메뉴 건너뛰기




Volumn 7, Issue , 2016, Pages 313-333

Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health

Author keywords

Bile acid; Cholesterol; Microbiota; Obesity; Probiotic

Indexed keywords

CHOLESTEROL; DISEASES; ELECTROLYTES; METABOLISM; NUTRITION; PHYSIOLOGY;

EID: 84959882996     PISSN: 19411413     EISSN: 19411421     Source Type: Journal    
DOI: 10.1146/annurev-food-041715-033159     Document Type: Article
Times cited : (172)

References (132)
  • 1
    • 84892616561 scopus 로고    scopus 로고
    • Roux-en-Y gastric bypass normalizes the blunted postprandial bile acid excursion associated with obesity
    • Ahmad NN, Pfalzer A, Kaplan LM. 2013. Roux-en-Y gastric bypass normalizes the blunted postprandial bile acid excursion associated with obesity. Int. J. Obes. 37:1553-59
    • (2013) Int. J. Obes. , vol.37 , pp. 1553-1559
    • Ahmad, N.N.1    Pfalzer, A.2    Kaplan, L.M.3
  • 2
    • 29144515343 scopus 로고    scopus 로고
    • Taurine interaction with neurotransmitter receptors in the CNS: An update
    • Albrecht J, Schousboe A. 2005. Taurine interaction with neurotransmitter receptors in the CNS: an update. Neurochem. Res. 30:1615-21
    • (2005) Neurochem. Res. , vol.30 , pp. 1615-1621
    • Albrecht, J.1    Schousboe, A.2
  • 3
    • 34548572892 scopus 로고    scopus 로고
    • Bile acid transporters: Structure, function, regulation and pathophysiological implications
    • Alrefai WA, Gill RK. 2007. Bile acid transporters: structure, function, regulation and pathophysiological implications. Pharm. Res. 24:1803-23
    • (2007) Pharm. Res. , vol.24 , pp. 1803-1823
    • Alrefai, W.A.1    Gill, R.K.2
  • 4
    • 84937763587 scopus 로고    scopus 로고
    • Influence of dietary sugar on cholesterol and bile acid metabolism in the rat: Marked reduction of hepatic Abcg5/8 expression following sucrose ingestion
    • Apro J, Beckman L, Angelin B, Rudling M. 2015. Influence of dietary sugar on cholesterol and bile acid metabolism in the rat: marked reduction of hepatic Abcg5/8 expression following sucrose ingestion. Biochem. Biophys. Res. Commun. 461:592-97
    • (2015) Biochem. Biophys. Res. Commun. , vol.461 , pp. 592-597
    • Apro, J.1    Beckman, L.2    Angelin, B.3    Rudling, M.4
  • 5
    • 0033858348 scopus 로고    scopus 로고
    • Chloride secretion by the intestinal epithelium: Molecular basis and regulatory aspects
    • Barrett KE, Keely SJ. 2000. Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects. Annu. Rev. Physiol. 62:535-72
    • (2000) Annu. Rev. Physiol. , vol.62 , pp. 535-572
    • Barrett, K.E.1    Keely, S.J.2
  • 6
    • 31444438528 scopus 로고    scopus 로고
    • Metabolism: Bile acids heat things up
    • Baxter JD, Webb P. 2006. Metabolism: bile acids heat things up. Nature 439:402-3
    • (2006) Nature , vol.439 , pp. 402-403
    • Baxter, J.D.1    Webb, P.2
  • 9
    • 12844275386 scopus 로고    scopus 로고
    • Contribution of three bile-associated loci, bsh, pva, and btlB, to gastrointestinal persistence and bile tolerance of Listeria monocytogenes
    • Begley M, Sleator RD, Gahan CG, Hill C. 2005. Contribution of three bile-associated loci, bsh, pva, and btlB, to gastrointestinal persistence and bile tolerance of Listeria monocytogenes. Infect. Immun. 73:894-904
    • (2005) Infect. Immun. , vol.73 , pp. 894-904
    • Begley, M.1    Sleator, R.D.2    Gahan, C.G.3    Hill, C.4
  • 10
    • 84872139636 scopus 로고    scopus 로고
    • Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation
    • Bennett BJ, de Aguiar Vallim TQ, Wang Z, Shih DM, Meng Y, et al. 2013. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab. 17:49-60
    • (2013) Cell Metab. , vol.17 , pp. 49-60
    • Bennett, B.J.1    De Aguiar Vallim, T.Q.2    Wang, Z.3    Shih, D.M.4    Meng, Y.5
  • 12
    • 84934952812 scopus 로고    scopus 로고
    • Improvement in the expression of hepatic genes involved in fatty acid metabolism in obese rats supplemented with taurine
    • Bonfleur ML, Borck PC, Ribeiro RA, Caetano LC, Soares GM, et al. 2015. Improvement in the expression of hepatic genes involved in fatty acid metabolism in obese rats supplemented with taurine. Life Sci. 135:15-21
    • (2015) Life Sci. , vol.135 , pp. 15-21
    • Bonfleur, M.L.1    Borck, P.C.2    Ribeiro, R.A.3    Caetano, L.C.4    Soares, G.M.5
  • 13
    • 5044242948 scopus 로고    scopus 로고
    • Bariatric surgery: A systematic review and meta-analysis
    • Buchwald H, Avidor Y, Braunwald E, Jensen MD, PoriesW, et al. 2004. Bariatric surgery: a systematic review and meta-analysis. JAMA 292:1724-37
    • (2004) JAMA , vol.292 , pp. 1724-1737
    • Buchwald, H.1    Avidor, Y.2    Braunwald, E.3    Jensen, M.D.4    Pories, W.5
  • 14
    • 84925500413 scopus 로고    scopus 로고
    • Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
    • Buffie CG, Bucci V, Stein RR, McKenney PT, Ling L, et al. 2015. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature 517:205-8
    • (2015) Nature , vol.517 , pp. 205-208
    • Buffie, C.G.1    Bucci, V.2    Stein, R.R.3    McKenney, P.T.4    Ling, L.5
  • 15
    • 84912132591 scopus 로고    scopus 로고
    • Shaping macrophages function and innate immunity by bile acids: Mechanisms and implication in cholestatic liver diseases
    • Calmus Y, Poupon R. 2014. Shaping macrophages function and innate immunity by bile acids: mechanisms and implication in cholestatic liver diseases. Clin. Res. Hepatol. Gastroenterol. 38:550-56
    • (2014) Clin. Res. Hepatol. Gastroenterol. , vol.38 , pp. 550-556
    • Calmus, Y.1    Poupon, R.2
  • 16
    • 84928785228 scopus 로고    scopus 로고
    • Bile acid diarrhea: Prevalence, pathogenesis, and therapy
