Automated quantification of 18F-flutemetamol PET activity for categorizing scans as negative or positive for brain amyloid: Concordance with visual image reads

Journal of Nuclear Medicine

Volumn 55, Issue 10, 2014, Pages 1623-1628

  Thurfjell, Lennart ^a,b   Lilja, Johan ^a   Lundqvist, Roger ^a   Buckley, Chris ^c   Smith, Adrian ^c   Vandenberghe, Rik ^d,e   Sherwin, Paul ^f  

^a BIACORE AB   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c GE HEALTHCARE   (United Kingdom)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^f GE HEALTHCARE   (United States)

Author keywords

18F flutemetamol; Amyloid imaging; Quantification

Indexed keywords

AMYLOID BETA PROTEIN; FLUTEMETAMOL F 18; AMYLOID; ANILINE DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; FLUTEMETAMOL;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANALYTICAL PARAMETERS; ARTICLE; AUTOPSY; BRAIN AMYLOID; BRAIN DISEASE; BRAIN REGION; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; MAJOR CLINICAL STUDY; MILD COGNITIVE IMPAIRMENT; MULTICENTER STUDY (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); POSITRON EMISSION TOMOGRAPHY; QUANTITATIVE ANALYSIS; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; SENILE PLAQUE; SENSITIVITY AND SPECIFICITY; STANDARDIZED UPTAKE VALUE RATIO; AREA UNDER THE CURVE; AUTOMATED PATTERN RECOGNITION; AUTOMATION; BRAIN; CEREBELLUM; DIAGNOSTIC USE; LABORATORY DIAGNOSIS; METABOLISM; NORMAL HUMAN; PATHOLOGY; PONS; PROCEDURES; REPRODUCIBILITY; SCINTISCANNING;

ALZHEIMER DISEASE; AMYLOID; ANILINE COMPOUNDS; AREA UNDER CURVE; AUTOMATION; AUTOPSY; BENZOTHIAZOLES; BRAIN; CEREBELLUM; COHORT STUDIES; FALSE POSITIVE REACTIONS; HEALTHY VOLUNTEERS; HUMANS; MILD COGNITIVE IMPAIRMENT; PATTERN RECOGNITION, AUTOMATED; PONS; POSITRON-EMISSION TOMOGRAPHY; REPRODUCIBILITY OF RESULTS; ROC CURVE; SENSITIVITY AND SPECIFICITY;

EID: 84907502637     PISSN: 01615505     EISSN: 2159662X     Source Type: Journal    
DOI: 10.2967/jnumed.114.142109     Document Type: Article

References (24)

1. Klunk WE, Engler H, Nordberg A, et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh compound-B. Ann Neurol. 2004;55:306-319.
2. Wong DF, Rosenberg PB, Zhou Y, et al. In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir F 18). J Nucl Med. 2010;51:913-920.
3. Clark CM, Schneider JA, Bedell BJ, et al. Use of florbetapir-PET for imaging beta-amyloid pathology. JAMA. 2011;305:275-283.
4. Barthel H, Gertz HJ, Dresel S, et al. Cerebral amyloid-beta PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study. Lancet Neurol. 2011;10:424-435.
5. Villemagne VL, Ong K, Mulligan RS, et al. Amyloid imaging with 18F-florbetaben in Alzheimer disease and other dementias. J Nucl Med. 2011;52:1210-1217.
6. Nelissen N, Van Laere K, Thurfjell L, et al. Phase I study of the PIB derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer's disease. J Nucl Med. 2009;50:1251-1259.
7. Vandenberghe R, Van Laere K, Ivanoiu A, et al. 18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial. Ann Neurol. 2010;68:319-329.
8. Rowe CC, Pejoska S, Mulligan RS, et al. Head-to-head comparison of 11C-PiB and 18F-AZD4694 (NAV4694) for b-amyloid imaging in aging and dementia. J Nucl Med. 2013;54:880-886.
9. Rowe CC, Bourgeat P, Ellis KA, et al. Predicting Alzheimer disease with β-amyloid imaging: results from the Australian imaging, biomarkers, and lifestyle study of ageing. Ann Neurol. 2013;74:905-913.
10. Lopresti BJ, Klunk WE, Mathis CA, et al. Simplified quantification of Pittsburgh compound B amyloid imaging PET studies: a comparative analysis. J Nucl Med. 2005;46:1959-1972.
11. Jagust WJ, Landau SM, Shaw LM, et al. Relationships between biomarkers in aging and dementia. Neurology. 2009;73:1193-1199.
12. Ng SY, Villemagne VL, Masters CL, Rowe CC. Evaluating atypical dementia syndromes using positron emission tomography with carbon 11 labeled Pittsburgh compound B. Arch Neurol. 2007;64:1140-1144.
13. Adamczuk K, De Weer AS, Nelissen N, et al. Polymorphism of brain derived neurotrophic factor influences β amyloid load in cognitively intact apolipoprotein E ε4 carriers. NeuroImage Clin. 2013;2:512-520.
14. Bridging study of C11 PiB and F18 flutemetamol brain PET. ClinicalTrials.gov website. http://clinicaltrials.gov/show/NCT01607476. Accessed August 6, 2014.
15. Litchfield S, Nagy Z. New temperature modification makes the Bielschowsky silver stain reproducible. Acta Neuropathol. 2001;101:17-21.
16. Mirra SS, Heyman A, McKeel D, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. 1991;41:479-486.
17. Vemuri P, Whitwell JL, Kantarci K, et al. Antemortem MRI based STructural Abnormality iNDex (STAND)-scores correlate with postmortem Braak neurofibrillary tangle stage. Neuroimage. 2008;42:559-567.
18. Lundqvist R, Lilja J, Thomas B, et al. Implementation and validation of an adaptive template registration method for [18F]flutemetamol imaging data. J Nucl Med. 2013;54:1472-1478.
19. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage. 2002;15:273-289.
20. The R Project for Statistical Computing website. http://www.R-project.org/. Accessed August 6, 2014.
21. Robin X, Turck N, Hainard A, et al. pROC: an open-source package for R and S1 to analyze and compare ROC curves. BMC Bioinformatics. 2011;12:77.
22. DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988;44:837-845.
23. Landau SM, Thomas BA, Thurfjell L, et al. Amyloid PET imaging in Alzheimer's disease: a comparison of three radiotracers. Eur J Nucl Med Mol Imaging. 2014;41: 1398-1407.
24. Mosconi L, Tsui WH, Herholz K, et al. Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias. J Nucl Med. 2008;49:390-398.