High LC3 expression correlates with poor survival in patients with oral squamous cell carcinoma

Human Pathology

Volumn 44, Issue 11, 2013, Pages 2558-2562

  Tang, Jen Yang ^a,b   Hsi, Edward ^a   Huang, Ya Chun ^a   Hsu, Nicholas Chung Heng ^a   Chu, Pei Yi ^c,d   Chai, Chee Yin ^a,b,e  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^d St Martin De Porres Hospital   (Taiwan)

^e NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Autophagy; Immunohistochemistry; Microtubule associated protein light chains 3; Oral squamous cell carcinoma; Survival

Indexed keywords

CYTOPLASM PROTEIN; LIGHT CHAIN 3; MICROTUBULE ASSOCIATED PROTEIN; UNCLASSIFIED DRUG;

ALCOHOL CONSUMPTION; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER PROGNOSIS; CANCER STAGING; CELL ORGANELLE; DIAGNOSTIC TEST ACCURACY STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIGHT CHAIN; LYMPH NODE; MAJOR CLINICAL STUDY; MOUTH SQUAMOUS CELL CARCINOMA; PATHOGENESIS; PHYSIOLOGICAL PROCESS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SMOKING; TUMOR VOLUME;

AUTOPHAGY; IMMUNOHISTOCHEMISTRY; MICROTUBULE-ASSOCIATED PROTEIN LIGHT CHAINS 3; ORAL SQUAMOUS CELL CARCINOMA; SURVIVAL;

ADULT; AGED; AUTOPHAGY; CARCINOMA, SQUAMOUS CELL; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; MOUTH NEOPLASMS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 84885645533     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2013.06.017     Document Type: Article

References (27)

1. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, and D. Forman Global cancer statistics CA Cancer J Clin 61 2011 69 90
2. D.M. Parkin, F. Bray, J. Ferlay, and P. Pisani Global cancer statistics, 2002 CA Cancer J Clin 55 2005 74 108
3. S.H. Landis, T. Murray, S. Bolden, and P.A. Wingo Cancer statistics, 1999 CA Cancer J Clin 49 1999 8 31
4. N. Mizushima Autophagy: process and function Genes Dev 21 2007 2861 2873
5. B. Levine, and J. Yuan Autophagy in cell death: an innocent convict? J Clin Invest 115 2005 2679 2688
6. S.S. Mann, and J.A. Hammarback Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B J Biol Chem 269 1994 11492 11497
7. C. He, and D.J. Klionsky Regulation mechanisms and signaling pathways of autophagy Annu Rev Genet 43 2009 67 93
8. Y. Kabeya, N. Mizushima, and T. Ueno LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing EMBO J 19 2000 5720 5728
9. R. Mathew, V. Karantza-Wadsworth, and E. White Role of autophagy in cancer Nat Rev Cancer 7 2007 961 967
10. Z.J. Yang, C.E. Chee, S. Huang, and F.A. Sinicrope The role of autophagy in cancer: therapeutic implications Mol Cancer Ther 10 2011 1533 1541
11. S.B. Edge, D.R. Byrd, C.C. Compton, A.G. Fritz, F.L. Greene, and A. Trotti AJCC Cancer Staging Manual 7th ed. 2010 Springer New York 29 40
12. B. Levine, and D.J. Klionsky Development by self-digestion: molecular mechanisms and biological functions of autophagy Dev Cell 6 2004 463 477
13. T. Yorimitsu, and D.J. Klionsky Autophagy: molecular machinery for self-eating Cell Death Differ 12 Suppl 2 2005 1542 1552
14. Z. Yang, and D.J. Klionsky Mammalian autophagy: core molecular machinery and signaling regulation Curr Opin Cell Biol 22 2010 124 131
15. N. Mizushima, B. Levine, A.M. Cuervo, and D.J. Klionsky Autophagy fights disease through cellular self-digestion Nature 451 2008 1069 1075
16. B. Levine, N. Mizushima, and H.W. Virgin Autophagy in immunity and inflammation Nature 469 2011 323 335
17. K. Degenhardt, R. Mathew, and B. Beaudoin Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis Cancer Cell 10 2006 51 64
18. N.M. Mazure, and J. Pouyssegur Hypoxia-induced autophagy: cell death or cell survival? Curr Opin Cell Biol 22 2010 177 180
19. V. Karantza-Wadsworth, S. Patel, and O. Kravchuk Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis Genes Dev 21 2007 1621 1635
20. J.J. Lum, D.E. Bauer, and M. Kong Growth factor regulation of autophagy and cell survival in the absence of apoptosis Cell 120 2005 237 248
21. V.M. Aita, X.H. Liang, and V.V. Murty Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21 Genomics 59 1999 59 65
22. X.H. Liang, S. Jackson, and M. Seaman Induction of autophagy and inhibition of tumorigenesis by beclin 1 Nature 402 1999 672 676
23. H. Nomura, K. Uzawa, and Y. Yamano Overexpression and altered subcellular localization of autophagy-related 16-like 1 in human oral squamous-cell carcinoma: correlation with lymphovascular invasion and lymph-node metastasis Hum Pathol 40 2009 83 91
24. V. Kapoor, D. Paliwal, S. Baskar Singh, B.K. Mohanti, and S.N. Das Deregulation of Beclin 1 in patients with tobacco-related oral squamous cell carcinoma Biochem Biophys Res Commun 422 2012 764 769
25. Y. Kabeya, N. Mizushima, A. Yamamoto, S. Oshitani-Okamoto, Y. Ohsumi, and T. Yoshimori LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation J Cell Sci 117 2004 2805 2812
26. A. Yoshioka, H. Miyata, and Y. Doki LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers Int J Oncol 33 2008 461 468
27. S. Fujii, S. Mitsunaga, and M. Yamazaki Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome Cancer Sci 99 2008 1813 1819