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Volumn 137, Issue 6, 2009, Pages 1148-1159

Dissociation of the Opioid Receptor Mechanisms that Control Mechanical and Heat Pain

Author keywords

MOLNEURO; SIGNALING

Indexed keywords

DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR AGONIST; MU OPIATE RECEPTOR; SUBSTANCE P;

EID: 66749154689     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2009.04.019     Document Type: Article
Times cited : (389)

References (58)
  • 2
    • 0034717937 scopus 로고    scopus 로고
    • mu-opioid receptors are present in vagal afferents and their dendritic targets in the medial nucleus tractus solitarius
    • Aicher S.A., Goldberg A., Sharma S., and Pickel V.M. mu-opioid receptors are present in vagal afferents and their dendritic targets in the medial nucleus tractus solitarius. J. Comp. Neurol. 422 (2000) 181-190
    • (2000) J. Comp. Neurol. , vol.422 , pp. 181-190
    • Aicher, S.A.1    Goldberg, A.2    Sharma, S.3    Pickel, V.M.4
  • 3
    • 0034195205 scopus 로고    scopus 로고
    • mu-Opioid receptors often colocalize with the substance P receptor (NK1) in the trigeminal dorsal horn
    • Aicher S.A., Punnoose A., and Goldberg A. mu-Opioid receptors often colocalize with the substance P receptor (NK1) in the trigeminal dorsal horn. J. Neurosci. 20 (2000) 4345-4354
    • (2000) J. Neurosci. , vol.20 , pp. 4345-4354
    • Aicher, S.A.1    Punnoose, A.2    Goldberg, A.3
  • 4
    • 0028985492 scopus 로고
    • delta-Opioid receptor immunoreactivity: distribution in brainstem and spinal cord, and relationship to biogenic amines and enkephalin
    • Arvidsson U., Dado R.J., Riedl M., Lee J.H., Law P.Y., Loh H.H., Elde R., and Wessendorf M.W. delta-Opioid receptor immunoreactivity: distribution in brainstem and spinal cord, and relationship to biogenic amines and enkephalin. J. Neurosci. 15 (1995) 1215-1235
    • (1995) J. Neurosci. , vol.15 , pp. 1215-1235
    • Arvidsson, U.1    Dado, R.J.2    Riedl, M.3    Lee, J.H.4    Law, P.Y.5    Loh, H.H.6    Elde, R.7    Wessendorf, M.W.8
  • 7
    • 33846029187 scopus 로고    scopus 로고
    • Trafficking of delta-opioid receptors and other G-protein-coupled receptors: implications for pain and analgesia
    • Cahill C.M., Holdridge S.V., and Morinville A. Trafficking of delta-opioid receptors and other G-protein-coupled receptors: implications for pain and analgesia. Trends Pharmacol. Sci. 28 (2007) 23-31
    • (2007) Trends Pharmacol. Sci. , vol.28 , pp. 23-31
    • Cahill, C.M.1    Holdridge, S.V.2    Morinville, A.3
  • 8
    • 0035478363 scopus 로고    scopus 로고
    • Prolonged morphine treatment targets delta opioid receptors to neuronal plasma membranes and enhances delta-mediated antinociception
    • Cahill C.M., Morinville A., Lee M.C., Vincent J.P., Collier B., and Beaudet A. Prolonged morphine treatment targets delta opioid receptors to neuronal plasma membranes and enhances delta-mediated antinociception. J. Neurosci. 21 (2001) 7598-7607
    • (2001) J. Neurosci. , vol.21 , pp. 7598-7607
    • Cahill, C.M.1    Morinville, A.2    Lee, M.C.3    Vincent, J.P.4    Collier, B.5    Beaudet, A.6
  • 9
    • 0035070120 scopus 로고    scopus 로고
    • Response properties of mechanoreceptors and nociceptors in mouse glabrous skin: an in vivo study