    • Camilleri M. 2015. Bile acid diarrhea: prevalence, pathogenesis, and therapy. Gut Liver 9:332-39
    • (2015) Gut Liver , vol.9 , pp. 332-339
    • Camilleri, M.1
  • 18
    • 70349430938 scopus 로고    scopus 로고
    • Bile acids: Regulation of synthesis
    • Chiang JY. 2009. Bile acids: regulation of synthesis. J. Lipid Res. 50:1955-66
    • (2009) J. Lipid Res. , vol.50 , pp. 1955-1966
    • Chiang, J.Y.1
  • 19
    • 84864722033 scopus 로고    scopus 로고
    • Gut microbiota composition correlates with diet and health in the elderly
    • Claesson MJ, Jeffery IB, Conde S, Power SE, O'Connor EM, et al. 2012. Gut microbiota composition correlates with diet and health in the elderly. Nature 488:178-84
    • (2012) Nature , vol.488 , pp. 178-184
    • Claesson, M.J.1    Jeffery, I.B.2    Conde, S.3    Power, S.E.4    O'Connor, E.M.5
  • 20
    • 84883057637 scopus 로고    scopus 로고
    • Dietary intervention impact on gutmicrobial gene richness
    • Cotillard A, Kennedy SP, Kong LC, Prifti E, Pons N, et al. 2013. Dietary intervention impact on gutmicrobial gene richness. Nature 500:585-88
    • (2013) Nature , vol.500 , pp. 585-588
    • Cotillard, A.1    Kennedy, S.P.2    Kong, L.C.3    Prifti, E.4    Pons, N.5
  • 21
    • 62949244071 scopus 로고    scopus 로고
    • Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium
    • D'Aldebert E, Biyeyeme Bi Mve MJ, Mergey M, Wendum D, Firrincieli D, et al. 2009. Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium. Gastroenterology 136:1435-43
    • (2009) Gastroenterology , vol.136 , pp. 1435-1443
    • D'Aldebert, E.1    Biyeyeme Bi Mve, M.J.2    Mergey, M.3    Wendum, D.4    Firrincieli, D.5
  • 24
    • 84898023722 scopus 로고    scopus 로고
    • Microbiotamodification with probiotics induces hepatic bile acid synthesis via downregulation of the Fxr-Fgf15 axis in mice
    • DegirolamoC, Rainaldi S, Bovenga F, Murzilli S, Moschetta A. 2014. Microbiotamodification with probiotics induces hepatic bile acid synthesis via downregulation of the Fxr-Fgf15 axis in mice. Cell Rep. 7:12-18
    • (2014) Cell Rep. , vol.7 , pp. 12-18
    • Degirolamo, C.1    Rainaldi, S.2    Bovenga, F.3    Murzilli, S.4    Moschetta, A.5
  • 25
    • 84869228196 scopus 로고    scopus 로고
    • Decreasedmucosal sulfide detoxification is related to an impaired butyrate oxidation in ulcerative colitis
    • De Preter V, Arijs I, Windey K, Vanhove W, Vermeire S, et al. 2012. Decreasedmucosal sulfide detoxification is related to an impaired butyrate oxidation in ulcerative colitis. Inflamm. Bowel Dis. 18:2371-80
    • (2012) Inflamm. Bowel Dis. , vol.18 , pp. 2371-2380
    • De Preter, V.1    Arijs, I.2    Windey, K.3    Vanhove, W.4    Vermeire, S.5
  • 26
    • 84863436944 scopus 로고    scopus 로고
    • Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10/ mice
    • Devkota S, Wang Y, Musch MW, Leone V, Fehlner-Peach H, et al. 2012. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10/ mice. Nature 487:104-8
    • (2012) Nature , vol.487 , pp. 104-108
    • Devkota, S.1    Wang, Y.2    Musch, M.W.3    Leone, V.4    Fehlner-Peach, H.5
  • 27
    • 84861201380 scopus 로고    scopus 로고
    • Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome
    • e246-47
    • Duboc H, Rainteau D, Rajca S, Humbert L, Farabos D, et al. 2012. Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome. Neurogastroenterol. Motil. 24:513-20, e246-47
    • (2012) Neurogastroenterol. Motil. , vol.24 , pp. 513-520
    • Duboc, H.1    Rainteau, D.2    Rajca, S.3    Humbert, L.4    Farabos, D.5
  • 28
    • 84874651768 scopus 로고    scopus 로고
    • Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases
    • Duboc H, Rajca S, Rainteau D, Benarous D, Maubert M-A, et al. 2013. Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases. Gut 62:531-39
    • (2013) Gut , vol.62 , pp. 531-539
    • Duboc, H.1    Rajca, S.2    Rainteau, D.3    Benarous, D.4    Maubert, M.-A.5
  • 29
    • 79955555959 scopus 로고    scopus 로고
    • Risk factors for parenteral nutrition-associated liver disease following surgical therapy for necrotizing enterocolitis: A Glaser Pediatric Research Network Study [corrected]
    • Duro D, Mitchell PD, Kalish LA, Martin C, McCarthy M, et al. 2011. Risk factors for parenteral nutrition-associated liver disease following surgical therapy for necrotizing enterocolitis: A Glaser Pediatric Research Network Study [corrected]. J. Pediatr. Gastroenterol. Nutr. 52:595-600
    • (2011) J. Pediatr. Gastroenterol. Nutr. , vol.52 , pp. 595-600
    • Duro, D.1    Mitchell, P.D.2    Kalish, L.A.3    Martin, C.4    McCarthy, M.5
  • 30
    • 0033958076 scopus 로고    scopus 로고
    • Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: A population-based study of African Americans
    • Evans RM, Emsley CL, Gao S, Sahota A, Hall KS, et al. 2000. Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: a population-based study of African Americans. Neurology 54:240-42
    • (2000) Neurology , vol.54 , pp. 240-242
    • Evans, R.M.1    Emsley, C.L.2    Gao, S.3    Sahota, A.4    Hall, K.S.5
  • 31
    • 0028108409 scopus 로고
    • Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA: Amino acid N-acyltransferase
    • Falany CN, Johnson MR, Barnes S, Diasio RB. 1994. Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. J. Biol. Chem. 269:19375-79
    • (1994) J. Biol. Chem. , vol.269 , pp. 19375-19379
    • Falany, C.N.1    Johnson, M.R.2    Barnes, S.3    Diasio, R.B.4
  • 32
    • 84925507991 scopus 로고    scopus 로고
    • Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
