Functional MRI assessment of task-induced deactivation of the default mode network in Alzheimer's disease and at-risk older individuals

Behavioural Neurology

Volumn 21, Issue 1-2, 2009, Pages 77-91

  Pihlajamäki, Maija ^a,b   Sperling, Reisa A ^a,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Aging; Alzheimer's disease (AD); Apolipoprotein E; Default mode network; Functional magnetic resonance imaging (fMRI); Memory; Mild cognitive impairment (MCI); Posterior cingulate cortex; Precuneus; Task induced deactivation

Indexed keywords

AGED; AGING; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EPOE E4 GENE; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE; GENOTYPE; HETEROZYGOTE; HIGH RISK POPULATION; HUMAN; IMAGE ANALYSIS; MALE; MILD COGNITIVE IMPAIRMENT; PRIORITY JOURNAL; TASK PERFORMANCE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEINS E; BRAIN; BRAIN MAPPING; COGNITION DISORDERS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MEMORY; NERVE NET; NEUROPSYCHOLOGICAL TESTS; PATIENT SELECTION; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 70350331591     PISSN: 09534180     EISSN: None     Source Type: Journal    
DOI: 10.1155/2009/276384     Document Type: Article

References (95)

1. A. Bakkour, J.C. Morris and B.C. Dickerson, The cortical signature of prodromal AD. Regional thinning predicts mild AD dementia, Neurology 72 (2009), 1048-1055.
2. C.F. Beckmann, M. Jenkinson and S.M. Smith, General multilevel linear modeling for group analysis in FMRI, Neuroimage 20 (2003), 1052-1063.
3. L. Bertram, M.B. McQueen, K. Mullin, D. Blacker and R.E. Tanzi, Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database, Nat Genet 39 (2007), 17-23.
4. H. Braak and E. Braak, Neuropathological stageing of Alzheimer-related changes, Acta Neuropathol (Berl) 82 (1991), 239-259.
5. K.M. Bradley, V.T. O'Sullivan, N.D. Soper, Z. Nagy, E.M. King, A.D. Smith and B.J. Shepstone, Cerebral perfusion SPET correlated with Braak pathological stage in Alzheimer's disease, Brain 125 (2002), 1772-1781.
6. R.L. Buckner, J.R. Andrews-Hanna and D.L. Schacter, The brain's default network: anatomy, function, and relevance to disease, Ann N Y Acad Sci 1124 (2008), 1-38.
7. R.L. Buckner, A.Z. Snyder, B.J. Shannon, G. LaRossa, R. Sachs, A.F. Fotenos, Y.I. Sheline, W.E. Klunk, C.A. Mathis, J.C. Morris and M.A. Mintun, Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory, J Neurosci 25 (2005), 7709-7717.
8. A.E. Cavanna and M.R. Trimble, The precuneus: a review of its functional anatomy and behavioural correlates, Brain 129 (2006), 564-583.
9. K.A. Celone, V.D. Calhoun, B.C. Dickerson, A. Atri, E.F. Chua, S.L. Miller, K. DePeau, D.M. Rentz, D.J. Selkoe, D. Blacker, M.S. Albert and R.A. Sperling, Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis, J Neurosci 26 (2006), 10222-10231.
10. G. Chetelat, B. Landeau, F. Eustache, F. Mezenge, F. Viader, V. de la Sayette, B. Desgranges and J.C. Baron, Using voxelbased morphometry to map the structural changes associated with rapid conversion in MCI: a longitudinal MRI study, Neuroimage 27 (2005), 934-946.
11. E.F. Chua, D.L. Schacter, E. Rand-Giovannetti and R.A. Sperling, Understanding metamemory: neural correlates of the cognitive process and subjective level of confidence in recognition memory, Neuroimage 29 (2006), 1150-1160.
12. J.S. Damoiseaux, S.A. Rombouts, F. Barkhof, P. Scheltens, C.J. Stam, S.M. Smith and C.F. Beckmann, Consistent restingstate networks across healthy subjects, Proc Natl Acad Sci U S A 103 (2006), 13848-13853.
13. S.M. Daselaar, S.E. Prince and R. Cabeza, When less means more: deactivations during encoding that predict subsequent memory, Neuroimage 23 (2004), 921-927.
