-
1
-
-
84875848761
-
The TGR5 receptor mediates bile acid-induced itch and analgesia
-
Alemi F., Kwon E., Poole D.P., Lieu T., Lyo V., Cattaruzza F., Cevikbas F., Steinhoff M., Nassini R., Materazzi S., et al. The TGR5 receptor mediates bile acid-induced itch and analgesia. J. Clin. Invest. 2013, 123:1513-1530.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 1513-1530
-
-
Alemi, F.1
Kwon, E.2
Poole, D.P.3
Lieu, T.4
Lyo, V.5
Cattaruzza, F.6
Cevikbas, F.7
Steinhoff, M.8
Nassini, R.9
Materazzi, S.10
-
2
-
-
2342604388
-
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia
-
Amadesi S., Nie J., Vergnolle N., Cottrell G.S., Grady E.F., Trevisani M., Manni C., Geppetti P., McRoberts J.A., Ennes H., et al. Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. J. Neurosci. 2004, 24:4300-4312.
-
(2004)
J. Neurosci.
, vol.24
, pp. 4300-4312
-
-
Amadesi, S.1
Nie, J.2
Vergnolle, N.3
Cottrell, G.S.4
Grady, E.F.5
Trevisani, M.6
Manni, C.7
Geppetti, P.8
McRoberts, J.A.9
Ennes, H.10
-
3
-
-
33747227271
-
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice
-
Amadesi S., Cottrell G.S., Divino L., Chapman K., Grady E.F., Bautista F., Karanjia R., Barajas-Lopez C., Vanner S., Vergnolle N., Bunnett N.W. Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice. J. Physiol. 2006, 575:555-571.
-
(2006)
J. Physiol.
, vol.575
, pp. 555-571
-
-
Amadesi, S.1
Cottrell, G.S.2
Divino, L.3
Chapman, K.4
Grady, E.F.5
Bautista, F.6
Karanjia, R.7
Barajas-Lopez, C.8
Vanner, S.9
Vergnolle, N.10
Bunnett, N.W.11
-
4
-
-
84892189154
-
Interaction of Protease-Activated Receptor 2 with G Proteins and β-Arrestin 1 Studied by Bioluminescence Resonance Energy Transfer
-
Ayoub M.A., Pin J.P. Interaction of Protease-Activated Receptor 2 with G Proteins and β-Arrestin 1 Studied by Bioluminescence Resonance Energy Transfer. Front. Endocrinol. (Lausanne) 2013, 4:196.
-
(2013)
Front. Endocrinol. (Lausanne)
, vol.4
, pp. 196
-
-
Ayoub, M.A.1
Pin, J.P.2
-
5
-
-
84896300470
-
Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn
-
Bardoni R., Tawfik V.L., Wang D., François A., Solorzano C., Shuster S.A., Choudhury P., Betelli C., Cassidy C., Smith K., et al. Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn. Neuron 2014, 81:1312-1327.
-
(2014)
Neuron
, vol.81
, pp. 1312-1327
-
-
Bardoni, R.1
Tawfik, V.L.2
Wang, D.3
François, A.4
Solorzano, C.5
Shuster, S.A.6
Choudhury, P.7
Betelli, C.8
Cassidy, C.9
Smith, K.10
-
6
-
-
70349845440
-
Cellular and molecular mechanisms of pain
-
Basbaum A.I., Bautista D.M., Scherrer G., Julius D. Cellular and molecular mechanisms of pain. Cell 2009, 139:267-284.
-
(2009)
Cell
, vol.139
, pp. 267-284
-
-
Basbaum, A.I.1
Bautista, D.M.2
Scherrer, G.3
Julius, D.4
-
7
-
-
84893730284
-
Why we scratch an itch: the molecules, cells and circuits of itch
-
Bautista D.M., Wilson S.R., Hoon M.A. Why we scratch an itch: the molecules, cells and circuits of itch. Nat. Neurosci. 2014, 17:175-182.
-
(2014)
Nat. Neurosci.
, vol.17
, pp. 175-182
-
-
Bautista, D.M.1
Wilson, S.R.2
Hoon, M.A.3
-
8
-
-
0033601341
-
Enhanced morphine analgesia in mice lacking beta-arrestin 2
-
Bohn L.M., Lefkowitz R.J., Gainetdinov R.R., Peppel K., Caron M.G., Lin F.T. Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science 1999, 286:2495-2498.
-
(1999)
Science
, vol.286
, pp. 2495-2498
-
-
Bohn, L.M.1
Lefkowitz, R.J.2
Gainetdinov, R.R.3
Peppel, K.4
Caron, M.G.5
Lin, F.T.6
-
9
-
-
84977895368
-
Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain
-
Bonnard E., Poras H., Nadal X., Maldonado R., Fournié-Zaluski M.C., Roques B.P. Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain. Pharmacol. Res. Perspect. 2015, 3:e00116.
-
(2015)
Pharmacol. Res. Perspect.
, vol.3
, pp. e00116
-
-
Bonnard, E.1
Poras, H.2
Nadal, X.3
Maldonado, R.4
Fournié-Zaluski, M.C.5
Roques, B.P.6
-
10
-
-
84890596350
-
Endogenous regulation of visceral pain via production of opioids by colitogenic CD4(+) T cells in mice
-
Boué J., Basso L., Cenac N., Blanpied C., Rolli-Derkinderen M., Neunlist M., Vergnolle N., Dietrich G. Endogenous regulation of visceral pain via production of opioids by colitogenic CD4(+) T cells in mice. Gastroenterology 2014, 146:166-175.
-
(2014)
Gastroenterology
, vol.146
, pp. 166-175
-
-
Boué, J.1
Basso, L.2
Cenac, N.3
Blanpied, C.4
Rolli-Derkinderen, M.5
Neunlist, M.6
Vergnolle, N.7
Dietrich, G.8
-
11
-
-
84925654067
-
Cell-autonomous regulation of Mu-opioid receptor recycling by substance P
-
Bowman S.L., Soohoo A.L., Shiwarski D.J., Schulz S., Pradhan A.A., Puthenveedu M.A. Cell-autonomous regulation of Mu-opioid receptor recycling by substance P. Cell Rep. 2015, 10:1925-1936.
-
(2015)
Cell Rep.
, vol.10
, pp. 1925-1936
-
-
Bowman, S.L.1
Soohoo, A.L.2
Shiwarski, D.J.3
Schulz, S.4
Pradhan, A.A.5
Puthenveedu, M.A.6
-
12
-
-
84879514548
-
Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor
-
Burford N.T., Clark M.J., Wehrman T.S., Gerritz S.W., Banks M., O'Connell J., Traynor J.R., Alt A. Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor. Proc. Natl. Acad. Sci. USA 2013, 110:10830-10835.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 10830-10835
-
-
Burford, N.T.1
Clark, M.J.2
Wehrman, T.S.3
Gerritz, S.W.4
Banks, M.5
O'Connell, J.6
Traynor, J.R.7
Alt, A.8
-
13
-
-
69249105154
-
Persistent cAMP-signals triggered by internalized G-protein-coupled receptors
-
Calebiro D., Nikolaev V.O., Gagliani M.C., de Filippis T., Dees C., Tacchetti C., Persani L., Lohse M.J. Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. PLoS Biol. 2009, 7:e1000172.
-
(2009)
PLoS Biol.
, vol.7
, pp. e1000172
-
-
Calebiro, D.1
Nikolaev, V.O.2
Gagliani, M.C.3
de Filippis, T.4
Dees, C.5
Tacchetti, C.6
Persani, L.7
Lohse, M.J.8
-
14
-
-
0033565226
-
Serotonergic modulation of hyperpolarization-activated current in acutely isolated rat dorsal root ganglion neurons
-
Cardenas C.G., Mar L.P., Vysokanov A.V., Arnold P.B., Cardenas L.M., Surmeier D.J., Scroggs R.S. Serotonergic modulation of hyperpolarization-activated current in acutely isolated rat dorsal root ganglion neurons. J. Physiol. 1999, 518:507-523.
-
(1999)
J. Physiol.
, vol.518
, pp. 507-523
-
-
Cardenas, C.G.1
Mar, L.P.2
Vysokanov, A.V.3
Arnold, P.B.4
Cardenas, L.M.5
Surmeier, D.J.6
Scroggs, R.S.7
-
15
-
-
66949127237
-
Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation
-
Cattaruzza F., Cottrell G.S., Vaksman N., Bunnett N.W. Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation. Br. J. Pharmacol. 2009, 156:730-739.
-
(2009)
Br. J. Pharmacol.
