851.bc, 16043812
    • Moonis M, Swearer JM, Dayaw MP, St George-Hyslop P, Rogaeva E, Kawarai T, Pollen DA. Familial Alzheimer disease: decreases in CSF Abeta42 levels precede cognitive decline. Neurology 2005, 65:323-325. 10.1212/01.wnl.0000171397.32851.bc, 16043812.
    • (2005) Neurology , vol.65 , pp. 323-325
    • Moonis, M.1    Swearer, J.M.2    Dayaw, M.P.3    St George-Hyslop, P.4    Rogaeva, E.5    Kawarai, T.6    Pollen, D.A.7
  • 95
    • 83255181779 scopus 로고    scopus 로고
    • Amyloid-beta plaque growth in cognitively normal adults: longitudinal [11C]Pittsburgh compound B data
    • 10.1002/ana.22608, 22162065
    • Vlassenko AG, Mintun MA, Xiong C, Sheline YI, Goate AM, Benzinger TL, Morris JC. Amyloid-beta plaque growth in cognitively normal adults: longitudinal [11C]Pittsburgh compound B data. Ann Neurol 2011, 70:857-861. 10.1002/ana.22608, 22162065.
    • (2011) Ann Neurol , vol.70 , pp. 857-861
    • Vlassenko, A.G.1    Mintun, M.A.2    Xiong, C.3    Sheline, Y.I.4    Goate, A.M.5    Benzinger, T.L.6    Morris, J.C.7
  • 96
    • 35648932901 scopus 로고    scopus 로고
    • Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease
    • 10.1093/brain/awm238, 17928318
    • Pike KE, Savage G, Villemagne VL, Ng S, Moss SA, Maruff P, Mathis CA, Klunk WE, Masters CL, Rowe CC. Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease. Brain 2007, 130:2837-2844. 10.1093/brain/awm238, 17928318.
    • (2007) Brain , vol.130 , pp. 2837-2844
    • Pike, K.E.1    Savage, G.2    Villemagne, V.L.3    Ng, S.4    Moss, S.A.5    Maruff, P.6    Mathis, C.A.7    Klunk, W.E.8    Masters, C.L.9    Rowe, C.C.10
  • 106
    • 73549092137 scopus 로고    scopus 로고
    • Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease
    • 10.1001/archneurol.2009.269, 2798814, 20008650
    • Morris JC, Roe CM, Grant EA, Head D, Storandt M, Goate AM, Fagan AM, Holtzman DM, Mintun MA. Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease. Arch Neurol 2009, 66:1469-1475. 10.1001/archneurol.2009.269, 2798814, 20008650.
    • (2009) Arch Neurol , vol.66 , pp. 1469-1475
    • Morris, J.C.1    Roe, C.M.2    Grant, E.A.3    Head, D.4    Storandt, M.5    Goate, A.M.6    Fagan, A.M.7    Holtzman, D.M.8    Mintun, M.A.9
  • 110
    • 77949701876 scopus 로고    scopus 로고
    • High PIB retention in Alzheimer's disease is an early event with complex relationship with CSF biomarkers and functional parameters
    • 10.2174/156720510790274446, 20205671
    • Forsberg A, Almkvist O, Engler H, Wall A, Långström B, Nordberg A. High PIB retention in Alzheimer's disease is an early event with complex relationship with CSF biomarkers and functional parameters. Curr Alzheimer Res 2010, 7:56-66. 10.2174/156720510790274446, 20205671.
    • (2010) Curr Alzheimer Res , vol.7 , pp. 56-66
    • Forsberg, A.1    Almkvist, O.2    Engler, H.3    Wall, A.4    Långström, B.5    Nordberg, A.6
  • 112
    • 79955768543 scopus 로고    scopus 로고
    • Longitudinal patterns of β-amyloid deposition in nondemented older adults
    • 10.1001/archneurol.2011.77, 3136195, 21555640
    • Sojkova J, Zhou Y, An Y, Kraut MA, Ferrucci L, Wong DF, Resnick SM. Longitudinal patterns of β-amyloid deposition in nondemented older adults. Arch Neurol 2011, 68:644-649. 10.1001/archneurol.2011.77, 3136195, 21555640.
