Dysbiosis modulates capacity for bile acid modification in the gut microbiomes of patients with inflammatory bowel disease: A mechanism and marker of disease?

Gut

Volumn 61, Issue 11, 2012, Pages 1642-1643

  Ogilvie, Lesley A ^a   Jones, Brian V ^a  

^a UNIVERSITY OF BRIGHTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BILE SALT; BILE SALT HYDROLASE; FARNESOID X RECEPTOR; HYDROLASE; UNCLASSIFIED DRUG;

ACTINOBACTERIA; AMINO ACID SEQUENCE; BACTERIUM TRANSFORMATION; BACTEROIDETES; BILE ACID METABOLISM; BILE ACID MODIFICATION; BIOAVAILABILITY; CATALYSIS; COMPUTER ANALYSIS; CROHN DISEASE; DISEASE COURSE; DISEASE MARKER; DYSBIOSIS; ENTERITIS; FIRMICUTES; FUSOBACTERIA; HUMAN; INTESTINE FLORA; LETTER; METAGENOME; MOLLICUTES; ORGANISMAL INTERACTION; PATHOPHYSIOLOGY; PHYLOGENY; PRIORITY JOURNAL; PROTEOBACTERIA; RECEPTOR BINDING; RECEPTOR UPREGULATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; ULCERATIVE COLITIS;

ANIMALS; CHENODEOXYCHOLIC ACID; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINAL ABSORPTION; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84867007455     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2012-302137     Document Type: Letter

References (6)

1. Gadaleta RM, van Erpecum KJ, Oldenburg B, et al. Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease. Gut 2011;60:463-72.
2. Thomas C, Pellicciari R, Pruzanski M, et al. Targeting bile-acid signalling for metabolic diseases. Nat Rev Drug Discov 2008; 7:678-93.
3. O'Keefe SJD. Nutrition and colonic health: the critical role of the microbiota. Curr Opin Gastroen 2008;24:51-8. (Pubitemid 350190898)
4. Ridlon JM, Kang DJ, Hylemon PB. Bile salt biotransformations by human intestinal bacteria. J Lipid Res 2006;47:241-59. (Pubitemid 43276911)
5. Jones BV, Begley M, Hill C, et al. Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. Proc Natl Acad Sci USA 2008;105:13580-5.
6. Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010;464:59-65.