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Volumn 54, Issue , 2016, Pages 1-6

The role of autophagy in squamous cell carcinoma of the head and neck

Author keywords

Antineoplastic protocols; Autophagy; Biological markers; Head and neck neoplasms

Indexed keywords

BECLIN 1; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P62; TUMOR MARKER;

EID: 84960497525     PISSN: 13688375     EISSN: 18790593     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2015.12.007     Document Type: Review
Times cited : (35)

References (87)
  • 2
    • 41449085148 scopus 로고    scopus 로고
    • Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers
    • M.L. Gillison, G. D'Souza, W. Westra, E. Sugar, W. Xiao, S. Begum, and et al. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers J Natl Cancer Inst 100 2008 407 420
    • (2008) J Natl Cancer Inst , vol.100 , pp. 407-420
    • Gillison, M.L.1    D'Souza, G.2    Westra, W.3    Sugar, E.4    Xiao, W.5    Begum, S.6
  • 3
    • 84876062521 scopus 로고    scopus 로고
    • Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer - Systematic review and meta-analysis of trends by time and region
    • H. Mehanna, T. Beech, T. Nicholson, I. El-Hariry, C. McConkey, V. Paleri, and et al. Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer - systematic review and meta-analysis of trends by time and region Head Neck 35 2013 747 755
    • (2013) Head Neck , vol.35 , pp. 747-755
    • Mehanna, H.1    Beech, T.2    Nicholson, T.3    El-Hariry, I.4    McConkey, C.5    Paleri, V.6
  • 4
    • 84941743483 scopus 로고    scopus 로고
    • Transoral laser microsurgery ± adjuvant therapy versus chemoradiotherapy for stage III and IVA oropharyngeal squamous cell carcinoma: Preliminary comparison of early swallowing outcomes
    • J. O'Hara, B. Cosway, C. Muirhead, N. Leonard, D. Goff, and J. Patterson Transoral laser microsurgery ± adjuvant therapy versus chemoradiotherapy for stage III and IVA oropharyngeal squamous cell carcinoma: Preliminary comparison of early swallowing outcomes Head Neck 37 2015 1488 1494
    • (2015) Head Neck , vol.37 , pp. 1488-1494
    • O'Hara, J.1    Cosway, B.2    Muirhead, C.3    Leonard, N.4    Goff, D.5    Patterson, J.6
  • 5
    • 79151484611 scopus 로고    scopus 로고
    • Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): A phase 3 multicentre randomised controlled trial
    • C.M. Nutting, J.P. Morden, K.J. Harrington, T.G. Urbano, S.A. Bhide, C. Clark, and et al. Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial Lancet Oncol 12 2011 127 136
    • (2011) Lancet Oncol , vol.12 , pp. 127-136
    • Nutting, C.M.1    Morden, J.P.2    Harrington, K.J.3    Urbano, T.G.4    Bhide, S.A.5    Clark, C.6
  • 6
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
    • J.A. Bonner, P.M. Harari, J. Giralt, N. Azarnia, D.M. Shin, R.B. Cohen, and et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck N Engl J Med 354 2006 567 578
    • (2006) N Engl J Med , vol.354 , pp. 567-578
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3    Azarnia, N.4    Shin, D.M.5    Cohen, R.B.6
  • 7
    • 14844321323 scopus 로고    scopus 로고
    • Trends in incidence and prognosis for head and neck cancer in the United States: A site-specific analysis of the SEER database
    • A.L. Carvalho, I.N. Nishimoto, J.A. Califano, and L.P. Kowalski Trends in incidence and prognosis for head and neck cancer in the United States: a site-specific analysis of the SEER database Int J Cancer 114 2005 806 816
    • (2005) Int J Cancer , vol.114 , pp. 806-816
    • Carvalho, A.L.1    Nishimoto, I.N.2    Califano, J.A.3    Kowalski, L.P.4
  • 9
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: Process and function
    • N. Mizushima Autophagy: process and function Genes Dev 21 2007 2861 2873
    • (2007) Genes Dev , vol.21 , pp. 2861-2873
    • Mizushima, N.1
  • 10
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • N. Mizushima, B. Levine, A.M. Cuervo, and D.J. Klionsky Autophagy fights disease through cellular self-digestion Nature 451 2008 1069 1075
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 11
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • C. He, and D.J. Klionsky Regulation mechanisms and signaling pathways of autophagy Annu Rev Genet 43 2009 67
