Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism

European Journal of Immunology

Volumn 43, Issue 1, 2013, Pages 75-84

  Danso Abeam, Dina ^a,b   Staats, Kim A ^b   Franckaert, Dean ^a,b   Van Den Bosch, Ludo ^b   Liston, Adrian ^a,b   Gray, Daniel H D ^c   Dooley, James ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Aire; Immune tolerance; Negative selection; Thymic epithelium

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; INSULIN; SOMATOSTATIN; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; THYMUS; TRANSCRIPTION REGULATION;

ANIMALS; AUTOANTIGENS; AUTOIMMUNITY; CELLS, CULTURED; CENTRAL TOLERANCE; CLONAL DELETION; EPITHELIAL CELLS; HOMEODOMAIN PROTEINS; INSULIN; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, IMMUNOLOGICAL; ORGAN SPECIFICITY; PANCREAS; PROMOTER REGIONS, GENETIC; T-LYMPHOCYTES; THYMUS GLAND; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84872494068     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201242761     Document Type: Article

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