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Volumn 3, Issue MAR, 2012, Pages

Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens

Author keywords

Aire; Autoantigen; Central tolerance; Desmoglein; Hassall's corpuscle; Thymic medullary epithelial cells; Thymus

Indexed keywords


EID: 84872711825     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2012.00019     Document Type: Article
Times cited : (91)

References (36)
  • 1
    • 73149115486 scopus 로고    scopus 로고
    • Aire's part-ners in the molecular control of immunological tolerance
    • Abramson, J., Giraud, M., Benoist, C., and Mathis, D. (2010). Aire's part-ners in the molecular control of immunological tolerance. Cell 140, 123-135.
    • (2010) Cell , vol.140 , pp. 123-135
    • Abramson, J.1    Giraud, M.2    Benoist, C.3    Mathis, D.4
  • 3
    • 79953097064 scopus 로고    scopus 로고
    • Aire and T cell development
    • Anderson, M. S., and Su, M. A. (2011). Aire and T cell development. Curr. Opin. Immunol. 23, 198-206.
    • (2011) Curr. Opin. Immunol. , vol.23 , pp. 198-206
    • Anderson, M.S.1    Su, M.A.2
  • 5
    • 0033945778 scopus 로고    scopus 로고
    • Novel insights into the function of the thymic Has-sall's bodies
    • Bodey, B., Bodey, B. Jr., Siegel, S. E., and Kaiser, H. E. (2000). Novel insights into the function of the thymic Has-sall's bodies. In vivo 14, 407-418.
    • (2000) In vivo , vol.14 , pp. 407-418
    • Bodey, B.1    Bodey Jr., B.2    Siegel, S.E.3    Kaiser, H.E.4
  • 7
    • 0035171545 scopus 로고    scopus 로고
    • Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
    • Derbinski, J., Schulte, A., Kyewski, B., and Klein, L. (2001). Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2, 1032-1039.
    • (2001) Nat. Immunol. , vol.2 , pp. 1032-1039
    • Derbinski, J.1    Schulte, A.2    Kyewski, B.3    Klein, L.4
  • 8
    • 54049121774 scopus 로고    scopus 로고
    • Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiation
    • Dooley, J., Erickson, M., and Farr, A. G. (2008). Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiation. J. Immunol. 181, 5225-5232.
    • (2008) J. Immunol. , vol.181 , pp. 5225-5232
    • Dooley, J.1    Erickson, M.2    Farr, A.G.3
  • 9
    • 37549071821 scopus 로고    scopus 로고
    • Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells
    • Gabler, J., Arnold, J., and Kyewski, B. (2007). Promiscuous gene expres-sion and the developmental dynam-ics of medullary thymic epithelial cells. Eur. J. Immunol. 37,3363-3372.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 3363-3372
    • Gabler, J.1    Arnold, J.2    Kyewski, B.3
  • 10
    • 33645071052 scopus 로고    scopus 로고
    • Central tolerance: good but imperfect
    • Gallegos, A. M., and Bevan, M. J. (2006). Central tolerance: good but imperfect. Immunol. Rev. 209, 290-296.
    • (2006) Immunol. Rev. , vol.209 , pp. 290-296
    • Gallegos, A.M.1    Bevan, M.J.2
  • 12
    • 33847350111 scopus 로고    scopus 로고
    • Aire-dependent alter-ations in medullary thymic epithe-lium indicate a role for Aire in thymic epithelial differentiation
    • Gillard, G. O., Dooley, J., Erickson, M., Peltonen, L., and Farr, A. G. (2007). Aire-dependent alter-ations in medullary thymic epithe-lium indicate a role for Aire in thymic epithelial differentiation. J. Immunol. 178, 3007-3015.
    • (2007) J. Immunol. , vol.178 , pp. 3007-3015
