Aberrant Expression of Beclin-1 and LC3 Correlates with Poor Prognosis of Human Hypopharyngeal Squamous Cell Carcinoma

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Wang, Juan ^a   Pan, Xin Liang ^a   Ding, Li Jie ^b   Liu, Da Yu ^a   Da Peng Lei, ^a   Jin, Tong ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; MESSENGER RNA; PROTEIN LC3; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE MARKER; EPITHELIUM; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOPHARYNGEAL SQUAMOUS CELL CARCINOMA; HYPOPHARYNX CARCINOMA; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SURVIVAL RATE; TUMOR DIFFERENTIATION;

AGED; APOPTOSIS REGULATORY PROTEINS; CARCINOMA, SQUAMOUS CELL; FEMALE; GENE EXPRESSION; HUMANS; HYPOPHARYNGEAL NEOPLASMS; HYPOPHARYNX; LYMPHATIC METASTASIS; MALE; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; SURVIVAL ANALYSIS;

EID: 84880785265     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069038     Document Type: Article

References (33)

1. Klionsky DJ, (2007) Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 8: 931-937. doi:10.1038/nrm2245. PubMed: 17712358.
2. Kroemer G, Jäättelä M, (2005) Lysosomes and autophagy in cell death control. Nat Rev Cancer 5: 886-897. doi:10.1038/nrc1738. PubMed: 16239905.
3. Eisenberg-Lerner A, Kimchi A, (2009) The paradox of autophagy and its implication in cancer etiology and therapy. Apoptosis 14: 376-391. doi:10.1007/s10495-008-0307-5. PubMed: 19172397.
4. Zois CE, Koukourakis MI, (2009) Radiation-induced autophagy in normal and cancer cells: towards novel cytoprotection and radio-sensitization policies? Autophagy 5: 442-450. doi:10.4161/auto.5.4.7667. PubMed: 19164950.
5. Cheong H, Klionsky DJ, (2008) Biochemical methods to monitor autophagy-related processes in yeast. Methods Enzymol 451: 1-26. doi:10.1016/S0076-6879(08)03201-1. PubMed: 19185709.
6. Eskelinen EL, Saftig P, (2009) Autophagy: a lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta 1793: 664-673. doi:10.1016/j.bbamcr.2008.07.014. PubMed: 18706940.
7. Cao Y, Klionsky DJ, (2007) Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell Res 17: 839-849. doi:10.1038/cr.2007.78. PubMed: 17893711.
8. Giatromanolaki A, Koukourakis MI, Koutsopoulos A, Chloropoulou P, Liberis V, et al. (2011) High Beclin 1 expression defines a poor prognosis in endometrial adenocarcinomas. Gynecol Oncol 123: 147-151. doi:10.1016/j.ygyno.2011.06.023. PubMed: 21741077.
9. Tanida I, Tanida-Miyake E, Ueno T, Kominami E, (2001) The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3. J Biol Chem 276: 1701-1706. PubMed: 11096062.
10. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, et al. (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19: 5720-5728. doi:10.1093/emboj/19.21.5720. PubMed: 11060023.
11. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4: 151-175. PubMed: 18188003.
12. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y, (2004) In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 15: 1101-1111. PubMed: 14699058.
13. Li BX, Li CY, Peng RQ, Wu XJ, Wang HY, et al. (2009) The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers. Autophagy 5: 303-306. doi:10.4161/auto.5.3.7491. PubMed: 19066461.
14. Miracco C, Cevenini G, Franchi A, Luzi P, Cosci E, et al. (2010) Beclin 1 and LC3 autophagic gene expression in cutaneous melanocytic lesions. Hum Pathol 41: 503-512. doi:10.1016/j.humpath.2009.09.004. PubMed: 20004946.
