메뉴 건너뛰기




Volumn 110, Issue , 2013, Pages 102-113

Diagnosis and management of Alzheimer's disease: Past, present and future ethical issues

Author keywords

Alzheimer's disease; Diagnosis; Ethical considerations; Treatment

Indexed keywords

AMYLOID BETA PROTEIN ANTIBODY; CHOLINESTERASE INHIBITOR; DONEPEZIL; FLORBETAPIR F 18; FLUORODEOXYGLUCOSE F 18; GALANTAMINE; MEMANTINE; PLACEBO; RIVASTIGMINE; TACRINE;

EID: 84886726315     PISSN: 03010082     EISSN: 18735118     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2013.01.003     Document Type: Review
Times cited : (80)

References (141)
  • 2
    • 84886721223 scopus 로고    scopus 로고
    • Alzheimer's Association, Voices of Alzheimer's disease: a summary report of the nationwide town hall meetings for people with early stage dementia. Available at: Accessed July 27, 2012.
    • Alzheimer's Association, 2008. Voices of Alzheimer's disease: a summary report of the nationwide town hall meetings for people with early stage dementia. Available at: Accessed July 27, 2012. http://www.alz.org/national/documents/report_townhall.pdf.
    • (2008)
  • 4
    • 0023672296 scopus 로고
    • Clinical determination of mental competence. A theory and a retrospective study
    • Alexander M.P. Clinical determination of mental competence. A theory and a retrospective study. Archives of Neurology 1988, 45:23-26.
    • (1988) Archives of Neurology , vol.45 , pp. 23-26
    • Alexander, M.P.1
  • 9
    • 85027951205 scopus 로고    scopus 로고
    • Making sense of nonsense: experiences of mild cognitive impairment
    • Beard R.L., Neary T.M. Making sense of nonsense: experiences of mild cognitive impairment. Sociology of Health & Illness 2013, 35:130-146.
    • (2013) Sociology of Health & Illness , vol.35 , pp. 130-146
    • Beard, R.L.1    Neary, T.M.2
  • 10
    • 70350023341 scopus 로고    scopus 로고
    • Managing disability and enjoying life: how we reframe dementia through personal narratives
    • Beard R.L., Knauss J., Moyer D. Managing disability and enjoying life: how we reframe dementia through personal narratives. Journal of Aging Studies 2009, 23:237-245.
    • (2009) Journal of Aging Studies , vol.23 , pp. 237-245
    • Beard, R.L.1    Knauss, J.2    Moyer, D.3
  • 11
    • 43049092675 scopus 로고    scopus 로고
    • Resisting social disenfranchisement: negotiating collective identities and everyday life with memory loss
    • Beard R.L., Fox P.J. Resisting social disenfranchisement: negotiating collective identities and everyday life with memory loss. Social Science & Medicine 2008, 66:1509-1520.
    • (2008) Social Science & Medicine , vol.66 , pp. 1509-1520
    • Beard, R.L.1    Fox, P.J.2
  • 12
    • 79451473209 scopus 로고    scopus 로고
    • The living dead? The construction of people with Alzheimer's disease as zombies
    • Behuniak S. The living dead? The construction of people with Alzheimer's disease as zombies. Ageing and Society 2011, 31:70-92.
    • (2011) Ageing and Society , vol.31 , pp. 70-92
    • Behuniak, S.1
  • 14
    • 0028851326 scopus 로고
    • How do patients with Alzheimer's disease cope with their illness? A clinical experience report
    • Bahro M., Silber E., Sunderland T. How do patients with Alzheimer's disease cope with their illness? A clinical experience report. Journal of the American Geriatrics Society 1995, 43:41-46.
    • (1995) Journal of the American Geriatrics Society , vol.43 , pp. 41-46
    • Bahro, M.1    Silber, E.2    Sunderland, T.3
  • 16
    • 0032823491 scopus 로고    scopus 로고
    • Decision-making for percutaneous endoscopic gastrostomy among older adults in a community setting
    • Callahan C.M., Haag K.M., Buchanan N.N., Nisi R. Decision-making for percutaneous endoscopic gastrostomy among older adults in a community setting. Journal of the American Geriatrics Society 1999, 47:1105-1109.
