P62/SQSTM1 accumulation in squamous cell carcinoma of head and neck predicts sensitivity to phosphatidylinositol 3-Kinase pathway inhibitors

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Kuo, Wen Liang ^a   Sharifi, Marina N ^a,b   Lingen, Mark W ^a   Ahmed, Omar ^a   Liu, Jing ^a   Nagilla, Madhavi ^a   Macleod, Kay F ^a,b   Cohen, Ezra E W ^a,c  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN; PROTEIN KINASE B INHIBITOR; PROTEIN P62; SQSTM1 PROTEIN; UNCLASSIFIED DRUG; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; ANTINEOPLASTIC AGENT; ATG7 PROTEIN, HUMAN; FUSED HETEROCYCLIC RINGS; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3CA PROTEIN, HUMAN; PILARALISIB; PROTEIN KINASE B; QUINOXALINE DERIVATIVE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, HUMAN; SULFONAMIDE; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; ATG7 GENE; AUTOPHAGY; BIOACCUMULATION; CANCER CELL; CONTROLLED STUDY; CORRELATIONAL STUDY; DNA MODIFICATION; DOWN REGULATION; DRUG ACTIVITY; DRUG RESISTANCE; DRUG SENSITIVITY; GENE; GENE SILENCING; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN TISSUE; NONHUMAN; NUCLEOTIDE SEQUENCE; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CARCINOMA, SQUAMOUS CELL; DRUG EFFECTS; GENE EXPRESSION; GENETICS; METABOLISM; MOUTH NEOPLASMS; MUTATION; TISSUE MICROARRAY; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTINEOPLASTIC AGENTS; AUTOPHAGY; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MOUTH NEOPLASMS; MUTATION; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; QUINOXALINES; SULFONAMIDES; TISSUE ARRAY ANALYSIS; UBIQUITIN-ACTIVATING ENZYMES;

EID: 84897128733     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090171     Document Type: Article

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