DNA-templated organic synthesis and selection of a library of macrocycles

Science

Volumn 305, Issue 5690, 2004, Pages 1601-1605

  Gartner, Zev J ^a   Tse, Brian N ^a   Grubina, Rozalina ^a   Doyon, Jeffrey B ^a   Snyder, Thomas M ^a   Liu, David R ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEIC ACIDS; PROTEINS; SYNTHESIS (CHEMICAL);

MACROCYCLES; PROTEIN AFFINITY;

DNA;

DNA; LYSINE; MACROCYCLIC COMPOUND; NUCLEIC ACID; OLIGONUCLEOTIDE; PROTEINASE; AMIDE; FUMARAMIDE; OLIGODEOXYRIBONUCLEOTIDE; SINGLE HETEROCYCLIC RINGS;

DNA;

ACYLATION; ARTICLE; BINDING AFFINITY; CODON; CONJUGATE; CYCLIZATION; DNA SEQUENCE; DNA TEMPLATE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; ORGANIC CHEMISTRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING; SYNTHESIS; BIOTINYLATION; CHEMISTRY; GENE LIBRARY; ISOLATION AND PURIFICATION; MASS SPECTROMETRY;

AMIDES; BIOTINYLATION; CODON; CYCLIZATION; DNA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE LIBRARY; HETEROCYCLIC COMPOUNDS, 1-RING; OLIGODEOXYRIBONUCLEOTIDES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 4644350506     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1102629     Document Type: Article

References (19)

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19. Supported by NIH (National Institute of General Medical Sciences R01GM065865), the Office of Naval Research (N00014-03-1-0749), the Arnold and Mabel Beckman Foundation, the Searle Scholars Foundation (00-C-101), and the Alfred P. Sloan Foundation (BR-4141). Z.J.G. is a Bristol-Myers Squibb Graduate Research Fellow. B.N.T. and T.M.S. are NSF Graduate Research Fellows. J.B.D. is a National Defense Science and Engineering Graduate Research Fellow. We are grateful to the Bauer Center for Genomics Research for MALDI-TOF mass spectrometric analyses, G. Verdine for LC-MS instrument access, and DNA Software for assistance with codon screening. The rights to commercial development of DNA-templated synthesis have been licensed to Ensemble Discovery, a company for which D.R.L. is a consultant and shareholder.