    • Fang S, Suh JM, Reilly SM, Yu E, Osborn O, et al. 2015. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat. Med. 21:159-65
    • (2015) Nat. Med. , vol.21 , pp. 159-165
    • Fang, S.1    Suh, J.M.2    Reilly, S.M.3    Yu, E.4    Osborn, O.5
  • 33
    • 79952535597 scopus 로고    scopus 로고
    • Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease
    • Gadaleta RM, van Erpecum KJ, Oldenburg B, Willemsen EC, RenooijW, et al. 2011. Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease. Gut 60:463-72
    • (2011) Gut , vol.60 , pp. 463-472
    • Gadaleta, R.M.1    Van Erpecum, K.J.2    Oldenburg, B.3    Willemsen, E.C.4    Renooij, W.5
  • 34
    • 78650799280 scopus 로고    scopus 로고
    • Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TORindependent manner, by modulating housekeeping longevity assurance processes
    • Goldberg AA, Richard VR, Kyryakov P, Bourque SD, Beach A, et al. 2010. Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TORindependent manner, by modulating housekeeping longevity assurance processes. Aging 2:393-414
    • (2010) Aging , vol.2 , pp. 393-414
    • Goldberg, A.A.1    Richard, V.R.2    Kyryakov, P.3    Bourque, S.D.4    Beach, A.5
  • 35
    • 33846078026 scopus 로고    scopus 로고
    • Relationship of dietary antimicrobial drug administration with broiler performance, decreased population levels of Lactobacillus salivarius, and reduced bile salt deconjugation in the ileum of broiler chickens
    • Guban J, Korver DR, Allison GE, Tannock GW. 2006. Relationship of dietary antimicrobial drug administration with broiler performance, decreased population levels of Lactobacillus salivarius, and reduced bile salt deconjugation in the ileum of broiler chickens. Poult. Sci. 85:2186-94
    • (2006) Poult. Sci. , vol.85 , pp. 2186-2194
    • Guban, J.1    Korver, D.R.2    Allison, G.E.3    Tannock, G.W.4
  • 36
    • 0022540676 scopus 로고
    • High serum bile acid level in obesity: Its decrease during and after total fasting
    • Halmy L, Feher T, Steczek K, Farkas A. 1986. High serum bile acid level in obesity: its decrease during and after total fasting. Acta Med. Hung. 43:55-58
    • (1986) Acta Med. Hung. , vol.43 , pp. 55-58
    • Halmy, L.1    Feher, T.2    Steczek, K.3    Farkas, A.4
  • 37
    • 30844436795 scopus 로고    scopus 로고
    • Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice
    • Hanniman EA, Lambert G, McCarthy TC, Sinal CJ. 2005. Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice. J. Lipid Res. 46:2595-604
    • (2005) J. Lipid Res. , vol.46 , pp. 2595-2604
    • Hanniman, E.A.1    Lambert, G.2    McCarthy, T.C.3    Sinal, C.J.4
  • 38
    • 84930589406 scopus 로고    scopus 로고
    • Relationship between obesity, gut microbiome and hepatocellular carcinoma development
    • Hara E. 2015. Relationship between obesity, gut microbiome and hepatocellular carcinoma development. Dig. Dis. 33:346-50
    • (2015) Dig. Dis. , vol.33 , pp. 346-350
    • Hara, E.1
  • 39
    • 84888798215 scopus 로고    scopus 로고
    • Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages
    • Haselow K, Bode JG, Wammers M, Ehlting C, Keitel V, et al. 2013. Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages. J. Leukoc. Biol. 94:1253-64
    • (2013) J. Leukoc. Biol. , vol.94 , pp. 1253-1264
    • Haselow, K.1    Bode, J.G.2    Wammers, M.3    Ehlting, C.4    Keitel, V.5
  • 40
    • 84959870498 scopus 로고    scopus 로고
    • Glycine receptor diversity in the mammalian retina
    • ed. H Kolb, E Fernandez, R Nelson. Salt Lake City, UT: Univ. Utah Health Sci. Cent
    • Haverkamp S. 2012. Glycine receptor diversity in the mammalian retina. In Webvision: The Organization of the Retina and Visual System, ed. H Kolb, E Fernandez, R Nelson. Salt Lake City, UT: Univ. Utah Health Sci. Cent.
    • (2012) Webvision: The Organization of the Retina and Visual System
    • Haverkamp, S.1
  • 41
    • 33645230000 scopus 로고    scopus 로고
    • How bile acids confer gut mucosal protection against bacteria
    • Hofmann AF, Eckmann L. 2006. How bile acids confer gut mucosal protection against bacteria. PNAS 103:4333-34
    • (2006) PNAS , vol.103 , pp. 4333-4334
    • Hofmann, A.F.1    Eckmann, L.2
  • 42
    • 84860253913 scopus 로고    scopus 로고
    • Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway
    • Ichikawa R, Takayama T, Yoneno K, Kamada N, Kitazume MT, et al. 2012. Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway. Immunology 136:153-62
    • (2012) Immunology , vol.136 , pp. 153-162
    • Ichikawa, R.1    Takayama, T.2    Yoneno, K.3    Kamada, N.4    Kitazume, M.T.5
  • 43
    • 84895903440 scopus 로고    scopus 로고
    • Potential role of taurine in the prevention of diabetes and metabolic syndrome
    • Imae M, Asano T, Murakami S. 2014. Potential role of taurine in the prevention of diabetes and metabolic syndrome. Amino Acids 46:81-88
    • (2014) Amino Acids , vol.46 , pp. 81-88
    • Imae, M.1    Asano, T.2    Murakami, S.3
  • 44
    • 33644867569 scopus 로고    scopus 로고
    • Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
    • Inagaki T, Moschetta A, Lee YK, Peng L, Zhao G, et al. 2006. Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. PNAS 103:3920-25
    • (2006) PNAS , vol.103 , pp. 3920-3925
    • Inagaki, T.1    Moschetta, A.2    Lee, Y.K.3    Peng, L.4    Zhao, G.5
  • 45
    • 80054862011 scopus 로고    scopus 로고
    • Bile acid is a host factor that regulates the composition of the cecal microbiota in rats
    • Islam KB, Fukiya S, Hagio M, Fujii N, Ishizuka S, et al. 2011. Bile acid is a host factor that regulates the composition of the cecal microbiota in rats. Gastroenterology 141:1773-81