    • (2009) Annu Rev Genet , vol.43 , pp. 67
    • He, C.1    Klionsky, D.J.2
  • 12
    • 33244481532 scopus 로고    scopus 로고
    • Autophagy: A forty-year search for a missing membrane source
    • G. Juhasz, and T.P. Neufeld Autophagy: a forty-year search for a missing membrane source PLoS Biol 4 2006 161
    • (2006) PLoS Biol , vol.4 , pp. 161
    • Juhasz, G.1    Neufeld, T.P.2
  • 13
    • 77957728513 scopus 로고    scopus 로고
    • The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy
    • S. Di Bartolomeo, M. Corazzari, F. Nazio, S. Oliverio, G. Lisi, M. Antonioli, and et al. The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy J Cell Biol 191 2010 155 168
    • (2010) J Cell Biol , vol.191 , pp. 155-168
    • Di Bartolomeo, S.1    Corazzari, M.2    Nazio, F.3    Oliverio, S.4    Lisi, G.5    Antonioli, M.6
  • 15
    • 34548077575 scopus 로고    scopus 로고
    • Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
    • S. Kimura, T. Noda, and T. Yoshimori Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3 Autophagy 3 2007 452 460
    • (2007) Autophagy , vol.3 , pp. 452-460
    • Kimura, S.1    Noda, T.2    Yoshimori, T.3
  • 16
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Y. Kabeya, N. Mizushima, T. Ueno, A. Yamamoto, T. Kirisako, T. Noda, and et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing EMBO J 19 2000 5720 5728
    • (2000) EMBO J , vol.19 , pp. 5720-5728
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3    Yamamoto, A.4    Kirisako, T.5    Noda, T.6
  • 17
    • 70349649219 scopus 로고    scopus 로고
    • The prognostic role of Beclin 1 protein expression in high-grade gliomas
    • L. Pirtoli, G. Cevenini, P. Tini, M. Vannini, G. Oliveri, S. Marsili, and et al. The prognostic role of Beclin 1 protein expression in high-grade gliomas Autophagy 5 2009 930 936
    • (2009) Autophagy , vol.5 , pp. 930-936
    • Pirtoli, L.1    Cevenini, G.2    Tini, P.3    Vannini, M.4    Oliveri, G.5    Marsili, S.6
  • 18
    • 65249135974 scopus 로고    scopus 로고
    • Prognostic significance of Beclin 1-dependent apoptotic activity in hepatocellular carcinoma
    • Y.-H. Shi, Z.-B. Ding, J. Zhou, S.-J. Qiu, and J. Fan Prognostic significance of Beclin 1-dependent apoptotic activity in hepatocellular carcinoma Autophagy 5 2009 380 382
    • (2009) Autophagy , vol.5 , pp. 380-382
    • Shi, Y.-H.1    Ding, Z.-B.2    Zhou, J.3    Qiu, S.-J.4    Fan, J.5
  • 20
    • 84856003912 scopus 로고    scopus 로고
    • Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome
    • R. Lazova, R.L. Camp, V. Klump, S.F. Siddiqui, R.K. Amaravadi, and J.M. Pawelek Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome Clin Cancer Res 18 2012 370 379
    • (2012) Clin Cancer Res , vol.18 , pp. 370-379
    • Lazova, R.1    Camp, R.L.2    Klump, V.3    Siddiqui, S.F.4    Amaravadi, R.K.5    Pawelek, J.M.6
  • 21
    • 79956003662 scopus 로고    scopus 로고
    • Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma
    • X.-H. Ma, S. Piao, D. Wang, Q.W. McAfee, K.L. Nathanson, J.J. Lum, and et al. Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma Clin Cancer Res 17 2011 3478 3489
    • (2011) Clin Cancer Res , vol.17 , pp. 3478-3489
    • Ma, X.-H.1    Piao, S.2    Wang, D.3    McAfee, Q.W.4    Nathanson, K.L.5    Lum, J.J.6
  • 22
    • 84904062323 scopus 로고    scopus 로고
    • Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma
    • R. Rangwala, R. Leone, Y.C. Chang, L.A. Fecher, L.M. Schuchter, A. Kramer, and et al. Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma Autophagy 10 2014 1369 1379
    • (2014) Autophagy , vol.10 , pp. 1369-1379
    • Rangwala, R.1    Leone, R.2    Chang, Y.C.3    Fecher, L.A.4    Schuchter, L.M.5    Kramer, A.6
  • 23
    • 84871940714 scopus 로고    scopus 로고
    • Chloroquine in cancer therapy: A double-edged sword of autophagy
    • T. Kimura, Y. Takabatake, A. Takahashi, and Y. Isaka Chloroquine in cancer therapy: a double-edged sword of autophagy Cancer Res 73 2013 3 7
    • (2013) Cancer Res , vol.73 , pp. 3-7
    • Kimura, T.1    Takabatake, Y.2    Takahashi, A.3    Isaka, Y.4
  • 24
    • 84874405394 scopus 로고    scopus 로고
    • Autophagy inhibition for chemosensitization and radiosensitization in cancer: Do the preclinical data support this therapeutic strategy?
