G15, a GPR30 antagonist, induces apoptosis and autophagy in human oral squamous carcinoma cells

Chemico-Biological Interactions

Volumn 206, Issue 2, 2013, Pages 375-384

  Bai, Li Yuan ^a,c   Weng, Jing Ru ^b   Hu, Jing Lan ^b   Wang, Dasheng ^e   Sargeant, Aaron M ^f   Chiu, Chang Fang ^c,d  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c Department of Internal Medicine   (China)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e OHIO STATE UNIVERSITY   (United States)

^f CHARLES RIVER LABORATORIES   (United States)

Author keywords

Apoptosis; Autophagy; G15; GPR30; Oral cancer

Indexed keywords

4 (6 BROMOBENZO[1,3]DIOXO 5 YL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE; CASPASE 3; CASPASE 9; CHLOROQUINE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 25C; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; G 15; G PROTEIN COUPLED RECEPTOR 30; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 8; PROTEIN KINASE B; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER INHIBITION; CELL VIABILITY; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; DRUG CYTOTOXICITY; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; MOUTH SQUAMOUS CELL CARCINOMA; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

APOPTOSIS; AUTOPHAGY; G15; GPR30; ORAL CANCER;

APOPTOSIS; AUTOPHAGY; BENZODIOXOLES; CARCINOMA, SQUAMOUS CELL; CASPASES; CELL LINE, TUMOR; CHLOROQUINE; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MICROTUBULE-ASSOCIATED PROTEINS; MOUTH NEOPLASMS; NF-KAPPA B; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; QUINOLINES; RECEPTORS, ESTROGEN; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84887125314     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2013.10.014     Document Type: Article

References (30)