    • (1999) Journal of the American Geriatrics Society , vol.47 , pp. 1105-1109
    • Callahan, C.M.1    Haag, K.M.2    Buchanan, N.N.3    Nisi, R.4
  • 19
    • 2142697993 scopus 로고    scopus 로고
    • Disclosing a dementia diagnosis: a review of opinion and practice, and a proposed research agenda
    • Carpenter B., Dave J. Disclosing a dementia diagnosis: a review of opinion and practice, and a proposed research agenda. Gerontologist 2004, 44:149-158.
    • (2004) Gerontologist , vol.44 , pp. 149-158
    • Carpenter, B.1    Dave, J.2
  • 21
    • 0030000230 scopus 로고    scopus 로고
    • Survival of Medicare patients after enrollment in hospice programs
    • Christakis N.A., Escarce J.J. Survival of Medicare patients after enrollment in hospice programs. The New England Journal of Medicine 1996, 335:172-178.
    • (1996) The New England Journal of Medicine , vol.335 , pp. 172-178
    • Christakis, N.A.1    Escarce, J.J.2
  • 24
    • 33846898170 scopus 로고    scopus 로고
    • The impact of the label of mild cognitive impairment on individual's sense of self
    • Corner L., Bond J. The impact of the label of mild cognitive impairment on individual's sense of self. Philosophy, Psychiatry, & Psychology 2006, 13:3-12.
    • (2006) Philosophy, Psychiatry, & Psychology , vol.13 , pp. 3-12
    • Corner, L.1    Bond, J.2
  • 25
    • 33947585327 scopus 로고    scopus 로고
    • How clinical diagnosis might exacerbate the stigma of mental illness
    • Corrigan P.W. How clinical diagnosis might exacerbate the stigma of mental illness. Social Work 2007, 52:31-39.
    • (2007) Social Work , vol.52 , pp. 31-39
    • Corrigan, P.W.1
  • 28
    • 0031665869 scopus 로고    scopus 로고
    • Suicidal ideation and the 'wish to die' in dementia patients: the role of depression
    • Draper B., MacCuspie-Moore C., Brodaty H. Suicidal ideation and the 'wish to die' in dementia patients: the role of depression. Age and Ageing 1998, 27:503-507.
    • (1998) Age and Ageing , vol.27 , pp. 503-507
    • Draper, B.1    MacCuspie-Moore, C.2    Brodaty, H.3
  • 30
    • 0026582462 scopus 로고
    • Should patients with Alzheimer's disease be told their diagnosis?
    • Drickamer M.A., Lachs M.S. Should patients with Alzheimer's disease be told their diagnosis?. The New England Journal of Medicine 1992, 326:947-951.
    • (1992) The New England Journal of Medicine , vol.326 , pp. 947-951
    • Drickamer, M.A.1    Lachs, M.S.2
  • 33
    • 0032975114 scopus 로고    scopus 로고
    • Deaths attributable to Alzheimer's disease in the United States
    • Ewbank D.C. Deaths attributable to Alzheimer's disease in the United States. American Journal of Public Health 1999, 89:90-92.
    • (1999) American Journal of Public Health , vol.89 , pp. 90-92
    • Ewbank, D.C.1
  • 34
    • 0031728926 scopus 로고    scopus 로고
    • New treatments in Alzheimer disease and the continued need for placebo-controlled trials
    • Farlow M.R. New treatments in Alzheimer disease and the continued need for placebo-controlled trials. Archives of Neurology 1998, 55:1396-1398.
    • (1998) Archives of Neurology , vol.55 , pp. 1396-1398
    • Farlow, M.R.1
  • 36
    • 0035964226 scopus 로고    scopus 로고
    • A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease
    • Donepezil MSAG Study Investigators Group
    • Feldman H., Gauthier S., Hecker J., Vellas B., Subbiah P., Whalen E. A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease. Neurology 2001, 57:613-620. Donepezil MSAG Study Investigators Group.
    • (2001) Neurology , vol.57 , pp. 613-620
    • Feldman, H.1    Gauthier, S.2    Hecker, J.3    Vellas, B.4    Subbiah, P.5    Whalen, E.6
  • 37
    • 68949169046 scopus 로고    scopus 로고
    • IV immunoglobulin is associated with a reduced risk of Alzheimer disease and related disorders
    • Fillit H., Hess G., Hill J., Bonnet P., Toso C. IV immunoglobulin is associated with a reduced risk of Alzheimer disease and related disorders. Neurology 2009, 73:180-185.