    • M.L. Bristol, S.M. Emery, P. Maycotte, A. Thorburn, S. Chakradeo, and D.A. Gewirtz Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy? J Pharmacol Exp Ther 344 2013 544 552
    • (2013) J Pharmacol Exp Ther , vol.344 , pp. 544-552
    • Bristol, M.L.1    Emery, S.M.2    Maycotte, P.3    Thorburn, A.4    Chakradeo, S.5    Gewirtz, D.A.6
  • 25
    • 84911906578 scopus 로고    scopus 로고
    • A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy
    • B. Ronan, O. Flamand, L. Vescovi, C. Dureuil, L. Durand, F. Fassy, and et al. A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy Nat Chem Biol 10 2014 1013 1019
    • (2014) Nat Chem Biol , vol.10 , pp. 1013-1019
    • Ronan, B.1    Flamand, O.2    Vescovi, L.3    Dureuil, C.4    Durand, L.5    Fassy, F.6
  • 26
    • 66449115318 scopus 로고    scopus 로고
    • Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
    • M. Salazar, A. Carracedo, Í.J. Salanueva, S. Hernández-Tiedra, M. Lorente, A. Egia, and et al. Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells J Clin Investig 119 2009 1359
    • (2009) J Clin Investig , vol.119 , pp. 1359
    • Salazar, M.1    Carracedo, A.2    Salanueva, Í.J.3    Hernández-Tiedra, S.4    Lorente, M.5    Egia, A.6
  • 28
    • 84906938119 scopus 로고    scopus 로고
    • Prognostic significance of p62/SQSTM1 subcellular localization and LC3B in oral squamous cell carcinoma
    • J.L. Liu, F.F. Chen, J. Lung, C.H. Lo, F.H. Lee, Y.C. Lu, and et al. Prognostic significance of p62/SQSTM1 subcellular localization and LC3B in oral squamous cell carcinoma Br J Cancer 111 2014 944 954
    • (2014) Br J Cancer , vol.111 , pp. 944-954
    • Liu, J.L.1    Chen, F.F.2    Lung, J.3    Lo, C.H.4    Lee, F.H.5    Lu, Y.C.6
  • 31
    • 84885645533 scopus 로고    scopus 로고
    • High LC3 expression correlates with poor survival in patients with oral squamous cell carcinoma
    • J.Y. Tang, E. Hsi, Y.C. Huang, N.C. Hsu, P.Y. Chu, and C.Y. Chai High LC3 expression correlates with poor survival in patients with oral squamous cell carcinoma Hum Pathol 44 2013 2558 2562
    • (2013) Hum Pathol , vol.44 , pp. 2558-2562
    • Tang, J.Y.1    Hsi, E.2    Huang, Y.C.3    Hsu, N.C.4    Chu, P.Y.5    Chai, C.Y.6
  • 32
    • 84923257034 scopus 로고    scopus 로고
    • Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma
    • K. Sakakura, H. Takahashi, K. Kaira, M. Toyoda, T. Oyama, and K. Chikamatsu Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma Cancer Sci 106 2015 1 8
    • (2015) Cancer Sci , vol.106 , pp. 1-8
    • Sakakura, K.1    Takahashi, H.2    Kaira, K.3    Toyoda, M.4    Oyama, T.5    Chikamatsu, K.6
  • 33
    • 33746108329 scopus 로고    scopus 로고
    • Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy
    • I. Tanida, N. Minematsu-Ikeguchi, T. Ueno, and E. Kominami Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy Autophagy 1 2005 84 91
    • (2005) Autophagy , vol.1 , pp. 84-91
    • Tanida, I.1    Minematsu-Ikeguchi, N.2    Ueno, T.3    Kominami, E.4
  • 35
    • 84907882109 scopus 로고    scopus 로고
    • Beclin 1 inhibits proliferation, migration and invasion in tongue squamous cell carcinoma cell lines
    • J. Weng, C. Wang, Y. Wang, H. Tang, J. Liang, X. Liu, and et al. Beclin 1 inhibits proliferation, migration and invasion in tongue squamous cell carcinoma cell lines Oral Oncol 50 2014 983 990
    • (2014) Oral Oncol , vol.50 , pp. 983-990
    • Weng, J.1    Wang, C.2    Wang, Y.3    Tang, H.4    Liang, J.5    Liu, X.6
  • 38
    • 80054795576 scopus 로고    scopus 로고
    • Apicidin, a histone deaceylase inhibitor, induces both apoptosis and autophagy in human oral squamous carcinoma cells
    • M.Y. Ahn, S.G. Ahn, and J.H. Yoon Apicidin, a histone deaceylase inhibitor, induces both apoptosis and autophagy in human oral squamous carcinoma cells Oral Oncol 47 2011 1032 1038
    • (2011) Oral Oncol , vol.47 , pp. 1032-1038
    • Ahn, M.Y.1    Ahn, S.G.2    Yoon, J.H.3
  • 39
    • 77955863457 scopus 로고    scopus 로고
    • Areca nut extract induced oxidative stress and upregulated hypoxia inducing factor leading to autophagy in oral cancer cells