    • (2011) Arch Neurol , vol.68 , pp. 644-649
    • Sojkova, J.1    Zhou, Y.2    An, Y.3    Kraut, M.A.4    Ferrucci, L.5    Wong, D.F.6    Resnick, S.M.7
  • 113
    • 80051528489 scopus 로고    scopus 로고
    • Early detection of Alzheimer disease: 11C-PiB PET in twins discordant for cognitive impairment
    • 10.1212/WNL.0b013e318225118e, 21700581
    • Scheinin NM, Aalto S, Kaprio J, Koskenvuo M, Räihä I, Rokka J, Hinkka-Yli-Salomäki S, Rinne JO. Early detection of Alzheimer disease: 11C-PiB PET in twins discordant for cognitive impairment. Neurology 2011, 77:453-460. 10.1212/WNL.0b013e318225118e, 21700581.
    • (2011) Neurology , vol.77 , pp. 453-460
    • Scheinin, N.M.1    Aalto, S.2    Kaprio, J.3    Koskenvuo, M.4    Räihä, I.5    Rokka, J.6    Hinkka-Yli-Salomäki, S.7    Rinne, J.O.8
  • 115
    • 34548219060 scopus 로고    scopus 로고
    • What does fluorodeoxyglucose PET imaging add to a clinical diagnosis of dementia?
    • 10.1212/01.wnl.0000269790.05105.16, 17724289
    • Jagust W, Reed B, Mungas D, Ellis W, Decarli C. What does fluorodeoxyglucose PET imaging add to a clinical diagnosis of dementia?. Neurology 2007, 69:871-877. 10.1212/01.wnl.0000269790.05105.16, 17724289.
    • (2007) Neurology , vol.69 , pp. 871-877
    • Jagust, W.1    Reed, B.2    Mungas, D.3    Ellis, W.4    Decarli, C.5
  • 118
    • 0347719366 scopus 로고    scopus 로고
    • Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
    • 10.1073/pnas.2635903100, 314177, 14688411
    • Reiman EM, Chen K, Alexander GE, Caselli RJ, Bandy D, Osborne D, Saunders AM, Hardy J. Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia. Proc Natl Acad Sci USA 2004, 101:284-289. 10.1073/pnas.2635903100, 314177, 14688411.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 284-289
    • Reiman, E.M.1    Chen, K.2    Alexander, G.E.3    Caselli, R.J.4    Bandy, D.5    Osborne, D.6    Saunders, A.M.7    Hardy, J.8
  • 120
    • 0029970342 scopus 로고    scopus 로고
    • Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E
    • 10.1056/NEJM199603213341202, 8592548
    • Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, Minoshima S, Thibodeau SN, Osborne D. Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med 1996, 334:752-758. 10.1056/NEJM199603213341202, 8592548.
    • (1996) N Engl J Med , vol.334 , pp. 752-758
    • Reiman, E.M.1    Caselli, R.J.2    Yun, L.S.3    Chen, K.4    Bandy, D.5    Minoshima, S.6    Thibodeau, S.N.7    Osborne, D.8
  • 121
    • 0035853154 scopus 로고    scopus 로고
    • Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease
    • 10.1073/pnas.061509598, 30654, 11248079
    • Reiman EM, Caselli RJ, Chen K, Alexander GE, Bandy D, Frost J. Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease. Proc Natl Acad Sci USA 2001, 98:3334-3339. 10.1073/pnas.061509598, 30654, 11248079.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3334-3339
    • Reiman, E.M.1    Caselli, R.J.2    Chen, K.3    Alexander, G.E.4    Bandy, D.5    Frost, J.6
  • 122
    • 20444395466 scopus 로고    scopus 로고
    • Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism
    • 10.1073/pnas.0500579102, 1149416, 15932949
    • Reiman EM, Chen K, Alexander GE, Caselli RJ, Bandy D, Osborne D, Saunders AM, Hardy J. Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism. Proc Natl Acad Sci USA 2005, 102:8299-8302. 10.1073/pnas.0500579102, 1149416, 15932949.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 8299-8302
    • Reiman, E.M.1    Chen, K.2    Alexander, G.E.3    Caselli, R.J.4    Bandy, D.5    Osborne, D.6    Saunders, A.M.7    Hardy, J.8
  • 129
    • 62149115284 scopus 로고    scopus 로고
    • Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease
    • 10.1212/01.wnl.0000333247.51383.43, 2677512, 19005175
    • Mosconi L, Mistur R, Switalski R, Brys M, Glodzik L, Rich K, Pirraglia E, Tsui W, De Santi S, de Leon MJ. Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease. Neurology 2009, 72:513-520. 10.1212/01.wnl.0000333247.51383.43, 2677512, 19005175.