, vol.156
, pp. 730-739
-
-
Cattaruzza, F.1
Cottrell, G.S.2
Vaksman, N.3
Bunnett, N.W.4
-
16
-
-
78049397086
-
Constitutively active μ-opioid receptors
-
Connor M., Traynor J. Constitutively active μ-opioid receptors. Methods Enzymol. 2010, 484:445-469.
-
(2010)
Methods Enzymol.
, vol.484
, pp. 445-469
-
-
Connor, M.1
Traynor, J.2
-
17
-
-
84884600291
-
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence
-
Corder G., Doolen S., Donahue R.R., Winter M.K., Jutras B.L., He Y., Hu X., Wieskopf J.S., Mogil J.S., Storm D.R., et al. Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence. Science 2013, 341:1394-1399.
-
(2013)
Science
, vol.341
, pp. 1394-1399
-
-
Corder, G.1
Doolen, S.2
Donahue, R.R.3
Winter, M.K.4
Jutras, B.L.5
He, Y.6
Hu, X.7
Wieskopf, J.S.8
Mogil, J.S.9
Storm, D.R.10
-
18
-
-
0001169515
-
Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins
-
Costa T., Herz A. Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins. Proc. Natl. Acad. Sci. USA 1989, 86:7321-7325.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 7321-7325
-
-
Costa, T.1
Herz, A.2
-
19
-
-
69249118195
-
Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling
-
Cottrell G.S., Padilla B.E., Amadesi S., Poole D.P., Murphy J.E., Hardt M., Roosterman D., Steinhoff M., Bunnett N.W. Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling. J. Biol. Chem. 2009, 284:22411-22425.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 22411-22425
-
-
Cottrell, G.S.1
Padilla, B.E.2
Amadesi, S.3
Poole, D.P.4
Murphy, J.E.5
Hardt, M.6
Roosterman, D.7
Steinhoff, M.8
Bunnett, N.W.9
-
20
-
-
34447121851
-
Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain
-
Dai Y., Wang S., Tominaga M., Yamamoto S., Fukuoka T., Higashi T., Kobayashi K., Obata K., Yamanaka H., Noguchi K. Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J. Clin. Invest. 2007, 117:1979-1987.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1979-1987
-
-
Dai, Y.1
Wang, S.2
Tominaga, M.3
Yamamoto, S.4
Fukuoka, T.5
Higashi, T.6
Kobayashi, K.7
Obata, K.8
Yamanaka, H.9
Noguchi, K.10
-
21
-
-
30044442319
-
Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series
-
Daniels D.J., Lenard N.R., Etienne C.L., Law P.Y., Roerig S.C., Portoghese P.S. Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series. Proc. Natl. Acad. Sci. USA 2005, 102:19208-19213.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 19208-19213
-
-
Daniels, D.J.1
Lenard, N.R.2
Etienne, C.L.3
Law, P.Y.4
Roerig, S.C.5
Portoghese, P.S.6
-
22
-
-
0034718604
-
The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex
-
DeFea K.A., Vaughn Z.D., O'Bryan E.M., Nishijima D., Déry O., Bunnett N.W. The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex. Proc. Natl. Acad. Sci. USA 2000, 97:11086-11091.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 11086-11091
-
-
DeFea, K.A.1
Vaughn, Z.D.2
O'Bryan, E.M.3
Nishijima, D.4
Déry, O.5
Bunnett, N.W.6
-
23
-
-
0034689003
-
Beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2
-
DeFea K.A., Zalevsky J., Thoma M.S., Déry O., Mullins R.D., Bunnett N.W. beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J. Cell Biol. 2000, 148:1267-1281.
-
(2000)
J. Cell Biol.
, vol.148
, pp. 1267-1281
-
-
DeFea, K.A.1
Zalevsky, J.2
Thoma, M.S.3
Déry, O.4
Mullins, R.D.5
Bunnett, N.W.6
-
24
-
-
84874406899
-
A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine
-
DeWire S.M., Yamashita D.S., Rominger D.H., Liu G., Cowan C.L., Graczyk T.M., Chen X.T., Pitis P.M., Gotchev D., Yuan C., et al. A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. J. Pharmacol. Exp. Ther. 2013, 344:708-717.
-
(2013)
J. Pharmacol. Exp. Ther.
, vol.344
, pp. 708-717
-
-
DeWire, S.M.1
Yamashita, D.S.2
Rominger, D.H.3
Liu, G.4
Cowan, C.L.5
Graczyk, T.M.6
Chen, X.T.7
Pitis, P.M.8
Gotchev, D.9
Yuan, C.10
-
25
-
-
0035822998
-
A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons
-
Dong X., Han S., Zylka M.J., Simon M.I., Anderson D.J. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell 2001, 106:619-632.
-
(2001)
Cell
, vol.106
, pp. 619-632
-
-
Dong, X.1
Han, S.2
Zylka, M.J.3
Simon, M.I.4
Anderson, D.J.5
-
26
-
-
84880633982
-
Eluxadoline benefits patients with irritable bowel syndrome with diarrhea in a phase 2 study
-
Dove L.S., Lembo A., Randall C.W., Fogel R., Andrae D., Davenport J.M., McIntyre G., Almenoff J.S., Covington P.S. Eluxadoline benefits patients with irritable bowel syndrome with diarrhea in a phase 2 study. Gastroenterology 2013, 145. 329-38.e1.
-
(2013)
Gastroenterology
, vol.145
, pp. 329-338
-
-
Dove, L.S.1
Lembo, A.2
Randall, C.W.3
Fogel, R.4
Andrae, D.5
Davenport, J.M.6
McIntyre, G.7
Almenoff, J.S.8
Covington, P.S.9
-
27
-
-
84873689852
-
Scaffolding by A-kinase anchoring protein enhances functional coupling between adenylyl cyclase and TRPV1 channel
-
Efendiev R., Bavencoffe A., Hu H., Zhu M.X., Dessauer C.W. Scaffolding by A-kinase anchoring protein enhances functional coupling between adenylyl cyclase and TRPV1 channel. J. Biol. Chem. 2013, 288:3929-3937.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 3929-3937
-
-
Efendiev, R.1
Bavencoffe, A.2
Hu, H.3
Zhu, M.X.4
Dessauer, C.W.5
-
28
-
-
76649125850
-
GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain
-
Eijkelkamp N., Heijnen C.J., Willemen H.L., Deumens R., Joosten E.A., Kleibeuker W., den Hartog I.J., van Velthoven C.T., Nijboer C., Nassar M.A., et al. GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain. J. Neurosci. 2010, 30:2138-2149.
-
(2010)
J. Neurosci.
, vol.30
, pp. 2138-2149
-
-
Eijkelkamp, N.1
Heijnen, C.J.2
Willemen, H.L.3
Deumens, R.4
Joosten, E.A.5
Kleibeuker, W.6
den Hartog, I.J.7
van Velthoven, C.T.8
Nijboer, C.9
Nassar, M.A.10
-
29
-
-
84895775893
-
A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks
-
Erbs E., Faget L., Scherrer G., Matifas A., Filliol D., Vonesch J.L., Koch M., Kessler P., Hentsch D., Birling M.C., et al. A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks. Brain Struct. Funct. 2015, 220:677-702.
-
(2015)
Brain Struct. Funct.
, vol.220
, pp. 677-702
-
-
Erbs, E.1
Faget, L.2
Scherrer, G.3
Matifas, A.4
Filliol, D.5
Vonesch, J.L.6
Koch, M.7
Kessler, P.8
Hentsch, D.9
Birling, M.C.10
-
30
-
-
84861304896
-
In vivo visualization of delta opioid receptors upon physiological activation uncovers a distinct internalization profile
-
Faget L., Erbs E., Le Merrer J., Scherrer G., Matifas A., Benturquia N., Noble F., Decossas M., Koch M., Kessler P., et al. In vivo visualization of delta opioid receptors upon physiological activation uncovers a distinct internalization profile. J. Neurosci. 2012, 32:7301-7310.
-
(2012)
J. Neurosci.
, vol.32
, pp. 7301-7310
-
-
Faget, L.1
Erbs, E.2
Le Merrer, J.3
Scherrer, G.4
Matifas, A.5
Benturquia, N.6
Noble, F.7
Decossas, M.8
Koch, M.9
Kessler, P.10
-
31
-
-
84924231852
-
Structural basis for bifunctional peptide recognition at human δ-opioid receptor
-
Fenalti G., Zatsepin N.A., Betti C., Giguere P., Han G.W., Ishchenko A., Liu W., Guillemyn K., Zhang H., James D., et al. Structural basis for bifunctional peptide recognition at human δ-opioid receptor. Nat. Struct. Mol. Biol. 2015, 22:265-268.
-
(2015)
Nat. Struct. Mol. Biol.