14. T. den Heijer, M. Oudkerk, L.J. Launer, C.M. van Duijn, A. Hofman and M.M. Breteler, Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes, Neurology 59 (2002), 746-748.
15. B.C. Dickerson, D.H. Salat, J.F. Bates, M. Atiya, R.J. Killiany, D.N. Greve, A.M. Dale, C.E. Stern, D. Blacker, M.S. Albert and R.A. Sperling, Medial temporal lobe function and structure in mild cognitive impairment, Ann Neurol 56 (2004), 27-35.
16. B.C. Dickerson, D.H. Salat, D.N. Greve, E.F. Chua, E. Rand- Giovannetti, D.M. Rentz, L. Bertram, K. Mullin, R.E. Tanzi, D. Blacker, M.S. Albert and R.A. Sperling, Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD, Neurology 65 (2005), 404-411.
17. P. Edison, H.A. Archer, R. Hinz, A. Hammers, N. Pavese, Y.F. Tai, G. Hotton, D. Cutler, N. Fox, A. Kennedy, M. Rossor and D.J. Brooks, Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study, Neurology 68 (2007), 501-508.
18. H. Eichenbaum, A cortical-hippocampal system for declarative memory, Nat Rev Neurosci 1 (2000), 41-50.
19. L.A. Farrer, L.A. Cupples, J.L. Haines, B. Hyman, W.A. Kukull, R. Mayeux, R.H. Myers, M.A. Pericak-Vance, N. Risch and C.M. van Duijn, Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium, JAMA 278 (1997), 1349-1356.
20. M.D. Fox and M.E. Raichle, Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging, Nat Rev Neurosci 8 (2007), 700-711.
21. P. Fransson and G. Marrelec, The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis, Neuroimage 42 (2008), 1178-1184.
22. C. Geroldi, M. Pihlajamäki, M.P. Laakso, C. DeCarli, A. Beltramello, A. Bianchetti, H. Soininen, M. Trabucchi and G.B. Frisoni, APOE-epsilon4 is associated with less frontal and more medial temporal lobe atrophy in AD, Neurology 53 (1999), 1825-1832.
23. T. Gomez Isla, R. Hollister, H. West, S. Mui, J.H. Growdon, R.C. Petersen, J.E. Parisi and B.T. Hyman, Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease, Ann Neurol 41 (1997), 17-24.
24. T. Gomez Isla, J.L. Price, D.W. McKeel, Jr., J.C. Morris, J.H. Growdon and B.T. Hyman, Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease, J Neurosci 16 (1996), 4491-4500.
25. C.L. Grady, M.V. Springer, D. Hongwanishkul, A.R. McIntosh and G. Winocur, Age-related changes in brain activity across the adult lifespan, J Cogn Neurosci 18 (2006), 227-241.
26. M.D. Greicius, B. Krasnow, A.L. Reiss and V. Menon, Functional connectivity in the resting brain: a network analysis of the default mode hypothesis, Proc Natl Acad Sci U S A 100 (2003), 253-258.
27. M.D. Greicius and V. Menon, Default-mode activity during a passive sensory task: uncoupled from deactivation but impacting activation, J Cogn Neurosci 16 (2004), 1484-1492.
28. M.D. Greicius, G. Srivastava, A.L. Reiss and V. Menon, Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI, Proc Natl Acad Sci U S A 101 (2004), 4637-4642.
29. M.D. Greicius, K. Supekar, V. Menon and R.F. Dougherty, Resting-state functional connectivity reflects structural connectivity in the default mode network, Cereb Cortex 19 (2009), 72-78.
30. D.A. Gusnard and M.E. Raichle, Searching for a baseline: functional imaging and the resting human brain, Nat Rev Neurosci 2 (2001), 685-694.
31. A. Hämäläinen, M. Pihlajamäki, H. Tanila, T. Hänninen, E. Niskanen, S. Tervo, P.A. Karjalainen, R.L. Vanninen and H. Soininen, Increased fMRI responses during encoding in mild cognitive impairment, Neurobiol Aging 28 (2007), 1889-1903.