    • (2009) Neurology , vol.73 , pp. 180-185
    • Fillit, H.1    Hess, G.2    Hill, J.3    Bonnet, P.4    Toso, C.5
  • 40
    • 0016823810 scopus 로고
    • "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician
    • Folstein M.F., Folstein S.E., McHugh P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 1975, 12:189-198.
    • (1975) Journal of Psychiatric Research , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 42
    • 0023185342 scopus 로고
    • Equipoise and the ethics of clinical research
    • Freedman B. Equipoise and the ethics of clinical research. The New England Journal of Medicine 1987, 317:141-145.
    • (1987) The New England Journal of Medicine , vol.317 , pp. 141-145
    • Freedman, B.1
  • 43
    • 0026085720 scopus 로고
    • Suicide attempts by the old and the very old
    • Frierson R.L. Suicide attempts by the old and the very old. Archives of Internal Medicine 1991, 151:141-144.
    • (1991) Archives of Internal Medicine , vol.151 , pp. 141-144
    • Frierson, R.L.1
  • 46
    • 84886721337 scopus 로고    scopus 로고
    • Management of Alzheimer's disease using disease-modifying drugs
    • Gauthier S. Management of Alzheimer's disease using disease-modifying drugs. Neurodegenerative Disease Management 2012, 2:375-378.
    • (2012) Neurodegenerative Disease Management , vol.2 , pp. 375-378
    • Gauthier, S.1
  • 48
    • 0032992697 scopus 로고    scopus 로고
    • Do we have a treatment for Alzheimer disease? Yes
    • Gauthier S. Do we have a treatment for Alzheimer disease? Yes. Archives of Neurology 1999, 56:738-739.
    • (1999) Archives of Neurology , vol.56 , pp. 738-739
    • Gauthier, S.1
  • 49
    • 0031596270 scopus 로고    scopus 로고
    • Current diagnostic methods and outcome variables for clinical investigation of Alzheimer's disease
    • Gauthier S., Panisset M. Current diagnostic methods and outcome variables for clinical investigation of Alzheimer's disease. Journal of Neural Transmission. Supplementum 1998, 53:251-254.
    • (1998) Journal of Neural Transmission. Supplementum , vol.53 , pp. 251-254
    • Gauthier, S.1    Panisset, M.2
  • 50
    • 0029283812 scopus 로고
    • Community-equipoise and the ethics of randomized clinical trials
    • Gifford F. Community-equipoise and the ethics of randomized clinical trials. Bioethics 1995, 9:127-148.
    • (1995) Bioethics , vol.9 , pp. 127-148
    • Gifford, F.1
  • 51
    • 0034688325 scopus 로고    scopus 로고
    • Rethinking the role of tube feeding in patients with advanced dementia
    • Gillick M.R. Rethinking the role of tube feeding in patients with advanced dementia. The New England Journal of Medicine 2000, 342:206-210.
    • (2000) The New England Journal of Medicine , vol.342 , pp. 206-210
    • Gillick, M.R.1
  • 53
    • 74249120181 scopus 로고    scopus 로고
    • Disclosure of the genetic risk of Alzheimer's disease
    • author reply 2
    • Gordon S.C., Landa D. Disclosure of the genetic risk of Alzheimer's disease. The New England Journal of Medicine 2010, 362:181-182. author reply 2.
    • (2010) The New England Journal of Medicine , vol.362 , pp. 181-182
    • Gordon, S.C.1    Landa, D.2
  • 56
    • 27844552424 scopus 로고    scopus 로고
    • Living stigma: the impact of labeling, stereotyping, separation, status loss, and discrimination in the lives of individuals with disabilities and their families
    • Green S., Davis C., Karshmer E., Marsh P., Straight B. Living stigma: the impact of labeling, stereotyping, separation, status loss, and discrimination in the lives of individuals with disabilities and their families. Sociological Inquiry 2005, 75:197-215.
    • (2005) Sociological Inquiry , vol.75 , pp. 197-215
    • Green, S.1    Davis, C.2    Karshmer, E.3    Marsh, P.4    Straight, B.5
  • 58
    • 38549103770 scopus 로고    scopus 로고
    • Palliative care in dementia: issues and evidence
    • Hughes J.C. Palliative care in dementia: issues and evidence. Advances in Psychiatric Treatment 2007, 13:251-260.