    • Cain D.M., Khasabov S.G., and Simone D.A. Response properties of mechanoreceptors and nociceptors in mouse glabrous skin: an in vivo study. J. Neurophysiol. 85 (2001) 1561-1574
    • (2001) J. Neurophysiol. , vol.85 , pp. 1561-1574
    • Cain, D.M.1    Khasabov, S.G.2    Simone, D.A.3
  • 12
    • 66749156637 scopus 로고    scopus 로고
    • Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli
    • 10.1073/pnas.0901507106 in press. Published online May 12, 2009
    • Cavanaugh D.J., Lee H., Lo L., Shields S.D., Zylka M.J., Basbaum A.I., and Anderson D.J. Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc. Natl. Acad. Sci. USA (2009) 10.1073/pnas.0901507106 in press. Published online May 12, 2009
    • (2009) Proc. Natl. Acad. Sci. USA
    • Cavanaugh, D.J.1    Lee, H.2    Lo, L.3    Shields, S.D.4    Zylka, M.J.5    Basbaum, A.I.6    Anderson, D.J.7
  • 15
    • 0034003076 scopus 로고    scopus 로고
    • Antihyperalgesic effects of delta opioid agonists in a rat model of chronic inflammation
    • Fraser G.L., Gaudreau G.A., Clarke P.B., Menard D.P., and Perkins M.N. Antihyperalgesic effects of delta opioid agonists in a rat model of chronic inflammation. Br. J. Pharmacol. 129 (2000) 1668-1672
    • (2000) Br. J. Pharmacol. , vol.129 , pp. 1668-1672
    • Fraser, G.L.1    Gaudreau, G.A.2    Clarke, P.B.3    Menard, D.P.4    Perkins, M.N.5
  • 16
    • 21344467278 scopus 로고    scopus 로고
    • A comparison of the antinociceptive and adverse effects of the mu-opioid agonist morphine and the delta-opioid agonist SNC80
    • Gallantine E.L., and Meert T.F. A comparison of the antinociceptive and adverse effects of the mu-opioid agonist morphine and the delta-opioid agonist SNC80. Basic Clin. Pharmacol. Toxicol. 97 (2005) 39-51
    • (2005) Basic Clin. Pharmacol. Toxicol. , vol.97 , pp. 39-51
    • Gallantine, E.L.1    Meert, T.F.2
  • 17
    • 32644440210 scopus 로고    scopus 로고
    • Morphine and pain-related stimuli enhance cell surface availability of somatic delta-opioid receptors in rat dorsal root ganglia
    • Gendron L., Lucido A.L., Mennicken F., O'Donnell D., Vincent J.P., Stroh T., and Beaudet A. Morphine and pain-related stimuli enhance cell surface availability of somatic delta-opioid receptors in rat dorsal root ganglia. J Neurosci 26 (2006) 953-962
    • (2006) J Neurosci , vol.26 , pp. 953-962
    • Gendron, L.1    Lucido, A.L.2    Mennicken, F.3    O'Donnell, D.4    Vincent, J.P.5    Stroh, T.6    Beaudet, A.7
  • 18
    • 36849030317 scopus 로고    scopus 로고
    • Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia
    • Gendron L., Pintar J.E., and Chavkin C. Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia. Neuroscience 150 (2007) 807-817
    • (2007) Neuroscience , vol.150 , pp. 807-817
    • Gendron, L.1    Pintar, J.E.2    Chavkin, C.3
  • 19
  • 20
    • 0034937698 scopus 로고    scopus 로고
    • G protein coupled receptor dimerization: implications in modulating receptor function
    • Gomes I., Jordan B.A., Gupta A., Rios C., Trapaidze N., and Devi L.A. G protein coupled receptor dimerization: implications in modulating receptor function. J. Mol. Med. 79 (2001) 226-242
    • (2001) J. Mol. Med. , vol.79 , pp. 226-242
    • Gomes, I.1    Jordan, B.A.2    Gupta, A.3    Rios, C.4    Trapaidze, N.5    Devi, L.A.6
  • 21
    • 0037178644 scopus 로고    scopus 로고