    • (2009) Neurology , vol.72 , pp. 513-520
    • Mosconi, L.1    Mistur, R.2    Switalski, R.3    Brys, M.4    Glodzik, L.5    Rich, K.6    Pirraglia, E.7    Tsui, W.8    De Santi, S.9    de Leon, M.J.10
  • 130
    • 0028796841 scopus 로고
    • Deficits in cerebral glucose metabolism demonstrated by positron emission tomography in individuals at risk of familial Alzheimer's disease
    • 10.1016/0304-3940(95)11270-7, 7783942
    • Kennedy AM, Frackowiak RS, Newman SK, Bloomfield PM, Seaward J, Roques P, Lewington G, Cunningham VJ, Rossor MN. Deficits in cerebral glucose metabolism demonstrated by positron emission tomography in individuals at risk of familial Alzheimer's disease. Neurosci Lett 1995, 186:17-20. 10.1016/0304-3940(95)11270-7, 7783942.
    • (1995) Neurosci Lett , vol.186 , pp. 17-20
    • Kennedy, A.M.1    Frackowiak, R.S.2    Newman, S.K.3    Bloomfield, P.M.4    Seaward, J.5    Roques, P.6    Lewington, G.7    Cunningham, V.J.8    Rossor, M.N.9
  • 132
    • 0031664361 scopus 로고    scopus 로고
    • High frequency of apolipoprotein E epsilon4 allele in young individuals with very mild Alzheimer's disease-related neurofibrillary changes
    • 10.1006/exnr.1998.6860, 9743577
    • Ghebremedhin E, Schultz C, Braak E, Braak H. High frequency of apolipoprotein E epsilon4 allele in young individuals with very mild Alzheimer's disease-related neurofibrillary changes. Exp Neurol 1998, 153:152-155. 10.1006/exnr.1998.6860, 9743577.
    • (1998) Exp Neurol , vol.153 , pp. 152-155
    • Ghebremedhin, E.1    Schultz, C.2    Braak, E.3    Braak, H.4
  • 133
    • 51649088252 scopus 로고    scopus 로고
    • Correlating cerebral hypometabolism with future memory decline in subsequent converters to amnestic pre-mild cognitive impairment
    • Caselli RJ, Chen K, Lee W, Alexander GE, Reiman EM. Correlating cerebral hypometabolism with future memory decline in subsequent converters to amnestic pre-mild cognitive impairment. Arch Neurol 2008, 651:1231-1236.
    • (2008) Arch Neurol , vol.651 , pp. 1231-1236
    • Caselli, R.J.1    Chen, K.2    Lee, W.3    Alexander, G.E.4    Reiman, E.M.5
  • 134
    • 29844447384 scopus 로고    scopus 로고
    • Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people
    • 10.1001/archpsyc.63.1.57, 16389197
    • den Heijer T, Geerlings MI, Hoebeek FE, Hofman A, Koudstaal PJ, Breteler MM. Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people. Arch Gen Psychiatry 2006, 63:57-62. 10.1001/archpsyc.63.1.57, 16389197.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 57-62
    • den Heijer, T.1    Geerlings, M.I.2    Hoebeek, F.E.3    Hofman, A.4    Koudstaal, P.J.5    Breteler, M.M.6
  • 135
    • 16244393409 scopus 로고    scopus 로고
    • Preclinical detection of Alzheimer's disease: hippocampal shape and volume predict dementia onset in the elderly
    • 10.1016/j.neuroimage.2004.12.036, 15808979
    • Csernansky JG, Wang L, Swank J, Miller JP, Gado M, McKeel D, Miller MI, Morris JC. Preclinical detection of Alzheimer's disease: hippocampal shape and volume predict dementia onset in the elderly. Neuroimage 2005, 25:783-792. 10.1016/j.neuroimage.2004.12.036, 15808979.
