Convergent genetic and expression data implicate immunity in Alzheimer's disease

Alzheimer's and Dementia

Volumn 11, Issue 6, 2015, Pages 658-671

  Jones, Lesley ^a   Lambert, Jean Charles ^b,c,d   Wang, Li San ^q   Choi, Seung Hoan ^h   Harold, Denise ^an   Vedernikov, Alexey ^a   Escott Price, Valentina ^a   Stone, Timothy ^a   Richards, Alexander ^a   Bellenguez, Céline ^b,c,d   Ibrahim Verbaas, Carla A ^e   Naj, Adam C ^f   Sims, Rebecca ^a   Gerrish, Amy ^a   Jun, Gyungah ^g,h   DeStefano, Anita L ^h   Bis, Joshua C ⁱ   Beecham, Gary W ^f   Grenier Boley, Benjamin ^b,c,d   Russo, Giancarlo ^j   Thornton Wells, Tricia A ^k   Jones, Nicola ^a   Smith, Albert V ^l,m   Chouraki, Vincent ^b,c,d   Thomas, Charlene ^a   Ikram, M Arfan ^e,n   Zelenika, Diana ^o   Vardarajan, Badri N ^g   Kamatani, Yoichiro ^p   Lin, Chiao Feng ^q   Schmidt, Helena ^r   Kunkle, Brian W ^f   Dunstan, Melanie L ^a   Ruiz, Agustin ^s   Bihoreau, Marie Thérèse ^o   Reitz, Christiane ^t,u   Pasquier, Florence ^c,v   Hollingworth, Paul ^a   Hanon, Olivier ^b   Fitzpatrick, Annette L ^i,x   Buxbaum, Joseph D ^y   Campion, Dominique ^z   Crane, Paul K ^x   Becker, Tim ^w   Gudnason, Vilmundur ^l,m   Cruchaga, Carlos ^aa   Craig, David ^ab   Amin, Najaf ^e   Berr, Claudine ^ac   Lopez, Oscar L ^ad   De Jager, Philip L ^ae,af   Deramecourt, Vincent ^b,v   Johnston, Janet A ^ab   Evans, Denis ^ag   Lovestone, Simon ^ah   Letteneur, Luc ^b   Kornhuber, Johanes ^ai   Tárraga, Lluís ^s   Rubinsztein, David C ^aj   Eiriksdottir, Gudny ^m   Sleegers, Kristel ^ak,al   Goate, Alison M ^aa   Fiévet, Nathalie ^b,d   Huentelman, Matthew J ^am   Gill, Michael ^an   Emilsson, Valur ^l,m   Brown, Kristelle ^ao   Kamboh, M Ilyas ^ad,ap   Keller, Lina ^aq   Barberger Gateau, Pascale ^b   McGuinness, Bernadette ^ab   Larson, Eric B ^x,ar   Myers, Amanda J ^f   Dufouil, Carole ^b   Todd, Stephen ^ab   Wallon, David ^z   Love, Seth ^as   Kehoe, Pat ^as   Rogaeva, Ekaterina ^at   Gallacher, John ^a   St George Hyslop, Peter ^aj,at   Clarimon, Jordi ^au,av   Lleò, Alberti ^au,av   Bayer, Anthony ^a   Tsuang, Debby W ⁱ   Yu, Lei ^aw   Tsolaki, Magda ^ax   Bossù, Paola ^ay   Spalletta, Gianfranco ^ay   Proitsi, Petra ^ah   Collinge, John ^az   Sorbi, Sandro ^ba   Sanchez Garcia, Florentino ^bb   Fox, Nick ^az   Hardy, John ^bc   Deniz Naranjo, Maria Candida ^bb   Razquin, Cristina ^ct   Bosco, Paola ^bd   Clarke, Robert ^be   Brayne, Carol ^bf   Galimberti, Daniela ^bg   Mancuso, Michelangelo ^bh   Moebus, Susanne ^bi   Mecocci, Patrizia ^bj   Del Zompo, Maria ^bk   Maier, Wolfgang ^w,cd   Hampel, Harald ^bl   Pilotto, Alberto ^bm   Bullido, Maria ^av,bn,bo   Panza, Francesco ^bp   Caffarra, Paolo ^bq,br   Nacmias, Benedetta ^ba   Gilbert, John R ^f   Mayhaus, Manuel ^bs   Jessen, Frank ^w,cd   Dichgans, Martin ^cd,cv   Lannfelt, Lars ^bt   Hakonarson, Hakon ^bu   Pichler, Sabrina ^bs   Carrasquillo, Minerva M ^bv   Ingelsson, Martin ^bt   Beekly, Duane ^x   Alavarez, Victoria ^bw   Zou, Fanggeng ^bv   Valladares, Otto ^q   Younkin, Steven G ^bv   Coto, Eliecer ^bw   Hamilton Nelson, Kara L ^f   Mateo, Ignacio ^bx   Owen, Michael J ^a   Faber, Kelley M ^by   Jonsson, Palmi V ^bz   Combarros, Onofre ^bx   O'Donovan, Michael C ^a   Cantwell, Laura B ^q   Soininen, Hilkka ^ca,cb   Blacker, Deborah ^ae,cc   Mead, Simon ^az   Mosley, Thomas H ^ce   Bennett, David A ^aw,ce   Harris, Tamara B ^cf   Fratiglioni, Laura ^aq,cg   Holmes, Clive ^ch   De Bruijn, Renee F A G ^e   Passmore, Peter ^ab   Montine, Thomas J ^x   Bettens, Karolien ^ak,al   Rotter, Jerome I ^ci   Brice, Alexis ^cj,ck   Morgan, Kevin ^ao   Foroud, Tatiana M ^by   Kukull, Walter A ^x   Hannequin, Didier ^z   Powell, John F ^ah   Nalls, Michael A ^cl   Ritchie, Karen ^ac   Lunetta, Kathryn L ^h   Kauwe, John S K ^aj   Boerwinkle, Eric ^cm,cn   Riemenschneider, Matthias ^bs   Boada, Mercè ^s   Hiltunen, Mikko ^ca,cb   Martin, Eden R ^f   Pastor, Pau ^av,cu   Schmidt, Reinhold ^r   Rujescu, Dan ^co,cw   Dartigues, Jean François ^b,cp   Mayeux, Richard ^t,u   Tzourio, Christophe ^b   Hofman, Albert ^e,n   Nöthen, Markus M ^w   Graff, Caroline ^cg,cq   Psaty, Bruce M ^i,x,ar   Haines, Jonathan L ^k,cr   Lathrop, Mark ^o,p,cs   Pericak Vance, Margaret A ^f   Launer, Lenore J ^cf   Farrer, Lindsay A ^g,h   Van Duijn, Cornelia M ^e   Van Broeckhoven, Christine ^ak,al   Ramirez, Alfredo ^w   Schellenberg, Gerard D ^q   Seshadri, Sudha ^g   Amouyel, Philippe ^b,c,d,v   Williams, Julie ^a   Holmans, Peter A ^a   MRC CFAS, ^cx   more..

