메뉴 건너뛰기




Volumn 16, Issue 4, 2016, Pages 247-258

AIRE expands: New roles in immune tolerance and beyond

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; AUTOANTIGEN; TRANSCRIPTION FACTOR;

EID: 84961218930     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri.2016.9     Document Type: Review
Times cited : (177)

References (92)
  • 2
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • Bennett, C. L. et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27, 20-21 (2001).
    • (2001) Nat. Genet. , vol.27 , pp. 20-21
    • Bennett, C.L.1
  • 3
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow, M. E. et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27, 68-73 (2001).
    • (2001) Nat. Genet. , vol.27 , pp. 68-73
    • Brunkow, M.E.1
  • 4
    • 0035163909 scopus 로고    scopus 로고
    • X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
    • Wildin, R. S. et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat. Genet. 27, 18-20 (2001).
    • (2001) Nat. Genet. , vol.27 , pp. 18-20
    • Wildin, R.S.1
  • 5
    • 84907909000 scopus 로고    scopus 로고
    • Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
    • Kuehn, H. S. et al. Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4. Science 345, 1623-1627 (2014).
    • (2014) Science , vol.345 , pp. 1623-1627
    • Kuehn, H.S.1
  • 6
    • 84938070889 scopus 로고    scopus 로고
    • Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations
    • Schubert, D. et al. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat. Med. 20, 1410-1416 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 1410-1416
    • Schubert, D.1
  • 7
    • 0346599403 scopus 로고    scopus 로고
    • An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
    • Finnish-German APECED Consortium. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat. Genet. 17, 399-403 (1997).
    • (1997) Nat. Genet. , vol.17 , pp. 399-403
  • 8
    • 16944367194 scopus 로고    scopus 로고
    • Positional cloning of the APECED gene
    • Nagamine, K. et al. Positional cloning of the APECED gene. Nat. Genet. 17, 393-398 (1997).
    • (1997) Nat. Genet. , vol.17 , pp. 393-398
    • Nagamine, K.1
  • 9
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the AIRE protein
    • Anderson, M. S. et al. Projection of an immunological self shadow within the thymus by the AIRE protein. Science 298, 1395-1401 (2002).
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1
  • 10
    • 33751513054 scopus 로고    scopus 로고
    • Spontaneous autoimmunity prevented by thymic expression of a single self-antigen
    • DeVoss, J. et al. Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J. Exp. Med. 203, 2727-2735 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 2727-2735
    • DeVoss, J.1
  • 11
    • 84861134199 scopus 로고    scopus 로고
    • Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy
    • Su, M. A. et al. Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy. J. Immunol. 188, 4906-4912 (2012).
    • (2012) J. Immunol. , vol.188 , pp. 4906-4912
    • Su, M.A.1
  • 12
    • 79954463242 scopus 로고    scopus 로고
    • Control of central and peripheral tolerance by Aire
    • Metzger, T. C. & Anderson, M. S. Control of central and peripheral tolerance by Aire. Immunol. Rev. 241, 89-103 (2011).
    • (2011) Immunol. Rev. , vol.241 , pp. 89-103
    • Metzger, T.C.1    Anderson, M.S.2
  • 13
    • 0034749749 scopus 로고    scopus 로고
    • A novel mutation of the autoimmune regulator gene in an Italian kindred with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, acting in a dominant fashion and strongly cosegregating with hypothyroid autoimmune thyroiditis
    • Cetani, F. et al. A novel mutation of the autoimmune regulator gene in an Italian kindred with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, acting in a dominant fashion and strongly cosegregating with hypothyroid autoimmune thyroiditis. J. Clin. Endocrinol. Metab. 86, 4747-4752 (2001).
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 4747-4752
    • Cetani, F.1
  • 14
    • 43049128502 scopus 로고    scopus 로고
    • Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire
    • Su, M. A. et al. Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire. J. Clin. Invest. 118, 1712-1726 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 1712-1726
    • Su, M.A.1
  • 15
    • 84937598338 scopus 로고    scopus 로고
    • Dominant mutations in the autoimmune regulator AIRE are associated with common organ-specific autoimmune diseases
    • Oftedal, B. E. et al. Dominant mutations in the autoimmune regulator AIRE are associated with common organ-specific autoimmune diseases. Immunity 42, 1185-1196 (2015).