    • H.H. Lu, S.Y. Kao, T.Y. Liu, S.T. Liu, W.P. Huang, K.W. Chang, and et al. Areca nut extract induced oxidative stress and upregulated hypoxia inducing factor leading to autophagy in oral cancer cells Autophagy 6 2010 725 737
    • (2010) Autophagy , vol.6 , pp. 725-737
    • Lu, H.H.1    Kao, S.Y.2    Liu, T.Y.3    Liu, S.T.4    Huang, W.P.5    Chang, K.W.6
  • 41
    • 84867505260 scopus 로고    scopus 로고
    • Carfilzomib and ONX 0912 inhibit cell survival and tumor growth of head and neck cancer and their activities are enhanced by suppression of Mcl-1 or autophagy
    • Y. Zang, S.M. Thomas, E.T. Chan, C.J. Kirk, M.L. Freilino, H.M. DeLancey, and et al. Carfilzomib and ONX 0912 inhibit cell survival and tumor growth of head and neck cancer and their activities are enhanced by suppression of Mcl-1 or autophagy Clin Cancer Res: Official J Am Assoc Cancer Res 18 2012 5639 5649
    • (2012) Clin Cancer Res: Official J Am Assoc Cancer Res , vol.18 , pp. 5639-5649
    • Zang, Y.1    Thomas, S.M.2    Chan, E.T.3    Kirk, C.J.4    Freilino, M.L.5    DeLancey, H.M.6
  • 42
    • 84867888123 scopus 로고    scopus 로고
    • Autophagy and reactive oxygen species modulate cytotoxicity induced by suppression of ATM kinase activity in head and neck cancer cells
    • C.S. Lin, Y.C. Wang, J.L. Huang, C.C. Hung, and J.Y. Chen Autophagy and reactive oxygen species modulate cytotoxicity induced by suppression of ATM kinase activity in head and neck cancer cells Oral Oncol 48 2012 1152 1158
    • (2012) Oral Oncol , vol.48 , pp. 1152-1158
    • Lin, C.S.1    Wang, Y.C.2    Huang, J.L.3    Hung, C.C.4    Chen, J.Y.5
  • 43
    • 84887125314 scopus 로고    scopus 로고
    • G15, a GPR30 antagonist, induces apoptosis and autophagy in human oral squamous carcinoma cells
    • L.Y. Bai, J.R. Weng, J.L. Hu, D. Wang, A.M. Sargeant, and C.F. Chiu G15, a GPR30 antagonist, induces apoptosis and autophagy in human oral squamous carcinoma cells Chem Biol Interact 206 2013 375 384
    • (2013) Chem Biol Interact , vol.206 , pp. 375-384
    • Bai, L.Y.1    Weng, J.R.2    Hu, J.L.3    Wang, D.4    Sargeant, A.M.5    Chiu, C.F.6
  • 44
    • 84879639056 scopus 로고    scopus 로고
    • Tetrandrine induces cell death in SAS human oral cancer cells through caspase activation-dependent apoptosis and LC3-I and LC3-II activation-dependent autophagy
    • A.C. Huang, J.C. Lien, M.W. Lin, J.S. Yang, P.P. Wu, S.J. Chang, and et al. Tetrandrine induces cell death in SAS human oral cancer cells through caspase activation-dependent apoptosis and LC3-I and LC3-II activation-dependent autophagy Int J Oncol 43 2013 485 494
    • (2013) Int J Oncol , vol.43 , pp. 485-494
    • Huang, A.C.1    Lien, J.C.2    Lin, M.W.3    Yang, J.S.4    Wu, P.P.5    Chang, S.J.6
  • 45
    • 84864460268 scopus 로고    scopus 로고
    • Curcumin-induced autophagy contributes to the decreased survival of oral cancer cells
    • J.Y. Kim, T.J. Cho, B.H. Woo, K.U. Choi, C.H. Lee, M.H. Ryu, and et al. Curcumin-induced autophagy contributes to the decreased survival of oral cancer cells Arch Oral Biol 57 2012 1018 1025
    • (2012) Arch Oral Biol , vol.57 , pp. 1018-1025
    • Kim, J.Y.1    Cho, T.J.2    Woo, B.H.3    Choi, K.U.4    Lee, C.H.5    Ryu, M.H.6
  • 46
    • 84902592121 scopus 로고    scopus 로고
    • The novel pterostilbene derivative ANK-199 induces autophagic cell death through regulating PI3 kinase class III/beclin 1/Atgrelated proteins in cisplatinresistant CAR human oral cancer cells
    • M.T. Hsieh, H.P. Chen, C.C. Lu, J.H. Chiang, T.S. Wu, D.H. Kuo, and et al. The novel pterostilbene derivative ANK-199 induces autophagic cell death through regulating PI3 kinase class III/beclin 1/Atgrelated proteins in cisplatinresistant CAR human oral cancer cells Int J Oncol 45 2014 782 794
    • (2014) Int J Oncol , vol.45 , pp. 782-794
    • Hsieh, M.T.1    Chen, H.P.2    Lu, C.C.3    Chiang, J.H.4    Wu, T.S.5    Kuo, D.H.6
  • 47
  • 48
    • 84957310463 scopus 로고    scopus 로고
    • Dual induction of apoptotic and autophagic cell death by targeting survivin in head neck squamous cell carcinoma
    • L. Zhang, W. Zhang, Y.F. Wang, B. Liu, W.F. Zhang, Y.F. Zhao, and et al. Dual induction of apoptotic and autophagic cell death by targeting survivin in head neck squamous cell carcinoma Cell Death Disease 6 2015 e1771