    • (2005) Neuroimage , vol.25 , pp. 783-792
    • Csernansky, J.G.1    Wang, L.2    Swank, J.3    Miller, J.P.4    Gado, M.5    McKeel, D.6    Miller, M.I.7    Morris, J.C.8
  • 136
    • 77952877416 scopus 로고    scopus 로고
    • Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment
    • 10.1016/j.neurobiolaging.2008.08.010, 2873058, 18809227
    • Martin SB, Smith CD, Collins HR, Schmitt FA, Gold BT. Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment. Neurobiol Aging 2010, 31:1099-1106. 10.1016/j.neurobiolaging.2008.08.010, 2873058, 18809227.
    • (2010) Neurobiol Aging , vol.31 , pp. 1099-1106
    • Martin, S.B.1    Smith, C.D.2    Collins, H.R.3    Schmitt, F.A.4    Gold, B.T.5
  • 137
    • 0345446720 scopus 로고    scopus 로고
    • Regional brain atrophy rate predicts future cognitive decline: 6-year longitudinal MR imaging study of normal aging
    • 10.1148/radiol.2293021299, 14657306
    • Rusinek H, De Santi S, Frid D, Tsui WH, Tarshish CY, Convit A, de Leon MJ. Regional brain atrophy rate predicts future cognitive decline: 6-year longitudinal MR imaging study of normal aging. Radiology 2003, 229:691-696. 10.1148/radiol.2293021299, 14657306.
    • (2003) Radiology , vol.229 , pp. 691-696
    • Rusinek, H.1    De Santi, S.2    Frid, D.3    Tsui, W.H.4    Tarshish, C.Y.5    Convit, A.6    de Leon, M.J.7
  • 142
    • 84857419176 scopus 로고    scopus 로고
    • MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults
    • 10.1212/WNL.0b013e31823efc6c, 22189451
    • Dickerson BC, Wolk DA. MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults. Neurology 2012, 78:84-90. 10.1212/WNL.0b013e31823efc6c, 22189451.
    • (2012) Neurology , vol.78 , pp. 84-90
    • Dickerson, B.C.1    Wolk, D.A.2
  • 143
    • 0035928402 scopus 로고    scopus 로고
    • Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images
    • 10.1016/S0140-6736(01)05408-3, 11476837
    • Fox NC, Crum WR, Scahill RI, Stevens JM, Janssen JC, Rossor MN. Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images. Lancet 2001, 358:201-205. 10.1016/S0140-6736(01)05408-3, 11476837.
    • (2001) Lancet , vol.358 , pp. 201-205
    • Fox, N.C.1    Crum, W.R.2    Scahill, R.I.3    Stevens, J.M.4    Janssen, J.C.5    Rossor, M.N.6
  • 144
    • 0030938170 scopus 로고    scopus 로고
    • Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia
    • 10.1212/WNL.48.5.1297, 9153461
    • Kaye JA, Swihart T, Howieson D, Dame A, Moore MM, Karnos T, Camicioli R, Ball M, Oken B, Sexton G. Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia. Neurology 1997, 48:1297-1304. 10.1212/WNL.48.5.1297, 9153461.
    • (1997) Neurology , vol.48 , pp. 1297-1304
    • Kaye, J.A.1    Swihart, T.2    Howieson, D.3    Dame, A.4    Moore, M.M.5    Karnos, T.6    Camicioli, R.7    Ball, M.8    Oken, B.9    Sexton, G.10
  • 145
    • 40549142131 scopus 로고    scopus 로고
    • Trajectories of brain loss in aging and the development of cognitive impairment
    • 10.1212/01.wnl.0000280577.43413.d9, 18046010
    • Carlson NE, Moore MM, Dame A, Howieson D, Silbert LC, Quinn JF, Kaye JA. Trajectories of brain loss in aging and the development of cognitive impairment. Neurology 2008, 70:828-833. 10.1212/01.wnl.0000280577.43413.d9, 18046010.