32. A. Hämäläinen, S. Tervo, M. Grau-Olivares, E. Niskanen, C. Pennanen, J. Huuskonen, M. Kivipelto, T. Hanninen, M. Tapiola, M. Vanhanen, M. Hallikainen, E.L. Helkala, A. Nissinen, R. Vanninen and H. Soininen, Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment, Neuroimage 37 (2007), 1122-1131. (Pubitemid 47385281)
33. K. Herholz, E. Salmon, D. Perani, J.C. Baron, V. Holthoff, L. Frolich, P. Schonknecht, K. Ito, R. Mielke, E. Kalbe, G. Zundorf, X. Delbeuck, O. Pelati, D. Anchisi, F. Fazio, N. Kerrouche, B. Desgranges, F. Eustache, B. Beuthien-Baumann, C. Menzel, J. Schroder, T. Kato, Y. Arahata, M. Henze and W.D. Heiss, Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET, Neuroimage 17 (2002), 302-316.
34. B.T. Hyman, G.W. Van Hoesen, A.R. Damasio and C.L. Barnes, Alzheimer's disease: cell-specific pathology isolates the hippocampal formation, Science 225 (1984), 1168-1170.
35. R. Insausti, D.G. Amaral and W.M. Cowan, The entorhinal cortex of the monkey: II. Cortical afferents, J Comp Neurol 264 (1987), 356-395. (Pubitemid 17150686)
36. K.A. Jellinger and C. Bancher, Neuropathology of Alzheimer's disease: a critical update, J Neural Transm Suppl 54 (1998), 77-95.
37. G.A. Jicha, J.E. Parisi, D.W. Dickson, K. Johnson, R. Cha, R.J. Ivnik, E.G. Tangalos, B.F. Boeve, D.S. Knopman, H. Braak and R.C. Petersen, Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia, Arch Neurol 63 (2006), 674-681.
38. S.C. Johnson, T.W. Schmitz, C.H. Moritz, M.E. Meyerand, H.A. Rowley, A.L. Alexander, K.W. Hansen, C.E. Gleason, C.M. Carlsson, M.L. Ries, S. Asthana, K. Chen, E.M. Reiman and G.E. Alexander, Activation of brain regions vulnerable to Alzheimer's disease: the effect of mild cognitive impairment, Neurobiol Aging 27 (2006), 1604-1612.
39. T.T. Kircher, S. Weis, K. Freymann, M. Erb, F. Jessen, W. Grodd, R. Heun and D.T. Leube, Hippocampal activation in patients with mild cognitive impairment is necessary for successful memory encoding, J Neurol Neurosurg Psychiatry 78 (2007), 812-818.
40. W.E. Klunk, H. Engler, A. Nordberg, Y. Wang, G. Blomqvist, D.P. Holt, M. Bergstrom, I. Savitcheva, G.F. Huang, S. Estrada, B. Ausen, M.L. Debnath, J. Barletta, J.C. Price, J. Sandell, B.J. Lopresti, A.Wall, P.Koivisto, G. Antoni, C.A. Mathis and B. Langstrom, Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B, Ann Neurol 55 (2004), 306-319. (Pubitemid 38269583)
41. D. Kogure, H. Matsuda, T. Ohnishi, T. Asada, M. Uno, T. Kunihiro, S. Nakano and M.Takasaki, Longitudinal evaluation of early Alzheimer's disease using brain perfusion SPECT, J Nucl Med 41 (2000), 1155-1162.
42. J.H. Kordower, Y. Chu, G.T. Stebbins, S.T. DeKosky, E.J. Cochran, D. Bennett and E.J. Mufson, Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment, Ann Neurol 49 (2001), 202-213.
43. G.R. Leichnetz, Connections of the medial posterior parietal cortex (area 7m) in the monkey, Anat Rec 263 (2001), 215-236.
44. C. Lustig, A.Z. Snyder,M. Bhakta, K.C. O'Brien, M.McAvoy, M.E. Raichle, J.C. Morris and R.L. Buckner, Functional deactivations: change with age and dementia of the Alzheimer type, Proc Natl Acad Sci U S A 100 (2003), 14504-14509.
