Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling

Journal of Biological Chemistry

Volumn 288, Issue 8, 2013, Pages 5790-5802

  Poole, Daniel P ^a,b   Amadesi, Silvia ^b   Veldhuis, Nicholas A ^a   Abogadie, Fe C ^c   Lieu, Tina Marie ^a   Darby, William ^d   Liedtke, Wolfgang ^e   Lew, Michael J ^d   McIntyre, Peter ^c,d   Bunnett, Nigel W ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF READING   (United Kingdom)

^d RMIT UNIVERSITY   (Australia)

^e DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLAMMATORY SIGNALING; PROTEASE-ACTIVATED RECEPTOR 2; SENSORY NERVES; TRANSIENT RECEPTOR POTENTIAL VANILLOID;

AMINO ACIDS; PATHOLOGY;

PROTEINS;

ARACHIDONIC ACID; CALCIUM ION; CYTOCHROME P450 REDUCTASE; PHOSPHOLIPASE A2; PROTEINASE ACTIVATED RECEPTOR 2; RUTHENIUM RED; TYROSINE; VANILLOID RECEPTOR 4;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; EXTRACELLULAR CALCIUM; GENE DELETION; HUMAN; HUMAN CELL; INFLAMMATION; INTRACELLULAR SIGNALING; MALE; MOUSE; NEUROGENIC INFLAMMATION; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; RECEPTOR BLOCKING; SPINAL GANGLION;

ANIMALS; CALCIUM; CYTOCHROME P-450 ENZYME SYSTEM; HEK293 CELLS; HUMANS; INFLAMMATION; MALE; MICE; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; PAIN; PHOSPHOLIPASES A2; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, PAR-2; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TRPV CATION CHANNELS; TYROSINE;

EID: 84874303694     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.438184     Document Type: Article

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