Diarylquinoline compounds induce autophagy-associated cell death by inhibiting the Akt pathway and increasing reactive oxygen species in human nasopharyngeal carcinoma cells

Oncology Reports

Volumn 29, Issue 3, 2013, Pages 983-992

  Cai, Yuchen ^a   Wang, Zhihui ^b   Sun, Tiemin ^c   Shi, Yanxia ^a   Sun, Yueli ^a   Huang, Peiyu ^a   Li, Su ^a   Jiang, Wenqi ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anticancer; Autophagy; Caspase independent cell death; Diarylquinoline compounds

Indexed keywords

2 [BENZYL(METHYL)AMINO] N [(6 BROMO 2 HYDROXYQUINOLIN 3 YL)(PHENYL)METHYL] N PHENYLACETAMIDE; 2 BENZAMIDE 3 PHENYLPROPYL 2 (2 HYDROXYBENZAMIDO) 3 PHENYLPROPANOATE; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; CALCIUM; CASPASE; DIARYLQUINOLINE COMPOUND; GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN LIGHT CHAIN 3; MAMMALIAN TARGET OF RAPAMYCIN; N [(6 BROMO 2 HYDROXYQUINOLIN 3 YL)(PHENYL)METHYL] 3 (DIMETHYLAMINO) N (4 TOLYL)PROPANAMIDE; N [(6 BROMO 2 METHOXYQUINOLIN 3 YL)(PHENYL)METHYL] 3 (1H IMIDAZOL 1 YL) N PHENYLPROPANAMIDE; N [(6 BROMO 2 METHOXYQUINOLIN 3 YL)(PHENYL)METHYL] 3 MORPHOLINO N (4 TOLYL)PROPANAMIDE; N [(6 BROMO 2 METHOXYQUINOLIN 3 YL)(PHENYL)METHYL] 3 MORPHOLINO N PHENYLPROPANAMIDE; N [(6 BROMO 2 METHOXYQUINOLIN 3 YL)(PHENYL)METHYL] 4 CHLORO N [2 (DIMETHYLAMINO)ETHYL]BENZAMIDE; N [(6 BROMO 2 METHOXYQUINOLIN 3 YL)(PHENYL)METHYL] N (3,4 DICHLOROPHENYL) 3 (4 METHYLPIPERAZIN 1 YL)PROPANAMIDE; N [(6 BROMO 2 METHOXYQUINOLIN 3 YL)(PHENYL)METHYL] N (4 METHOXYPHENYL) 2 MORPHOLINOACETAMIDE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; STM 120; STM 143; STM 157; STM 35; STM 39; STM 57; STM 73; STM 91; STM 99; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; AUTOPHAGY; CALCIUM CELL LEVEL; CANCER CELL CULTURE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MITOCHONDRIAL MEMBRANE POTENTIAL; NASOPHARYNX CARCINOMA; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE, TUMOR; DIARYLQUINOLINES; DRUG SCREENING ASSAYS, ANTITUMOR; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; NASOPHARYNGEAL NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84872810600     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.2207     Document Type: Article

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