    • (2011) Gastroenterology , vol.141 , pp. 1773-1781
    • Islam, K.B.1    Fukiya, S.2    Hagio, M.3    Fujii, N.4    Ishizuka, S.5
  • 46
    • 36348994975 scopus 로고    scopus 로고
    • Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: A population-based cohort study
    • JacksonH, Solaymani-DodaranM, Card TR, Aithal GP, Logan R, West J. 2007. Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: a population-based cohort study. Hepatology 46:1131-37
    • (2007) Hepatology , vol.46 , pp. 1131-1137
    • Jackson, H.1    Solaymani-Dodaran, M.2    Card, T.R.3    Aithal, G.P.4    Logan, R.5    West, J.6
  • 47
    • 51649086648 scopus 로고    scopus 로고
    • Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome
    • Jones BV, Begley M, Hill C, GahanCG, Marchesi JR. 2008. Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. PNAS 105:13580-85
    • (2008) PNAS , vol.105 , pp. 13580-13585
    • Jones, B.V.1    Begley, M.2    Hill, C.3    Gahan, C.G.4    Marchesi, J.R.5
  • 48
    • 84874911481 scopus 로고    scopus 로고
    • Cholesterol lowering with bile salt hydrolase-active probiotic bacteria, mechanism of action, clinical evidence, and future direction for heart health applications
    • Jones ML, Tomaro-Duchesneau C, Martoni CJ, Prakash S. 2013. Cholesterol lowering with bile salt hydrolase-active probiotic bacteria, mechanism of action, clinical evidence, and future direction for heart health applications. Expert Opin. Biol. Ther. 13:631-42
    • (2013) Expert Opin. Biol. Ther. , vol.13 , pp. 631-642
    • Jones, M.L.1    Tomaro-Duchesneau, C.2    Martoni, C.J.3    Prakash, S.4
  • 49
    • 84894049857 scopus 로고    scopus 로고
    • The gut microbiota and themetabolic health of the host
    • Joyce SA, GahanCG. 2014. The gut microbiota and themetabolic health of the host. Curr. Opin. Gastroenterol. 30:120-27
    • (2014) Curr. Opin. Gastroenterol. , vol.30 , pp. 120-127
    • Joyce, S.A.1    Gahan, C.G.2
  • 50
    • 84901020405 scopus 로고    scopus 로고
    • Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut
    • Joyce SA, MacSharry J, Casey PG, Kinsella M, Murphy EF, et al. 2014a. Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. PNAS 111:7421-26
    • (2014) PNAS , vol.111 , pp. 7421-7426
    • Joyce, S.A.1    MacSharry, J.2    Casey, P.G.3    Kinsella, M.4    Murphy, E.F.5
  • 51
    • 84922021716 scopus 로고    scopus 로고
    • Bacterial bile salt hydrolase in host metabolism: Potential for influencing gastrointestinal microbe-host crosstalk
    • Joyce SA, Shanahan F, Hill C, Gahan CG. 2014b. Bacterial bile salt hydrolase in host metabolism: potential for influencing gastrointestinal microbe-host crosstalk. Gut Microbes 5:669-74
    • (2014) Gut Microbes , vol.5 , pp. 669-674
    • Joyce, S.A.1    Shanahan, F.2    Hill, C.3    Gahan, C.G.4
  • 52
    • 84902355023 scopus 로고    scopus 로고
    • Integrated physiology and systems biology of PPAR
    • Kersten S. 2014. Integrated physiology and systems biology of PPAR. Mol. Metab. 3:354-71
    • (2014) Mol. Metab. , vol.3 , pp. 354-371
    • Kersten, S.1
  • 53
    • 84877331372 scopus 로고    scopus 로고
    • Intestinal microbiotametabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
    • Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, et al. 2013. Intestinal microbiotametabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat. Med. 19:576-85
    • (2013) Nat. Med. , vol.19 , pp. 576-585
    • Koeth, R.A.1    Wang, Z.2    Levison, B.S.3    Buffa, J.A.4    Org, E.5
  • 54
    • 0034910937 scopus 로고    scopus 로고
    • Tauroursodesoxycholate-induced choleresis involves p38 (MAPK) activation and translocation of the bile salt export pump in rats
    • Kurz AK, Graf D, Schmitt M, Vom Dahl S, Haussinger D. 2001. Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats. Gastroenterology 121:407-19
    • (2001) Gastroenterology , vol.121 , pp. 407-419
    • Kurz, A.K.1    Graf, D.2    Schmitt, M.3    Vom Dahl, S.4    Haussinger, D.5
  • 55
    • 84883110880 scopus 로고    scopus 로고
    • Richness of human gut microbiome correlates with metabolic markers
    • Le Chatelier E, Nielsen T, Qin J, Prifti E, Hildebrand F, et al. 2013. Richness of human gut microbiome correlates with metabolic markers. Nature 500:541-46
    • (2013) Nature , vol.500 , pp. 541-546
    • Le Chatelier, E.1    Nielsen, T.2    Qin, J.3    Prifti, E.4    Hildebrand, F.5
  • 56
    • 84887960056 scopus 로고    scopus 로고
    • Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
    • Li F, Jiang C, Krausz KW, Li Y, Albert I, et al. 2013. Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity. Nat. Commun. 4:2384
    • (2013) Nat. Commun. , vol.4 , pp. 2384
    • Li, F.1    Jiang, C.2    Krausz, K.W.3    Li, Y.4    Albert, I.5
  • 57
    • 84905257719 scopus 로고    scopus 로고
    • Bile acid signaling in metabolic disease and drug therapy
    • Li T, Chiang JY. 2014. Bile acid signaling in metabolic disease and drug therapy. Pharmacol. Rev. 66:948-83
    • (2014) Pharmacol. Rev. , vol.66 , pp. 948-983
    • Li, T.1    Chiang, J.Y.2
  • 58
    • 84937207192 scopus 로고    scopus 로고
    • Ursodeoxycholic acid effectively kills drug-resistant gastric cancer cells through induction of autophagic death
    • Lim SC, Han SI. 2015. Ursodeoxycholic acid effectively kills drug-resistant gastric cancer cells through induction of autophagic death. Oncol. Rep. 34:1261-68
    • (2015) Oncol. Rep. , vol.34 , pp. 1261-1268
    • Lim, S.C.1    Han, S.I.2
  • 59
    • 84897589789 scopus 로고    scopus 로고
    • Antibiotic growth promoters enhance animal production by targeting intestinal bile salt hydrolase and its producers