    • (2015) Cell Death Disease , vol.6
    • Zhang, L.1    Zhang, W.2    Wang, Y.F.3    Liu, B.4    Zhang, W.F.5    Zhao, Y.F.6
  • 49
    • 33750697911 scopus 로고    scopus 로고
    • Induction of non-apoptotic cell death by morphinone in human promyelocytic leukemia HL-60 cells
    • R. Takeuchi, H. Hoshijima, H. Nagasaka, S.A. Chowdhury, H. Kikuchi, Y. Kanda, and et al. Induction of non-apoptotic cell death by morphinone in human promyelocytic leukemia HL-60 cells Anticancer Res 26 2006 3343 3348
    • (2006) Anticancer Res , vol.26 , pp. 3343-3348
    • Takeuchi, R.1    Hoshijima, H.2    Nagasaka, H.3    Chowdhury, S.A.4    Kikuchi, H.5    Kanda, Y.6
  • 50
    • 33847684889 scopus 로고    scopus 로고
    • Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines
    • T. Sekine, J. Takahashi, M. Nishishiro, A. Arai, H. Wakabayashi, T. Kurihara, and et al. Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines Anticancer Res 27 2007 133 143
    • (2007) Anticancer Res , vol.27 , pp. 133-143
    • Sekine, T.1    Takahashi, J.2    Nishishiro, M.3    Arai, A.4    Wakabayashi, H.5    Kurihara, T.6
  • 51
    • 84897128733 scopus 로고    scopus 로고
    • P62/SQSTM1 accumulation in squamous cell carcinoma of head and neck predicts sensitivity to phosphatidylinositol 3-kinase pathway inhibitors
    • W.L. Kuo, M.N. Sharifi, M.W. Lingen, O. Ahmed, J. Liu, M. Nagilla, and et al. P62/SQSTM1 accumulation in squamous cell carcinoma of head and neck predicts sensitivity to phosphatidylinositol 3-kinase pathway inhibitors PLoS ONE 9 2014 e90171
    • (2014) PLoS ONE , vol.9
    • Kuo, W.L.1    Sharifi, M.N.2    Lingen, M.W.3    Ahmed, O.4    Liu, J.5    Nagilla, M.6
  • 52
    • 0033559576 scopus 로고    scopus 로고
    • Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma
    • Y.M.D. Lo, L.Y.S. Chan, K.-W. Lo, S.-F. Leung, J. Zhang, A.T.C. Chan, and et al. Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma Cancer Res 59 1999 1188 1191
    • (1999) Cancer Res , vol.59 , pp. 1188-1191
    • Lo, Y.M.D.1    Chan, L.Y.S.2    Lo, K.-W.3    Leung, S.-F.4    Zhang, J.5    Chan, A.T.C.6
  • 53
    • 77953708091 scopus 로고    scopus 로고
    • Elevated Beclin 1 expression is correlated with HIF-1α in predicting poor prognosis of nasopharyngeal carcinoma
    • X.-B. Wan, X.-J. Fan, M.-Y. Chen, J. Xiang, P.-Y. Huang, L. Guo, and et al. Elevated Beclin 1 expression is correlated with HIF-1α in predicting poor prognosis of nasopharyngeal carcinoma Autophagy 6 2010 395 404
    • (2010) Autophagy , vol.6 , pp. 395-404
    • Wan, X.-B.1    Fan, X.-J.2    Chen, M.-Y.3    Xiang, J.4    Huang, P.-Y.5    Guo, L.6
  • 54
    • 84876243689 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 regulates the mechanism of irradiation-induced CNE-2 human nasopharyngeal carcinoma cell autophagy and inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells
    • Z.R. Zhou, X.D. Zhu, W. Zhao, S. Qu, F. Su, S.T. Huang, and et al. Poly(ADP-ribose) polymerase-1 regulates the mechanism of irradiation-induced CNE-2 human nasopharyngeal carcinoma cell autophagy and inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells Oncol Rep 29 2013 2498 2506
    • (2013) Oncol Rep , vol.29 , pp. 2498-2506
    • Zhou, Z.R.1    Zhu, X.D.2    Zhao, W.3    Qu, S.4    Su, F.5    Huang, S.T.6
  • 55
    • 84890934164 scopus 로고    scopus 로고
    • Blocked autophagy enhances radiosensitivity of nasopharyngeal carcinoma cell line CNE-2 in vitro
    • Y. Wang, W. Yin, and X. Zhu Blocked autophagy enhances radiosensitivity of nasopharyngeal carcinoma cell line CNE-2 in vitro Acta Otolaryngol 134 2014 105 110
    • (2014) Acta Otolaryngol , vol.134 , pp. 105-110
    • Wang, Y.1    Yin, W.2    Zhu, X.3
  • 56
    • 84907285869 scopus 로고    scopus 로고
    • Inhibition of autophagy enhances the radiosensitivity of nasopharyngeal carcinoma by reducing Rad51 expression
    • N. Mo, Y.-K. Lu, W.-M. Xie, Y. Liu, W.-X. Zhou, H.-X. Wang, and et al. Inhibition of autophagy enhances the radiosensitivity of nasopharyngeal carcinoma by reducing Rad51 expression Oncol Rep 32 2014 1905 1912