45. M.M. Machulda, H.A. Ward, B. Borowski, J.L. Gunter, R.H. Cha, P.C. O'Brien, R.C. Petersen, B.F. Boeve, D. Knopman, D.F. Tang-Wai, R.J. Ivnik, G.E. Smith, E.G. Tangalos and C.R. Jack, Jr., Comparison of memory fMRI response among normal, MCI, and Alzheimer's patients, Neurology 61 (2003), 500-506.
46. B. Mazoyer, L. Zago, E. Mellet, S. Bricogne, O. Etard, O. Houde, F. Crivello, M. Joliot, L. Petit and N. Tzourio-Mazoyer, Cortical networks for working memory and executive functions sustain the conscious resting state in man, Brain Res Bull 54 (2001), 287-298.
47. G. McKhann, D. Drachman, M. Folstein, R. Katzman, D. Price and E.M. Stadlan, Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease, Neurology 34 (1984), 939-944.
48. K. Meguro, X. Blaizot, Y. Kondoh, C. Le Mestric, J.C. Baron and C. Chavoix, Neocortical and hippocampal glucose hypometabolism following neurotoxic lesions of the entorhinal and perirhinal cortices in the non-human primate as shown by PET. Implications for Alzheimer's disease, Brain 122 (1999), 1519-1531.
49. M.M. Mesulam, From sensation to cognition, Brain 121 (1998), 1013-1052.
50. S.L. Miller, K. Celone, K. Depeau, E. Diamond, B.C. Dickerson, D. Rentz, M. Pihlajamäki and R.A. Sperling, Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation, Proc Natl Acad Sci U S A 105 (2008), 2181-2186.
51. S. Minoshima, B. Giordani, S. Berent, K.A. Frey, N.L. Foster and D.E. Kuhl, Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease, Ann Neurol 42 (1997), 85-94.
52. M.A. Mintun, G.N. Larossa, Y.I. Sheline, C.S. Dence, S.Y. Lee, R.H. Mach, W.E. Klunk, C.A. Mathis, S.T. DeKosky and J.C. Morris, [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease, Neurology 67 (2006), 446-452.
53. A.M. Morcom and P.C. Fletcher, Does the brain have a baseline? Why we should be resisting a rest, Neuroimage 37 (2007), 1073-1082.
54. J.C. Morris, Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type, Int Psychogeriatr 9(Suppl 1) (1997), 173-176; discussion 177-178.
55. L. Mosconi, W.H. Tsui, K. Herholz, A. Pupi, A. Drzezga, G. Lucignani, E.M. Reiman, V. Holthoff, E. Kalbe, S. Sorbi, J. Diehl-Schmid, R. Perneczky, F. Clerici, R. Caselli, B. Beuthien-Baumann, A. Kurz, S. Minoshima and M.J. De Leon, Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias, J Nucl Med 49 (2008), 390-398.
56. P.J. Nestor, T.D. Fryer, P. Smielewski and J.R. Hodges, Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment, Ann Neurol 54 (2003), 343-351.
57. L.J. Otten and M.D. Rugg, When more means less: neural activity related to unsuccessful memory encoding, Curr Biol 11 (2001), 1528-1530.
58. J. Persson, J. Lind, A. Larsson, M. Ingvar, K. Sleegers, C. Van Broeckhoven, R. Adolfsson, L.G. Nilsson and L. Nyberg, Altered deactivation in individuals with genetic risk for Alzheimer's disease, Neuropsychologia 46 (2008), 1679-1687.
59. R.C. Petersen, R. Doody, A. Kurz, R.C. Mohs, J.C. Morris, P.V. Rabins, K. Ritchie, M. Rossor, L. Thal and B. Winblad, Current concepts in mild cognitive impairment, Arch Neurol 58 (2001), 1985-1992.
60. R.C. Petersen, G.E. Smith, S.C. Waring, R.J. Ivnik, E. Kokmen and E.G. Tangelos, Aging, memory, and mild cognitive impairment, Int Psychogeriatr 9(Suppl 1) (1997), 65-69.
61. J.R. Petrella, S.E. Prince, L. Wang, C. Hellegers and P.M. Doraiswamy, Prognostic value of posteromedial cortex deactivation in mild cognitive impairment, PLoS ONE 2 (2007), e1104.