^a CARDIFF UNIVERSITY   (United Kingdom)

^b INSERM   (France)

^c UNIV LILLE   (France)

^d INSTITUT PASTEUR DE LILLE   (France)

^e ERASMUS MEDICAL CENTER   (Netherlands)

^f UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^g BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

ⁱ UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^j FUNCTIONAL GENOMICS CENTER ZURICH   (Switzerland)

^k VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^l UNIVERSITY OF ICELAND   (Iceland)

^m ICELANDIC HEART ASSOCIATION   (Iceland)

ⁿ Netherlands Consortium for Healthy Ageing   (Netherlands)

^o CENTRE NATIONAL DE GÉNOTYPAGE   (France)

^p FONDATION JEAN DAUSSET CEPH   (France)

^q UNIVERSITY OF PENNSYLVANIA   (United States)

^r MEDICAL UNIVERSITY OF GRAZ   (Austria)

^s Institut Catala de Neurociencies Aplicades   (Spain)

^t Och Spine at New York Presbyterian Hospitals   (United States)

^u Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^v LILLE UNIVERSITY HOSPITAL   (France)

^w UNIVERSITY OF BONN   (Germany)

^x UNIVERSITY OF WASHINGTON   (United States)

^y MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^z CHS du Rouvray   (France)

^aa WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ab QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^ac Montpellier 1 University   (France)

^ad UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^ae MASSACHUSETTS GENERAL HOSPITAL   (United States)

^af BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^ag RUSH UNIVERSITY MEDICAL CENTER   (United States)

^ah KING'S COLLEGE LONDON   (United Kingdom)