    • Quantitative autoradiographic mapping of opioid receptors in the brain of delta-opioid receptor gene knockout mice
    • Goody R.J., Oakley S.M., Filliol D., Kieffer B.L., and Kitchen I. Quantitative autoradiographic mapping of opioid receptors in the brain of delta-opioid receptor gene knockout mice. Brain Res. 945 (2002) 9-19
    • (2002) Brain Res. , vol.945 , pp. 9-19
    • Goody, R.J.1    Oakley, S.M.2    Filliol, D.3    Kieffer, B.L.4    Kitchen, I.5
  • 22
    • 23944455412 scopus 로고    scopus 로고
    • Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia
    • Guan J.S., Xu Z.Z., Gao H., He S.Q., Ma G.Q., Sun T., Wang L.H., Zhang Z.N., Lena I., Kitchen I., et al. Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia. Cell 122 (2005) 619-631
    • (2005) Cell , vol.122 , pp. 619-631
    • Guan, J.S.1    Xu, Z.Z.2    Gao, H.3    He, S.Q.4    Ma, G.Q.5    Sun, T.6    Wang, L.H.7    Zhang, Z.N.8    Lena, I.9    Kitchen, I.10
  • 23
    • 0006982482 scopus 로고
    • Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P
    • Hökfelt T., Ljungdahl A., Terenius L., Elde R., and Nilsson G. Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P. Proc. Natl. Acad. Sci. USA 74 (1977) 3081-3085
    • (1977) Proc. Natl. Acad. Sci. USA , vol.74 , pp. 3081-3085
    • Hökfelt, T.1    Ljungdahl, A.2    Terenius, L.3    Elde, R.4    Nilsson, G.5
  • 24
    • 0034143366 scopus 로고    scopus 로고
    • The analgesic effects of supraspinal mu and delta opioid receptor agonists are potentiated during persistent inflammation
    • Hurley R.W., and Hammond D.L. The analgesic effects of supraspinal mu and delta opioid receptor agonists are potentiated during persistent inflammation. J. Neurosci. 20 (2000) 1249-1259
    • (2000) J. Neurosci. , vol.20 , pp. 1249-1259
    • Hurley, R.W.1    Hammond, D.L.2
  • 25
    • 0017622848 scopus 로고
    • Opiate analgesics inhibit substance P release from rat trigeminal nucleus
    • Jessell T.M., and Iversen L.L. Opiate analgesics inhibit substance P release from rat trigeminal nucleus. Nature 268 (1977) 549-551
    • (1977) Nature , vol.268 , pp. 549-551
    • Jessell, T.M.1    Iversen, L.L.2
  • 26
    • 0029416910 scopus 로고
    • Expression of mu-, delta-, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation
    • Ji R.R., Zhang Q., Law P.Y., Low H.H., Elde R., and Hokfelt T. Expression of mu-, delta-, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation. J Neurosci 15 (1995) 8156-8166
    • (1995) J Neurosci , vol.15 , pp. 8156-8166
    • Ji, R.R.1    Zhang, Q.2    Law, P.Y.3    Low, H.H.4    Elde, R.5    Hokfelt, T.6
  • 27
    • 1642390536 scopus 로고    scopus 로고
    • Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats
    • Jutkiewicz E.M., Eller E.B., Folk J.E., Rice K.C., Traynor J.R., and Woods J.H. Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats. J. Pharmacol. Exp. Ther. 309 (2004) 173-181
    • (2004) J. Pharmacol. Exp. Ther. , vol.309 , pp. 173-181
    • Jutkiewicz, E.M.1    Eller, E.B.2    Folk, J.E.3    Rice, K.C.4    Traynor, J.R.5    Woods, J.H.6
  • 28
    • 0036095186 scopus 로고    scopus 로고
    • Exploring the opioid system by gene knockout
    • Kieffer B.L., and Gaveriaux-Ruff C. Exploring the opioid system by gene knockout. Prog. Neurobiol. 66 (2002) 285-306
    • (2002) Prog. Neurobiol. , vol.66 , pp. 285-306