    • (2015) Immunity , vol.42 , pp. 1185-1196
    • Oftedal, B.E.1
  • 16
    • 0038824426 scopus 로고    scopus 로고
    • The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein
    • Pitkanen, J. et al. The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein. J. Biol. Chem. 275, 16802-16809 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 16802-16809
    • Pitkanen, J.1
  • 17
    • 56749174388 scopus 로고    scopus 로고
    • Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity
    • Koh, A. S. et al. Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc. Natl Acad. Sci. USA 105, 15878-15883 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 15878-15883
    • Koh, A.S.1
  • 18
    • 45849137524 scopus 로고    scopus 로고
    • The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression
    • Org, T. et al. The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression. EMBO Rep. 9, 370-376 (2008).
    • (2008) EMBO Rep. , vol.9 , pp. 370-376
    • Org, T.1
  • 19
    • 84894431935 scopus 로고    scopus 로고
    • The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance
    • Waterfield, M. et al. The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. Nat. Immunol. 15, 258-265 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 258-265
    • Waterfield, M.1
  • 20
    • 77952302980 scopus 로고    scopus 로고
    • Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation
    • Nishikawa, Y. et al. Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation. J. Exp. Med. 207, 963-971 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 963-971
    • Nishikawa, Y.1
  • 21
    • 84884332897 scopus 로고    scopus 로고
    • Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4+ T cells
    • Gardner, J. M. et al. Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4+ T cells. Immunity 39, 560-572 (2013).
    • (2013) Immunity , vol.39 , pp. 560-572
    • Gardner, J.M.1
  • 22
    • 84937631527 scopus 로고    scopus 로고
    • Thymic B cells are licensed to present self antigens for central T cell tolerance induction
    • Yamano, T. et al. Thymic B cells are licensed to present self antigens for central T cell tolerance induction. Immunity 42, 1048-1061 (2015).
    • (2015) Immunity , vol.42 , pp. 1048-1061
    • Yamano, T.1
  • 23
    • 84885854982 scopus 로고    scopus 로고
    • Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population
    • Metzger, T. C. et al. Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population. Cell Rep. 5, 166-179 (2013).
    • (2013) Cell Rep. , vol.5 , pp. 166-179
    • Metzger, T.C.1
  • 24
    • 84961281515 scopus 로고    scopus 로고
    • Identification of a novel cis-regulatory element essential for immune tolerance
    • LaFlam, T. N. et al. Identification of a novel cis-regulatory element essential for immune tolerance. J. Exp. Med. 212, 1993-2002 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 1993-2002
    • LaFlam, T.N.1
  • 25
    • 84952639529 scopus 로고    scopus 로고
    • A highly conserved NF-κB-responsive enhancer is critical for thymic expression of Aire in mice
    • Haljasorg, U. et al. A highly conserved NF-κB-responsive enhancer is critical for thymic expression of Aire in mice. Eur. J. Immunol. 45, 3246-3256 (2015).
    • (2015) Eur. J. Immunol. , vol.45 , pp. 3246-3256
    • Haljasorg, U.1
  • 26
    • 84946600428 scopus 로고    scopus 로고
    • Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus
    • Yanagihara, T. et al. Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus. Nat. Commun. 6, 8820 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 8820
    • Yanagihara, T.1
  • 27
    • 84872494068 scopus 로고    scopus 로고
    • Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism
    • Danso-Abeam, D. et al. Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism. Eur. J. Immunol. 43, 75-84 (2013).
    • (2013) Eur. J. Immunol. , vol.43 , pp. 75-84
    • Danso-Abeam, D.1
  • 28
    • 84913594338 scopus 로고    scopus 로고
    • Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia
    • Sansom, S. N. et al. Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia. Genome Res. 24, 1918-1931 (2014).