, vol.22
, pp. 265-268
-
-
Fenalti, G.1
Zatsepin, N.A.2
Betti, C.3
Giguere, P.4
Han, G.W.5
Ishchenko, A.6
Liu, W.7
Guillemyn, K.8
Zhang, H.9
James, D.10
-
32
-
-
84893642127
-
G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives
-
Ferré S., Casadó V., Devi L.A., Filizola M., Jockers R., Lohse M.J., Milligan G., Pin J.P., Guitart X. G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives. Pharmacol. Rev. 2014, 66:413-434.
-
(2014)
Pharmacol. Rev.
, vol.66
, pp. 413-434
-
-
Ferré, S.1
Casadó, V.2
Devi, L.A.3
Filizola, M.4
Jockers, R.5
Lohse, M.J.6
Milligan, G.7
Pin, J.P.8
Guitart, X.9
-
34
-
-
84876576815
-
Disrupting sensitization of transient receptor potential vanilloid subtype 1 inhibits inflammatory hyperalgesia
-
Fischer M.J., Btesh J., McNaughton P.A. Disrupting sensitization of transient receptor potential vanilloid subtype 1 inhibits inflammatory hyperalgesia. J. Neurosci. 2013, 33:7407-7414.
-
(2013)
J. Neurosci.
, vol.33
, pp. 7407-7414
-
-
Fischer, M.J.1
Btesh, J.2
McNaughton, P.A.3
-
35
-
-
0035341213
-
Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function
-
Galvez T., Duthey B., Kniazeff J., Blahos J., Rovelli G., Bettler B., Prézeau L., Pin J.P. Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function. EMBO J. 2001, 20:2152-2159.
-
(2001)
EMBO J.
, vol.20
, pp. 2152-2159
-
-
Galvez, T.1
Duthey, B.2
Kniazeff, J.3
Blahos, J.4
Rovelli, G.5
Bettler, B.6
Prézeau, L.7
Pin, J.P.8
-
36
-
-
84859571481
-
Antidromic vasodilatation and the migraine mechanism
-
Geppetti P., Rossi E., Chiarugi A., Benemei S. Antidromic vasodilatation and the migraine mechanism. J. Headache Pain 2012, 13:103-111.
-
(2012)
J. Headache Pain
, vol.13
, pp. 103-111
-
-
Geppetti, P.1
Rossi, E.2
Chiarugi, A.3
Benemei, S.4
-
37
-
-
1842687121
-
A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia
-
Gomes I., Gupta A., Filipovska J., Szeto H.H., Pintar J.E., Devi L.A. A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia. Proc. Natl. Acad. Sci. USA 2004, 101:5135-5139.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 5135-5139
-
-
Gomes, I.1
Gupta, A.2
Filipovska, J.3
Szeto, H.H.4
Pintar, J.E.5
Devi, L.A.6
-
38
-
-
63449115392
-
Metabotropic receptors for glutamate and GABA in pain
-
Goudet C., Magnaghi V., Landry M., Nagy F., Gereau R.W., Pin J.P. Metabotropic receptors for glutamate and GABA in pain. Brain Res. Brain Res. Rev. 2009, 60:43-56.
-
(2009)
Brain Res. Brain Res. Rev.
, vol.60
, pp. 43-56
-
-
Goudet, C.1
Magnaghi, V.2
Landry, M.3
Nagy, F.4
Gereau, R.W.5
Pin, J.P.6
-
39
-
-
84861075468
-
Structure of the δ-opioid receptor bound to naltrindole
-
Granier S., Manglik A., Kruse A.C., Kobilka T.S., Thian F.S., Weis W.I., Kobilka B.K. Structure of the δ-opioid receptor bound to naltrindole. Nature 2012, 485:400-404.
-
(2012)
Nature
, vol.485
, pp. 400-404
-
-
Granier, S.1
Manglik, A.2
Kruse, A.C.3
Kobilka, T.S.4
Thian, F.S.5
Weis, W.I.6
Kobilka, B.K.7
-
40
-
-
34547865012
-
Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity
-
Griffin R.S., Costigan M., Brenner G.J., Ma C.H., Scholz J., Moss A., Allchorne A.J., Stahl G.L., Woolf C.J. Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity. J. Neurosci. 2007, 27:8699-8708.
-
(2007)
J. Neurosci.
, vol.27
, pp. 8699-8708
-
-
Griffin, R.S.1
Costigan, M.2
Brenner, G.J.3
Ma, C.H.4
Scholz, J.5
Moss, A.6
Allchorne, A.J.7
Stahl, G.L.8
Woolf, C.J.9
-
41
-
-
77957680486
-
Mas-related G-protein-coupled receptors inhibit pathological pain in mice
-
Guan Y., Liu Q., Tang Z., Raja S.N., Anderson D.J., Dong X. Mas-related G-protein-coupled receptors inhibit pathological pain in mice. Proc. Natl. Acad. Sci. USA 2010, 107:15933-15938.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 15933-15938
-
-
Guan, Y.1
Liu, Q.2
Tang, Z.3
Raja, S.N.4
Anderson, D.J.5
Dong, X.6
-
42
-
-
77956635370
-
Increased abundance of opioid receptor heteromers after chronic morphine administration
-
Gupta A., Mulder J., Gomes I., Rozenfeld R., Bushlin I., Ong E., Lim M., Maillet E., Junek M., Cahill C.M., et al. Increased abundance of opioid receptor heteromers after chronic morphine administration. Sci. Signal. 2010, 3:ra54.
-
(2010)
Sci. Signal.
, vol.3
, pp. ra54
-
-
Gupta, A.1
Mulder, J.2
Gomes, I.3
Rozenfeld, R.4
Bushlin, I.5
Ong, E.6
Lim, M.7
Maillet, E.8
Junek, M.9
Cahill, C.M.10
-
43
-
-
84904215099
-
Opioid receptor function is regulated by post-endocytic peptide processing
-
Gupta A., Gomes I., Wardman J., Devi L.A. Opioid receptor function is regulated by post-endocytic peptide processing. J. Biol. Chem. 2014, 289:19613-19626.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 19613-19626
-
-
Gupta, A.1
Gomes, I.2
Wardman, J.3
Devi, L.A.4
-
44
-
-
84920132543
-
Endothelin-converting enzyme 2 differentially regulates opioid receptor activity
-
Gupta A., Fujita W., Gomes I., Bobeck E., Devi L.A. Endothelin-converting enzyme 2 differentially regulates opioid receptor activity. Br. J. Pharmacol. 2015, 172:704-719.
-
(2015)
Br. J. Pharmacol.
, vol.172
, pp. 704-719
-
-
Gupta, A.1
Fujita, W.2
Gomes, I.3
Bobeck, E.4
Devi, L.A.5
-
45
-
-
84922708295
-
GABA blocks pathological but not acute TRPV1 pain signals
-
Hanack C., Moroni M., Lima W.C., Wende H., Kirchner M., Adelfinger L., Schrenk-Siemens K., Tappe-Theodor A., Wetzel C., Kuich P.H., et al. GABA blocks pathological but not acute TRPV1 pain signals. Cell 2015, 160:759-770.
-
(2015)
Cell
, vol.160
, pp. 759-770
-
-
Hanack, C.1
Moroni, M.2
Lima, W.C.3
Wende, H.4
Kirchner, M.5
Adelfinger, L.6
Schrenk-Siemens, K.7
Tappe-Theodor, A.8
Wetzel, C.9
Kuich, P.H.10
-
46
-
-
0035855910
-
Visual transduction in Drosophila
-
Hardie R.C., Raghu P. Visual transduction in Drosophila. Nature 2001, 413:186-193.
-
(2001)
Nature
, vol.413
, pp. 186-193
-
-
Hardie, R.C.1
Raghu, P.2
-
47
-
-
70350514475
-
Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2
-
Hasdemir B., Murphy J.E., Cottrell G.S., Bunnett N.W. Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2. J. Biol. Chem. 2009, 284:28453-28466.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 28453-28466
-
-
Hasdemir, B.1
Murphy, J.E.2
Cottrell, G.S.3
Bunnett, N.W.4
-
48
-
-
78650958254
-
Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation
-
He S.Q., Zhang Z.N., Guan J.S., Liu H.R., Zhao B., Wang H.B., Li Q., Yang H., Luo J., Li Z.Y., et al. Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation. Neuron 2011, 69:120-131.
