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Volumn 5, Issue FEB, 2014, Pages

Antibiotic growth promoters enhance animal production by targeting intestinal bile salt hydrolase and its producers

Author keywords

Antibiotic growth promoters; Bile salt hydrolase; Lactobacilli

Indexed keywords

ANTIBIOTIC AGENT; BILE SALT HYDROLASE; GROWTH PROMOTOR; HYDROLASE; PROBIOTIC AGENT; ROXARSONE; TETRACYCLINE; UNCLASSIFIED DRUG;

EID: 84897589789     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2014.00033     Document Type: Short Survey
Times cited : (80)

References (37)
  • 1
    • 33745547408 scopus 로고    scopus 로고
    • Effects of copper source and level on intestinal physiology and growth of broiler chickens
    • Arias, V. J., and Koutsos, E. A. (2006). Effects of copper source and level on intestinal physiology and growth of broiler chickens. Poult. Sci. 85, 999-1007.
    • (2006) Poult. Sci. , vol.85 , pp. 999-1007
    • Arias, V.J.1    Koutsos, E.A.2
  • 2
    • 2342656377 scopus 로고    scopus 로고
    • Effect of dietary copper source (cupric citrate and cupric sulfate) and concentration on growth performance and fecal copper excretion in weanling pigs
    • Armstrong, T. A., Cook, D. R., Ward, M. M., Williams, C. M., and Spears, J. W. (2004). Effect of dietary copper source (cupric citrate and cupric sulfate) and concentration on growth performance and fecal copper excretion in weanling pigs. J. Anim. Sci. 82, 1234-1240.
    • (2004) J. Anim. Sci. , vol.82 , pp. 1234-1240
    • Armstrong, T.A.1    Cook, D.R.2    Ward, M.M.3    Williams, C.M.4    Spears, J.W.5
  • 3
    • 33644941373 scopus 로고    scopus 로고
    • Bile salt hydrolase activity in probiotics
    • doi: 10.1128/AEM.72.3.1729-1738.2006
    • Begley, M., Hill, C., and Gahan, C. G. (2006). Bile salt hydrolase activity in probiotics. Appl. Environ. Microbiol. 72, 1729-1738. doi: 10.1128/AEM.72.3.1729-1738.2006
    • (2006) Appl. Environ. Microbiol. , vol.72 , pp. 1729-1738
    • Begley, M.1    Hill, C.2    Gahan, C.G.3
  • 4
    • 0036519089 scopus 로고    scopus 로고
    • Use of antibiotics and roxarsone in broiler chickens in the USA: analysis for the years 1995 to 2000
    • Chapman, H. D., and Johnson, Z. B. (2002). Use of antibiotics and roxarsone in broiler chickens in the USA: analysis for the years 1995 to 2000. Poult. Sci. 81, 356-364.
    • (2002) Poult. Sci. , vol.81 , pp. 356-364
    • Chapman, H.D.1    Johnson, Z.B.2
  • 5
    • 2142648807 scopus 로고    scopus 로고
    • Molecular ecological analysis of porcine ileal microbiota responses to antimicrobial growth promoters
    • Collier, C. T., Smiricky-Tjardes, M. R., Albin, D. M., Wubben, J. E., Gabert, V. M., Deplancke, B. et al. (2003). Molecular ecological analysis of porcine ileal microbiota responses to antimicrobial growth promoters. J. Anim. Sci. 81, 3035-3045.