    • Lin J. 2014. Antibiotic growth promoters enhance animal production by targeting intestinal bile salt hydrolase and its producers. Front. Microbiol. 5:33
    • (2014) Front. Microbiol. , vol.5 , pp. 33
    • Lin, J.1
  • 60
    • 84959871036 scopus 로고    scopus 로고
    • Effect of bile salt hydrolase inhibitors on a bile salt hydrolase from Lactobacillus acidophilus
    • Lin J, Negga R, Zeng X, Smith K. 2014. Effect of bile salt hydrolase inhibitors on a bile salt hydrolase from Lactobacillus acidophilus. Pathogens 3:947-56
    • (2014) Pathogens , vol.3 , pp. 947-956
    • Lin, J.1    Negga, R.2    Zeng, X.3    Smith, K.4
  • 62
    • 84860225393 scopus 로고    scopus 로고
    • Cytochrome P450s in the synthesis of cholesterol and bile acids- from mouse models to human diseases
    • Lorbek G, Lewinska M, Rozman D. 2012. Cytochrome P450s in the synthesis of cholesterol and bile acids- from mouse models to human diseases. FEBS J. 279:1516-33
    • (2012) FEBS J. , vol.279 , pp. 1516-1533
    • Lorbek, G.1    Lewinska, M.2    Rozman, D.3
  • 63
    • 0038265008 scopus 로고    scopus 로고
    • Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
    • Lund EG, Xie C, Kotti T, Turley SD, Dietschy JM, Russell DW. 2003. Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J. Biol. Chem. 278:22980-88
    • (2003) J. Biol. Chem. , vol.278 , pp. 22980-22988
    • Lund, E.G.1    Xie, C.2    Kotti, T.3    Turley, S.D.4    Dietschy, J.M.5    Russell, D.W.6
  • 64
    • 84922726981 scopus 로고    scopus 로고
    • A nontumorigenic variant of FGF19 treats cholestatic liver diseases
    • Luo J, Ko B, Elliott M, Zhou M, Lindhout DA, et al. 2014. A nontumorigenic variant of FGF19 treats cholestatic liver diseases. Sci. Transl. Med. 6:247ra100
    • (2014) Sci. Transl. Med. , vol.6 , pp. 247ra100
    • Luo, J.1    Ko, B.2    Elliott, M.3    Zhou, M.4    Lindhout, D.A.5
  • 65
    • 33645509321 scopus 로고    scopus 로고
    • Farnesoid X receptor is essential for normal glucose homeostasis
    • Ma K, Saha PK, Chan L, Moore DD. 2006. Farnesoid X receptor is essential for normal glucose homeostasis. J. Clin. Investig. 116:1102-9
    • (2006) J. Clin. Investig. , vol.116 , pp. 1102-1109
    • Ma, K.1    Saha, P.K.2    Chan, L.3    Moore, D.D.4
  • 67
    • 1242297067 scopus 로고    scopus 로고
    • Presence of protein-bound unconjugated bile acids in the cytoplasmic fraction of rat brain
    • Mano N, Goto T, Uchida M, Nishimura K, Ando M, et al. 2004. Presence of protein-bound unconjugated bile acids in the cytoplasmic fraction of rat brain. J. Lipid Res. 45:295-300
    • (2004) J. Lipid Res. , vol.45 , pp. 295-300
    • Mano, N.1    Goto, T.2    Uchida, M.3    Nishimura, K.4    Ando, M.5
  • 71
    • 77952674868 scopus 로고    scopus 로고
    • The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis
    • Mencarelli A, Renga B, Migliorati M, Cipriani S, Distrutti E, et al. 2009. The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis. J. Immunol. 183:6657-66
    • (2009) J. Immunol. , vol.183 , pp. 6657-6666
    • Mencarelli, A.1    Renga, B.2    Migliorati, M.3    Cipriani, S.4    Distrutti, E.5
  • 72
    • 84896318206 scopus 로고    scopus 로고
    • Can medical therapy mimic the clinical efficacy or physiological effects of bariatric surgery
    • Miras AD, le Roux CW. 2014. Can medical therapy mimic the clinical efficacy or physiological effects of bariatric surgery? Int. J. Obes. 38:325-33
    • (2014) Int. J. Obes. , vol.38 , pp. 325-333
    • Miras, A.D.1    Le Roux, C.W.2
  • 73
    • 73349101418 scopus 로고    scopus 로고
    • Administration of ampicillin elevates hepatic primary bile acid synthesis through suppression of ileal fibroblast growth factor 15 expression
    • Miyata M, Takamatsu Y, Kuribayashi H, Yamazoe Y. 2009. Administration of ampicillin elevates hepatic primary bile acid synthesis through suppression of ileal fibroblast growth factor 15 expression. J. Pharmacol. Exp. Ther. 331:1079-85
    • (2009) J. Pharmacol. Exp. Ther. , vol.331 , pp. 1079-1085
    • Miyata, M.1    Takamatsu, Y.2    Kuribayashi, H.3    Yamazoe, Y.4
  • 75
    • 84898011280 scopus 로고    scopus 로고
    • Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo
    • Mroz MS, Keating N, Ward JB, Sarker R, Amu S, et al. 2014. Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo. Gut 63:808-17
    • (2014) Gut , vol.63 , pp. 808-817
    • Mroz, M.S.1    Keating, N.2    Ward, J.B.3    Sarker, R.4    Amu, S.5
  • 76
    • 84880664792 scopus 로고    scopus 로고
    • Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
    • Mudaliar S, Henry RR, Sanyal AJ, Morrow L, Marschall HU, et al. 2013. Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology 145:574-82. E1
    • (2013) Gastroenterology , vol.145 , pp. 574-82e1
    • Mudaliar, S.1    Henry, R.R.2    Sanyal, A.J.3    Morrow, L.4    Marschall, H.U.5
  • 77
  • 78
    • 84898038511 scopus 로고    scopus 로고
    • Beyond weight loss: Evaluating the multiple benefits of bariatric surgery after Roux-en-Y gastric bypass and adjustable gastric band
    • Neff KJ, Chuah LL, Aasheim ET, Jackson S, Dubb SS, et al. 2014. Beyond weight loss: evaluating the multiple benefits of bariatric surgery after Roux-en-Y gastric bypass and adjustable gastric band. Obes. Surg. 24:684-91
    • (2014) Obes. Surg. , vol.24 , pp. 684-691
    • Neff, K.J.1    Chuah, L.L.2    Aasheim, E.T.3    Jackson, S.4    Dubb, S.S.5
  • 79
    • 84867007455 scopus 로고    scopus 로고
    • Dysbiosis modulates capacity for bile acid modification in the gut microbiomes of patients with inflammatory bowel disease: A mechanism and marker of disease