15. Shen Y, Li DD, Wang LL, Deng R, Zhu XF, (2008) Decreased expression of autophagy-related proteins in malignant epithelial ovarian cancer. Autophagy 4: 1067-1068. PubMed: 18776739.
16. Jiang ZF, Shao LJ, Wang WM, Yan XB, Liu RY, (2012) Decreased expression of Beclin-1 and LC3 in human lung cancer. Mol Biol Rep 39: 259-267. doi:10.1007/s11033-011-0734-1. PubMed: 21556768.
17. Miracco C, Cosci E, Oliveri G, Luzi P, Pacenti L, et al. (2007) Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours. Int J Oncol 30: 429-436. PubMed: 17203225.
18. Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, et al. (1999) Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402: 672-676. doi:10.1038/45257. PubMed: 10604474.
19. Ding ZB, Shi YH, Zhou J, Qiu SJ, Xu Y, et al. (2008) Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res 68: 9167-9175. doi:10.1158/0008-5472.CAN-08-1573. PubMed: 19010888.
20. Wycliffe ND, Grover RS, Kim PD, Simental A Jr, (2007) Hypopharyngeal Cancer. Top Magn Reson Imaging 18: 243-258. doi:10.1097/RMR.0b013e3181570c3f. PubMed: 17893590.
21. Shanmugaratnam K, Sobin LH, (1993) The World Health Organization histological classification of tumours of the upper respiratory tract and ear Cancer 71: 387-392.
22. Tu YF, Kaipparettu BA, Ma Y, Wong LJ, (2011) Mitochondria of highly metastatic breast cancer cell line MDA-MB-231 exhibits increased autophagic properties. Biochim Biophys Acta 1807: 1125-1132. doi:10.1016/j.bbabio.2011.04.015. PubMed: 21570379.
23. Liang C, Guo S, Yang L, (2013) All-trans retinoic acid upregulates VEGF expression in glioma cells in vitro. J Biomed Res 27: 51-55. doi:10.7555/JBR.27.20120048. PubMed: 23554794.
24. Huang JJ, Li HR, Huang Y, Jiang WQ, Xu RH, et al. (2010) Beclin 1 expression: a predictor of prognosis in patients with extranodal natural killer T-cell lymphoma, nasal type. Autophagy 6: 777-783. doi:10.4161/auto.6.6.12784. PubMed: 20639699.
25. Lomonaco SL, Finniss S, Xiang C, Decarvalho A, Umansky F, et al. (2009) The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells. Int J Cancer 125: 717-722. doi:10.1002/ijc.24402. PubMed: 19431142.
26. Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, et al. (1998) Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol 72: 8586-8596. PubMed: 9765397.
27. Ahn CH, Jeong EG, Lee JW, Kim MS, Kim SH, et al. (2007) Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers. APMIS 115: 1344-1349. doi:10.1111/j.1600-0463.2007.00858.x. PubMed: 18184403.
28. Aoki H, Kondo Y, Aldape K, Yamamoto A, Iwado E, et al. (2008) Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3. Autophagy 4: 467-475. PubMed: 18259115.
29. Yoshioka A, Miyata H, Doki Y, Yamasaki M, Sohma I, et al. (2008) LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers. Int J Oncol 33: 461-468. PubMed: 18695874.
30. Coates JM, Galante JM, Bold RJ, (2010) Cancer therapy beyond apoptosis: autophagy and anoikis as mechanisms of cell death. J Surg Res 164: 301-308. doi:10.1016/j.jss.2009.07.011. PubMed: 20031162.
31. Djavaheri-Mergny M, Maiuri MC, Kroemer G, (2010) Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1. Oncogene 29: 1717-1719. doi:10.1038/onc.2009.519. PubMed: 20101204.
32. Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, et al. (2006) Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10: 51-64. doi:10.1016/j.ccr.2006.06.001. PubMed: 16843265.
33. Amaravadi RK, Yu D, Lum JJ, Bui T, Christophorou MA, et al. (2007) Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest 117: 326-336. doi:10.1172/JCI28833. PubMed: 17235397.