    • (2014) Genome Res. , vol.24 , pp. 1918-1931
    • Sansom, S.N.1
  • 29
    • 33845239216 scopus 로고    scopus 로고
    • Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells
    • Gray, D. H. et al. Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood 108, 3777-3785 (2006).
    • (2006) Blood , vol.108 , pp. 3777-3785
    • Gray, D.H.1
  • 30
    • 84939600854 scopus 로고    scopus 로고
    • Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells
    • Brennecke, P. et al. Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells. Nat. Immunol. 16, 933-941 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 933-941
    • Brennecke, P.1
  • 31
    • 84939622896 scopus 로고    scopus 로고
    • Aire controls gene expression in the thymic epithelium with ordered stochasticity
    • Meredith, M., Zemmour, D., Mathis, D. & Benoist, C. Aire controls gene expression in the thymic epithelium with ordered stochasticity. Nat. Immunol. 16, 942-949 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 942-949
    • Meredith, M.1    Zemmour, D.2    Mathis, D.3    Benoist, C.4
  • 32
    • 38649131259 scopus 로고    scopus 로고
    • Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism
    • Derbinski, J., Pinto, S., Rosch, S., Hexel, K. & Kyewski, B. Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism. Proc. Natl Acad. Sci. USA 105, 657-662 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 657-662
    • Derbinski, J.1    Pinto, S.2    Rosch, S.3    Hexel, K.4    Kyewski, B.5
  • 33
    • 56749184864 scopus 로고    scopus 로고
    • Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated
    • Villasenor, J., Besse, W., Benoist, C. & Mathis, D. Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated. Proc. Natl Acad. Sci. USA 105, 15854-15859 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 15854-15859
    • Villasenor, J.1    Besse, W.2    Benoist, C.3    Mathis, D.4
  • 34
    • 84883798955 scopus 로고    scopus 로고
    • Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity
    • Pinto, S. et al. Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity. Proc. Natl Acad. Sci. USA 110, E3497-E3505 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. E3497-E3505
    • Pinto, S.1
  • 35
    • 73149115486 scopus 로고    scopus 로고
    • Aire's partners in the molecular control of immunological tolerance
    • Abramson, J., Giraud, M., Benoist, C. & Mathis, D. Aire's partners in the molecular control of immunological tolerance. Cell 140, 123-135 (2010).
    • (2010) Cell , vol.140 , pp. 123-135
    • Abramson, J.1    Giraud, M.2    Benoist, C.3    Mathis, D.4
  • 36
    • 84871186320 scopus 로고    scopus 로고
    • AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome
    • Gaetani, M. et al. AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome. Nucleic Acids Res. 40, 11756-11768 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , pp. 11756-11768
    • Gaetani, M.1
  • 37
    • 84893370802 scopus 로고    scopus 로고
    • An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription
    • Giraud, M. et al. An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription. Proc. Natl Acad. Sci. USA 111, 1491-1496 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 1491-1496
    • Giraud, M.1
  • 38
    • 66249141300 scopus 로고    scopus 로고
    • The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation
    • Chignola, F. et al. The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation. Nucleic Acids Res. 37, 2951-2961 (2009).
    • (2009) Nucleic Acids Res. , vol.37 , pp. 2951-2961
    • Chignola, F.1
  • 39
    • 77955602966 scopus 로고    scopus 로고
    • Global relevance of Aire binding to hypomethylated lysine-4 of histone-3
    • Koh, A. S., Kingston, R. E., Benoist, C. & Mathis, D. Global relevance of Aire binding to hypomethylated lysine-4 of histone-3. Proc. Natl Acad. Sci. USA 107, 13016-13021 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 13016-13021
    • Koh, A.S.1    Kingston, R.E.2    Benoist, C.3    Mathis, D.4
  • 40
    • 84861325370 scopus 로고    scopus 로고
    • Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes
    • Zumer, K., Low, A. K., Jiang, H., Saksela, K. & Peterlin, B. M. Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes. Mol. Cell. Biol. 32, 1354-1362 (2012).