^ai UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^aj UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^ak DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^al UNIVERSITY OF ANTWERP   (Belgium)

^am TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^an ST JAMES S HOSPITAL   (Ireland)

^ao UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^ap UNIVERSITY OF PITTSBURGH   (United States)

^aq STOCKHOLM UNIVERSITY   (Sweden)

^ar GROUP HEALTH RESEARCH INSTITUTE   (United States)

^as UNIVERSITY OF BRISTOL   (United Kingdom)

^at UNIVERSITY OF TORONTO   (Canada)

^au UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^av CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^aw RUSH UNIVERSITY MEDICAL CENTER   (United States)

^ax ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^ay IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^az UNIVERSITY COLLEGE LONDON   (United Kingdom)

^ba UNIVERSITY OF FLORENCE   (Italy)

^bb HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

^bc UNIVERSITY COLLEGE LONDON   (United Kingdom)

^bd OASI RESEARCH INSTITUTE IRCCS   (Italy)

^be UNIVERSITY OF OXFORD   (United Kingdom)

^bf UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^bg UNIVERSITY OF MILAN   (Italy)

^bh UNIVERSITY OF PISA   (Italy)

^bi UNIVERSITY HOSPITAL ESSEN   (Germany)

^bj UNIVERSITY OF PERUGIA   (Italy)

^bk UNIVERSITY OF CAGLIARI   (Italy)

^bl SORBONNE UNIVERSITÉ   (France)

^bm CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^bn CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

^bo HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^bp UNIVERSITY OF BARI   (Italy)

^bq UNIVERSITY OF PARMA   (Italy)

^br Center for Cognitive Disorders AUSL   (Italy)

^bs University Hospital   (Germany)

^bt UPPSALA UNIVERSITY   (Sweden)

^bu CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^bv MAYO GRADUATE SCHOOL   (United States)

^bw Genetica Molecular Huca Oviedo   (Spain)

^bx UNIVERSITY OF CANTABRIA   (Spain)

^by INDIANA UNIVERSITY   (United States)

^bz LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^ca UNIVERSITY OF EASTERN FINLAND   (Finland)

^cb KUOPIO UNIVERSITY HOSPITAL   (Finland)

^cc HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^cd GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^ce RUSH UNIVERSITY MEDICAL CENTER   (United States)

^cf NATIONAL INSTITUTES OF HEALTH   (United States)

^cg KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^ch UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^ci CEDARS SINAI MEDICAL CENTER   (United States)

^cj INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE   (France)

^ck PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^cl NATIONAL INSTITUTE ON AGING   (United States)

^cm BAYLOR COLLEGE OF MEDICINE   (United States)

^cn UNIVERSITY OF TEXAS   (United States)

^co UNIVERSITY OF MUNICH   (Germany)

^cp BORDEAUX UNIVERSITY HOSPITAL   (France)

^cq KAROLINSKA INSTITUTE   (Sweden)

^cr VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^cs MCGILL UNIVERSITY   (Canada)

^ct UNIVERSITY OF NAVARRA   (Spain)

^cu UNIVERSITY CLINIC OF NAVARRA   (Spain)

^cv LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^cw MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^cx St James's Hospital ^*

more..

Author keywords

ALIGATOR; Alzheimer's disease; Cholesterol metabolism; Dementia; Endocytosis; Immune response; Neurodegeneration; Pathway analysis; Ubiquitination; Weighted gene co expression network analysis

Indexed keywords

CLATHRIN; PROTEASOME; TRANSCRIPTION FACTOR AP 2; UBIQUITIN;

ALGORITHM; ALZHEIMER DISEASE; ARTICLE; CELL LINEAGE; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; ENDOCYTOSIS; GENE EXPRESSION; GENE FUNCTION; GENE LINKAGE DISEQUILIBRIUM; GENE REGULATORY NETWORK; GENETIC ASSOCIATION; HEMATOPOIETIC CELL; HEMOSTASIS; HUMAN; IMMUNE RESPONSE; IMMUNITY; PRIORITY JOURNAL; PROTEIN FOLDING; SINGLE NUCLEOTIDE POLYMORPHISM; UBIQUITINATION; BRAIN; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; METABOLISM;

ALGORITHMS; ALZHEIMER DISEASE; BRAIN; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84931560814     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2014.05.1757     Document Type: Article

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