    • (2007) Advances in Psychiatric Treatment , vol.13 , pp. 251-260
    • Hughes, J.C.1
  • 59
    • 11844302879 scopus 로고    scopus 로고
    • Specialist palliative care in dementia
    • Hughes J.C., Robinson L., Volicer L. Specialist palliative care in dementia. BMJ 2005, 330:57-58.
    • (2005) BMJ , vol.330 , pp. 57-58
    • Hughes, J.C.1    Robinson, L.2    Volicer, L.3
  • 60
    • 0033024662 scopus 로고    scopus 로고
    • The psychological consequences of learning a diagnosis of dementia: three case examples
    • Husband H.J. The psychological consequences of learning a diagnosis of dementia: three case examples. Aging & Mental Health 1999, 3:179-183.
    • (1999) Aging & Mental Health , vol.3 , pp. 179-183
    • Husband, H.J.1
  • 63
    • 82955235703 scopus 로고    scopus 로고
    • Addressing the ethical, policy, and social challenges of preclinical Alzheimer's disease
    • Karlawish J. Addressing the ethical, policy, and social challenges of preclinical Alzheimer's disease. Neurology 2011, 77:1487-1493.
    • (2011) Neurology , vol.77 , pp. 1487-1493
    • Karlawish, J.1
  • 64
    • 0032948562 scopus 로고    scopus 로고
    • A consensus-based approach to providing palliative care to patients who lack decision-making capacity. ACP-ASIM End-of-Life Care Consensus Panel. American College of Physicians-American Society of Internal Medicine
    • Karlawish J.H., Quill T., Meier D.E. A consensus-based approach to providing palliative care to patients who lack decision-making capacity. ACP-ASIM End-of-Life Care Consensus Panel. American College of Physicians-American Society of Internal Medicine. Annals of Internal Medicine 1999, 130:835-840.
    • (1999) Annals of Internal Medicine , vol.130 , pp. 835-840
    • Karlawish, J.H.1    Quill, T.2    Meier, D.E.3
  • 65
    • 0031759238 scopus 로고    scopus 로고
    • Is the placebo control obsolete in a world after donepezil and vitamin E?
    • Karlawish J.H., Whitehouse P.J. Is the placebo control obsolete in a world after donepezil and vitamin E?. Archives of Neurology 1998, 55:1420-1424.
    • (1998) Archives of Neurology , vol.55 , pp. 1420-1424
    • Karlawish, J.H.1    Whitehouse, P.J.2
  • 68
    • 84971733620 scopus 로고
    • The dialectics of dementia: with particular reference to Alzheimer's disease
    • Kitwood T. The dialectics of dementia: with particular reference to Alzheimer's disease. Ageing Society 1990, 10:177-196.
    • (1990) Ageing Society , vol.10 , pp. 177-196
    • Kitwood, T.1
  • 69
    • 33746951395 scopus 로고    scopus 로고
    • Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study
    • Kivipelto M., Ngandu T., Laatikainen T., Winblad W., Soininen H., Tuomilehto J. Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurology 2006, 5:735-741.
    • (2006) Lancet Neurology , vol.5 , pp. 735-741
    • Kivipelto, M.1    Ngandu, T.2    Laatikainen, T.3    Winblad, W.4    Soininen, H.5    Tuomilehto, J.6
  • 70
    • 0028270519 scopus 로고
    • A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. The Tacrine Study Group
    • Knapp M.J., Knopman D.S., Solomon P.R., Pendlebury W.W., Davis C.S., Gracon S.I. A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. The Tacrine Study Group. JAMA 1994, 271:985-991.
    • (1994) JAMA , vol.271 , pp. 985-991
    • Knapp, M.J.1    Knopman, D.S.2    Solomon, P.R.3    Pendlebury, W.W.4    Davis, C.S.5    Gracon, S.I.6
  • 71
    • 0031759502 scopus 로고    scopus 로고
    • Clinical research designs for emerging treatments for Alzheimer disease: moving beyond placebo-controlled trials
    • Knopman D., Kahn J., Miles S. Clinical research designs for emerging treatments for Alzheimer disease: moving beyond placebo-controlled trials. Archives of Neurology 1998, 55:1425-1429.