    • Kieffer, B.L.1    Gaveriaux-Ruff, C.2
  • 29
    • 0030821372 scopus 로고    scopus 로고
    • Receptive properties of mouse sensory neurons innervating hairy skin
    • Koltzenburg M., Stucky C.L., and Lewin G.R. Receptive properties of mouse sensory neurons innervating hairy skin. J. Neurophysiol. 78 (1997) 1841-1850
    • (1997) J. Neurophysiol. , vol.78 , pp. 1841-1850
    • Koltzenburg, M.1    Stucky, C.L.2    Lewin, G.R.3
  • 30
    • 66749088182 scopus 로고    scopus 로고
    • Cloning of Delta Opioid Receptors
    • Chang K.-J., Porreca F., and Woods J. (Eds), Informa Healthcare, USA
    • Lacoste A., and Evans C.J. Cloning of Delta Opioid Receptors. In: Chang K.-J., Porreca F., and Woods J. (Eds). The Delta Receptor (2003), Informa Healthcare, USA 15-30
    • (2003) The Delta Receptor , pp. 15-30
    • Lacoste, A.1    Evans, C.J.2
  • 31
    • 0030881680 scopus 로고    scopus 로고
    • Preserved acute pain and reduced neuropathic pain in mice lacking PKCγ
    • Malmberg A.B., Chen C., Tonegawa S., and Basbaum A.I. Preserved acute pain and reduced neuropathic pain in mice lacking PKCγ. Science 278 (1997) 279-283
    • (1997) Science , vol.278 , pp. 279-283
    • Malmberg, A.B.1    Chen, C.2    Tonegawa, S.3    Basbaum, A.I.4
  • 33
    • 0141544986 scopus 로고    scopus 로고
    • Phylogenetic changes in the expression of delta opioid receptors in spinal cord and dorsal root ganglia
    • Mennicken F., Zhang J., Hoffert C., Ahmad S., Beaudet A., and O'Donnell D. Phylogenetic changes in the expression of delta opioid receptors in spinal cord and dorsal root ganglia. J. Comp. Neurol. 465 (2003) 349-360
    • (2003) J. Comp. Neurol. , vol.465 , pp. 349-360
    • Mennicken, F.1    Zhang, J.2    Hoffert, C.3    Ahmad, S.4    Beaudet, A.5    O'Donnell, D.6
  • 34
    • 0029041881 scopus 로고
    • Double in situ hybridization study on coexistence of mu-, delta- and kappa-opioid receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root ganglia
    • Minami M., Maekawa K., Yabuuchi K., and Satoh M. Double in situ hybridization study on coexistence of mu-, delta- and kappa-opioid receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root ganglia. Brain Res. Mol. Brain Res. 30 (1995) 203-210
    • (1995) Brain Res. Mol. Brain Res. , vol.30 , pp. 203-210
    • Minami, M.1    Maekawa, K.2    Yabuuchi, K.3    Satoh, M.4
  • 35
    • 0037741017 scopus 로고    scopus 로고
    • Regulation of delta-opioid receptor trafficking via mu-opioid receptor stimulation: evidence from mu-opioid receptor knock-out mice
    • Morinville A., Cahill C.M., Esdaile M.J., Aibak H., Collier B., Kieffer B.L., and Beaudet A. Regulation of delta-opioid receptor trafficking via mu-opioid receptor stimulation: evidence from mu-opioid receptor knock-out mice. J Neurosci 23 (2003) 4888-4898
    • (2003) J Neurosci , vol.23 , pp. 4888-4898
    • Morinville, A.1    Cahill, C.M.2    Esdaile, M.J.3    Aibak, H.4    Collier, B.5    Kieffer, B.L.6    Beaudet, A.7
  • 37
    • 33748538102 scopus 로고    scopus 로고
    • Delta opioid receptor-mediated antinociception/analgesia
    • In The, K.-J. Chang, F. Porreca, and J. Woods, eds, pp
    • Narita, M., and Suzuki, T. (2003). Delta opioid receptor-mediated antinociception/analgesia. In The Delta Receptor, K.-J. Chang, F. Porreca, and J. Woods, eds., pp. 331-354.