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 1354-1362
    • Zumer, K.1    Low, A.K.2    Jiang, H.3    Saksela, K.4    Peterlin, B.M.5
  • 41
    • 37549060329 scopus 로고    scopus 로고
    • AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells
    • Oven, I. et al. AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells. Mol. Cell. Biol. 27, 8815-8823 (2007).
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 8815-8823
    • Oven, I.1
  • 42
    • 80054065566 scopus 로고    scopus 로고
    • Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription
    • Zumer, K., Plemenitas, A., Saksela, K. & Peterlin, B. M. Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription. Nucleic Acids Res. 39, 7908-7919 (2011).
    • (2011) Nucleic Acids Res. , vol.39 , pp. 7908-7919
    • Zumer, K.1    Plemenitas, A.2    Saksela, K.3    Peterlin, B.M.4
  • 43
    • 84855995571 scopus 로고    scopus 로고
    • Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells
    • Giraud, M. et al. Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells. Proc. Natl Acad. Sci. USA 109, 535-540 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 535-540
    • Giraud, M.1
  • 44
    • 84908005156 scopus 로고    scopus 로고
    • AIRE acetylation and deacetylation: Effect on protein stability and transactivation activity
    • Incani, F. et al. AIRE acetylation and deacetylation: effect on protein stability and transactivation activity. J. Biomed. Sci. 21, 85 (2014).
    • (2014) J. Biomed. Sci. , vol.21 , pp. 85
    • Incani, F.1
  • 45
    • 84862884365 scopus 로고    scopus 로고
    • Autoimmune regulator is acetylated by transcription coactivator CBP/p300
    • Saare, M., Rebane, A., Rajashekar, B., Vilo, J. & Peterson, P. Autoimmune regulator is acetylated by transcription coactivator CBP/p300. Exp. Cell Res. 318, 1767-1778 (2012).
    • (2012) Exp. Cell Res. , vol.318 , pp. 1767-1778
    • Saare, M.1    Rebane, A.2    Rajashekar, B.3    Vilo, J.4    Peterson, P.5
  • 46
    • 84931432951 scopus 로고    scopus 로고
    • The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance
    • Chuprin, A. et al. The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance. Nat. Immunol. 16, 737-745 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 737-745
    • Chuprin, A.1
  • 47
    • 38049026826 scopus 로고    scopus 로고
    • DNA-PK contributes to the phosphorylation of AIRE: Importance in transcriptional activity
    • Liiv, I. et al. DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity. Biochim. Biophys. Acta 1783, 74-83 (2008).
    • (2008) Biochim. Biophys. Acta , vol.1783 , pp. 74-83
    • Liiv, I.1
  • 48
    • 84921446420 scopus 로고    scopus 로고
    • Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells
    • Rattay, K. et al. Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells. J. Immunol. 194, 921-928 (2015).
    • (2015) J. Immunol. , vol.194 , pp. 921-928
    • Rattay, K.1
  • 49
    • 84873107959 scopus 로고    scopus 로고
    • Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance
    • Yang, S., Bansal, K., Lopes, J., Benoist, C. & Mathis, D. Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance. Proc. Natl Acad. Sci. USA 110, 1833-1838 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 1833-1838
    • Yang, S.1    Bansal, K.2    Lopes, J.3    Benoist, C.4    Mathis, D.5
  • 50
    • 84877322025 scopus 로고    scopus 로고
    • On your histone mark, SET, methylate!
    • Binda, O. On your histone mark, SET, methylate! Epigenetics 8, 457-463 (2013).
    • (2013) Epigenetics , vol.8 , pp. 457-463
    • Binda, O.1
  • 51
    • 33745255099 scopus 로고    scopus 로고
    • A topoisomerase IIβ-mediated dsDNA break required for regulated transcription
    • Ju, B. G. et al. A topoisomerase IIβ-mediated dsDNA break required for regulated transcription. Science 312, 1798-1802 (2006).