    • (2003) J. Anim. Sci. , vol.81 , pp. 3035-3045
    • Collier, C.T.1    Smiricky-Tjardes, M.R.2    Albin, D.M.3    Wubben, J.E.4    Gabert, V.M.5    Deplancke, B.6
  • 6
    • 81155128154 scopus 로고    scopus 로고
    • Modulations of the chicken cecal microbiome and metagenome in response to anticoccidial and growth promoter treatment
    • doi: 10.1371/journal.pone.0027949
    • Danzeisen, J. L., Kim, H. B., Isaacson, R. E., Tu, Z. J., and Johnson, T. J. (2011). Modulations of the chicken cecal microbiome and metagenome in response to anticoccidial and growth promoter treatment. PLoS ONE 6:e27949. doi: 10.1371/journal.pone.0027949
    • (2011) PLoS ONE , vol.6
    • Danzeisen, J.L.1    Kim, H.B.2    Isaacson, R.E.3    Tu, Z.J.4    Johnson, T.J.5
  • 7
    • 0031892684 scopus 로고    scopus 로고
    • Cholesterol lowering in pigs through enhanced bacterial bile salt hydrolase activity
    • doi: 10.1079/BJN19980030
    • De, S., I., De Boever, P., and Verstraete, W. (1998). Cholesterol lowering in pigs through enhanced bacterial bile salt hydrolase activity. Br. J. Nutr. 79, 185-194. doi: 10.1079/BJN19980030
    • (1998) Br. J. Nutr. , vol.79 , pp. 185-194
    • De, S.I.1    De Boever, P.2    Verstraete, W.3
  • 8
    • 2042523570 scopus 로고    scopus 로고
    • The digestive system: challenges and opportunities
    • Dibner, J. J., and Richards, J. D. (2004). The digestive system: challenges and opportunities. J. Appl. Poult. Res. 13, 86-93.
    • (2004) J. Appl. Poult. Res. , vol.13 , pp. 86-93
    • Dibner, J.J.1    Richards, J.D.2
  • 9
    • 18944406651 scopus 로고    scopus 로고
    • Antibiotic growth promoters in agriculture: history and mode of action
    • Dibner, J. J., and Richards, J. D. (2005). Antibiotic growth promoters in agriculture: history and mode of action. Poult. Sci. 84, 634-643.
    • (2005) Poult. Sci. , vol.84 , pp. 634-643
    • Dibner, J.J.1    Richards, J.D.2
  • 10
    • 33646112924 scopus 로고    scopus 로고
    • Characterization of intestinal microbiota and response to dietary virginiamycin supplementation in the broiler chicken
    • doi: 10.1128/AEM.72.4.2815-2823.2006
    • Dumonceaux, T. J., Hill, J. E., Hemmingsen, S. M., and Van Kessel, A. G. (2006). Characterization of intestinal microbiota and response to dietary virginiamycin supplementation in the broiler chicken. Appl. Environ. Microbiol. 72, 2815-2823. doi: 10.1128/AEM.72.4.2815-2823.2006
    • (2006) Appl. Environ. Microbiol. , vol.72 , pp. 2815-2823
    • Dumonceaux, T.J.1    Hill, J.E.2    Hemmingsen, S.M.3    Van Kessel, A.G.4
  • 11
    • 0034277195 scopus 로고    scopus 로고
    • Effect of zinc bacitracin and salinomycin on intestinal microflora and performance of broilers
    • Engberg, R. M., Hedemann, M. S., Leser, T. D., and Jensen, B. B. (2000). Effect of zinc bacitracin and salinomycin on intestinal microflora and performance of broilers. Poult. Sci. 79, 1311-1319.
    • (2000) Poult. Sci. , vol.79 , pp. 1311-1319
    • Engberg, R.M.1    Hedemann, M.S.2    Leser, T.D.3    Jensen, B.B.4
  • 12
    • 0032014501 scopus 로고    scopus 로고
    • Studies on the feeding of cupric sulfate pentahydrate, cupric citrate, and copper oxychloride to broiler chickens
    • Ewing, H. P., Pesti, G. M., Bakalli, R. I., and Menten, J. F. M. (1998). Studies on the feeding of cupric sulfate pentahydrate, cupric citrate, and copper oxychloride to broiler chickens. Poult. Sci. 77, 445-448.