-
(2011)
Neuron
, vol.69
, pp. 120-131
-
-
He, S.Q.1
Zhang, Z.N.2
Guan, J.S.3
Liu, H.R.4
Zhao, B.5
Wang, H.B.6
Li, Q.7
Yang, H.8
Luo, J.9
Li, Z.Y.10
-
49
-
-
67749127754
-
Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes
-
Hislop J.N., Henry A.G., Marchese A., von Zastrow M. Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes. J. Biol. Chem. 2009, 284:19361-19370.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 19361-19370
-
-
Hislop, J.N.1
Henry, A.G.2
Marchese, A.3
von Zastrow, M.4
-
50
-
-
84939780109
-
Ligand Residence Time at G-protein-Coupled Receptors-Why We Should Take Our Time To Study It
-
Hoffmann C., Castro M., Rinken A., Leurs R., Hill S.J., Vischer H.F. Ligand Residence Time at G-protein-Coupled Receptors-Why We Should Take Our Time To Study It. Mol. Pharmacol. 2015, 88:552-560.
-
(2015)
Mol. Pharmacol.
, vol.88
, pp. 552-560
-
-
Hoffmann, C.1
Castro, M.2
Rinken, A.3
Leurs, R.4
Hill, S.J.5
Vischer, H.F.6
-
51
-
-
78650772784
-
H3 receptors and pain modulation: peripheral, spinal, and brain interactions
-
Hough L.B., Rice F.L. H3 receptors and pain modulation: peripheral, spinal, and brain interactions. J. Pharmacol. Exp. Ther. 2011, 336:30-37.
-
(2011)
J. Pharmacol. Exp. Ther.
, vol.336
, pp. 30-37
-
-
Hough, L.B.1
Rice, F.L.2
-
53
-
-
84875604499
-
Conformational biosensors reveal GPCR signalling from endosomes
-
Irannejad R., Tomshine J.C., Tomshine J.R., Chevalier M., Mahoney J.P., Steyaert J., Rasmussen S.G., Sunahara R.K., El-Samad H., Huang B., von Zastrow M. Conformational biosensors reveal GPCR signalling from endosomes. Nature 2013, 495:534-538.
-
(2013)
Nature
, vol.495
, pp. 534-538
-
-
Irannejad, R.1
Tomshine, J.C.2
Tomshine, J.R.3
Chevalier, M.4
Mahoney, J.P.5
Steyaert, J.6
Rasmussen, S.G.7
Sunahara, R.K.8
El-Samad, H.9
Huang, B.10
von Zastrow, M.11
-
54
-
-
18144412332
-
C-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2
-
Jacob C., Cottrell G.S., Gehringer D., Schmidlin F., Grady E.F., Bunnett N.W. c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2. J. Biol. Chem. 2005, 280:16076-16087.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 16076-16087
-
-
Jacob, C.1
Cottrell, G.S.2
Gehringer, D.3
Schmidlin, F.4
Grady, E.F.5
Bunnett, N.W.6
-
55
-
-
84904489168
-
Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals
-
Jensen D.D., Halls M.L., Murphy J.E., Canals M., Cattaruzza F., Poole D.P., Lieu T., Koon H.W., Pothoulakis C., Bunnett N.W. Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals. J. Biol. Chem. 2014, 289:20283-20294.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 20283-20294
-
-
Jensen, D.D.1
Halls, M.L.2
Murphy, J.E.3
Canals, M.4
Cattaruzza, F.5
Poole, D.P.6
Lieu, T.7
Koon, H.W.8
Pothoulakis, C.9
Bunnett, N.W.10
-
56
-
-
70350621238
-
A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1
-
Jeske N.A., Patwardhan A.M., Ruparel N.B., Akopian A.N., Shapiro M.S., Henry M.A. A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1. Pain 2009, 146:301-307.
-
(2009)
Pain
, vol.146
, pp. 301-307
-
-
Jeske, N.A.1
Patwardhan, A.M.2
Ruparel, N.B.3
Akopian, A.N.4
Shapiro, M.S.5
Henry, M.A.6
-
57
-
-
84899838945
-
Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord
-
Kardon A.P., Polgár E., Hachisuka J., Snyder L.M., Cameron D., Savage S., Cai X., Karnup S., Fan C.R., Hemenway G.M., et al. Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron 2014, 82:573-586.
-
(2014)
Neuron
, vol.82
, pp. 573-586
-
-
Kardon, A.P.1
Polgár, E.2
Hachisuka, J.3
Snyder, L.M.4
Cameron, D.5
Savage, S.6
Cai, X.7
Karnup, S.8
Fan, C.R.9
Hemenway, G.M.10
-
58
-
-
84875227396
-
Signalling bias in new drug discovery: detection, quantification and therapeutic impact
-
Kenakin T., Christopoulos A. Signalling bias in new drug discovery: detection, quantification and therapeutic impact. Nat. Rev. Drug Discov. 2013, 12:205-216.
-
(2013)
Nat. Rev. Drug Discov.
, vol.12
, pp. 205-216
-
-
Kenakin, T.1
Christopoulos, A.2
-
59
-
-
84902166170
-
Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus
-
Kido-Nakahara M., Buddenkotte J., Kempkes C., Ikoma A., Cevikbas F., Akiyama T., Nunes F., Seeliger S., Hasdemir B., Mess C., et al. Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus. J. Clin. Invest. 2014, 124:2683-2695.
-
(2014)
J. Clin. Invest.
, vol.124
, pp. 2683-2695
-
-
Kido-Nakahara, M.1
Buddenkotte, J.2
Kempkes, C.3
Ikoma, A.4
Cevikbas, F.5
Akiyama, T.6
Nunes, F.7
Seeliger, S.8
Hasdemir, B.9
Mess, C.10
-
60
-
-
2342466078
-
Histamine-induced Ca(2+) influx via the PLA(2)/lipoxygenase/TRPV1 pathway in rat sensory neurons
-
Kim B.M., Lee S.H., Shim W.S., Oh U. Histamine-induced Ca(2+) influx via the PLA(2)/lipoxygenase/TRPV1 pathway in rat sensory neurons. Neurosci. Lett. 2004, 361:159-162.
-
(2004)
Neurosci. Lett.
, vol.361
, pp. 159-162
-
-
Kim, B.M.1
Lee, S.H.2
Shim, W.S.3
Oh, U.4
-
61
-
-
84889564886
-
Activation and allosteric modulation of a muscarinic acetylcholine receptor
-
Kruse A.C., Ring A.M., Manglik A., Hu J., Hu K., Eitel K., Hübner H., Pardon E., Valant C., Sexton P.M., et al. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature 2013, 504:101-106.
-
(2013)
Nature
, vol.504
, pp. 101-106
-
-
Kruse, A.C.1
Ring, A.M.2
Manglik, A.3
Hu, J.4
Hu, K.5
Eitel, K.6
Hübner, H.7
Pardon, E.8
Valant, C.9
Sexton, P.M.10
-
62
-
-
70350381113
-
Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2
-
Kuszak A.J., Pitchiaya S., Anand J.P., Mosberg H.I., Walter N.G., Sunahara R.K. Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2. J. Biol. Chem. 2009, 284:26732-26741.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 26732-26741
-
-
Kuszak, A.J.1
Pitchiaya, S.2
Anand, J.P.3
Mosberg, H.I.4
Walter, N.G.5
Sunahara, R.K.6
-
63
-
-
84864881068
-
Impairment of GABAB receptor dimer by endogenous 14-3-3ζ in chronic pain conditions
-
Laffray S., Bouali-Benazzouz R., Papon M.A., Favereaux A., Jiang Y., Holm T., Spriet C., Desbarats P., Fossat P., Le Feuvre Y., et al. Impairment of GABAB receptor dimer by endogenous 14-3-3ζ in chronic pain conditions. EMBO J. 2012, 31:3239-3251.
-
(2012)
EMBO J.
, vol.31
, pp. 3239-3251
-
-
Laffray, S.1
Bouali-Benazzouz, R.2
Papon, M.A.3
Favereaux, A.4
Jiang, Y.5
Holm, T.6
Spriet, C.7
Desbarats, P.8
Fossat, P.9
Le Feuvre, Y.10
-
64
-
-
84913533041
-
The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice
-
Lieu T., Jayaweera G., Zhao P., Poole D.P., Jensen D., Grace M., McIntyre P., Bron R., Wilson Y.M., Krappitz M., et al. The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice. Gastroenterology 2014, 147:1417-1428.
-
(2014)
Gastroenterology
, vol.147
, pp. 1417-1428
-
-
Lieu, T.1
Jayaweera, G.2
Zhao, P.3
Poole, D.P.4
Jensen, D.5
Grace, M.6
McIntyre, P.7
Bron, R.8
Wilson, Y.M.9
Krappitz, M.10
-
65
-
-
79251562487
-
Serotonin receptor 5-HT2B mediates serotonin-induced mechanical hyperalgesia
-
Lin S.Y., Chang W.J., Lin C.S., Huang C.Y., Wang H.F., Sun W.H. Serotonin receptor 5-HT2B mediates serotonin-induced mechanical hyperalgesia. J. Neurosci. 2011, 31:1410-1418.