    • (2006) Science , vol.312 , pp. 1798-1802
    • Ju, B.G.1
  • 52
    • 84874848684 scopus 로고    scopus 로고
    • The mechanism of tissue-restricted antigen gene expression by AIRE
    • Zumer, K., Saksela, K. & Peterlin, B. M. The mechanism of tissue-restricted antigen gene expression by AIRE. J. Immunol. 190, 2479-2482 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 2479-2482
    • Zumer, K.1    Saksela, K.2    Peterlin, B.M.3
  • 53
    • 84938921551 scopus 로고    scopus 로고
    • Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells
    • Yoshida, H. et al. Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells. Proc. Natl Acad. Sci. USA 112, E4448-4457 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. E4448-4457
    • Yoshida, H.1
  • 55
    • 23844558032 scopus 로고    scopus 로고
    • The cellular mechanism of Aire control of T cell tolerance
    • Anderson, M. S. et al. The cellular mechanism of Aire control of T cell tolerance. Immunity 23, 227-239 (2005).
    • (2005) Immunity , vol.23 , pp. 227-239
    • Anderson, M.S.1
  • 56
    • 84861212351 scopus 로고    scopus 로고
    • Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection
    • Taniguchi, R. T. et al. Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc. Natl Acad. Sci. USA 109, 7847-7852 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 7847-7852
    • Taniguchi, R.T.1
  • 57
    • 34248598295 scopus 로고    scopus 로고
    • Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
    • Aschenbrenner, K. et al. Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat. Immunol. 8, 351-358 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 351-358
    • Aschenbrenner, K.1
  • 58
    • 79951715831 scopus 로고    scopus 로고
    • Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
    • Lei, Y. et al. Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J. Exp. Med. 208, 383-394 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 383-394
    • Lei, Y.1
  • 59
    • 84928581675 scopus 로고    scopus 로고
    • Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance
    • Yang, S., Fujikado, N., Kolodin, D., Benoist, C. & Mathis, D. Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance. Science 348, 589-594 (2015).
    • (2015) Science , vol.348 , pp. 589-594
    • Yang, S.1    Fujikado, N.2    Kolodin, D.3    Benoist, C.4    Mathis, D.5
  • 60
    • 84874745221 scopus 로고    scopus 로고
    • Aire-dependent thymic development of tumor-associated regulatory T cells
    • Malchow, S. et al. Aire-dependent thymic development of tumor-associated regulatory T cells. Science 339, 1219-1224 (2013).
    • (2013) Science , vol.339 , pp. 1219-1224
    • Malchow, S.1
  • 61
    • 84907982768 scopus 로고    scopus 로고
    • Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus
    • Perry, J. S. et al. Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus. Immunity 41, 414-426 (2014).
    • (2014) Immunity , vol.41 , pp. 414-426
    • Perry, J.S.1
  • 62
    • 67549104034 scopus 로고    scopus 로고
    • Neonatal tolerance revisited: A perinatal window for Aire control of autoimmunity
    • Guerau-de-Arellano, M., Martinic, M., Benoist, C. & Mathis, D. Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity. J. Exp. Med. 206, 1245-1252 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 1245-1252
    • Guerau-De-Arellano, M.1    Martinic, M.2    Benoist, C.3    Mathis, D.4
  • 63
    • 13544262691 scopus 로고    scopus 로고
    • Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice
    • Kuroda, N. et al. Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J. Immunol. 174, 1862-1870 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 1862-1870
    • Kuroda, N.1
  • 64
    • 26844450449 scopus 로고    scopus 로고
    • How defects in central tolerance impinge on a deficiency in regulatory T cells
    • Chen, Z., Benoist, C. & Mathis, D. How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc. Natl Acad. Sci. USA 102, 14735-14740 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 14735-14740
    • Chen, Z.1    Benoist, C.2    Mathis, D.3
  • 65
    • 80052423824 scopus 로고    scopus 로고
    • Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance
    • Hubert, F. X. et al. Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance. Blood 118, 2462-2472 (2011).