    • (1998) Poult. Sci. , vol.77 , pp. 445-448
    • Ewing, H.P.1    Pesti, G.M.2    Bakalli, R.I.3    Menten, J.F.M.4
  • 13
    • 69949083658 scopus 로고    scopus 로고
    • Allelic variation of bile salt hydrolase genes in Lactobacillus salivarius does not determine bile resistance levels
    • doi: 10.1128/JB.00506-09
    • Fang, F., Li, Y., Bumann, M., Raftis, E. J., Casey, P. G., Cooney, J. C. et al. (2009). Allelic variation of bile salt hydrolase genes in Lactobacillus salivarius does not determine bile resistance levels. J. Bacteriol. 191, 5743-5757. doi: 10.1128/JB.00506-09
    • (2009) J. Bacteriol. , vol.191 , pp. 5743-5757
    • Fang, F.1    Li, Y.2    Bumann, M.3    Raftis, E.J.4    Casey, P.G.5    Cooney, J.C.6
  • 14
    • 0023096281 scopus 로고
    • Subtherapeutic levels of antibiotics in poultry feeds and their effects on weight gain, feed efficiency, and bacterial cholyltaurine hydrolase activity
    • Feighner, S. D., and Dashkevicz, M. P. (1987). Subtherapeutic levels of antibiotics in poultry feeds and their effects on weight gain, feed efficiency, and bacterial cholyltaurine hydrolase activity. Appl. Environ. Microbiol. 53, 331-336.
    • (1987) Appl. Environ. Microbiol. , vol.53 , pp. 331-336
    • Feighner, S.D.1    Dashkevicz, M.P.2
  • 15
    • 0036557817 scopus 로고    scopus 로고
    • Antibiotics as growth promotants: mode of action
    • doi: 10.1081/ABIO-120005768
    • Gaskins, H. R., Collier, C. T., and Anderson, D. B. (2002). Antibiotics as growth promotants: mode of action. Anim. Biotechnol. 13, 29-42. doi: 10.1081/ABIO-120005768
    • (2002) Anim. Biotechnol. , vol.13 , pp. 29-42
    • Gaskins, H.R.1    Collier, C.T.2    Anderson, D.B.3
  • 16
    • 33846078026 scopus 로고    scopus 로고
    • Relationship of dietary antimicrobial drug administration with broiler performance, decreased population levels of Lactobacillus salivarius, and reduced bile salt deconjugation in the ileum of broiler chickens
    • Guban, J., Korver, D. R., Allison, G. E., and Tannock, G. W. (2006). Relationship of dietary antimicrobial drug administration with broiler performance, decreased population levels of Lactobacillus salivarius, and reduced bile salt deconjugation in the ileum of broiler chickens. Poult. Sci. 85, 2186-2194.
    • (2006) Poult. Sci. , vol.85 , pp. 2186-2194
    • Guban, J.1    Korver, D.R.2    Allison, G.E.3    Tannock, G.W.4
  • 17
    • 0034166645 scopus 로고    scopus 로고
    • Growth promotion effects and plasma changes from feeding high dietary concentrations of zinc and copper to weanling pigs (regional study)
    • Hill, G. M., Cromwell, G. L., Crenshaw, T. D., Dove, C. R., Ewan, R. C., Knabe, D. A. et al. (2000). Growth promotion effects and plasma changes from feeding high dietary concentrations of zinc and copper to weanling pigs (regional study). J. Anim. Sci. 78, 1010-1016.
    • (2000) J. Anim. Sci. , vol.78 , pp. 1010-1016
    • Hill, G.M.1    Cromwell, G.L.2    Crenshaw, T.D.3    Dove, C.R.4    Ewan, R.C.5    Knabe, D.A.6
  • 18
    • 51649086648 scopus 로고    scopus 로고
    • Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome
    • doi: 10.1073/pnas.0804437105
    • Jones, B. V., Begley, M., Hill, C., Gahan, C. G. M., and Marchesi, J. R. (2008). Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. Proc. Natl. Acad. Sci. U.S.A. 105, 13580-13585. doi: 10.1073/pnas.0804437105
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 13580-13585
    • Jones, B.V.1    Begley, M.2    Hill, C.3    Gahan, C.G.M.4    Marchesi, J.R.5
  • 19
    • 84863604437 scopus 로고    scopus 로고
    • Cholesterol-lowering efficacy of a microencapsulated bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic adults
    • doi: 10.1017/S0007114511004703
    • Jones, M. L., Martoni, C. J., Parent, M., and Prakash, S. (2012). Cholesterol-lowering efficacy of a microencapsulated bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic adults. Br. J. Nutr. 107, 1505-1513. doi: 10.1017/S0007114511004703