62. J.R. Petrella, L. Wang, S. Krishnan, M.J. Slavin, S.E. Prince, T.T. Tran and P.M. Doraiswamy, Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging, Radiology 245 (2007), 224-235. (Pubitemid 47417806)
63. M. Pihlajamäki, K.M. Depeau, D. Blacker and R.A. Sperling, Impaired Medial Temporal Repetition Suppression is Related to Failure of Parietal Deactivation in Alzheimer Disease, Am J Geriatr Psychiatry 16 (2008), 283-292.
64. M. Pihlajamäki, K. O'Keefe, L. Bertram, R.E. Tanzi, B.C. Dickerson, D. Blacker, Marilyn S. Albert and Reisa A. Sperling, Evidence of altered posteromedial cortical fMRI activity in subjects at risk for Alzheimer disease, Alzheimer Dis Assoc Disord, in press.
65. M.E. Raichle, A.M. MacLeod, A.Z. Snyder,W.J. Powers, D.A. Gusnard and G.L. Shulman, A default mode of brain function, Proc Natl Acad Sci U S A 98 (2001), 676-682.
66. S.I. Rapoport, Positron emission tomography in Alzheimer's disease in relation to disease pathogenesis: a critical review, Cerebrovasc Brain Metab Rev 3 (1991), 297-335.
67. E.M. Reiman, R.J. Caselli, L.S. Yun, K. Chen, D. Bandy, S. Minoshima, S.N. Thibodeau and D. Osborne, Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E [see comments], N Engl J Med 334 (1996), 752-758.
68. E.M. Reiman, A. Uecker, R.J. Caselli, S. Lewis, D. Bandy, M.J. de Leon, S. De Santi, A. Convit, D. Osborne, A. Weaver and S.N. Thibodeau, Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease, Ann Neurol 44 (1998), 288-291.
69. M.L. Ries, T.W. Schmitz, T.N. Kawahara, B.M. Torgerson, M.A. Trivedi and S.C. Johnson, Task-dependent posterior cingulate activation in mild cognitive impairment, Neuroimage 29 (2006), 485-492.
70. S.A. Rombouts, F. Barkhof, R. Goekoop, C.J. Stam and P. Scheltens, Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: an fMRI study, Hum Brain Mapp 26 (2005), 231-239.
71. S.A. Rombouts, R. Goekoop, C.J. Stam, F. Barkhof and P. Scheltens, Delayed rather than decreased BOLD response as a marker for early Alzheimer's disease, Neuroimage 26 (2005), 1078-1085.
72. A.M. Saunders,W.J. Strittmatter, D. Schmechel, P.H. George- Hyslop, M.A. Pericak-Vance, S.H. Joo, B.L. Rosi, J.F. Gusella, D.R. Crapper-MacLachlan, M.J. Alberts and et al., Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease, Neurology 43 (1993), 1467-1472. (Pubitemid 23230526)
73. R.I. Scahill, J.M. Schott, J.M. Stevens, M.N. Rossor and N.C. Fox, Mapping the evolution of regional atrophy in Alzheimer's disease: unbiased analysis of fluid-registered serial MRI, Proc Natl Acad Sci U S A 99 (2002), 4703-4707.
74. S.W. Scheff, D.A. Price, F.A. Schmitt and E.J. Mufson, Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment, Neurobiol Aging 27 (2006), 1372-1384.
75. D.J. Selkoe, Alzheimer's disease is a synaptic failure, Science 298 (2002), 789-791.
76. G.L. Shulman, J.A. Fiez, M. Corbetta, R.L. Buckner, F.M. Miezin and M.E. Raichle, Common blood flow changes across visual tasks: II. Decreases in cerebral cortex, J Cogn Neurosci 9 (1997), 648-663.
77. A.G. Siapas, E.V. Lubenov and M.A.Wilson, Prefrontal phase locking to hippocampal theta oscillations, Neuron 46 (2005), 141-151.
78. G.W. Small, J.C. Mazziotta, M.T. Collins, L.R. Baxter, M.E. Phelps, M.A. Mandelkern, A. Kaplan, A. La Rue, C.F. Adamson, L. Chang and et al., Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease, JAMA 273 (1995), 942-947.