    • (2011) Blood , vol.118 , pp. 2462-2472
    • Hubert, F.X.1
  • 66
    • 33646413687 scopus 로고    scopus 로고
    • Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice
    • Niki, S. et al. Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. J. Clin. Invest. 116, 1292-1301 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 1292-1301
    • Niki, S.1
  • 67
    • 76249101988 scopus 로고    scopus 로고
    • Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes
    • Laan, M. et al. Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes. J. Immunol. 183, 7682-7691 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 7682-7691
    • Laan, M.1
  • 68
    • 35748941369 scopus 로고    scopus 로고
    • Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
    • Gray, D., Abramson, J., Benoist, C. & Mathis, D. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J. Exp. Med. 204, 2521-2528 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 2521-2528
    • Gray, D.1    Abramson, J.2    Benoist, C.3    Mathis, D.4
  • 69
    • 4544258485 scopus 로고    scopus 로고
    • Self-representation in the thymus: An extended view
    • Kyewski, B. & Derbinski, J. Self-representation in the thymus: an extended view. Nat. Rev. Immunol. 4, 688-698 (2004).
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 688-698
    • Kyewski, B.1    Derbinski, J.2
  • 70
    • 84897508383 scopus 로고    scopus 로고
    • Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program
    • Nishikawa, Y. et al. Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program. J. Immunol. 192, 2585-2592 (2014).
    • (2014) J. Immunol. , vol.192 , pp. 2585-2592
    • Nishikawa, Y.1
  • 71
    • 84872711825 scopus 로고    scopus 로고
    • Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens
    • Wang, X. et al. Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens. Front. Immunol. 3, 19 (2012).
    • (2012) Front. Immunol. , vol.3 , pp. 19
    • Wang, X.1
  • 72
    • 78650376503 scopus 로고    scopus 로고
    • Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla
    • Matsumoto, M. Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla. Eur. J. Immunol. 41, 12-17 (2011).
    • (2011) Eur. J. Immunol. , vol.41 , pp. 12-17
    • Matsumoto, M.1
  • 73
    • 58149316251 scopus 로고    scopus 로고
    • Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance
    • Yano, M. et al. Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance. J. Exp. Med. 205, 2827-2838 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 2827-2838
    • Yano, M.1
  • 74
    • 84859589258 scopus 로고    scopus 로고
    • The immune response to melanoma is limited by thymic selection of self-antigens
    • Trager, U. et al. The immune response to melanoma is limited by thymic selection of self-antigens. PLoS ONE 7, e35005 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e35005
    • Trager, U.1
  • 75
    • 84875995284 scopus 로고    scopus 로고
    • Aire deficiency promotes TRP-1-specific immune rejection of melanoma
    • Zhu, M. L., Nagavalli, A. & Su, M. A. Aire deficiency promotes TRP-1-specific immune rejection of melanoma. Cancer Res. 73, 2104-2116 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 2104-2116
    • Zhu, M.L.1    Nagavalli, A.2    Su, M.A.3
  • 76
    • 0942288397 scopus 로고    scopus 로고
    • Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters
    • Gotter, J., Brors, B., Hergenhahn, M. & Kyewski, B. Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. J. Exp. Med. 199, 155-166 (2004).
    • (2004) J. Exp. Med. , vol.199 , pp. 155-166
    • Gotter, J.1    Brors, B.2    Hergenhahn, M.3    Kyewski, B.4
  • 77
    • 77953019686 scopus 로고    scopus 로고
    • The role of AIRE polymorphisms in melanoma
    • Conteduca, G. et al. The role of AIRE polymorphisms in melanoma. Clin. Immunol. 136, 96-104 (2010).
    • (2010) Clin. Immunol. , vol.136 , pp. 96-104
    • Conteduca, G.1
  • 78
    • 84911890115 scopus 로고    scopus 로고
    • Limitation of immune tolerance-inducing thymic epithelial cell development by Spi-B-mediated negative feedback regulation
    • Akiyama, N. et al. Limitation of immune tolerance-inducing thymic epithelial cell development by Spi-B-mediated negative feedback regulation. J. Exp. Med. 211, 2425-2438 (2014).