    • (2012) Br. J. Nutr. , vol.107 , pp. 1505-1513
    • Jones, M.L.1    Martoni, C.J.2    Parent, M.3    Prakash, S.4
  • 20
    • 84866551081 scopus 로고    scopus 로고
    • Microbial shifts in the swine distal gut in response to the treatment with antimicrobial growth promoter, tylosin
    • doi: 10.1073/pnas.1205147109
    • Kim, H. B., Borewicz, K., White, B. A., Singer, R. S., Sreevatsan, S., Tu, Z. J., et al. (2012). Microbial shifts in the swine distal gut in response to the treatment with antimicrobial growth promoter, tylosin. Proc. Natl. Acad. Sci. U.S.A. 109, 15485-15490. doi: 10.1073/pnas.1205147109
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 15485-15490
    • Kim, H.B.1    Borewicz, K.2    White, B.A.3    Singer, R.S.4    Sreevatsan, S.5    Tu, Z.J.6
  • 21
    • 2642588267 scopus 로고    scopus 로고
    • Dietary antibiotic growth promoters enhance the bioavailability of alpha-tocopheryl acetate in broilers by altering lipid absorption
    • Knarreborg, A., Lauridsen, C., Engberg, R. M., and Jensen, S. K. (2004). Dietary antibiotic growth promoters enhance the bioavailability of alpha-tocopheryl acetate in broilers by altering lipid absorption. J. Nutr. 134, 1487-1492.
    • (2004) J. Nutr. , vol.134 , pp. 1487-1492
    • Knarreborg, A.1    Lauridsen, C.2    Engberg, R.M.3    Jensen, S.K.4
  • 22
    • 0242515761 scopus 로고    scopus 로고
    • Effects of dietary fat source and subtherapeutic levels of antibiotic on the bacterial community in the ileum of broiler chickens at various ages
    • doi: 10.1128/AEM.68.12.5918-5924.2002
    • Knarreborg, A., Simon, M. A., Engberg, R. M., Jensen, B. B., and Tannock, G. W. (2002). Effects of dietary fat source and subtherapeutic levels of antibiotic on the bacterial community in the ileum of broiler chickens at various ages. Appl. Environ. Microbiol. 68, 5918-5924. doi: 10.1128/AEM.68.12.5918-5924.2002
    • (2002) Appl. Environ. Microbiol. , vol.68 , pp. 5918-5924
    • Knarreborg, A.1    Simon, M.A.2    Engberg, R.M.3    Jensen, B.B.4    Tannock, G.W.5
  • 23
    • 79951677024 scopus 로고    scopus 로고
    • Hypocholesterolaemic effect of dietary inclusion of two putative probiotic bile salt hydrolase-producing Lactobacillus plantarum strains in Sprague-Dawley rats
    • doi: 10.1017/S0007114510003740
    • Kumar, R., Grover, S., and Batish, V. K. (2011). Hypocholesterolaemic effect of dietary inclusion of two putative probiotic bile salt hydrolase-producing Lactobacillus plantarum strains in Sprague-Dawley rats. Br. J. Nutr. 105, 561-573. doi: 10.1017/S0007114510003740
    • (2011) Br. J. Nutr. , vol.105 , pp. 561-573
    • Kumar, R.1    Grover, S.2    Batish, V.K.3
  • 24
    • 84876140625 scopus 로고    scopus 로고
    • Response of intestinal microbiota to antibiotic growth promoters in chickens
    • doi: 10.1089/fpd.2012.1348
    • Lin, J., Hunkapiller, A. A., Layton, A. C., Chang, Y. J., and Robbins, K. R. (2013). Response of intestinal microbiota to antibiotic growth promoters in chickens. Foodborne Pathog. Dis. 10, 331-337. doi: 10.1089/fpd.2012.1348
    • (2013) Foodborne Pathog. Dis. , vol.10 , pp. 331-337
    • Lin, J.1    Hunkapiller, A.A.2    Layton, A.C.3    Chang, Y.J.4    Robbins, K.R.5
  • 25
    • 0032012813 scopus 로고    scopus 로고
    • The effect of dietary supplementation with copper sulfate or tribasic copper chloride on broiler performance, relative copper bioavailability, and dietary prooxidant activity
    • Miles, R. D., O'Keefe, S. F., Henry, P. R., Ammerman, C. B., and Luo, X. G. (1998). The effect of dietary supplementation with copper sulfate or tribasic copper chloride on broiler performance, relative copper bioavailability, and dietary prooxidant activity. Poult. Sci. 77, 416-425.