    • (1998) Archives of Neurology , vol.55 , pp. 1425-1429
    • Knopman, D.1    Kahn, J.2    Miles, S.3
  • 72
    • 0030730113 scopus 로고    scopus 로고
    • An update on primary drug therapies for Alzheimer disease
    • Knopman D.S., Morris J.C. An update on primary drug therapies for Alzheimer disease. Archives of Neurology 1997, 54:1406-1409.
    • (1997) Archives of Neurology , vol.54 , pp. 1406-1409
    • Knopman, D.S.1    Morris, J.C.2
  • 73
    • 33847044863 scopus 로고    scopus 로고
    • Stigma sentiments and self-meanings: exploring the modified labeling theory of mental illness
    • Kroska A., Harkness S.K. Stigma sentiments and self-meanings: exploring the modified labeling theory of mental illness. Social Psychology Quarterly 2006, 69:325-348.
    • (2006) Social Psychology Quarterly , vol.69 , pp. 325-348
    • Kroska, A.1    Harkness, S.K.2
  • 75
    • 0024443991 scopus 로고
    • Hazards of inference: the active control investigation
    • discussion S4-8
    • Leber P.D. Hazards of inference: the active control investigation. Epilepsia 1989, 30(Suppl. 1):S57-S63. discussion S4-8.
    • (1989) Epilepsia , vol.30 , Issue.1 SUPPL.
    • Leber, P.D.1
  • 77
  • 79
    • 0029841297 scopus 로고    scopus 로고
    • Family members' attitudes toward telling the patient with Alzheimer's disease their diagnosis
    • Maguire C.P., Kirby M., Coen R., Coakley D., Lawlor B.A., O'Neill D. Family members' attitudes toward telling the patient with Alzheimer's disease their diagnosis. BMJ 1996, 313:529-530.
    • (1996) BMJ , vol.313 , pp. 529-530
    • Maguire, C.P.1    Kirby, M.2    Coen, R.3    Coakley, D.4    Lawlor, B.A.5    O'Neill, D.6
  • 80
    • 0026665034 scopus 로고
    • Heterogeneity in Alzheimer's disease: progression rate segregated by distinct neuropsychological and cerebral metabolic profiles
    • Mann U.M., Mohr E., Gearing M., Chase T.N. Heterogeneity in Alzheimer's disease: progression rate segregated by distinct neuropsychological and cerebral metabolic profiles. Journal of Neurology, Neurosurgery, and Psychiatry 1992, 55(10):956-959.
    • (1992) Journal of Neurology, Neurosurgery, and Psychiatry , vol.55 , Issue.10 , pp. 956-959
    • Mann, U.M.1    Mohr, E.2    Gearing, M.3    Chase, T.N.4
  • 81
    • 0027392815 scopus 로고
    • Telling the diagnosis of Alzheimer's disease
    • Markle GBt. Telling the diagnosis of Alzheimer's disease. The New England Journal of Medicine 1993, 328:736.
    • (1993) The New England Journal of Medicine , vol.328 , pp. 736
    • Markle, G.1
  • 82
    • 0034958991 scopus 로고    scopus 로고
    • Loss of competency in Alzheimer's disease: conceptual and psychometric approaches
    • Marson D.C. Loss of competency in Alzheimer's disease: conceptual and psychometric approaches. International Journal of Law and Psychiatry 2001, 24:267-283.
    • (2001) International Journal of Law and Psychiatry , vol.24 , pp. 267-283
    • Marson, D.C.1
  • 83
    • 0032602771 scopus 로고    scopus 로고
    • Executive dysfunction and loss of capacity to consent to medical treatment in patients with Alzheimer's disease
    • Marson D.C., Harrell L. Executive dysfunction and loss of capacity to consent to medical treatment in patients with Alzheimer's disease. Seminars in Clinical Neuropsychiatry 1999, 4:41-49.
    • (1999) Seminars in Clinical Neuropsychiatry , vol.4 , pp. 41-49
    • Marson, D.C.1    Harrell, L.2
  • 85
    • 0029165803 scopus 로고
    • Neuropsychologic predictors of competency in Alzheimer's disease using a rational reasons legal standard
    • Marson D.C., Cody H.A., Ingram K.K., Harrell L.E. Neuropsychologic predictors of competency in Alzheimer's disease using a rational reasons legal standard. Archives of Neurology 1995, 52:955-959.