-
(2011)
J. Neurosci.
, vol.31
, pp. 1410-1418
-
-
Lin, S.Y.1
Chang, W.J.2
Lin, C.S.3
Huang, C.Y.4
Wang, H.F.5
Sun, W.H.6
-
66
-
-
72249113172
-
Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus
-
Liu Q., Tang Z., Surdenikova L., Kim S., Patel K.N., Kim A., Ru F., Guan Y., Weng H.J., Geng Y., et al. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell 2009, 139:1353-1365.
-
(2009)
Cell
, vol.139
, pp. 1353-1365
-
-
Liu, Q.1
Tang, Z.2
Surdenikova, L.3
Kim, S.4
Patel, K.N.5
Kim, A.6
Ru, F.7
Guan, Y.8
Weng, H.J.9
Geng, Y.10
-
67
-
-
80054709876
-
Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids
-
Liu X.Y., Liu Z.C., Sun Y.G., Ross M., Kim S., Tsai F.F., Li Q.F., Jeffry J., Kim J.Y., Loh H.H., Chen Z.F. Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids. Cell 2011, 147:447-458.
-
(2011)
Cell
, vol.147
, pp. 447-458
-
-
Liu, X.Y.1
Liu, Z.C.2
Sun, Y.G.3
Ross, M.4
Kim, S.5
Tsai, F.F.6
Li, Q.F.7
Jeffry, J.8
Kim, J.Y.9
Loh, H.H.10
Chen, Z.F.11
-
68
-
-
84862776738
-
Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR
-
Liu J.J., Horst R., Katritch V., Stevens R.C., Wüthrich K. Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR. Science 2012, 335:1106-1110.
-
(2012)
Science
, vol.335
, pp. 1106-1110
-
-
Liu, J.J.1
Horst, R.2
Katritch, V.3
Stevens, R.C.4
Wüthrich, K.5
-
69
-
-
84919905519
-
Disruption of the Na+ ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor
-
Livingston K.E., Traynor J.R. Disruption of the Na+ ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor. Proc. Natl. Acad. Sci. USA 2014, 111:18369-18374.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 18369-18374
-
-
Livingston, K.E.1
Traynor, J.R.2
-
70
-
-
84936802493
-
Mediation of opioid analgesia by a truncated 6-transmembrane GPCR
-
Lu Z., Xu J., Rossi G.C., Majumdar S., Pasternak G.W., Pan Y.X. Mediation of opioid analgesia by a truncated 6-transmembrane GPCR. J. Clin. Invest. 2015, 125:2626-2630.
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 2626-2630
-
-
Lu, Z.1
Xu, J.2
Rossi, G.C.3
Majumdar, S.4
Pasternak, G.W.5
Pan, Y.X.6
-
71
-
-
84861096654
-
Crystal structure of the μ-opioid receptor bound to a morphinan antagonist
-
Manglik A., Kruse A.C., Kobilka T.S., Thian F.S., Mathiesen J.M., Sunahara R.K., Pardo L., Weis W.I., Kobilka B.K., Granier S. Crystal structure of the μ-opioid receptor bound to a morphinan antagonist. Nature 2012, 485:321-326.
-
(2012)
Nature
, vol.485
, pp. 321-326
-
-
Manglik, A.1
Kruse, A.C.2
Kobilka, T.S.3
Thian, F.S.4
Mathiesen, J.M.5
Sunahara, R.K.6
Pardo, L.7
Weis, W.I.8
Kobilka, B.K.9
Granier, S.10
-
72
-
-
0028999848
-
Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation
-
Mantyh P.W., DeMaster E., Malhotra A., Ghilardi J.R., Rogers S.D., Mantyh C.R., Liu H., Basbaum A.I., Vigna S.R., Maggio J.E., et al. Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science 1995, 268:1629-1632.
-
(1995)
Science
, vol.268
, pp. 1629-1632
-
-
Mantyh, P.W.1
DeMaster, E.2
Malhotra, A.3
Ghilardi, J.R.4
Rogers, S.D.5
Mantyh, C.R.6
Liu, H.7
Basbaum, A.I.8
Vigna, S.R.9
Maggio, J.E.10
-
73
-
-
0033667466
-
A trafficking checkpoint controls GABA(B) receptor heterodimerization
-
Margeta-Mitrovic M., Jan Y.N., Jan L.Y. A trafficking checkpoint controls GABA(B) receptor heterodimerization. Neuron 2000, 27:97-106.
-
(2000)
Neuron
, vol.27
, pp. 97-106
-
-
Margeta-Mitrovic, M.1
Jan, Y.N.2
Jan, L.Y.3
-
74
-
-
84925521365
-
Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions
-
McNeil B.D., Pundir P., Meeker S., Han L., Undem B.J., Kulka M., Dong X. Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. Nature 2015, 519:237-241.
-
(2015)
Nature
, vol.519
, pp. 237-241
-
-
McNeil, B.D.1
Pundir, P.2
Meeker, S.3
Han, L.4
Undem, B.J.5
Kulka, M.6
Dong, X.7
-
75
-
-
84874541752
-
Protease activity enhances production of thymic stromal lymphopoietin and basophil accumulation in flaky tail mice
-
Moniaga C.S., Jeong S.K., Egawa G., Nakajima S., Hara-Chikuma M., Jeon J.E., Lee S.H., Hibino T., Miyachi Y., Kabashima K. Protease activity enhances production of thymic stromal lymphopoietin and basophil accumulation in flaky tail mice. Am. J. Pathol. 2013, 182:841-851.
-
(2013)
Am. J. Pathol.
, vol.182
, pp. 841-851
-
-
Moniaga, C.S.1
Jeong, S.K.2
Egawa, G.3
Nakajima, S.4
Hara-Chikuma, M.5
Jeon, J.E.6
Lee, S.H.7
Hibino, T.8
Miyachi, Y.9
Kabashima, K.10
-
76
-
-
84912550371
-
Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief
-
Moriconi A., Cunha T.M., Souza G.R., Lopes A.H., Cunha F.Q., Carneiro V.L., Pinto L.G., Brandolini L., Aramini A., Bizzarri C., et al. Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief. Proc. Natl. Acad. Sci. USA 2014, 111:16937-16942.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 16937-16942
-
-
Moriconi, A.1
Cunha, T.M.2
Souza, G.R.3
Lopes, A.H.4
Cunha, F.Q.5
Carneiro, V.L.6
Pinto, L.G.7
Brandolini, L.8
Aramini, A.9
Bizzarri, C.10
-
77
-
-
84937516283
-
HTR7 mediates serotonergic acute and chronic itch
-
Morita T., McClain S.P., Batia L.M., Pellegrino M., Wilson S.R., Kienzler M.A., Lyman K., Olsen A.S., Wong J.F., Stucky C.L., et al. HTR7 mediates serotonergic acute and chronic itch. Neuron 2015, 87:124-138.
-
(2015)
Neuron
, vol.87
, pp. 124-138
-
-
Morita, T.1
McClain, S.P.2
Batia, L.M.3
Pellegrino, M.4
Wilson, S.R.5
Kienzler, M.A.6
Lyman, K.7
Olsen, A.S.8
Wong, J.F.9
Stucky, C.L.10
-
78
-
-
70449552889
-
Endosomes: a legitimate platform for the signaling train
-
Murphy J.E., Padilla B.E., Hasdemir B., Cottrell G.S., Bunnett N.W. Endosomes: a legitimate platform for the signaling train. Proc. Natl. Acad. Sci. USA 2009, 106:17615-17622.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 17615-17622
-
-
Murphy, J.E.1
Padilla, B.E.2
Hasdemir, B.3
Cottrell, G.S.4
Bunnett, N.W.5
-
79
-
-
80053186587
-
Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor
-
Murphy J.E., Roosterman D., Cottrell G.S., Padilla B.E., Feld M., Brand E., Cedron W.J., Bunnett N.W., Steinhoff M. Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor. Am. J. Physiol. Cell Physiol. 2011, 301:C780-C791.
-
(2011)
Am. J. Physiol. Cell Physiol.
, vol.301
, pp. C780-C791
-
-
Murphy, J.E.1
Roosterman, D.2
Cottrell, G.S.3
Padilla, B.E.4
Feld, M.5
Brand, E.6
Cedron, W.J.7
Bunnett, N.W.8
Steinhoff, M.9
-
80
-
-
84888040704
-
Development of allosteric modulators of GPCRs for treatment of CNS disorders
-
Nickols H.H., Conn P.J. Development of allosteric modulators of GPCRs for treatment of CNS disorders. Neurobiol. Dis. 2014, 61:55-71.