    • (2008) Neurology , vol.70 , pp. 828-833
    • Carlson, N.E.1    Moore, M.M.2    Dame, A.3    Howieson, D.4    Silbert, L.C.5    Quinn, J.F.6    Kaye, J.A.7
  • 147
    • 57449102084 scopus 로고    scopus 로고
    • Improved predictive model for pre-symptomatic mild cognitive impairment and Alzheimer's disease
    • 10.1179/174313208X327973, 18768112
    • Smith CD, Chebrolu H, Markesbery WR, Liu J. Improved predictive model for pre-symptomatic mild cognitive impairment and Alzheimer's disease. Neurol Res 2008, 30:1091-1096. 10.1179/174313208X327973, 18768112.
    • (2008) Neurol Res , vol.30 , pp. 1091-1096
    • Smith, C.D.1    Chebrolu, H.2    Markesbery, W.R.3    Liu, J.4
  • 148
    • 45749108963 scopus 로고    scopus 로고
    • Basal forebrain atrophy is a presymptomatic marker for Alzheimer's disease
    • 10.1016/j.jalz.2008.04.005, 2517158, 18631978
    • Hall AM, Moore RY, Lopez OL, Kuller L, Becker JT. Basal forebrain atrophy is a presymptomatic marker for Alzheimer's disease. Alzheimers Dement 2008, 4:271-279. 10.1016/j.jalz.2008.04.005, 2517158, 18631978.
    • (2008) Alzheimers Dement , vol.4 , pp. 271-279
    • Hall, A.M.1    Moore, R.Y.2    Lopez, O.L.3    Kuller, L.4    Becker, J.T.5
  • 154
    • 79960623804 scopus 로고    scopus 로고
    • Functional disconnection and compensation in mild cognitive impairment: evidence from DLPFC connectivity using resting-state fMRI
    • 10.1371/journal.pone.0022153, 3141010, 21811568
    • Liang P, Wang Z, Yang Y, Jia X, Li K. Functional disconnection and compensation in mild cognitive impairment: evidence from DLPFC connectivity using resting-state fMRI. PLoS One 2011, 6:e22153. 10.1371/journal.pone.0022153, 3141010, 21811568.
    • (2011) PLoS One , vol.6
    • Liang, P.1    Wang, Z.2    Yang, Y.3    Jia, X.4    Li, K.5
  • 155
    • 80054002592 scopus 로고    scopus 로고
    • Altered connectivity pattern of hubs in default-mode network with Alzheimer's disease: an Granger causality modeling approach
    • 10.1371/journal.pone.0025546, 3191142, 22022410
    • Miao X, Wu X, Li R, Chen K, Yao L. Altered connectivity pattern of hubs in default-mode network with Alzheimer's disease: an Granger causality modeling approach. PLoS One 2011, 6:e25546. 10.1371/journal.pone.0025546, 3191142, 22022410.
    • (2011) PLoS One , vol.6
    • Miao, X.1    Wu, X.2    Li, R.3    Chen, K.4    Yao, L.5
  • 156
    • 78249275549 scopus 로고    scopus 로고
    • Loss of 'small-world' networks in Alzheimer's disease: graph analysis of FMRI resting-state functional connectivity
    • 10.1371/journal.pone.0013788, 2967467, 21072180
    • Sanz-Arigita EJ, Schoonheim MM, Damoiseaux JS, Rombouts SA, Maris E, Barkhof F, Scheltens P, Stam CJ. Loss of 'small-world' networks in Alzheimer's disease: graph analysis of FMRI resting-state functional connectivity. PLoS One 2010, 5:e13788. 10.1371/journal.pone.0013788, 2967467, 21072180.