    • (2014) Oncol Rep , vol.32 , pp. 1905-1912
    • Mo, N.1    Lu, Y.-K.2    Xie, W.-M.3    Liu, Y.4    Zhou, W.-X.5    Wang, H.-X.6
  • 58
    • 84894464496 scopus 로고    scopus 로고
    • Resveratrol induced ER expansion and ER caspase-mediated apoptosis in human nasopharyngeal carcinoma cells
    • S.E. Chow, C.H. Kao, Y.T. Liu, M.L. Cheng, Y.W. Yang, Y.K. Huang, and et al. Resveratrol induced ER expansion and ER caspase-mediated apoptosis in human nasopharyngeal carcinoma cells Apoptosis: Int J Programmed Cell Death 19 2014 527 541
    • (2014) Apoptosis: Int J Programmed Cell Death , vol.19 , pp. 527-541
    • Chow, S.E.1    Kao, C.H.2    Liu, Y.T.3    Cheng, M.L.4    Yang, Y.W.5    Huang, Y.K.6
  • 59
    • 84875252908 scopus 로고    scopus 로고
    • MTOR inhibitor RAD001 (everolimus) induces apoptotic, not autophagic cell death, in human nasopharyngeal carcinoma cells
    • Y. Cai, Q. Xia, Q. Su, R. Luo, Y. Sun, Y. Shi, and et al. MTOR inhibitor RAD001 (everolimus) induces apoptotic, not autophagic cell death, in human nasopharyngeal carcinoma cells Int J Mol Med 31 2013 904 912
    • (2013) Int J Mol Med , vol.31 , pp. 904-912
    • Cai, Y.1    Xia, Q.2    Su, Q.3    Luo, R.4    Sun, Y.5    Shi, Y.6
  • 60
    • 84872810600 scopus 로고    scopus 로고
    • Diarylquinoline compounds induce autophagy-associated cell death by inhibiting the Akt pathway and increasing reactive oxygen species in human nasopharyngeal carcinoma cells
    • Y. Cai, Z. Wan, T. Sun, Y. Shi, Y. Sun, P. Huang, and et al. Diarylquinoline compounds induce autophagy-associated cell death by inhibiting the Akt pathway and increasing reactive oxygen species in human nasopharyngeal carcinoma cells Oncol Rep 29 2013 983 992
    • (2013) Oncol Rep , vol.29 , pp. 983-992
    • Cai, Y.1    Wan, Z.2    Sun, T.3    Shi, Y.4    Sun, Y.5    Huang, P.6
  • 61
    • 81255129000 scopus 로고    scopus 로고
    • Novel phosphoinositide 3-kinase/mTOR dual inhibitor, NVP-BGT226, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo
    • K.Y. Chang, S.Y. Tsai, C.M. Wu, C.J. Yen, B.F. Chuang, and J.Y. Chang Novel phosphoinositide 3-kinase/mTOR dual inhibitor, NVP-BGT226, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo Clin Cancer Res: Official J Am Assoc Cancer Res 17 2011 7116 7126
    • (2011) Clin Cancer Res: Official J Am Assoc Cancer Res , vol.17 , pp. 7116-7126
    • Chang, K.Y.1    Tsai, S.Y.2    Wu, C.M.3    Yen, C.J.4    Chuang, B.F.5    Chang, J.Y.6
  • 62
    • 84868369654 scopus 로고    scopus 로고
    • Inhibition of autophagy-potentiated chemosensitivity to cisplatin in laryngeal cancer Hep-2 cells
    • R. Kang, Z.H. Wang, B.Q. Wang, C.M. Zhang, W. Gao, Y. Feng, and et al. Inhibition of autophagy-potentiated chemosensitivity to cisplatin in laryngeal cancer Hep-2 cells Am J Otolaryngol 33 2012 678 684
    • (2012) Am J Otolaryngol , vol.33 , pp. 678-684
    • Kang, R.1    Wang, Z.H.2    Wang, B.Q.3    Zhang, C.M.4    Gao, W.5    Feng, Y.6
  • 63
    • 84941994651 scopus 로고    scopus 로고
    • The role of autophagy in the cytotoxicity induced by recombinant human arginase in laryngeal squamous cell carcinoma
    • C. Lin, Z. Wang, L. Li, Y. He, J. Fan, Z. Liu, and et al. The role of autophagy in the cytotoxicity induced by recombinant human arginase in laryngeal squamous cell carcinoma Appl Microbiol Biotechnol 2015
    • (2015) Appl Microbiol Biotechnol
    • Lin, C.1    Wang, Z.2    Li, L.3    He, Y.4    Fan, J.5    Liu, Z.6
  • 64
    • 84880785265 scopus 로고    scopus 로고
    • Aberrant expression of Beclin-1 and LC3 correlates with poor prognosis of human hypopharyngeal squamous cell carcinoma
    • J. Wang, X.L. Pan, L.J. Ding, D.Y. Liu, L. Da-Peng, and T. Jin Aberrant expression of Beclin-1 and LC3 correlates with poor prognosis of human hypopharyngeal squamous cell carcinoma PLoS ONE 8 2013 e69038
    • (2013) PLoS ONE , vol.8
    • Wang, J.1    Pan, X.L.2    Ding, L.J.3    Liu, D.Y.4    Da-Peng, L.5    Jin, T.6
  • 66
    • 84923197605 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of head and neck squamous cell carcinomas
    • Cancer Genome Atlas N. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature; 2015; 517: 576-82.