-
(2014)
Neurobiol. Dis.
, vol.61
, pp. 55-71
-
-
Nickols, H.H.1
Conn, P.J.2
-
81
-
-
0033527663
-
Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization
-
Oakley R.H., Laporte S.A., Holt J.A., Barak L.S., Caron M.G. Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization. J. Biol. Chem. 1999, 274:32248-32257.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 32248-32257
-
-
Oakley, R.H.1
Laporte, S.A.2
Holt, J.A.3
Barak, L.S.4
Caron, M.G.5
-
82
-
-
0034595860
-
Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors
-
Oakley R.H., Laporte S.A., Holt J.A., Caron M.G., Barak L.S. Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors. J. Biol. Chem. 2000, 275:17201-17210.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 17201-17210
-
-
Oakley, R.H.1
Laporte, S.A.2
Holt, J.A.3
Caron, M.G.4
Barak, L.S.5
-
83
-
-
36849078884
-
Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins
-
Padilla B.E., Cottrell G.S., Roosterman D., Pikios S., Muller L., Steinhoff M., Bunnett N.W. Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. J. Cell Biol. 2007, 179:981-997.
-
(2007)
J. Cell Biol.
, vol.179
, pp. 981-997
-
-
Padilla, B.E.1
Cottrell, G.S.2
Roosterman, D.3
Pikios, S.4
Muller, L.5
Steinhoff, M.6
Bunnett, N.W.7
-
84
-
-
84902144481
-
Constitutively active rhodopsin and retinal disease
-
Park P.S. Constitutively active rhodopsin and retinal disease. Adv. Pharmacol. 2014, 70:1-36.
-
(2014)
Adv. Pharmacol.
, vol.70
, pp. 1-36
-
-
Park, P.S.1
-
85
-
-
84867705860
-
Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors
-
Petho G., Reeh P.W. Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors. Physiol. Rev. 2012, 92:1699-1775.
-
(2012)
Physiol. Rev.
, vol.92
, pp. 1699-1775
-
-
Petho, G.1
Reeh, P.W.2
-
86
-
-
33847419390
-
International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers
-
Pin J.P., Neubig R., Bouvier M., Devi L., Filizola M., Javitch J.A., Lohse M.J., Milligan G., Palczewski K., Parmentier M., Spedding M. International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacol. Rev. 2007, 59:5-13.
-
(2007)
Pharmacol. Rev.
, vol.59
, pp. 5-13
-
-
Pin, J.P.1
Neubig, R.2
Bouvier, M.3
Devi, L.4
Filizola, M.5
Javitch, J.A.6
Lohse, M.J.7
Milligan, G.8
Palczewski, K.9
Parmentier, M.10
Spedding, M.11
-
87
-
-
80052119573
-
Localization and regulation of fluorescently labeled delta opioid receptor, expressed in enteric neurons of mice
-
Poole D.P., Pelayo J.C., Scherrer G., Evans C.J., Kieffer B.L., Bunnett N.W. Localization and regulation of fluorescently labeled delta opioid receptor, expressed in enteric neurons of mice. Gastroenterology 2011, 141:982-991.e1, 8.
-
(2011)
Gastroenterology
, vol.141
, pp. 982-991
-
-
Poole, D.P.1
Pelayo, J.C.2
Scherrer, G.3
Evans, C.J.4
Kieffer, B.L.5
Bunnett, N.W.6
-
88
-
-
84874303694
-
Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling
-
Poole D.P., Amadesi S., Veldhuis N.A., Abogadie F.C., Lieu T., Darby W., Liedtke W., Lew M.J., McIntyre P., Bunnett N.W. Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling. J. Biol. Chem. 2013, 288:5790-5802.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 5790-5802
-
-
Poole, D.P.1
Amadesi, S.2
Veldhuis, N.A.3
Abogadie, F.C.4
Lieu, T.5
Darby, W.6
Liedtke, W.7
Lew, M.J.8
McIntyre, P.9
Bunnett, N.W.10
-
89
-
-
84875194289
-
Phosphorylation regulates TRPV1 association with β-arrestin-2
-
Por E.D., Gomez R., Akopian A.N., Jeske N.A. Phosphorylation regulates TRPV1 association with β-arrestin-2. Biochem. J. 2013, 451:101-109.
-
(2013)
Biochem. J.
, vol.451
, pp. 101-109
-
-
Por, E.D.1
Gomez, R.2
Akopian, A.N.3
Jeske, N.A.4
-
90
-
-
78650048600
-
Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance
-
Pradhan A.A., Walwyn W., Nozaki C., Filliol D., Erbs E., Matifas A., Evans C., Kieffer B.L. Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance. J. Neurosci. 2010, 30:16459-16468.
-
(2010)
J. Neurosci.
, vol.30
, pp. 16459-16468
-
-
Pradhan, A.A.1
Walwyn, W.2
Nozaki, C.3
Filliol, D.4
Erbs, E.5
Matifas, A.6
Evans, C.7
Kieffer, B.L.8
-
92
-
-
80051658642
-
Crystal structure of the β2 adrenergic receptor-Gs protein complex
-
Rasmussen S.G., DeVree B.T., Zou Y., Kruse A.C., Chung K.Y., Kobilka T.S., Thian F.S., Chae P.S., Pardon E., Calinski D., et al. Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature 2011, 477:549-555.
-
(2011)
Nature
, vol.477
, pp. 549-555
-
-
Rasmussen, S.G.1
DeVree, B.T.2
Zou, Y.3
Kruse, A.C.4
Chung, K.Y.5
Kobilka, T.S.6
Thian, F.S.7
Chae, P.S.8
Pardon, E.9
Calinski, D.10
-
93
-
-
43749117724
-
Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors
-
Reddy V.B., Iuga A.O., Shimada S.G., LaMotte R.H., Lerner E.A. Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors. J. Neurosci. 2008, 28:4331-4335.
-
(2008)
J. Neurosci.
, vol.28
, pp. 4331-4335
-
-
Reddy, V.B.1
Iuga, A.O.2
Shimada, S.G.3
LaMotte, R.H.4
Lerner, E.A.5
-
94
-
-
84938151125
-
Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs
-
Reddy V.B., Sun S., Azimi E., Elmariah S.B., Dong X., Lerner E.A. Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs. Nat. Commun. 2015, 6:7864.
-
(2015)
Nat. Commun.
, vol.6
, pp. 7864
-
-
Reddy, V.B.1
Sun, S.2
Azimi, E.3
Elmariah, S.B.4
Dong, X.5
Lerner, E.A.6
-
95
-
-
0029903640
-
Metabotropic glutamate receptor 5 is a disulfide-linked dimer
-
Romano C., Yang W.L., O'Malley K.L. Metabotropic glutamate receptor 5 is a disulfide-linked dimer. J. Biol. Chem. 1996, 271:28612-28616.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 28612-28616
-
-
Romano, C.1
Yang, W.L.2
O'Malley, K.L.3
-
96
-
-
34547459014
-
Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling
-
Roosterman D., Cottrell G.S., Padilla B.E., Muller L., Eckman C.B., Bunnett N.W., Steinhoff M. Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling. Proc. Natl. Acad. Sci. USA 2007, 104:11838-11843.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 11838-11843
-
-
Roosterman, D.1
Cottrell, G.S.2
Padilla, B.E.3
Muller, L.4
Eckman, C.B.5
Bunnett, N.W.6
Steinhoff, M.7
-
97
-
-
84881622768
-
The role of histamine in neurogenic inflammation
-
Rosa A.C., Fantozzi R. The role of histamine in neurogenic inflammation. Br. J. Pharmacol. 2013, 170:38-45.
-
(2013)
Br. J. Pharmacol.
, vol.170
, pp. 38-45
-
-
Rosa, A.C.1
Fantozzi, R.2
-
98
-
-
66749154689
-
Dissociation of the opioid receptor mechanisms that control mechanical and heat pain
-
Scherrer G., Imamachi N., Cao Y.Q., Contet C., Mennicken F., O'Donnell D., Kieffer B.L., Basbaum A.I. Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. Cell 2009, 137:1148-1159.