    • (1995) Archives of Neurology , vol.52 , pp. 955-959
    • Marson, D.C.1    Cody, H.A.2    Ingram, K.K.3    Harrell, L.E.4
  • 86
    • 0032764018 scopus 로고    scopus 로고
    • Error behaviors associated with loss of competency in Alzheimer's disease
    • Marson D., Annis S., McInturff B., Bartolucci A., Harrell L. Error behaviors associated with loss of competency in Alzheimer's disease. Neurology 1999, 53:1983-1992.
    • (1999) Neurology , vol.53 , pp. 1983-1992
    • Marson, D.1    Annis, S.2    McInturff, B.3    Bartolucci, A.4    Harrell, L.5
  • 88
    • 77955939164 scopus 로고    scopus 로고
    • To know or not to know: ethical issues related to early diagnosis of Alzheimer's disease
    • Mattsson N., Brax D., Zetterberg H. To know or not to know: ethical issues related to early diagnosis of Alzheimer's disease. International Journal of Alzheimer's Disease 2010, 2010:1-4.
    • (2010) International Journal of Alzheimer's Disease , vol.2010 , pp. 1-4
    • Mattsson, N.1    Brax, D.2    Zetterberg, H.3
  • 89
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984, 34:939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 91
    • 85008308525 scopus 로고    scopus 로고
    • Telling patients they have Alzheimer's disease
    • Meyers B.S. Telling patients they have Alzheimer's disease. BMJ 1997, 314:321-322.
    • (1997) BMJ , vol.314 , pp. 321-322
    • Meyers, B.S.1
  • 97
    • 0033564582 scopus 로고    scopus 로고
    • Decision-making for long-term tube-feeding in cognitively impaired elderly people
    • Mitchell S.L., Lawson F.M. Decision-making for long-term tube-feeding in cognitively impaired elderly people. CMAJ: Canadian Medical Association Journal 1999, 160:1705-1709.
    • (1999) CMAJ: Canadian Medical Association Journal , vol.160 , pp. 1705-1709
    • Mitchell, S.L.1    Lawson, F.M.2
  • 98
    • 0031842293 scopus 로고    scopus 로고
    • Metrifonate benefits cognitive, behavioral, and global function in patients with Alzheimer's disease
    • Morris J.C., Cyrus P.A., Orazem J., Mas J., Bieber F., Ruzincka B.B., Gulanski B. Metrifonate benefits cognitive, behavioral, and global function in patients with Alzheimer's disease. Neurology 1998, 50:1222-1230.
    • (1998) Neurology , vol.50 , pp. 1222-1230
    • Morris, J.C.1    Cyrus, P.A.2    Orazem, J.3    Mas, J.4    Bieber, F.5    Ruzincka, B.B.6    Gulanski, B.7
  • 102
    • 0028152357 scopus 로고
    • Severe impairment battery. A neuropsychological test for severely demented patients
    • Panisset M., Roudier M., Saxton J., Boller F. Severe impairment battery. A neuropsychological test for severely demented patients. Archives of Neurology 1994, 51:41-45.
    • (1994) Archives of Neurology , vol.51 , pp. 41-45
    • Panisset, M.1    Roudier, M.2    Saxton, J.3    Boller, F.4
  • 103
    • 44449083975 scopus 로고    scopus 로고
    • Disclosing a diagnosis of Alzheimer's disease
    • Pepersack T. Disclosing a diagnosis of Alzheimer's disease. Revue Medicale de Bruxelles 2008, 29:89-93.
    • (2008) Revue Medicale de Bruxelles , vol.29 , pp. 89-93
    • Pepersack, T.1
  • 108
    • 0028848520 scopus 로고
    • Fairhill guidelines on ethics of the care of people with Alzheimer's disease: a clinical summary. Center for Biomedical Ethics, Case Western Reserve University and the Alzheimer's Association
    • Post S.G., Whitehouse P.J. Fairhill guidelines on ethics of the care of people with Alzheimer's disease: a clinical summary. Center for Biomedical Ethics, Case Western Reserve University and the Alzheimer's Association. Journal of the American Geriatrics Society 1995, 43:1423-1429.
    • (1995) Journal of the American Geriatrics Society , vol.43 , pp. 1423-1429
    • Post, S.G.1    Whitehouse, P.J.2
  • 110
    • 0032999743 scopus 로고    scopus 로고
    • Do we have drugs for dementia? No
    • Pryse-Phillips W. Do we have drugs for dementia? No. Archives of Neurology 1999, 56:735-737.
