Systematic evaluation and optimization of modification reactions of oligonucleotides with amines and carboxylic acids for the synthesis of dna-encoded chemical libraries

Bioconjugate Chemistry

Volumn 25, Issue 8, 2014, Pages 1453-1461

  Franzini, Raphael M ^a   Samain, Florent ^b   Abd Elrahman, Maaly ^a   Mikutis, Gediminas ^b   Nauer, Angela ^a   Zimmermann, Mauro ^a   Scheuermann, Jörg ^a   Hall, Jonathan ^a   Neri, Dario ^a  

^a ETH ZURICH   (Switzerland)

^b PHILOCHEM AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINATION; AMINES; CARBOXYLIC ACIDS; CHEMICAL MODIFICATION; LIBRARIES; OLIGONUCLEOTIDES;

BUILDING BLOCKES; CHEMICAL LIBRARIES; DNA-ENCODED CHEMICAL LIBRARIES; MODIFICATION REACTIONS; PRIMARY AMINES; REDUCTIVE AMINATION; SECONDARY AMINES; SYNTHETIC METHODS; SYSTEMATIC EVALUATION; SYSTEMATIC OPTIMIZATION;

DNA;

2 ETHOXY 1(2H) QUINOLINECARBOXYLIC ACID ETHYL ESTER; AMINE; ANION EXCHANGE RESIN; BENZYLAMINE DERIVATIVE; CARBOXYLIC ACID; CHLOROACETAMIDE; CHLOROACETIC ACID; DNA; IODOACETIC ACID; OLIGONUCLEOTIDE; ALDEHYDE; ION EXCHANGE RESIN; MOLECULAR LIBRARY;

ALKYLATION; AMINATION; AQUEOUS SOLUTION; ARTICLE; CHEMICAL MODIFICATION; COVALENT BOND; DNA LIBRARY; DNA STRUCTURE; DNA SYNTHESIS; ELECTROPHILICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICROWAVE IRRADIATION; NUCLEOPHILICITY; PH; REACTION ANALYSIS; REACTION TIME; SOLID PHASE SYNTHESIS; STEREOSPECIFICITY; CHEMISTRY; MOLECULAR LIBRARY; OXIDATION REDUCTION REACTION; SYNTHESIS;

ALDEHYDES; AMINATION; AMINES; CARBOXYLIC ACIDS; CHEMISTRY TECHNIQUES, SYNTHETIC; DNA; ION EXCHANGE RESINS; OLIGONUCLEOTIDES; OXIDATION-REDUCTION; SMALL MOLECULE LIBRARIES;

EID: 84906330932     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc500212n     Document Type: Article

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