    • Gillard, G.O.1    Dooley, J.2    Erickson, M.3    Peltonen, L.4    Farr, A.G.5
  • 13
    • 22344434168 scopus 로고    scopus 로고
    • Contrasting models of promiscuous gene expression by thymic epithe-lium
    • Gillard, G. O., and Farr, A. G. (2005). Contrasting models of promiscuous gene expression by thymic epithe-lium. J. Exp. Med. 202, 15-19.
    • (2005) J. Exp. Med. , vol.202 , pp. 15-19
    • Gillard, G.O.1    Farr, A.G.2
  • 14
    • 35748941369 scopus 로고    scopus 로고
    • Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
    • Gray, D., Abramson, J., Benoist, C., and Mathis, D. (2007). Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J. Exp. Med. 204, 2521-2528.
    • (2007) J. Exp. Med. , vol.204 , pp. 2521-2528
    • Gray, D.1    Abramson, J.2    Benoist, C.3    Mathis, D.4
  • 15
    • 0346103716 scopus 로고    scopus 로고
    • Corticosteroids regulate epithelial cell differentiation and Hassall body formation in the human thymus
    • Hale, L. P., and Markert, M. L. (2004). Corticosteroids regulate epithelial cell differentiation and Hassall body formation in the human thymus. J. Immunol. 172, 617-624.
    • (2004) J. Immunol. , vol.172 , pp. 617-624
    • Hale, L.P.1    Markert, M.L.2
  • 17
    • 44849114330 scopus 로고    scopus 로고
    • A spe-cific anti-Aire antibody reveals Aire expression is restricted to medullary thymic epithelial cells and not expressed in periphery
    • Hubert, F. X., Kinkel, S. A., Webster, K. E., Cannon, P., Crewther, P. E., Proeitto, A. I., Wu, L., Heath, W. R., and Scott, H. S. (2008). A spe-cific anti-Aire antibody reveals Aire expression is restricted to medullary thymic epithelial cells and not expressed in periphery. J. Immunol. 180, 3824-3832.
    • (2008) J. Immunol. , vol.180 , pp. 3824-3832
    • Hubert, F.X.1    Kinkel, S.A.2    Webster, K.E.3    Cannon, P.4    Crewther, P.E.5    Proeitto, A.I.6    Wu, L.7    Heath, W.R.8    Scott, H.S.9
  • 19
    • 34548285420 scopus 로고    scopus 로고
    • Modulation of Aire regulates the expression of tissue-restricted antigens
    • Kont, V., Laan, M., Kisand, K., Mer-its, A., Scott, H. S., and Peterson, P. (2008). Modulation of Aire regulates the expression of tissue-restricted antigens. Mol. Immunol. 45, 25-33.
    • (2008) Mol. Immunol. , vol.45 , pp. 25-33
    • Kont, V.1    Laan, M.2    Kisand, K.3    Mer-its, A.4    Scott, H.S.5    Peterson, P.6
  • 20
    • 4544258485 scopus 로고    scopus 로고
    • Self-representation in the thy-mus: an extended view
    • Kyewski, B., and Derbinski, J. (2004). Self-representation in the thy-mus: an extended view. Nat. Rev. Immunol. 4, 688-698.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 688-698
    • Kyewski, B.1    Derbinski, J.2
  • 21
    • 76249101988 scopus 로고    scopus 로고
    • Autoimmune regu-lator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes
    • Laan, M., Kisand, K., Kont, V., Moll, K., Tserel, L., Scott, H. S., and Peterson, P. (2009). Autoimmune regu-lator deficiency results in decreased expression of CCR4 and CCR7 lig-ands and in delayed migration of CD4+ thymocytes. J. Immunol. 183, 7682-7691.
    • (2009) J. Immunol. , vol.183 , pp. 7682-7691
    • Laan, M.1    Kisand, K.2    Kont, V.3    Moll, K.4    Tserel, L.5    Scott, H.S.6    Peter-son, P.7
  • 24
    • 78650376503 scopus 로고    scopus 로고
    • Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla
    • Matsumoto, M. (2011). Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla. Eur. J. Immunol. 41, 12-17.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 12-17
    • Matsumoto, M.1
  • 26
    • 77952302980 scopus 로고    scopus 로고
    • Biphasic Aire expres-sion in early embryos and in medullary thymic epithelial cells before end-stage terminal dif-ferentiation
    • Nishikawa, Y., Hirota, F., Yano, M., Kita-jima, H., Miyazaki, J., Kawamoto, H., Mouri, Y., and Matsumoto, M. (2010). Biphasic Aire expres-sion in early embryos and in medullary thymic epithelial cells before end-stage terminal dif-ferentiation. J. Exp. Med. 207, 963-971.
    • (2010) J. Exp. Med. , vol.207 , pp. 963-971
    • Nishikawa, Y.1    Hirota, F.2    Yano, M.3    Kita-jima, H.4    Miyazaki, J.5    Kawamoto, H.6    Mouri, Y.7    Matsumoto, M.8
  • 27
    • 0029834592 scopus 로고    scopus 로고
    • Patterns of desmo-collin synthesis in human epithe-lia: immunolocalization of desmo-collins 1 and 3 in special epithelia and in cultured cells
    • Nuber, U. A., Schafer, S., Stehr, S., Rackwitz, H. R., and Franke, W. W. (1996). Patterns of desmo-collin synthesis in human epithe-lia: immunolocalization of desmo-collins 1 and 3 in special epithelia and in cultured cells. Eur. J. Cell Biol. 71, 1-13.
    • (1996) Eur. J. Cell Biol. , vol.71 , pp. 1-13
    • Nuber, U.A.1    Schafer, S.2    Stehr, S.3    Rackwitz, H.R.4    Franke, W.W.5
  • 28
    • 33748758730 scopus 로고    scopus 로고
    • Immuno-histochemical staining of transgenic beta-galactosidase in burned skin is a better indicator of transfection efficiency than histochemical tech-niques
    • Pereira, C., Maamar-Tayeb, M., Burke, A., Perez-Polo, R., Herndon, D. N., and Jeschke, M. G. (2006). Immuno-histochemical staining of transgenic beta-galactosidase in burned skin is a better indicator of transfection efficiency than histochemical tech-niques. J. Immunol. Methods 315, 75-79.
    • (2006) J. Immunol. Methods , vol.315 , pp. 75-79
    • Pereira, C.1    Maamar-Tayeb, M.2    Burke, A.3    Perez-Polo, R.4    Herndon, D.N.5    Jeschke, M.G.6
  • 29
    • 56749161528 scopus 로고    scopus 로고
    • Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
    • Peterson, P., Org, T., and Rebane, A. (2008). Transcriptional regulation by AIRE: molecular mechanisms of central tolerance. Nat. Rev. Immunol. 8, 948-957.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 948-957
    • Peterson, P.1    Org, T.2    Rebane, A.3
  • 30
    • 28444438159 scopus 로고    scopus 로고
    • Autoimmune polyendocrinopathy syndrome type 1 (APS1) and AIRE gene: new views on molecular basis of autoimmunity
    • Peterson, P., and Peltonen, L. (2005). Autoimmune polyendocrinopathy syndrome type 1 (APS1) and AIRE gene: new views on molecular basis of autoimmunity. J. Autoimmun. 25(Suppl.), 49-55.
    • (2005) J. Autoimmun. , vol.25 , Issue.SUPPL. , pp. 49-55
    • Peterson, P.1    Peltonen, L.2
  • 34
    • 24144480562 scopus 로고    scopus 로고
    • Hassall's cor-puscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus
    • Watanabe, N., Wang, Y. H., Lee, H. K., Ito, T., Wang, Y. H., Cao, W., and Liu, Y. J. (2005). Hassall's cor-puscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature 436, 1181-1185.
    • (2005) Nature , vol.436 , pp. 1181-1185
    • Watanabe, N.1    Wang, Y.H.2    Lee, H.K.3    Ito, T.4    Wang, Y.H.5    Cao, W.6    Liu, Y.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.