    • (1998) Poult. Sci. , vol.77 , pp. 416-425
    • Miles, R.D.1    O'Keefe, S.F.2    Henry, P.R.3    Ammerman, C.B.4    Luo, X.G.5
  • 26
    • 72249102841 scopus 로고    scopus 로고
    • Effects of probiotic inclusion levels in broiler nutrition on growth performance, nutrient digestibility, plasma immunoglobulins, and cecal microflora composition
    • doi: 10.3382/ps.2009-00308
    • Mountzouris, K. C., Tsitrsikos, P., Palamidi, I., Arvaniti, A., Mohnl, M., Schatzmayr, G., et al. (2010). Effects of probiotic inclusion levels in broiler nutrition on growth performance, nutrient digestibility, plasma immunoglobulins, and cecal microflora composition. Poult. Sci. 89, 58-67. doi: 10.3382/ps.2009-00308
    • (2010) Poult. Sci. , vol.89 , pp. 58-67
    • Mountzouris, K.C.1    Tsitrsikos, P.2    Palamidi, I.3    Arvaniti, A.4    Mohnl, M.5    Schatzmayr, G.6
  • 27
    • 77952891233 scopus 로고    scopus 로고
    • Probiotic bile salt hydrolase: current developments and perspectives
    • doi: 10.1007/s12010-009-8738-1
    • Patel, A. K., Singhania, R. R., Pandey, A., and Chincholkar, S. B. (2010). Probiotic bile salt hydrolase: current developments and perspectives. Appl. Biochem. Biotechnol. 162, 166-180. doi: 10.1007/s12010-009-8738-1
    • (2010) Appl. Biochem. Biotechnol. , vol.162 , pp. 166-180
    • Patel, A.K.1    Singhania, R.R.2    Pandey, A.3    Chincholkar, S.B.4
  • 29
    • 84857976372 scopus 로고    scopus 로고
    • Effects of flavomycin and probiotic supplementation to diets containing different sources of fat on growth performance, intestinal morphology, apparent metabolizable energy, and fat digestibility in broiler chickens
    • doi: 10.3382/ps.2011-01844
    • Sharifi, S. D., Dibamehr, A., Lotfollahian, H., and Baurhoo, B. (2012). Effects of flavomycin and probiotic supplementation to diets containing different sources of fat on growth performance, intestinal morphology, apparent metabolizable energy, and fat digestibility in broiler chickens. Poult. Sci. 91, 918-927. doi: 10.3382/ps.2011-01844
    • (2012) Poult. Sci. , vol.91 , pp. 918-927
    • Sharifi, S.D.1    Dibamehr, A.2    Lotfollahian, H.3    Baurhoo, B.4
  • 30
    • 13244284583 scopus 로고    scopus 로고
    • Mucin dynamics and microbial populations in chicken small intestine are changed by dietary probiotic and antibiotic growth promoter supplementation
    • Smirnov, A., Perez, R., Amit-Romach, E., Sklan, D., and Uni, Z. (2005). Mucin dynamics and microbial populations in chicken small intestine are changed by dietary probiotic and antibiotic growth promoter supplementation. J. Nutr. 135, 187-192.
    • (2005) J. Nutr. , vol.135 , pp. 187-192
    • Smirnov, A.1    Perez, R.2    Amit-Romach, E.3    Sklan, D.4    Uni, Z.5
  • 31
    • 0031182949 scopus 로고    scopus 로고
    • Effects of the interrelationship between zinc oxide and copper sulfate on growth performance of early-weaned pigs
    • Smith, J. W., Tokach, M. D., Goodband, R. D., Nelssen, J. L., and Richert, B. T. (1997). Effects of the interrelationship between zinc oxide and copper sulfate on growth performance of early-weaned pigs. J. Anim. Sci. 75, 1861-1866.