    • (2014) J. Exp. Med. , vol.211 , pp. 2425-2438
    • Akiyama, N.1
  • 79
    • 34250336454 scopus 로고    scopus 로고
    • - inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla
    • - inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J. Exp. Med. 204, 1267-1272 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1267-1272
    • Rossi, S.W.1
  • 80
    • 84899767409 scopus 로고    scopus 로고
    • Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance
    • Khan, I. S. et al. Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance. J. Exp. Med. 211, 761-768 (2014).
    • (2014) J. Exp. Med. , vol.211 , pp. 761-768
    • Khan, I.S.1
  • 81
    • 84927130807 scopus 로고    scopus 로고
    • Immune checkpoint targeting in cancer therapy: Toward combination strategies with curative potential
    • Sharma, P. & Allison, J. P. Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell 161, 205-214 (2015).
    • (2015) Cell , vol.161 , pp. 205-214
    • Sharma, P.1    Allison, J.P.2
  • 82
    • 84938249046 scopus 로고    scopus 로고
    • Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes
    • Hobbs, R. P. et al. Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes. Nat. Genet. 47, 933-938 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 933-938
    • Hobbs, R.P.1
  • 84
    • 84886394447 scopus 로고    scopus 로고
    • Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD
    • Dertschnig, S. et al. Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD. Blood 122, 837-841 (2013).
    • (2013) Blood , vol.122 , pp. 837-841
    • Dertschnig, S.1
  • 85
    • 79957573654 scopus 로고    scopus 로고
    • Mucocutaneous candidiasis and autoimmunity against cytokines in APECED and thymoma patients: Clinical and pathogenetic implications
    • Kisand, K. et al. Mucocutaneous candidiasis and autoimmunity against cytokines in APECED and thymoma patients: clinical and pathogenetic implications. Eur. J. Immunol. 41, 1517-1527 (2011).
    • (2011) Eur. J. Immunol. , vol.41 , pp. 1517-1527
    • Kisand, K.1
  • 86
    • 84881120386 scopus 로고    scopus 로고
    • Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development
    • Parent, A. V. et al. Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development. Cell Stem Cell 13, 219-229 (2013).
    • (2013) Cell Stem Cell , vol.13 , pp. 219-229
    • Parent, A.V.1
  • 87
    • 84881123537 scopus 로고    scopus 로고
    • Directed differentiation of human embryonic stem cells into thymic epithelial progenitor-like cells reconstitutes the thymic microenvironment in vivo
    • Sun, X. et al. Directed differentiation of human embryonic stem cells into thymic epithelial progenitor-like cells reconstitutes the thymic microenvironment in vivo. Cell Stem Cell 13, 230-236 (2013).
    • (2013) Cell Stem Cell , vol.13 , pp. 230-236
    • Sun, X.1
  • 88
    • 84913594397 scopus 로고    scopus 로고
    • Genome editing. The new frontier of genome engineering with CRISPR-Cas9
    • Doudna, J. A. & Charpentier, E. Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science 346, 1258096 (2014).
    • (2014) Science , vol.346 , pp. 1258096
    • Doudna, J.A.1    Charpentier, E.2
  • 89
    • 84946214324 scopus 로고    scopus 로고
    • Fezf2 orchestrates a thymic program of self-antigen expression for immune tolerance
    • Takaba, H. et al. Fezf2 orchestrates a thymic program of self-antigen expression for immune tolerance. Cell 163, 975-987 (2015).
    • (2015) Cell , vol.163 , pp. 975-987
    • Takaba, H.1
  • 90
    • 79961051162 scopus 로고    scopus 로고
    • low regulatory T lymphocytes fail to control experimental colitis
    • low regulatory T lymphocytes fail to control experimental colitis. Proc. Natl Acad. Sci. USA 108, 12437-12442 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 12437-12442
    • Pomie, C.1
  • 91
    • 85047690427 scopus 로고    scopus 로고
    • - T cells in an autoimmune disease model
    • - T cells in an autoimmune disease model. J. Clin. Invest. 112, 1037-1048 (2003).
    • (2003) J. Clin. Invest. , vol.112 , pp. 1037-1048
    • Najafian, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.