    • (1999) Archives of Neurology , vol.56 , pp. 735-737
    • Pryse-Phillips, W.1
  • 111
    • 0032567128 scopus 로고    scopus 로고
    • Cholinesterase inhibition for Alzhemer disease. A meta-analysis of the Tacrine trials
    • Qizilbash N., Whitehead A., Higins J., Wilcock G., Schneider L., Farlow M. Cholinesterase inhibition for Alzhemer disease. A meta-analysis of the Tacrine trials. JAMA 1998, 280:1777-1782.
    • (1998) JAMA , vol.280 , pp. 1777-1782
    • Qizilbash, N.1    Whitehead, A.2    Higins, J.3    Wilcock, G.4    Schneider, L.5    Farlow, M.6
  • 113
    • 0032507788 scopus 로고    scopus 로고
    • Donepezil improves cogntion and global function in Alzheimer disease
    • and the Donoepezil Study Group
    • Rogers S.L., Doody R.S., Mohs R.C., Friedhoff L.T. Donepezil improves cogntion and global function in Alzheimer disease. Archives of Internal Medicine 1998, 158:1021-1031. and the Donoepezil Study Group.
    • (1998) Archives of Internal Medicine , vol.158 , pp. 1021-1031
    • Rogers, S.L.1    Doody, R.S.2    Mohs, R.C.3    Friedhoff, L.T.4
  • 118
    • 0024382303 scopus 로고
    • Psychopathology of very mild dementia of the Alzheimer type
    • Rubin E.H., Kinscherf D.A. Psychopathology of very mild dementia of the Alzheimer type. The American Journal of Psychiatry 1989, 146:1017-1021.
    • (1989) The American Journal of Psychiatry , vol.146 , pp. 1017-1021
    • Rubin, E.H.1    Kinscherf, D.A.2
  • 126
    • 84886730058 scopus 로고    scopus 로고
    • Revised estimates of incidence and risk factors for amyloid related imaging abnormalities (ARIA) in the phase 2 studies of bapineuzumab for mild-to-moderate Alzheimer's disease
    • Sperling R., Salloway S., Arrighi M., Morris K., Lu Y., Liu E., Black R., Brashear R.H., Grundman M. Revised estimates of incidence and risk factors for amyloid related imaging abnormalities (ARIA) in the phase 2 studies of bapineuzumab for mild-to-moderate Alzheimer's disease. Alzheimers's & Dementia 2011, 7(Suppl.):e64. http://www.alzheimersanddementia.com/article/S1552-5260(11)02853-6/abstract.
    • (2011) Alzheimers's & Dementia , vol.7 , Issue.SUPPL.
    • Sperling, R.1    Salloway, S.2    Arrighi, M.3    Morris, K.4    Lu, Y.5    Liu, E.6    Black, R.7    Brashear, R.H.8    Grundman, M.9
  • 127
    • 0040448394 scopus 로고
    • Stigma deviance and social control: some conceptual issues
    • Plenum, New York, S.C. Ainlay, G. Becker, L.M. Coleman (Eds.)
    • Stafford M.C., Scott R.R. Stigma deviance and social control: some conceptual issues. The Dilemma of Difference: A Multidisciplinary View of Stigma 1986, 77-91. Plenum, New York. S.C. Ainlay, G. Becker, L.M. Coleman (Eds.).
    • (1986) The Dilemma of Difference: A Multidisciplinary View of Stigma , pp. 77-91
    • Stafford, M.C.1    Scott, R.R.2
  • 129
    • 0034687072 scopus 로고    scopus 로고
    • Placebo-controlled trials and active-control trials in the evaluation of new treatments. Part 1: ethical and scientific issues
    • Temple R., Ellenberg S.S. Placebo-controlled trials and active-control trials in the evaluation of new treatments. Part 1: ethical and scientific issues. Annals of Internal Medicine 2000, 133:455-463.
    • (2000) Annals of Internal Medicine , vol.133 , pp. 455-463
    • Temple, R.1    Ellenberg, S.S.2
  • 130
    • 10544220019 scopus 로고    scopus 로고
    • A multicenter double-blind study of controlled-release physostigmine for the treatment of symptoms secondary to Alzheimer's disease. Physostigmine Study Group
    • Thal L.J., Schwartz G., Sano M., Weiner M., Knopman D., Harrell L., Bodenheimer S., Rossor M., Philpot M., Schor J., Goldberg A. A multicenter double-blind study of controlled-release physostigmine for the treatment of symptoms secondary to Alzheimer's disease. Physostigmine Study Group. Neurology 1996, 47:1389-1395.