79. H. Soininen, K. Partanen, A. Pitkänen, M. Hallikainen, T. Hänninen, S. Helisalmi, A. Mannermaa, M. Ryynänen, K. Koivisto and P. Riekkinen, Sr., Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E epsilon 4 allele, Neurology 45 (1995), 391-392.
80. C. Sorg, V. Riedl, M. Muhlau, V.D. Calhoun, T. Eichele, L. Laer, A. Drzezga, H. Forstl, A. Kurz, C. Zimmer and A.M. Wohlschlager, Selective changes of resting-state networks in individuals at risk for Alzheimer's disease, Proc Natl Acad Sci U S A 104 (2007), 18760-18765.
81. R.A. Sperling, J.F. Bates, E.F. Chua, A.J. Cocchiarella, D.M. Rentz, B.R. Rosen, D.L. Schacter and M.S. Albert, fMRI studies of associative encoding in young and elderly controls and mild Alzheimer's disease, J Neurol Neurosurg Psychiatry 74 (2003), 44-50.
82. R.A. Sperling, J.F. Bates, A.J. Cocchiarella, D.L. Schacter, B.R. Rosen and M.S. Albert, Encoding novel face-name associations: a functional MRI study, Hum Brain Mapp 14 (2001), 129-139.
83. C.E. Stark and L.R. Squire, When zero is not zero: the problem of ambiguous baseline conditions in fMRI, Proc Natl Acad Sci U S A 98 (2001), 12760-12766.
84. K. Supekar, V. Menon, D. Rubin, M. Musen and M.D. Greicius, Network analysis of intrinsic functional brain connectivity in Alzheimer's disease, PLoS Comput Biol 4 (2008), e1000100.
85. W.A. Suzuki and D.G. Amaral, Perirhinal and parahippocampal cortices of the macaque monkey: cortical afferents, J Comp Neurol 350 (1994), 497-533.
86. R.E. Tanzi, The synaptic Abeta hypothesis of Alzheimer disease, Nat Neurosci 8 (2005), 977-979.
87. P.M. Thompson, K.M. Hayashi, G. de Zubicaray, A.L. Janke, S.E. Rose, J. Semple, D. Herman, M.S. Hong, S.S. Dittmer, D.M. Doddrell and A.W. Toga, Dynamics of gray matter loss in Alzheimer's disease, J Neurosci 23 (2003), 994-1005.
88. J.L. Vincent, A.Z. Snyder, M.D. Fox, B.J. Shannon, J.R. Andrews, M.E. Raichle and R.L. Buckner, Coherent spontaneous activity identifies a hippocampal-parietal memory network, J Neurophysiol 96 (2006), 3517-3531.
89. B.A. Vogt, L. Vogt and S. Laureys, Cytology and functionally correlated circuits of human posterior cingulate areas, Neuroimage 29 (2006), 452-466.
90. K. Wang, M. Liang, L. Wang, L. Tian, X. Zhang, K. Li and T. Jiang, Altered functional connectivity in early Alzheimer's disease: a resting-state fMRI study, Hum Brain Mapp 28 (2007), 967-978.
91. D.H. Weissman, K.C. Roberts, K.M. Visscher and M.G. Woldorff, The neural bases of momentary lapses in attention, Nat Neurosci 9 (2006), 971-978.
92. J.L. Whitwell, M.M. Shiung, S.A. Przybelski, S.D. Weigand, D.S. Knopman, B.F. Boeve, R.C. Petersen and C.R. Jack, Jr., MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment, Neurology 70 (2008), 512-520.
93. M.W. Woolrich, T.E. Behrens, C.F. Beckmann, M. Jenkinson and S.M. Smith, Multilevel linear modelling for FMRI group analysis using Bayesian inference, Neuroimage 21 (2004), 1732-1747.
94. K.J. Worsley, A.C. Evans, S. Marrett and P. Neelin, A threedimensional statistical analysis for CBF activation studies in human brain [see comments], J Cereb Blood Flow Metab 12 (1992), 900-918.
95. Y. Zhou, J.H. Dougherty, Jr., K.F. Hubner, B. Bai, R.L. Cannon and R.K. Hutson, Abnormal connectivity in the posterior cingulate and hippocampus in early Alzheimer's disease and mild cognitive impairment, Alzheimers Dement 4 (2008), 265-270.