    • (2015) Nature , vol.517 , pp. 576-582
    • Cancer Genome Atlas N.1
  • 68
    • 84933678053 scopus 로고    scopus 로고
    • Targeting the PI3K/AKT/mTOR pathway in squamous cell carcinoma of the head and neck
    • D.R. Simpson, L.K. Mell, and E.E.W. Cohen Targeting the PI3K/AKT/mTOR pathway in squamous cell carcinoma of the head and neck Oral Oncol 51 2015 291 298
    • (2015) Oral Oncol , vol.51 , pp. 291-298
    • Simpson, D.R.1    Mell, L.K.2    Cohen, E.E.W.3
  • 69
    • 84869856108 scopus 로고    scopus 로고
    • Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235
    • G.J. Cerniglia, J. Karar, S. Tyagi, M. Christofidou-Solomidou, R. Rengan, C. Koumenis, and et al. Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 Mol Pharmacol 82 2012 1230 1240
    • (2012) Mol Pharmacol , vol.82 , pp. 1230-1240
    • Cerniglia, G.J.1    Karar, J.2    Tyagi, S.3    Christofidou-Solomidou, M.4    Rengan, R.5    Koumenis, C.6
  • 70
    • 84876727894 scopus 로고    scopus 로고
    • Increasing the therapeutic efficacy of docetaxel for cutaneous squamous cell carcinoma through the combined inhibition of phosphatidylinositol 3-kinase/AKT signalling and autophagy
    • T.J. Wright, C. McKee, M.A. Birch-Machin, R. Ellis, J.L. Armstrong, and P.E. Lovat Increasing the therapeutic efficacy of docetaxel for cutaneous squamous cell carcinoma through the combined inhibition of phosphatidylinositol 3-kinase/AKT signalling and autophagy Clin Exp Dermatol 38 2013 421 423
    • (2013) Clin Exp Dermatol , vol.38 , pp. 421-423
    • Wright, T.J.1    McKee, C.2    Birch-Machin, M.A.3    Ellis, R.4    Armstrong, J.L.5    Lovat, P.E.6
  • 71
    • 0032478998 scopus 로고    scopus 로고
    • Levels of TGF-α and EGFR protein in head and neck squamous cell carcinoma and patient survival
    • J.R. Grandis, M.F. Melhem, W.E. Gooding, R. Day, V.A. Holst, M.M. Wagener, and et al. Levels of TGF-α and EGFR protein in head and neck squamous cell carcinoma and patient survival J Natl Cancer Inst 90 1998 824 832
    • (1998) J Natl Cancer Inst , vol.90 , pp. 824-832
    • Grandis, J.R.1    Melhem, M.F.2    Gooding, W.E.3    Day, R.4    Holst, V.A.5    Wagener, M.M.6
  • 72
    • 0037115674 scopus 로고    scopus 로고
    • Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma
    • K.K. Ang, B.A. Berkey, X. Tu, H.-Z. Zhang, R. Katz, E.H. Hammond, and et al. Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma Cancer Res 62 2002 7350 7356
    • (2002) Cancer Res , vol.62 , pp. 7350-7356
    • Ang, K.K.1    Berkey, B.A.2    Tu, X.3    Zhang, H.-Z.4    Katz, R.5    Hammond, E.H.6
  • 73
    • 84884262668 scopus 로고    scopus 로고
    • EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance
    • Y. Wei, Z. Zou, N. Becker, M. Anderson, R. Sumpter, G. Xiao, and et al. EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance Cell 154 2013 1269 1284
    • (2013) Cell , vol.154 , pp. 1269-1284
    • Wei, Y.1    Zou, Z.2    Becker, N.3    Anderson, M.4    Sumpter, R.5    Xiao, G.6
  • 74
    • 84920945138 scopus 로고    scopus 로고
    • A kinase-independent role for EGF receptor in autophagy initiation
    • X. Tan, N. Thapa, Y. Sun, and R.A. Anderson A kinase-independent role for EGF receptor in autophagy initiation Cell 160 2015 145 160
    • (2015) Cell , vol.160 , pp. 145-160
    • Tan, X.1    Thapa, N.2    Sun, Y.3    Anderson, R.A.4
  • 75
    • 79955496795 scopus 로고    scopus 로고
    • Evaluation of EGFR gene copy number as a predictive biomarker for the efficacy of cetuximab in combination with chemotherapy in the first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck: EXTREME study
    • L. Licitra, R. Mesia, F. Rivera, E. Remenar, R. Hitt, J. Erfan, and et al. Evaluation of EGFR gene copy number as a predictive biomarker for the efficacy of cetuximab in combination with chemotherapy in the first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck: EXTREME study Ann Oncol 22 2011 1078 1087
    • (2011) Ann Oncol , vol.22 , pp. 1078-1087
    • Licitra, L.1    Mesia, R.2    Rivera, F.3    Remenar, E.4    Hitt, R.5    Erfan, J.6
  • 76
    • 77955038334 scopus 로고    scopus 로고
    • The epidermal growth factor receptor antibody cetuximab induces autophagy in cancer cells by downregulating HIF-1α and Bcl-2 and activating the beclin 1/hVps34 complex
    • X. Li, and Z. Fan The epidermal growth factor receptor antibody cetuximab induces autophagy in cancer cells by downregulating HIF-1α and Bcl-2 and activating the beclin 1/hVps34 complex Cancer Res 70 2010 5942 5952