    • (1997) J. Anim. Sci. , vol.75 , pp. 1861-1866
    • Smith, J.W.1    Tokach, M.D.2    Goodband, R.D.3    Nelssen, J.L.4    Richert, B.T.5
  • 32
    • 84897621880 scopus 로고    scopus 로고
    • Discovery of bile salt hydrolase inhibitors using an efficient high-throughput screening system
    • doi: 10.1371/jounal.pone.0085344
    • Smith, K., Zeng, X., and Lin, J. (2014). Discovery of bile salt hydrolase inhibitors using an efficient high-throughput screening system. PLoS ONE 9:e85344. doi: 10.1371/jounal.pone.0085344
    • (2014) PLoS ONE , vol.9
    • Smith, K.1    Zeng, X.2    Lin, J.3
  • 33
    • 0347287024 scopus 로고    scopus 로고
    • Antibiotic use in animals-prejudices, perceptions and realities
    • doi: 10.1093/jac/dkg493
    • Turnidge, J. (2004). Antibiotic use in animals-prejudices, perceptions and realities. J. Antimicrob. Chemother. 53, 26-27. doi: 10.1093/jac/dkg493
    • (2004) J. Antimicrob. Chemother. , vol.53 , pp. 26-27
    • Turnidge, J.1
  • 34
    • 84871016728 scopus 로고    scopus 로고
    • Identification and characterization of a bile salt hydrolase from Lactobacillus salivarius for development of novel alternatives to antibiotic growth promoters
    • doi: 10.1128/AEM.02519-12
    • Wang, Z., Zeng, X., Mo, Y., Smith, K., Guo, Y., and Lin, J. (2012). Identification and characterization of a bile salt hydrolase from Lactobacillus salivarius for development of novel alternatives to antibiotic growth promoters. Appl. Environ. Microbiol. 78, 8795-8802. doi: 10.1128/AEM.02519-12
    • (2012) Appl. Environ. Microbiol. , vol.78 , pp. 8795-8802
    • Wang, Z.1    Zeng, X.2    Mo, Y.3    Smith, K.4    Guo, Y.5    Lin, J.6
  • 35
    • 0242386463 scopus 로고    scopus 로고
    • Antibiotics in animal feed and their role in resistance development
    • doi: 10.1016/j.mib.2003.09.009
    • Wegener, H. C. (2003). Antibiotics in animal feed and their role in resistance development. Curr. Opin. Microbiol. 6, 439-445. doi: 10.1016/j.mib.2003.09.009
    • (2003) Curr. Opin. Microbiol. , vol.6 , pp. 439-445
    • Wegener, H.C.1
  • 36
    • 33947378258 scopus 로고    scopus 로고
    • Quantitative analysis of the intestinal bacterial community in one-to three-week-old commercially reared broiler chickens fed conventional or antibiotic-free vegetable-based diets
    • doi: 10.1111/j.1365-2672.2006.03153.x
    • Wise, M. G., and Siragusa, G. R. (2007). Quantitative analysis of the intestinal bacterial community in one-to three-week-old commercially reared broiler chickens fed conventional or antibiotic-free vegetable-based diets. J. Appl. Microbiol. 102, 1138-1149. doi: 10.1111/j.1365-2672.2006.03153.x
    • (2007) J. Appl. Microbiol. , vol.102 , pp. 1138-1149
    • Wise, M.G.1    Siragusa, G.R.2
  • 37
    • 36849042557 scopus 로고    scopus 로고
    • Appropriate chicken sample size for identifying the composition of broiler intestinal microbiota affected by dietary antibiotics, using the polymerase chain reaction-denaturing gradient gel electrophoresis technique
    • doi: 10.3382/ps.2007-00267
    • Zhou, H., Gong, J., Brisbin, J. T., Yu, H., Sanei, B., Sabour, P., et al. (2007). Appropriate chicken sample size for identifying the composition of broiler intestinal microbiota affected by dietary antibiotics, using the polymerase chain reaction-denaturing gradient gel electrophoresis technique. Poult. Sci. 86, 2541-2549.doi: 10.3382/ps.2007-00267
    • (2007) Poult. Sci. , vol.86 , pp. 2541-2549
    • Zhou, H.1    Gong, J.2    Brisbin, J.T.3    Yu, H.4    Sanei, B.5    Sabour, P.6


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