-
(2009)
Cell
, vol.137
, pp. 1148-1159
-
-
Scherrer, G.1
Imamachi, N.2
Cao, Y.Q.3
Contet, C.4
Mennicken, F.5
O'Donnell, D.6
Kieffer, B.L.7
Basbaum, A.I.8
-
99
-
-
0037022687
-
Heterologous regulation of trafficking and signaling of G protein-coupled receptors: beta-arrestin-dependent interactions between neurokinin receptors
-
Schmidlin F., Déry O., Bunnett N.W., Grady E.F. Heterologous regulation of trafficking and signaling of G protein-coupled receptors: beta-arrestin-dependent interactions between neurokinin receptors. Proc. Natl. Acad. Sci. USA 2002, 99:3324-3329.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 3324-3329
-
-
Schmidlin, F.1
Déry, O.2
Bunnett, N.W.3
Grady, E.F.4
-
100
-
-
0141568089
-
The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins
-
Schmidlin F., Roosterman D., Bunnett N.W. The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins. Am. J. Physiol. Cell Physiol. 2003, 285:C945-C958.
-
(2003)
Am. J. Physiol. Cell Physiol.
, vol.285
, pp. C945-C958
-
-
Schmidlin, F.1
Roosterman, D.2
Bunnett, N.W.3
-
101
-
-
17944367990
-
Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1))
-
Schuler V., Lüscher C., Blanchet C., Klix N., Sansig G., Klebs K., Schmutz M., Heid J., Gentry C., Urban L., et al. Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)). Neuron 2001, 31:47-58.
-
(2001)
Neuron
, vol.31
, pp. 47-58
-
-
Schuler, V.1
Lüscher, C.2
Blanchet, C.3
Klix, N.4
Sansig, G.5
Klebs, K.6
Schmutz, M.7
Heid, J.8
Gentry, C.9
Urban, L.10
-
102
-
-
33847400543
-
TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase
-
Shim W.S., Tak M.H., Lee M.H., Kim M., Kim M., Koo J.Y., Lee C.H., Kim M., Oh U. TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase. J. Neurosci. 2007, 27:2331-2337.
-
(2007)
J. Neurosci.
, vol.27
, pp. 2331-2337
-
-
Shim, W.S.1
Tak, M.H.2
Lee, M.H.3
Kim, M.4
Kim, M.5
Koo, J.Y.6
Lee, C.H.7
Kim, M.8
Oh, U.9
-
103
-
-
33847081648
-
Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity
-
Smit M.J., Vischer H.F., Bakker R.A., Jongejan A., Timmerman H., Pardo L., Leurs R. Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity. Annu. Rev. Pharmacol. Toxicol. 2007, 47:53-87.
-
(2007)
Annu. Rev. Pharmacol. Toxicol.
, vol.47
, pp. 53-87
-
-
Smit, M.J.1
Vischer, H.F.2
Bakker, R.A.3
Jongejan, A.4
Timmerman, H.5
Pardo, L.6
Leurs, R.7
-
104
-
-
84926407374
-
Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers
-
Soergel D.G., Subach R.A., Burnham N., Lark M.W., James I.E., Sadler B.M., Skobieranda F., Violin J.D., Webster L.R. Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers. Pain 2014, 155:1829-1835.
-
(2014)
Pain
, vol.155
, pp. 1829-1835
-
-
Soergel, D.G.1
Subach, R.A.2
Burnham, N.3
Lark, M.W.4
James, I.E.5
Sadler, B.M.6
Skobieranda, F.7
Violin, J.D.8
Webster, L.R.9
-
105
-
-
84920972659
-
Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns
-
Solorzano C., Villafuerte D., Meda K., Cevikbas F., Bráz J., Sharif-Naeini R., Juarez-Salinas D., Llewellyn-Smith I.J., Guan Z., Basbaum A.I. Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. J. Neurosci. 2015, 35:648-657.
-
(2015)
J. Neurosci.
, vol.35
, pp. 648-657
-
-
Solorzano, C.1
Villafuerte, D.2
Meda, K.3
Cevikbas, F.4
Bráz, J.5
Sharif-Naeini, R.6
Juarez-Salinas, D.7
Llewellyn-Smith, I.J.8
Guan, Z.9
Basbaum, A.I.10
-
106
-
-
0033971235
-
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
-
Steinhoff M., Vergnolle N., Young S.H., Tognetto M., Amadesi S., Ennes H.S., Trevisani M., Hollenberg M.D., Wallace J.L., Caughey G.H., et al. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat. Med. 2000, 6:151-158.
-
(2000)
Nat. Med.
, vol.6
, pp. 151-158
-
-
Steinhoff, M.1
Vergnolle, N.2
Young, S.H.3
Tognetto, M.4
Amadesi, S.5
Ennes, H.S.6
Trevisani, M.7
Hollenberg, M.D.8
Wallace, J.L.9
Caughey, G.H.10
-
107
-
-
0038720558
-
Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin
-
Steinhoff M., Neisius U., Ikoma A., Fartasch M., Heyer G., Skov P.S., Luger T.A., Schmelz M. Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J. Neurosci. 2003, 23:6176-6180.
-
(2003)
J. Neurosci.
, vol.23
, pp. 6176-6180
-
-
Steinhoff, M.1
Neisius, U.2
Ikoma, A.3
Fartasch, M.4
Heyer, G.5
Skov, P.S.6
Luger, T.A.7
Schmelz, M.8
-
108
-
-
13044264447
-
Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P
-
Sturiale S., Barbara G., Qiu B., Figini M., Geppetti P., Gerard N., Gerard C., Grady E.F., Bunnett N.W., Collins S.M. Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P. Proc. Natl. Acad. Sci. USA 1999, 96:11653-11658.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 11653-11658
-
-
Sturiale, S.1
Barbara, G.2
Qiu, B.3
Figini, M.4
Geppetti, P.5
Gerard, N.6
Gerard, C.7
Grady, E.F.8
Bunnett, N.W.9
Collins, S.M.10
-
109
-
-
34547726181
-
A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord
-
Sun Y.G., Chen Z.F. A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 2007, 448:700-703.
-
(2007)
Nature
, vol.448
, pp. 700-703
-
-
Sun, Y.G.1
Chen, Z.F.2
-
110
-
-
0037022586
-
Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+
-
Tsuchiya D., Kunishima N., Kamiya N., Jingami H., Morikawa K. Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+. Proc. Natl. Acad. Sci. USA 2002, 99:2660-2665.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 2660-2665
-
-
Tsuchiya, D.1
Kunishima, N.2
Kamiya, N.3
Jingami, H.4
Morikawa, K.5
-
111
-
-
84916207732
-
The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation
-
Veldhuis N.A., Poole D.P., Grace M., McIntyre P., Bunnett N.W. The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation. Pharmacol. Rev. 2015, 67:36-73.
-
(2015)
Pharmacol. Rev.
, vol.67
, pp. 36-73
-
-
Veldhuis, N.A.1
Poole, D.P.2
Grace, M.3
McIntyre, P.4
Bunnett, N.W.5
-
112
-
-
0034927070
-
Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway
-
Vergnolle N., Bunnett N.W., Sharkey K.A., Brussee V., Compton S.J., Grady E.F., Cirino G., Gerard N., Basbaum A.I., Andrade-Gordon P., et al. Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. Nat. Med. 2001, 7:821-826.
-
(2001)
Nat. Med.
, vol.7
, pp. 821-826
-
-
Vergnolle, N.1
Bunnett, N.W.2
Sharkey, K.A.3
Brussee, V.4
Compton, S.J.5
Grady, E.F.6
Cirino, G.7
Gerard, N.8
Basbaum, A.I.9
Andrade-Gordon, P.10
-
113
-
-
84877631485
-
Structural features for functional selectivity at serotonin receptors
-
Wacker D., Wang C., Katritch V., Han G.W., Huang X.P., Vardy E., McCorvy J.D., Jiang Y., Chu M., Siu F.Y., et al. Structural features for functional selectivity at serotonin receptors. Science 2013, 340:615-619.
-
(2013)
Science
, vol.340
, pp. 615-619
-
-
Wacker, D.1
Wang, C.2
Katritch, V.3
Han, G.W.4
Huang, X.P.5
Vardy, E.6
McCorvy, J.D.7
Jiang, Y.8
Chu, M.9
Siu, F.Y.10
-
114
-
-
34248382512
-
Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons
-
Walwyn W., Evans C.J., Hales T.G. Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons. J. Neurosci. 2007, 27:5092-5104.
-
(2007)
J. Neurosci.
, vol.27
, pp. 5092-5104
-
-
Walwyn, W.1
Evans, C.J.2
Hales, T.G.3
-
115
-
-
77955606622
-
Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons
-
Wang H.B., Zhao B., Zhong Y.Q., Li K.C., Li Z.Y., Wang Q., Lu Y.J., Zhang Z.N., He S.Q., Zheng H.C., et al. Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons. Proc. Natl. Acad. Sci. USA 2010, 107:13117-13122.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 13117-13122
-
-
Wang, H.B.1
Zhao, B.2
Zhong, Y.Q.3
Li, K.C.4
Li, Z.Y.5
Wang, Q.6
Lu, Y.J.7
Zhang, Z.N.8
He, S.Q.9
Zheng, H.C.10
-
116
-
-
84861064804
-
Crystal structures of a stabilized β1-adrenoceptor bound to the biased agonists bucindolol and carvedilol
-
Warne T., Edwards P.C., Leslie A.G., Tate C.G. Crystal structures of a stabilized β1-adrenoceptor bound to the biased agonists bucindolol and carvedilol. Structure 2012, 20:841-849.