    • (2010) PLoS One , vol.5
    • Sanz-Arigita, E.J.1    Schoonheim, M.M.2    Damoiseaux, J.S.3    Rombouts, S.A.4    Maris, E.5    Barkhof, F.6    Scheltens, P.7    Stam, C.J.8
  • 158
    • 28944444529 scopus 로고    scopus 로고
    • Identification of Alzheimer disease risk by functional magnetic resonance imaging
    • 10.1001/archneur.62.12.1881, 16344346
    • Fleisher AS, Houston WS, Eyler LT, Frye S, Jenkins C, Thal LJ, Bondi MW. Identification of Alzheimer disease risk by functional magnetic resonance imaging. Arch Neurol 2005, 62:1881-1888. 10.1001/archneur.62.12.1881, 16344346.
    • (2005) Arch Neurol , vol.62 , pp. 1881-1888
    • Fleisher, A.S.1    Houston, W.S.2    Eyler, L.T.3    Frye, S.4    Jenkins, C.5    Thal, L.J.6    Bondi, M.W.7
  • 159
    • 13244274910 scopus 로고    scopus 로고
    • FMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease
    • 10.1212/01.WNL.0000150885.00929.7E, 1761695, 15699382
    • Bondi MW, Houston WS, Eyler LT, Brown GG. fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease. Neurology 2005, 64:501-508. 10.1212/01.WNL.0000150885.00929.7E, 1761695, 15699382.
    • (2005) Neurology , vol.64 , pp. 501-508
    • Bondi, M.W.1    Houston, W.S.2    Eyler, L.T.3    Brown, G.G.4
  • 160
    • 69449103287 scopus 로고    scopus 로고
    • Semantic memory activation in individuals at risk for developing Alzheimer disease
    • 10.1212/WNL.0b013e3181b389ad, 2731619, 19704080
    • Seidenberg M, Guidotti L, Nielson KA, Woodard JL, Durgerian S, Antuono P, Zhang Q, Rao SM. Semantic memory activation in individuals at risk for developing Alzheimer disease. Neurology 2009, 73:612-620. 10.1212/WNL.0b013e3181b389ad, 2731619, 19704080.
    • (2009) Neurology , vol.73 , pp. 612-620
    • Seidenberg, M.1    Guidotti, L.2    Nielson, K.A.3    Woodard, J.L.4    Durgerian, S.5    Antuono, P.6    Zhang, Q.7    Rao, S.M.8
  • 161
  • 162
    • 33646271130 scopus 로고    scopus 로고
    • Familial risk for Alzheimer's disease alters fMRI activation patterns
    • 10.1093/brain/awl089, 2744898, 16627465
    • Bassett SS, Yousem DM, Cristinzio C, Kusevic I, Yassa MA, Caffo BS, Zeger SL. Familial risk for Alzheimer's disease alters fMRI activation patterns. Brain 2006, 129:1229-1239. 10.1093/brain/awl089, 2744898, 16627465.
    • (2006) Brain , vol.129 , pp. 1229-1239
    • Bassett, S.S.1    Yousem, D.M.2    Cristinzio, C.3    Kusevic, I.4    Yassa, M.A.5    Caffo, B.S.6    Zeger, S.L.7
  • 163
    • 43649092488 scopus 로고    scopus 로고
    • Altered fMRI activation during mental rotation in those at genetic risk for Alzheimer disease
    • 10.1212/01.wnl.0000312288.45119.d1, 2671804, 18474845
    • Yassa MA, Verduzco G, Cristinzio C, Bassett SS. Altered fMRI activation during mental rotation in those at genetic risk for Alzheimer disease. Neurology 2008, 70:1898-1904. 10.1212/01.wnl.0000312288.45119.d1, 2671804, 18474845.
    • (2008) Neurology , vol.70 , pp. 1898-1904
    • Yassa, M.A.1    Verduzco, G.2    Cristinzio, C.3    Bassett, S.S.4
  • 164
    • 80053630949 scopus 로고    scopus 로고
    • Subjective cognitive impairment: functional MRI during a divided attention task
    • Rodda J, Dannhauser T, Cutinha DJ, Shergill SS, Walker Z. Subjective cognitive impairment: functional MRI during a divided attention task. Eur Psychiatry 2011, 26:457-462.