    • Ogilvie LA, Jones BV. 2012. Dysbiosis modulates capacity for bile acid modification in the gut microbiomes of patients with inflammatory bowel disease: a mechanism and marker of disease? Gut 61:1642-43
    • (2012) Gut , vol.61 , pp. 1642-1643
    • Ogilvie, L.A.1    Jones, B.V.2
  • 80
    • 0030843430 scopus 로고    scopus 로고
    • Disorder of bile acid metabolism in children with short bowel syndrome
    • Ohkohchi N, Andoh T, Izumi U, Igarashi Y, Ohi R. 1997. Disorder of bile acid metabolism in children with short bowel syndrome. J. Gastroenterol. 32:472-79
    • (1997) J. Gastroenterol. , vol.32 , pp. 472-479
    • Ohkohchi, N.1    Andoh, T.2    Izumi, U.3    Igarashi, Y.4    Ohi, R.5
  • 82
    • 84929606430 scopus 로고    scopus 로고
    • Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease
    • Pereira-Fantini PM, Lapthorne S, Joyce SA, Dellios NL, Wilson G, et al. 2014. Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease. J. Hepatol. 61:1115-25
    • (2014) J. Hepatol. , vol.61 , pp. 1115-1125
    • Pereira-Fantini, P.M.1    Lapthorne, S.2    Joyce, S.A.3    Dellios, N.L.4    Wilson, G.5
  • 83
    • 0037315190 scopus 로고    scopus 로고
    • Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor
    • Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, Staels B. 2003. Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor. Mol. Endocrinol. 17:259-72
    • (2003) Mol. Endocrinol. , vol.17 , pp. 259-272
    • Pineda Torra, I.1    Claudel, T.2    Duval, C.3    Kosykh, V.4    Fruchart, J.C.5    Staels, B.6
  • 84
    • 79960838523 scopus 로고    scopus 로고
    • FarnesoidXreceptor deficiency improves glucose homeostasis in mouse models of obesity
    • Prawitt J, Abdelkarim M, Stroeve JH, Popescu I, DuezH, et al. 2011. FarnesoidXreceptor deficiency improves glucose homeostasis in mouse models of obesity. Diabetes 60:1861-71
    • (2011) Diabetes , vol.60 , pp. 1861-1871
    • Prawitt, J.1    Abdelkarim, M.2    Stroeve, J.H.3    Popescu, I.4    Duez, H.5
  • 85
    • 84934766054 scopus 로고    scopus 로고
    • Plasma bile acids show a positive correlation with body mass index and are negatively associated with cognitive restraint of eating in obese patients
    • Prinz P, Hofmann T, Ahnis A, Elbelt U, Goebel-Stengel M, et al. 2015. Plasma bile acids show a positive correlation with body mass index and are negatively associated with cognitive restraint of eating in obese patients. Front. Neurosci. 9:199
    • (2015) Front. Neurosci. , vol.9 , pp. 199
    • Prinz, P.1    Hofmann, T.2    Ahnis, A.3    Elbelt, U.4    Goebel-Stengel, M.5
  • 86
    • 84902537307 scopus 로고    scopus 로고
    • Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms
    • Quinn M, McMillin M, Galindo C, Frampton G, Pae HY, DeMorrow S. 2014. Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms. Dig. Liver Dis. 46:527-34
    • (2014) Dig. Liver Dis. , vol.46 , pp. 527-534
    • Quinn, M.1    McMillin, M.2    Galindo, C.3    Frampton, G.4    Pae, H.Y.5    DeMorrow, S.6
  • 87
    • 84883478660 scopus 로고    scopus 로고
    • Gut microbiota from twins discordant for obesity modulate metabolism in mice
    • Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, et al. 2013. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341:1241214
    • (2013) Science , vol.341 , pp. 1241214
    • Ridaura, V.K.1    Faith, J.J.2    Rey, F.E.3    Cheng, J.4    Duncan, A.E.5
  • 88
    • 84883442887 scopus 로고    scopus 로고
    • Cirrhosis, bile acids and gut microbiota: Unraveling a complex relationship
    • Ridlon JM, Alves JM, Hylemon PB, Bajaj JS. 2013. Cirrhosis, bile acids and gut microbiota: unraveling a complex relationship. Gut Microbes 4:382-87
    • (2013) Gut Microbes , vol.4 , pp. 382-387
    • Ridlon, J.M.1    Alves, J.M.2    Hylemon, P.B.3    Bajaj, J.S.4
  • 89
    • 84455192400 scopus 로고    scopus 로고
    • Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7-dehydroxylating intestinal bacterium
    • Ridlon JM, Hylemon PB. 2012. Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7-dehydroxylating intestinal bacterium. J. Lipid Res. 53:66-76
    • (2012) J. Lipid Res. , vol.53 , pp. 66-76
    • Ridlon, J.M.1    Hylemon, P.B.2
  • 90
    • 33244467651 scopus 로고    scopus 로고
    • Bile salt biotransformations by human intestinal bacteria
    • Ridlon JM, Kang DJ, Hylemon PB. 2006. Bile salt biotransformations by human intestinal bacteria. J. Lipid Res. 47:241-59
    • (2006) J. Lipid Res. , vol.47 , pp. 241-259
    • Ridlon, J.M.1    Kang, D.J.2    Hylemon, P.B.3
  • 92
    • 84870002886 scopus 로고    scopus 로고
    • Review: Taurine: a "very essential" amino acid
    • Ripps H, ShenW. 2012. Review: taurine: a "very essential" amino acid. Mol. Vis. 18:2673-86
    • (2012) Mol. Vis. , vol.18 , pp. 2673-2686
    • Ripps, H.1    Shen, W.2
  • 94
    • 84873342775 scopus 로고    scopus 로고
    • Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-muricholic acid, a naturally occurring FXR antagonist
    • Sayin SI, Wahlstrom A, Felin J, Jantti S, Marschall HU, et al. 2013. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 17:225-35
    • (2013) Cell Metab. , vol.17 , pp. 225-235
    • Sayin, S.I.1    Wahlstrom, A.2    Felin, J.3    Jantti, S.4    Marschall, H.U.5
  • 96
    • 84860136615 scopus 로고    scopus 로고
    • Bariatric surgery versus intensive medical therapy in obese patients with diabetes
    • Schauer PR, Kashyap SR, Wolski K, Brethauer SA, Kirwan JP, et al. 2012. Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N. Engl. J. Med. 366:1567-76
    • (2012) N. Engl. J. Med. , vol.366 , pp. 1567-1576