-
(2012)
Structure
, vol.20
, pp. 841-849
-
-
Warne, T.1
Edwards, P.C.2
Leslie, A.G.3
Tate, C.G.4
-
117
-
-
0037178754
-
Modulation of postendocytic sorting of G protein-coupled receptors
-
Whistler J.L., Enquist J., Marley A., Fong J., Gladher F., Tsuruda P., Murray S.R., Von Zastrow M. Modulation of postendocytic sorting of G protein-coupled receptors. Science 2002, 297:615-620.
-
(2002)
Science
, vol.297
, pp. 615-620
-
-
Whistler, J.L.1
Enquist, J.2
Marley, A.3
Fong, J.4
Gladher, F.5
Tsuruda, P.6
Murray, S.R.7
Von Zastrow, M.8
-
118
-
-
84874290339
-
Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance
-
Williams J.T., Ingram S.L., Henderson G., Chavkin C., von Zastrow M., Schulz S., Koch T., Evans C.J., Christie M.J. Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharmacol. Rev. 2013, 65:223-254.
-
(2013)
Pharmacol. Rev.
, vol.65
, pp. 223-254
-
-
Williams, J.T.1
Ingram, S.L.2
Henderson, G.3
Chavkin, C.4
von Zastrow, M.5
Schulz, S.6
Koch, T.7
Evans, C.J.8
Christie, M.J.9
-
119
-
-
79955385137
-
TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch
-
Wilson S.R., Gerhold K.A., Bifolck-Fisher A., Liu Q., Patel K.N., Dong X., Bautista D.M. TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nat. Neurosci. 2011, 14:595-602.
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 595-602
-
-
Wilson, S.R.1
Gerhold, K.A.2
Bifolck-Fisher, A.3
Liu, Q.4
Patel, K.N.5
Dong, X.6
Bautista, D.M.7
-
120
-
-
84878331790
-
The ion channel TRPA1 is required for chronic itch
-
Wilson S.R., Nelson A.M., Batia L., Morita T., Estandian D., Owens D.M., Lumpkin E.A., Bautista D.M. The ion channel TRPA1 is required for chronic itch. J. Neurosci. 2013, 33:9283-9294.
-
(2013)
J. Neurosci.
, vol.33
, pp. 9283-9294
-
-
Wilson, S.R.1
Nelson, A.M.2
Batia, L.3
Morita, T.4
Estandian, D.5
Owens, D.M.6
Lumpkin, E.A.7
Bautista, D.M.8
-
121
-
-
84885674640
-
The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch
-
Wilson S.R., Thé L., Batia L.M., Beattie K., Katibah G.E., McClain S.P., Pellegrino M., Estandian D.M., Bautista D.M. The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch. Cell 2013, 155:285-295.
-
(2013)
Cell
, vol.155
, pp. 285-295
-
-
Wilson, S.R.1
Thé, L.2
Batia, L.M.3
Beattie, K.4
Katibah, G.E.5
McClain, S.P.6
Pellegrino, M.7
Estandian, D.M.8
Bautista, D.M.9
-
122
-
-
84881271660
-
Emerging paradigms in GPCR allostery: implications for drug discovery
-
Wootten D., Christopoulos A., Sexton P.M. Emerging paradigms in GPCR allostery: implications for drug discovery. Nat. Rev. Drug Discov. 2013, 12:630-644.
-
(2013)
Nat. Rev. Drug Discov.
, vol.12
, pp. 630-644
-
-
Wootten, D.1
Christopoulos, A.2
Sexton, P.M.3
-
123
-
-
84862777742
-
Structure of the human κ-opioid receptor in complex with JDTic
-
Wu H., Wacker D., Mileni M., Katritch V., Han G.W., Vardy E., Liu W., Thompson A.A., Huang X.P., Carroll F.I., et al. Structure of the human κ-opioid receptor in complex with JDTic. Nature 2012, 485:327-332.
-
(2012)
Nature
, vol.485
, pp. 327-332
-
-
Wu, H.1
Wacker, D.2
Mileni, M.3
Katritch, V.4
Han, G.W.5
Vardy, E.6
Liu, W.7
Thompson, A.A.8
Huang, X.P.9
Carroll, F.I.10
-
124
-
-
58149397654
-
Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons
-
Yu Y.J., Arttamangkul S., Evans C.J., Williams J.T., von Zastrow M. Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons. J. Neurosci. 2009, 29:222-233.
-
(2009)
J. Neurosci.
, vol.29
, pp. 222-233
-
-
Yu, Y.J.1
Arttamangkul, S.2
Evans, C.J.3
Williams, J.T.4
von Zastrow, M.5
-
125
-
-
48749115596
-
Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150
-
Zhang X., Li L., McNaughton P.A. Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150. Neuron 2008, 59:450-461.
-
(2008)
Neuron
, vol.59
, pp. 450-461
-
-
Zhang, X.1
Li, L.2
McNaughton, P.A.3
-
126
-
-
84907916606
-
Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4
-
Zhao P., Lieu T., Barlow N., Metcalf M., Veldhuis N.A., Jensen D.D., Kocan M., Sostegni S., Haerteis S., Baraznenok V., et al. Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4. J. Biol. Chem. 2014, 289:27215-27234.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 27215-27234
-
-
Zhao, P.1
Lieu, T.2
Barlow, N.3
Metcalf, M.4
Veldhuis, N.A.5
Jensen, D.D.6
Kocan, M.7
Sostegni, S.8
Haerteis, S.9
Baraznenok, V.10
-
128
-
-
84918841467
-
Descending control of itch transmission by the serotonergic system via 5-HT1A-facilitated GRP-GRPR signaling
-
Zhao Z.Q., Liu X.Y., Jeffry J., Karunarathne W.K., Li J.L., Munanairi A., Zhou X.Y., Li H., Sun Y.G., Wan L., et al. Descending control of itch transmission by the serotonergic system via 5-HT1A-facilitated GRP-GRPR signaling. Neuron 2014, 84:821-834.
-
(2014)
Neuron
, vol.84
, pp. 821-834
-
-
Zhao, Z.Q.1
Liu, X.Y.2
Jeffry, J.3
Karunarathne, W.K.4
Li, J.L.5
Munanairi, A.6
Zhou, X.Y.7
Li, H.8
Sun, Y.G.9
Wan, L.10
-
129
-
-
84930619167
-
Neutrophil Elastase activates protease-activated receptor-2 (PAR2) and transient receptor potential vanilloid 4 (TRPV4) to cause inflammation and pain
-
Zhao P., Lieu T., Barlow N., Sostegni S., Haerteis S., Korbmacher C., Liedtke W., Jimenez-Vargas N.N., Vanner S.J., Bunnett N.W. Neutrophil Elastase activates protease-activated receptor-2 (PAR2) and transient receptor potential vanilloid 4 (TRPV4) to cause inflammation and pain. J. Biol. Chem. 2015, 290:13875-13887.
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 13875-13887
-
-
Zhao, P.1
Lieu, T.2
Barlow, N.3
Sostegni, S.4
Haerteis, S.5
Korbmacher, C.6
Liedtke, W.7
Jimenez-Vargas, N.N.8
Vanner, S.J.9
Bunnett, N.W.10
-
130
-
-
84890890929
-
Functional selectivity of GPCR signaling in animals
-
Zhou L., Bohn L.M. Functional selectivity of GPCR signaling in animals. Curr. Opin. Cell Biol. 2014, 27:102-108.
-
(2014)
Curr. Opin. Cell Biol.
, vol.27
, pp. 102-108
-
-
Zhou, L.1
Bohn, L.M.2
-
131
-
-
0033198831
-
Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice
-
Zhu Y., King M.A., Schuller A.G., Nitsche J.F., Reidl M., Elde R.P., Unterwald E., Pasternak G.W., Pintar J.E. Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice. Neuron 1999, 24:243-252.
-
(1999)
Neuron
, vol.24
, pp. 243-252
-
-
Zhu, Y.1
King, M.A.2
Schuller, A.G.3
Nitsche, J.F.4
Reidl, M.5
Elde, R.P.6
Unterwald, E.7
Pasternak, G.W.8
Pintar, J.E.9
|