    • (2011) Eur Psychiatry , vol.26 , pp. 457-462
    • Rodda, J.1    Dannhauser, T.2    Cutinha, D.J.3    Shergill, S.S.4    Walker, Z.5
  • 169
    • 4544335597 scopus 로고    scopus 로고
    • Mild cognitive impairment as a diagnostic entity
    • 10.1111/j.1365-2796.2004.01388.x, 15324362
    • Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004, 256:183-194. 10.1111/j.1365-2796.2004.01388.x, 15324362.
    • (2004) J Intern Med , vol.256 , pp. 183-194
    • Petersen, R.C.1
  • 170
    • 0036156958 scopus 로고    scopus 로고
    • Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment
    • 10.1002/ana.10069, 11835370
    • DeKosky ST, Ikonomovic MD, Styren SD, Beckett L, Wisniewski S, Bennett DA, Cochran EJ, Kordower JH, Mufson EJ. Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann Neurol 2002, 51:145-155. 10.1002/ana.10069, 11835370.
    • (2002) Ann Neurol , vol.51 , pp. 145-155
    • DeKosky, S.T.1    Ikonomovic, M.D.2    Styren, S.D.3    Beckett, L.4    Wisniewski, S.5    Bennett, D.A.6    Cochran, E.J.7    Kordower, J.H.8    Mufson, E.J.9
  • 171
    • 2942536284 scopus 로고    scopus 로고
    • Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer disease
    • Peng S, Wuu J, Mufson EJ, Fahnestock M. Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer disease. J Neuropathol Exp Neurol 2004, 63:641-649.
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 641-649
    • Peng, S.1    Wuu, J.2    Mufson, E.J.3    Fahnestock, M.4
  • 173
    • 82955235703 scopus 로고    scopus 로고
    • Addressing the ethical, policy, and social challenges of preclinical Alzheimer disease
    • 10.1212/WNL.0b013e318232ac1a, 21917767
    • Karlawish J. Addressing the ethical, policy, and social challenges of preclinical Alzheimer disease. Neurology 2011, 77:1487-1493. 10.1212/WNL.0b013e318232ac1a, 21917767.
    • (2011) Neurology , vol.77 , pp. 1487-1493
    • Karlawish, J.1
  • 174
    • 76849091134 scopus 로고    scopus 로고
    • Can Alzheimer disease be prevented by amyloid-beta immunotherapy?
    • 10.1038/nrneurol.2009.219, 2864089, 20140000
    • Lemere CA, Masliah E. Can Alzheimer disease be prevented by amyloid-beta immunotherapy?. Nat Rev Neurol 2010, 6:108-119. 10.1038/nrneurol.2009.219, 2864089, 20140000.
    • (2010) Nat Rev Neurol , vol.6 , pp. 108-119
    • Lemere, C.A.1    Masliah, E.2
  • 176
    • 84859634304 scopus 로고    scopus 로고
    • Apolipoprotein epsilon 3 alleles are associated with indicators of neuronal resilience
    • 10.1186/1741-7015-10-35, 3352297, 22502727
    • Aboud O, Mrak RE, Boop F, Griffin ST. Apolipoprotein epsilon 3 alleles are associated with indicators of neuronal resilience. BMC Med 2012, 10:35. 10.1186/1741-7015-10-35, 3352297, 22502727.
    • (2012) BMC Med , vol.10 , pp. 35
    • Aboud, O.1    Mrak, R.E.2    Boop, F.3    Griffin, S.T.4
  • 177
    • 84859651399 scopus 로고    scopus 로고
    • Evidence that an APOE4 'double whammy' increases risk for Alzheimer's disease
    • 10.1186/1741-7015-10-36, 3356233, 22502767
    • Caesar I, Gandy S. Evidence that an APOE4 'double whammy' increases risk for Alzheimer's disease. BMC Med 2012, 10:36. 10.1186/1741-7015-10-36, 3356233, 22502767.
    • (2012) BMC Med , vol.10 , pp. 36
    • Caesar, I.1    Gandy, S.2


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