Automated screening for small organic ligands using DNA-encoded chemical libraries

Nature Protocols

Volumn 11, Issue 4, 2016, Pages 764-780

  Decurtins, Willy ^a   Wichert, Moreno ^a,b   Franzini, Raphael M ^a,c   Buller, Fabian ^a,d   Stravs, Michael A ^a,e   Zhang, Yixin ^a,f   Neri, Dario ^a   Scheuermann, Jörg ^a  

^a ETH ZURICH   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c UNIVERSITY OF UTAH   (United States)

^d Covagen AG ^*  (Switzerland)

^e SWISS FEDERAL INSTITUTE OF AQUATIC SCIENCE AND TECHNOLOGY   (Switzerland)

^f DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; LIGAND; OLIGONUCLEOTIDE; ORGANIC COMPOUND; DNA ADDUCT; MOLECULAR LIBRARY; PROTEIN BINDING;

AFFINITY LABELING; ARTICLE; COMBINATORIAL CHEMISTRY; COMPUTER PROGRAM; DNA ENCODED CHEMICAL LIBRARY; DNA SEQUENCE; GENETIC CODE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SEQUENCING; LABORATORY AUTOMATION; MASS SPECTROMETRY; MOLECULAR LIBRARY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN TARGETING; SCREENING; ANALYSIS; CHEMISTRY; DNA ADDUCT; GENETICS; MASS SCREENING; PROCEDURES;

DNA ADDUCTS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; LIGANDS; MASS SCREENING; OLIGONUCLEOTIDES; PROTEIN BINDING; SMALL MOLECULE LIBRARIES;

EID: 84962232638     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2016.039     Document Type: Article

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