    • (1996) Neurology , vol.47 , pp. 1389-1395
    • Thal, L.J.1    Schwartz, G.2    Sano, M.3    Weiner, M.4    Knopman, D.5    Harrell, L.6    Bodenheimer, S.7    Rossor, M.8    Philpot, M.9    Schor, J.10    Goldberg, A.11
  • 131
    • 0004756576 scopus 로고
    • CBT with early stage Alzheimer's disease patients: an exploratory view of the utility of this approach
    • Hemisphere, New York, E. Light, B.D. Lebowitz (Eds.)
    • Thompson L.W., Wenger G., Zeuss J.D., Gallagher D. CBT with early stage Alzheimer's disease patients: an exploratory view of the utility of this approach. Alzheimer's Disease-Treatment and Family Stress 1990, 383-397. Hemisphere, New York. E. Light, B.D. Lebowitz (Eds.).
    • (1990) Alzheimer's Disease-Treatment and Family Stress , pp. 383-397
    • Thompson, L.W.1    Wenger, G.2    Zeuss, J.D.3    Gallagher, D.4
  • 132
    • 84886716691 scopus 로고    scopus 로고
    • United States Food and Drug Administration, Available at, Accessed June 15, 2012
    • United States Food and Drug Administration Approval of a Novel PET Radiopharmaceutical for Amyloid 2012, Available at: Accessed June 15, 2012. http://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/202008_Florbetapir_Orig1s000TOC.cfm.
    • (2012) Approval of a Novel PET Radiopharmaceutical for Amyloid
  • 134
    • 0030803133 scopus 로고    scopus 로고
    • Ethical complexities of conducting research in developing countries
    • Varmus H., Satcher D. Ethical complexities of conducting research in developing countries. The New England Journal of Medicine 1997, 337:1003-1005.
    • (1997) The New England Journal of Medicine , vol.337 , pp. 1003-1005
    • Varmus, H.1    Satcher, D.2
  • 135
    • 0034947608 scopus 로고    scopus 로고
    • Diagnostic attributions versus labeling: impact of Alzheimer's disease and major depression diagnoses on emotions, beliefs, and helping intentions of family members
    • Wadley V.G., Haley W.E. Diagnostic attributions versus labeling: impact of Alzheimer's disease and major depression diagnoses on emotions, beliefs, and helping intentions of family members. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences 2001, 56:244-252.
    • (2001) The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences , vol.56 , pp. 244-252
    • Wadley, V.G.1    Haley, W.E.2
  • 136
    • 0028316959 scopus 로고
    • Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease
    • Watkins P.B., Zimmerman H.J., Knapp M.J., Gracon S.I., Lewis K.W. Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. JAMA 1994, 271:992-998.
    • (1994) JAMA , vol.271 , pp. 992-998
    • Watkins, P.B.1    Zimmerman, H.J.2    Knapp, M.J.3    Gracon, S.I.4    Lewis, K.W.5
  • 139
    • 33645741379 scopus 로고    scopus 로고
    • Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study
    • Severe Alzheimer's Disease Study Group
    • Winblad B., Kilander L., Eriksson S., Minthon L., Batsman S., Wetterholm A.L., Jansson-Blixt C., Haglund A. Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study. Lancet 2006, 367:1057-1065. Severe Alzheimer's Disease Study Group.
    • (2006) Lancet , vol.367 , pp. 1057-1065
    • Winblad, B.1    Kilander, L.2    Eriksson, S.3    Minthon, L.4    Batsman, S.5    Wetterholm, A.L.6    Jansson-Blixt, C.7    Haglund, A.8
  • 140
    • 84555202769 scopus 로고    scopus 로고
    • Use of biomarkers in clinical trials of Alzheimer disease: from concept to application
    • Wu L., Rosa-Neto P., Gauthier S. Use of biomarkers in clinical trials of Alzheimer disease: from concept to application. Molecular Diagnosis & Therapy 2011, 15:313-325.
    • (2011) Molecular Diagnosis & Therapy , vol.15 , pp. 313-325
    • Wu, L.1    Rosa-Neto, P.2    Gauthier, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.