    • (2010) Cancer Res , vol.70 , pp. 5942-5952
    • Li, X.1    Fan, Z.2
  • 77
    • 84890432985 scopus 로고    scopus 로고
    • P53 status determines the role of autophagy in pancreatic tumour development
    • M.T. Rosenfeldt, J. O'Prey, J.P. Morton, C. Nixon, G. MacKay, A. Mrowinska, and et al. P53 status determines the role of autophagy in pancreatic tumour development Nature 504 2013 296 300
    • (2013) Nature , vol.504 , pp. 296-300
    • Rosenfeldt, M.T.1    O'Prey, J.2    Morton, J.P.3    Nixon, C.4    MacKay, G.5    Mrowinska, A.6
  • 78
    • 67649607465 scopus 로고    scopus 로고
    • Autophagy, immunity, and microbial adaptations
    • V. Deretic, and B. Levine Autophagy, immunity, and microbial adaptations Cell Host Microbe 5 2009 527 549
    • (2009) Cell Host Microbe , vol.5 , pp. 527-549
    • Deretic, V.1    Levine, B.2
  • 79
    • 84874716169 scopus 로고    scopus 로고
    • Cellular entry of human papillomavirus type 16 involves activation of the phosphatidylinositol 3-kinase/Akt/mTOR pathway and inhibition of autophagy
    • Z. Surviladze, R.T. Sterk, S.A. DeHaro, and M.A. Ozbun Cellular entry of human papillomavirus type 16 involves activation of the phosphatidylinositol 3-kinase/Akt/mTOR pathway and inhibition of autophagy J Virol 87 2013 2508 2517
    • (2013) J Virol , vol.87 , pp. 2508-2517
    • Surviladze, Z.1    Sterk, R.T.2    DeHaro, S.A.3    Ozbun, M.A.4
  • 80
    • 84873080242 scopus 로고    scopus 로고
    • Human papillomavirus infection is inhibited by host autophagy in primary human keratinocytes
    • L.M. Griffin, L. Cicchini, and D. Pyeon Human papillomavirus infection is inhibited by host autophagy in primary human keratinocytes Virology 437 2013 12 19
    • (2013) Virology , vol.437 , pp. 12-19
    • Griffin, L.M.1    Cicchini, L.2    Pyeon, D.3
  • 81
    • 84908001653 scopus 로고    scopus 로고
    • EBV blocks the autophagic flux and appropriates the autophagic machinery to enhance viral replication
    • 02199-14
    • M. Granato, R. Santarelli, A. Farina, R. Gonnella, L.V. Lotti, A. Faggioni, and et al. EBV blocks the autophagic flux and appropriates the autophagic machinery to enhance viral replication J Virol JVI 2014 02199-14
    • (2014) J Virol , vol.JVI
    • Granato, M.1    Santarelli, R.2    Farina, A.3    Gonnella, R.4    Lotti, L.V.5    Faggioni, A.6
  • 82
    • 84900522505 scopus 로고    scopus 로고
    • Xenophagy in Helicobacter pylori-and Epstein-Barr virus-induced gastric cancer
    • L. Zhang, J.J.Y. Sung, J. Yu, S.C. Ng, S.H. Wong, C.H. Cho, and et al. Xenophagy in Helicobacter pylori-and Epstein-Barr virus-induced gastric cancer J Pathol 233 2014 103 112
    • (2014) J Pathol , vol.233 , pp. 103-112
    • Zhang, L.1    Sung, J.J.Y.2    Yu, J.3    Ng, S.C.4    Wong, S.H.5    Cho, C.H.6
  • 83
    • 84922062342 scopus 로고    scopus 로고
    • Macroautophagy proteins assist Epstein barr virus production and get incorporated into the virus particles
    • H. Nowag, B. Guhl, K. Thriene, S. Romao, U. Ziegler, J. Dengjel, and et al. Macroautophagy proteins assist Epstein barr virus production and get incorporated into the virus particles EBioMedicine 1 2014 116 125
    • (2014) EBioMedicine , vol.1 , pp. 116-125
    • Nowag, H.1    Guhl, B.2    Thriene, K.3    Romao, S.4    Ziegler, U.5    Dengjel, J.6
  • 84
    • 84907907894 scopus 로고    scopus 로고
    • Regulation of autophagic activation by Rta of Epstein-Barr virus via the extracellular signal-regulated kinase pathway
    • C.-H. Hung, L.-W. Chen, W.-H. Wang, P.-J. Chang, Y.-F. Chiu, C.-C. Hung, and et al. Regulation of autophagic activation by Rta of Epstein-Barr virus via the extracellular signal-regulated kinase pathway J Virol 88 2014 12133 12145
    • (2014) J Virol , vol.88 , pp. 12133-12145
    • Hung, C.-H.1    Chen, L.-W.2    Wang, W.-H.3    Chang, P.-J.4    Chiu, Y.-F.5    Hung, C.-C.6
  • 86
    • 84877337914 scopus 로고    scopus 로고
    • Inhibiting autophagy potentiates the anticancer activity of IFN1@/IFNα in chronic myeloid leukemia cells
    • S. Zhu, L. Cao, Y. Yu, L. Yang, M. Yang, K. Liu, and et al. Inhibiting autophagy potentiates the anticancer activity of IFN1@/IFNα in chronic myeloid leukemia cells Autophagy 9 2013 317 327
    • (2013) Autophagy , vol.9 , pp. 317-327
    • Zhu, S.1    Cao, L.2    Yu, Y.3    Yang, L.4    Yang, M.5    Liu, K.6


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