Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms

Digestive and Liver Disease

Volumn 46, Issue 6, 2014, Pages 527-534

  Quinn, Matthew ^a   McMillin, Matthew ^a   Galindo, Cheryl ^a   Frampton, Gabriel ^a   Pae, Hae Yong ^a   DeMorrow, Sharon ^a,b,c  

^a TEXAS A M COLLEGE OF MEDICINE   (United States)

^b SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Bile duct ligation; Occludin; Rac1; Tight junction proteins

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; BILE ACID; CHENODEOXYCHOLIC ACID; DEOXYCHOLIC ACID; OCCLUDIN; PROTEIN ZO1; PROTEIN ZO2; RAC1 PROTEIN; AMINOQUINOLINE DERIVATIVE; MESSENGER RNA; PYRIMIDINE DERIVATIVE; RAC1 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE ACID BLOOD LEVEL; BILE DUCT LIGATION; BIOLOGICAL ACTIVITY; BLOOD BRAIN BARRIER; BRAIN CAPILLARY ENDOTHELIAL CELL; CELL FRACTIONATION; CELL MEMBRANE PERMEABILITY; CHOLESTASIS; ENDOTHELIUM CELL; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; ANIMAL CELL; ANIMAL TISSUE; CONTROLLED STUDY; PHOSPHORYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BILE DUCT; BLOOD; DISEASE MODEL; DRUG EFFECTS; GENETICS; LIGATION; METABOLISM; MICROVASCULATURE; PATHOPHYSIOLOGY; PERMEABILITY; SPRAGUE DAWLEY RAT; SURGERY; TIGHT JUNCTION; TISSUE CULTURE TECHNIQUE;

AMINOQUINOLINES; ANIMALS; BILE DUCTS; BLOOD-BRAIN BARRIER; CHENODEOXYCHOLIC ACID; CHOLESTASIS; DEOXYCHOLIC ACID; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; LIGATION; MALE; MICROVESSELS; OCCLUDIN; PERMEABILITY; PHOSPHORYLATION; PYRIMIDINES; RAC1 GTP-BINDING PROTEIN; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TIGHT JUNCTIONS; TISSUE CULTURE TECHNIQUES; ZONULA OCCLUDENS-1 PROTEIN; ZONULA OCCLUDENS-2 PROTEIN;

EID: 84902537307     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2014.01.159     Document Type: Article

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