1. J.B. Vermorken, E. Remenar, C. van Herpen, T. Gorlia, R. Mesia, M. Degardin, J.S. Stewart, S. Jelic, J. Betka, J.H. Preiss, D. van den Weyngaert, A. Awada, D. Cupissol, H.R. Kienzer, A. Rey, I. Desaunois, J. Bernier, and J.L. Lefebvre Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer N. Engl. J. Med. 357 17 2007 1695 1704
2. E.R. Prossnitz, J.B. Arterburn, H.O. Smith, T.I. Oprea, L.A. Sklar, and H.J. Hathaway Estrogen signaling through the transmembrane G protein-coupled receptor GPR30 Annu. Rev. Physiol. 70 2008 165 190
3. E.R. Prossnitz, and M. Barton Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER Prostaglandins Other Lipid Mediat. 89 3-4 2009 89 97
4. E.J. Filardo, C.T. Graeber, J.A. Quinn, M.B. Resnick, D. Giri, R.A. DeLellis, M.M. Steinhoff, and E. Sabo Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinicopathologic determinants of tumor progression Clin. Cancer Res. 12 21 2006 6359 6366
5. H.O. Smith, K.K. Leslie, M. Singh, C.R. Qualls, C.M. Revankar, N.E. Joste, and E.R. Prossnitz GPR30: a novel indicator of poor survival for endometrial carcinoma Am. J. Obstet. Gynecol. 196 4 2007 386.e381 386.e389 discussion 386.e389-e311
6. H.O. Smith, H. Arias-Pulido, D.Y. Kuo, T. Howard, C.R. Qualls, S.J. Lee, C.F. Verschraegen, H.J. Hathaway, N.E. Joste, and E.R. Prossnitz GPR30 predicts poor survival for ovarian cancer Gynecol. Oncol. 114 3 2009 465 471
7. H. Ishida, K. Wada, T. Masuda, M. Okura, K. Kohama, Y. Sano, A. Nakajima, M. Kogo, and Y. Kamisaki Critical role of estrogen receptor on anoikis and invasion of squamous cell carcinoma Cancer Sci. 98 5 2007 636 643
8. M.J. Kim, J.H. Lee, Y.K. Kim, H. Myoung, and P.Y. Yun The role of tamoxifen in combination with cisplatin on oral squamous cell carcinoma cell lines Cancer Lett. 245 1-2 2007 284 292
9. M. Mau, M. Mielenz, K.H. Sudekum, and A.G. Obukhov Expression of GPR30 and GPR43 in oral tissues: deriving new hypotheses on the role of diet in animal physiology and the development of oral cancers J. Anim. Physiol. Anim. Nutr. (Berl.) 95 3 2011 280 285
10. M.K. Dennis, R. Burai, C. Ramesh, W.K. Petrie, S.N. Alcon, T.K. Nayak, C.G. Bologa, A. Leitao, E. Brailoiu, E. Deliu, N.J. Dun, L.A. Sklar, H.J. Hathaway, J.B. Arterburn, T.I. Oprea, and E.R. Prossnitz In vivo effects of a GPR30 antagonist Nat. Chem. Biol. 5 6 2009 421 427
11. J.R. Weng, L.Y. Bai, H.A. Omar, A.M. Sargeant, C.T. Yeh, Y.Y. Chen, M.H. Tsai, and C.F. Chiu A novel indole-3-carbinol derivative inhibits the growth of human oral squamous cell carcinoma in vitro Oral Oncol. 46 10 2010 748 754
12. R. Lappano, C. Rosano, P. De Marco, E.M. De Francesco, V. Pezzi, and M. Maggiolini Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells Mol. Cell. Endocrinol. 320 1-2 2010 162 170
13. D. Marazziti, C. Di Pietro, E. Golini, S. Mandillo, R. Matteoni, and G.P. Tocchini-Valentini Induction of macroautophagy by overexpression of the Parkinson's disease-associated GPR37 receptor FASEB J. 23 6 2009 1978 1987
14. W. Bursch, A. Ellinger, C. Gerner, U. Frohwein, and R. Schulte-Hermann Programmed cell death (PCD). Apoptosis, autophagic PCD, or others? Ann. N. Y. Acad. Sci. 926 2000 1 12
15. M.C. Maiuri, E. Zalckvar, A. Kimchi, and G. Kroemer Self-eating and self-killing: crosstalk between autophagy and apoptosis Nat. Rev. Mol. Cell Biol. 8 9 2007 741 752
16. J. Lim, J.H. Kim, J.Y. Paeng, M.J. Kim, S.D. Hong, J.I. Lee, and S.P. Hong Prognostic value of activated Akt expression in oral squamous cell carcinoma J. Clin. Pathol. 58 11 2005 1199 1205
17. A.O. Rehman, and C.Y. Wang CXCL12/SDF-1 alpha activates NF-kappaB and promotes oral cancer invasion through the Carma3/Bcl10/Malt1 complex Int. J. Oral Sci. 1 3 2009 105 118
18. R. Mishra Glycogen synthase kinase 3 beta: can it be a target for oral cancer Mol. Cancer 9 2010 144
19. H. Nakayama, T. Ikebe, and K. Shirasuna Effects of IkappaB kinase alpha on the differentiation of squamous carcinoma cells Oral Oncol. 41 7 2005 729 737
20. H.H. Lu, C.J. Liu, T.Y. Liu, S.Y. Kao, S.C. Lin, and K.W. Chang Areca-treated fibroblasts enhance tumorigenesis of oral epithelial cells J. Dent. Res. 87 11 2008 1069 1074
21. S.C. Lin, S.Y. Lu, S.Y. Lee, C.Y. Lin, C.H. Chen, and K.W. Chang Areca (betel) nut extract activates mitogen-activated protein kinases and NF-kappaB in oral keratinocytes Int. J. Cancer 116 4 2005 526 535
22. C.G. Bologa, C.M. Revankar, S.M. Young, B.S. Edwards, J.B. Arterburn, A.S. Kiselyov, M.A. Parker, S.E. Tkachenko, N.P. Savchuck, L.A. Sklar, T.I. Oprea, and E.R. Prossnitz Virtual and biomolecular screening converge on a selective agonist for GPR30 Nat. Chem. Biol. 2 4 2006 207 212
23. J. Kuhn, O.A. Dina, C. Goswami, V. Suckow, J.D. Levine, and T. Hucho GPR30 estrogen receptor agonists induce mechanical hyperalgesia in the rat Eur. J. Neurosci. 27 7 2008 1700 1709
24. J.S. Sebolt-Leopold Development of anticancer drugs targeting the MAP kinase pathway Oncogene 19 56 2000 6594 6599
25. B. Kleuser, D. Malek, R. Gust, H.H. Pertz, and H. Potteck 17-Beta-estradiol inhibits transforming growth factor-beta signaling and function in breast cancer cells via activation of extracellular signal-regulated kinase through the G protein-coupled receptor 30 Mol. Pharmacol. 74 6 2008 1533 1543
26. Y.Y. He, B. Cai, Y.X. Yang, X.L. Liu, and X.P. Wan Estrogenic G protein-coupled receptor 30 signaling is involved in regulation of endometrial carcinoma by promoting proliferation, invasion potential, and interleukin-6 secretion via the MEK/ERK mitogen-activated protein kinase pathway Cancer Sci. 100 6 2009 1051 1061
27. Y.L. Liu, P.M. Yang, C.T. Shun, M.S. Wu, J.R. Weng, and C.C. Chen Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma Autophagy 6 8 2010 1057 1065
28. K. Sato, K. Tsuchihara, S. Fujii, M. Sugiyama, T. Goya, Y. Atomi, T. Ueno, A. Ochiai, and H. Esumi Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation Cancer Res. 67 20 2007 9677 9684
29. B. Levine Cell biology: autophagy and cancer Nature 446 7137 2007 745 747
30. H. Nomura, K. Uzawa, Y. Yamano, K. Fushimi, T. Ishigami, Y. Kouzu, H. Koike, M. Siiba, H. Bukawa, H. Yokoe, H. Kubosawa, and H. Tanzawa Overexpression and altered subcellular localization of autophagy-related 16-like 1 in human oral squamous-cell carcinoma: correlation with lymphovascular invasion and lymph-node metastasis Hum. Pathol. 40 1 2009 83 91