    • Schauer, P.R.1    Kashyap, S.R.2    Wolski, K.3    Brethauer, S.A.4    Kirwan, J.P.5
  • 97
    • 84916884469 scopus 로고    scopus 로고
    • Bacteria from diverse habitats colonize and compete in the mouse gut
    • Seedorf H, Griffin NW, Ridaura VK, Reyes A, Cheng J, et al. 2014. Bacteria from diverse habitats colonize and compete in the mouse gut. Cell 159:253-66
    • (2014) Cell , vol.159 , pp. 253-266
    • Seedorf, H.1    Griffin, N.W.2    Ridaura, V.K.3    Reyes, A.4    Cheng, J.5
  • 98
    • 84924594572 scopus 로고    scopus 로고
    • The role of gut adaptation in the potent effects of multiple bariatric surgeries on obesity and diabetes
    • Seeley RJ, Chambers AP, Sandoval DA. 2015. The role of gut adaptation in the potent effects of multiple bariatric surgeries on obesity and diabetes. Cell Metab. 21:369-78
    • (2015) Cell Metab. , vol.21 , pp. 369-378
    • Seeley, R.J.1    Chambers, A.P.2    Sandoval, D.A.3
  • 99
    • 84872382364 scopus 로고    scopus 로고
    • Alzheimer's disease, cholesterol, and statins: The junctions of important metabolic pathways
    • Silva T, Teixeira J, Remiao F, Borges F. 2013. Alzheimer's disease, cholesterol, and statins: the junctions of important metabolic pathways. Angew. Chem. Int. Ed. Engl. 52:1110-21
    • (2013) Angew. Chem. Int. Ed. Engl. , vol.52 , pp. 1110-1121
    • Silva, T.1    Teixeira, J.2    Remiao, F.3    Borges, F.4
  • 100
    • 67649344115 scopus 로고    scopus 로고
    • Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): A prospective, controlled intervention trial
    • Sjostrom L, Gummesson A, Sjostrom CD, Narbro K, Peltonen M, et al. 2009. Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial. Lancet Oncol. 10:653-62
    • (2009) Lancet Oncol. , vol.10 , pp. 653-662
    • Sjostrom, L.1    Gummesson, A.2    Sjostrom, C.D.3    Narbro, K.4    Peltonen, M.5
  • 103
    • 84897621880 scopus 로고    scopus 로고
    • Discovery of bile salt hydrolase inhibitors using an efficient high-throughput screening system
    • Smith K, Zeng X, Lin J. 2014. Discovery of bile salt hydrolase inhibitors using an efficient high-throughput screening system. PLOS ONE 9:e85344
    • (2014) PLOS ONE , vol.9 , pp. e85344
    • Smith, K.1    Zeng, X.2    Lin, J.3
  • 104
    • 41549142775 scopus 로고    scopus 로고
    • Bile salts and glycine as cogerminants for Clostridium difficile spores
    • Sorg JA, Sonenshein AL. 2008. Bile salts and glycine as cogerminants for Clostridium difficile spores. J. Bacteriol. 190:2505-12
    • (2008) J. Bacteriol. , vol.190 , pp. 2505-2512
    • Sorg, J.A.1    Sonenshein, A.L.2
  • 105
    • 79952749979 scopus 로고    scopus 로고
    • Systemic gut microbial modulation of bile acid metabolism in host tissue compartments
    • Swann JR, Want EJ, Geier FM, Spagou K, Wilson ID, et al. 2011. Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. PNAS 108(Suppl. 1):4523-30
    • (2011) PNAS , vol.108 , pp. 4523-4530
    • Swann, J.R.1    Want, E.J.2    Geier, F.M.3    Spagou, K.4    Wilson, I.D.5
  • 106
    • 84910003335 scopus 로고    scopus 로고
    • Metabolic surgery: Action via hormonal milieu changes, changes in bile acids or gut microbiota A summary of the literature
    • Sweeney TE, Morton JM. 2014. Metabolic surgery: action via hormonal milieu changes, changes in bile acids or gut microbiota A summary of the literature. Best Pract. Res. Clin. Gastroenterol. 28:727-40
    • (2014) Best Pract. Res. Clin. Gastroenterol. , vol.28 , pp. 727-740
    • Sweeney, T.E.1    Morton, J.M.2
  • 107
    • 84876563088 scopus 로고    scopus 로고
    • Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
    • Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, et al. 2013. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N. Engl. J. Med. 368:1575-84
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1575-1584
    • Tang, W.H.1    Wang, Z.2    Levison, B.S.3    Koeth, R.A.4    Britt, E.B.5
  • 108
    • 84908302963 scopus 로고    scopus 로고
    • Transkingdom control ofmicrobiota diurnal oscillations promotes metabolic homeostasis
    • Thaiss CA, Zeevi D, Levy M, Zilberman-Schapira G, Suez J, et al. 2014. Transkingdom control ofmicrobiota diurnal oscillations promotes metabolic homeostasis. Cell 159:514-29
    • (2014) Cell , vol.159 , pp. 514-529
    • Thaiss, C.A.1    Zeevi, D.2    Levy, M.3    Zilberman-Schapira, G.4    Suez, J.5
  • 110
    • 78349287022 scopus 로고    scopus 로고
    • Diet and age interactions with regards to cholesterol regulation and brain pathogenesis
    • Uranga RM, Keller JN. 2010. Diet and age interactions with regards to cholesterol regulation and brain pathogenesis. Curr. Gerontol. Geriatr. Res. 2010:219683
    • (2010) Curr. Gerontol. Geriatr. Res. , vol.2010 , pp. 219683
    • Uranga, R.M.1    Keller, J.N.2
  • 111
    • 84905172448 scopus 로고    scopus 로고
    • The unexpected uses of urso-and tauroursodeoxycholic acid in the treatment of non-liver diseases
    • Vang S, Longley K, Steer CJ, Low WC. 2014. The unexpected uses of urso-and tauroursodeoxycholic acid in the treatment of non-liver diseases. Glob. Adv. Health Med. 3:58-69
    • (2014) Glob. Adv. Health Med. , vol.3 , pp. 58-69
    • Vang, S.1    Longley, K.2    Steer, C.J.3    Low, W.C.4
  • 112
    • 84884703484 scopus 로고    scopus 로고
    • Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition
    • Vaquero J, Monte MJ, Dominguez M, Muntane J, Marin JJ. 2013. Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition. Biochem. Pharmacol. 86:926-39
    • (2013) Biochem. Pharmacol. , vol.86 , pp. 926-939
    • Vaquero, J.1    Monte, M.J.2    Dominguez, M.3    Muntane, J.4    Marin, J.J.5
  • 114
