Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 37, 2013, Pages

  Pinto, Sheena ^a   Michel, Chloé ^a   Schmidt Glenewinkel, Hannah ^b   Harder, Nathalie ^c   Rohr, Karl ^c   Wild, Stefan ^d   Brors, Benedikt ^a   Kyewski, Bruno ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d MILTENYI BIOTEC GMBH   (Germany)

Author keywords

Central tolerance; Human thymic epithelial cells; Promiscuous gene expression

Indexed keywords

ANTIGEN; CARCINOEMBRYONIC ANTIGEN; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 6; CELL ADHESION MOLECULE; COMPLEMENTARY DNA; MESSENGER RNA; MONOCLONAL ANTIBODY; MUCIN 1; MUCIN 4; PROSTAGLANDIN E; PROSTATE STEM CELL ANTIGEN;

ARTICLE; CELL ADHESION; CELL LINE; CELL SURFACE; CHROMOSOMAL LOCALIZATION; CHROMOSOME TRANSLOCATION; COMPARATIVE STUDY; DOWN REGULATION; EPITHELIUM CELL; GENE; GENE CLUSTER; GENE CONTROL; GENE LOCUS; GENE OVEREXPRESSION; GENE POOL; GENOME; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; MEDULLARY THYMIC EPITHELIAL CELL; MOSAICISM; MULTIGENE FAMILY; PRIORITY JOURNAL; RNA ISOLATION; UPREGULATION;

CENTRAL TOLERANCE; HUMAN THYMIC EPITHELIAL CELLS; PROMISCUOUS GENE EXPRESSION;

ANTIGENIC VARIATION; AUTOANTIGENS; CELL DIFFERENTIATION; EPITHELIAL CELLS; GENE EXPRESSION; HUMANS; MULTIGENE FAMILY; SELF TOLERANCE; THYMUS GLAND;

EID: 84883798955     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1308311110     Document Type: Article

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