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Angewandte Chemie - International Edition

Volumn 54, Issue 13, 2015, Pages 3927-3931

Identification of structure-activity relationships from screening a structurally compact DNA-encoded chemical library

(14) Franzini, Raphael M a Ekblad, Torun c Zhong, Nan b Wichert, Moreno a Decurtins, Willy a Nauer, Angela a Zimmermann, Mauro a Samain, Florent d Scheuermann, Jörg a Brown, Peter J b Hall, Jonathan a Gräslund, Susanne b Schüler, Herwig c Neri, Dario a

a ETH ZURICH (Switzerland)

b UNIVERSITY OF TORONTO (Canada)

c KAROLINSKA INSTITUTE (Sweden)

d PHILOCHEM AG (Switzerland)

Author keywords

combinatorial chemistry; drug discovery; encoded libraries; high throughput screening; structure activity relationships

Indexed keywords

BINDING ENERGY; BIOASSAY; BIOCHIPS; DNA; DNA SEQUENCES; DRUG PRODUCTS; ENZYME INHIBITION; GENE ENCODING; LIBRARIES; MICROARRAYS; PROTEINS; THROUGHPUT;

COMBINATORIAL CHEMISTRY; DNA SEQUENCING ANALYSIS; DNA-ENCODED CHEMICAL LIBRARIES; DRUG DISCOVERY; HIGH THROUGHPUT SCREENING; IDENTIFICATION OF STRUCTURES; PROSTATE-SPECIFIC MEMBRANE ANTIGENS; STRUCTURE ACTIVITY RELATIONSHIPS;

CHEMICAL COMPOUNDS;

DNA; DNA PROBE; ENZYME INHIBITOR; LIGAND; MOLECULAR LIBRARY; PROSTATE SPECIFIC ANTIGEN; SERUM ALBUMIN; TANKYRASE; TNKS PROTEIN, HUMAN;

ANTAGONISTS AND INHIBITORS; CHEMISTRY; DNA FINGERPRINTING; DNA PROBE; DRUG EFFECTS; HIGH THROUGHPUT SCREENING; HUMAN; MOLECULAR LIBRARY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

DNA; DNA FINGERPRINTING; DNA PROBES; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGANDS; PROSTATE-SPECIFIC ANTIGEN; SERUM ALBUMIN; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; TANKYRASES;

EID: 84924914352 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201410736 Document Type: Article

Times cited : (89)

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