    • 84896401262 scopus 로고    scopus 로고
    • Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity
    • Vrieze A, Out C, Fuentes S, Jonker L, Reuling I, et al. 2014. Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity. J. Hepatol. 60:824-31
    • (2014) J. Hepatol. , vol.60 , pp. 824-831
    • Vrieze, A.1    Out, C.2    Fuentes, S.3    Jonker, L.4    Reuling, I.5
  • 115
    • 85015488360 scopus 로고    scopus 로고
    • A variant of FGF19 for treatment of disorders of cholestasis and bile acid metabolism
    • Walters JR, Appleby RN. 2015. A variant of FGF19 for treatment of disorders of cholestasis and bile acid metabolism. Ann. Transl. Med. 3:S7
    • (2015) Ann. Transl. Med. , vol.3 , pp. S7
    • Walters, J.R.1    Appleby, R.N.2
  • 119
    • 79953733693 scopus 로고    scopus 로고
    • Gut florametabolism of phosphatidylcholine promotes cardiovascular disease
    • Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, et al. 2011. Gut florametabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472:57-63
    • (2011) Nature , vol.472 , pp. 57-63
    • Wang, Z.1    Klipfell, E.2    Bennett, B.J.3    Koeth, R.4    Levison, B.S.5
  • 120
    • 84880136128 scopus 로고    scopus 로고
    • The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon
    • Ward JB, Mroz MS, Keely SJ. 2013. The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon. Neurogastroenterol. Motil. 25:708-11
    • (2013) Neurogastroenterol. Motil. , vol.25 , pp. 708-711
    • Ward, J.B.1    Mroz, M.S.2    Keely, S.J.3
  • 121
    • 79960695556 scopus 로고    scopus 로고
    • Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure
    • Watanabe M, Horai Y, Houten SM, Morimoto K, Sugizaki T, et al. 2011. Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. J. Biol. Chem. 286:26913-20
    • (2011) J. Biol. Chem. , vol.286 , pp. 26913-26920
    • Watanabe, M.1    Horai, Y.2    Houten, S.M.3    Morimoto, K.4    Sugizaki, T.5
  • 122
    • 31444454037 scopus 로고    scopus 로고
    • Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
    • Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, et al. 2006. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439:484-89
    • (2006) Nature , vol.439 , pp. 484-489
    • Watanabe, M.1    Houten, S.M.2    Mataki, C.3    Christoffolete, M.A.4    Kim, B.W.5
  • 123
    • 69949136438 scopus 로고    scopus 로고
    • Systematic review: The prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoeapredominant irritable bowel syndrome
    • Wedlake L, A'Hern R, Russell D, Thomas K, Walters JR, Andreyev HJ. 2009. Systematic review: the prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoeapredominant irritable bowel syndrome. Aliment. Pharmacol. Ther. 30:707-17
    • (2009) Aliment. Pharmacol. Ther. , vol.30 , pp. 707-717
    • Wedlake, L.1    A'Hern, R.2    Russell, D.3    Thomas, K.4    Walters, J.R.5    Andreyev, H.J.6
  • 124
    • 84898455521 scopus 로고    scopus 로고
    • Fasting serum taurine-conjugated bile acids are elevated in type 2 diabetes and do not change with intensification of insulin
    • Wewalka M, Patti M-E, Barbato C, Houten SM, Goldfine AB. 2014. Fasting serum taurine-conjugated bile acids are elevated in type 2 diabetes and do not change with intensification of insulin. J. Clin. Endocrinol. Metab. 99:1442-51
    • (2014) J. Clin. Endocrinol. Metab. , vol.99 , pp. 1442-1451
    • Wewalka, M.1    Patti, M.-E.2    Barbato, C.3    Houten, S.M.4    Goldfine, A.B.5
  • 126
    • 84883395327 scopus 로고    scopus 로고
    • Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption
    • Xie G, Zhong W, Li H, Li Q, Qiu Y, et al. 2013. Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption. FASEB J. 27:3583-93
    • (2013) FASEB J. , vol.27 , pp. 3583-3593
    • Xie, G.1    Zhong, W.2    Li, H.3    Li, Q.4    Qiu, Y.5
  • 127
    • 84879888338 scopus 로고    scopus 로고
    • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    • Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, et al. 2013. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 499:97-101
    • (2013) Nature , vol.499 , pp. 97-101
    • Yoshimoto, S.1    Loo, T.M.2    Atarashi, K.3    Kanda, H.4    Sato, S.5
  • 128
    • 67649210759 scopus 로고    scopus 로고
    • Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis
    • Zhang S, Wang J, Liu Q, Harnish DC. 2009. Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis. J. Hepatol. 51:380-88
    • (2009) J. Hepatol. , vol.51 , pp. 380-388
    • Zhang, S.1    Wang, J.2    Liu, Q.3    Harnish, D.C.4
  • 129
    • 32244447570 scopus 로고    scopus 로고
    • Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
    • Zhang Y, Lee FY, Barrera G, Lee H, Vales C, et al. 2006. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. PNAS 103:1006-11
    • (2006) PNAS , vol.103 , pp. 1006-1011
    • Zhang, Y.1    Lee, F.Y.2    Barrera, G.3    Lee, H.4    Vales, C.5
  • 131
    • 38949174197 scopus 로고    scopus 로고
    • A cell-based high-throughput screening assay for Farnesoid X receptor agonists
    • Zheng ZH, Lv GP, Si SY, Dong YS, Zhao BH, et al. 2007. A cell-based high-throughput screening assay for Farnesoid X receptor agonists. Biomed. Environ. Sci. 20:465-69
    • (2007) Biomed. Environ. Sci. , vol.20 , pp. 465-469
    • Zheng, Z.H.1    Lv, G.P.2    Si, S.Y.3    Dong, Y.S.4    Zhao, B.H.5
  • 132
    • 84901365815 scopus 로고    scopus 로고
    • Bile acids are nutrient signaling hormones
    • Zhou H, Hylemon PB. 2014. Bile acids are nutrient signaling hormones. Steroids 86:62-68
    • (2014) Steroids , vol.86 , pp. 62-68
    • Zhou, H.1    Hylemon, P.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.