    • (2003) Delta Receptor , pp. 331-354
    • Narita, M.1    Suzuki, T.2
  • 38
    • 51149102303 scopus 로고    scopus 로고
    • Innocuous, not noxious, input activates PKCγ interneurons of the spinal dorsal horn via myelinated afferent fibers
    • Neumann S., Braz J.M., Skinner K., Llewellyn-Smith I.J., and Basbaum A.I. Innocuous, not noxious, input activates PKCγ interneurons of the spinal dorsal horn via myelinated afferent fibers. J. Neurosci. 28 (2008) 7936-7944
    • (2008) J. Neurosci. , vol.28 , pp. 7936-7944
    • Neumann, S.1    Braz, J.M.2    Skinner, K.3    Llewellyn-Smith, I.J.4    Basbaum, A.I.5
  • 39
    • 0020628205 scopus 로고
    • Intrathecal delta-receptor ligand produces analgesia in man
    • Onofrio B.M., and Yaksh T.L. Intrathecal delta-receptor ligand produces analgesia in man. Lancet 1 (1983) 1386-1387
    • (1983) Lancet , vol.1 , pp. 1386-1387
    • Onofrio, B.M.1    Yaksh, T.L.2
  • 40
    • 66749103926 scopus 로고
    • Characterization of supraspinal antinociceptive actions of opioid delta agonists in the rat. Pain 62, 287-293
    • Ossipov M.H., Kovelowski C.J., Nichols M.L., Hruby V.J., and Porreca F. Characterization of supraspinal antinociceptive actions of opioid delta agonists in the rat. Pain 62, 287-293. J. Neurosci. 25 (1995) 8825-8832
    • (1995) J. Neurosci. , vol.25 , pp. 8825-8832
    • Ossipov, M.H.1    Kovelowski, C.J.2    Nichols, M.L.3    Hruby, V.J.4    Porreca, F.5
  • 41
    • 25644461151 scopus 로고    scopus 로고
    • Bradykinin-induced functional competence and trafficking of the delta-opioid receptor in trigeminal nociceptors
    • Patwardhan A.M., Berg K.A., Akopain A.N., Jeske N.A., Gamper N., Clarke W.P., and Hargreaves K.M. Bradykinin-induced functional competence and trafficking of the delta-opioid receptor in trigeminal nociceptors. J Neurosci 25 (2005) 8825-8832
    • (2005) J Neurosci , vol.25 , pp. 8825-8832
    • Patwardhan, A.M.1    Berg, K.A.2    Akopain, A.N.3    Jeske, N.A.4    Gamper, N.5    Clarke, W.P.6    Hargreaves, K.M.7
  • 42
    • 0023180328 scopus 로고
    • Role of mu and delta receptors in the supraspinal and spinal analgesic effects of [D-Pen2, D-Pen5]enkephalin in the mouse
    • Porreca F., Heyman J.S., Mosberg H.I., Omnaas J.R., and Vaught J.L. Role of mu and delta receptors in the supraspinal and spinal analgesic effects of [D-Pen2, D-Pen5]enkephalin in the mouse. J. Pharmacol. Exp. Ther. 241 (1987) 393-400
    • (1987) J. Pharmacol. Exp. Ther. , vol.241 , pp. 393-400
    • Porreca, F.1    Heyman, J.S.2    Mosberg, H.I.3    Omnaas, J.R.4    Vaught, J.L.5
  • 43
    • 0025316399 scopus 로고
    • Naltrindole 5′-isothiocyanate: a nonequilibrium, highly selective delta opioid receptor antagonist
    • Portoghese P.S., Sultana M., and Takemori A.E. Naltrindole 5′-isothiocyanate: a nonequilibrium, highly selective delta opioid receptor antagonist. J. Med. Chem. 33 (1990) 1547-1548
    • (1990) J. Med. Chem. , vol.33 , pp. 1547-1548
    • Portoghese, P.S.1    Sultana, M.2    Takemori, A.E.3
  • 44
    • 0141705322 scopus 로고    scopus 로고
    • Inhibition of neurokinin-1-substance P receptor and prostanoid activity prevents and reverses the development of morphine tolerance in vivo and the morphine-induced increase in CGRP expression in cultured dorsal root ganglion neurons
    • Powell K.J., Quirion R., and Jhamandas K. Inhibition of neurokinin-1-substance P receptor and prostanoid activity prevents and reverses the development of morphine tolerance in vivo and the morphine-induced increase in CGRP expression in cultured dorsal root ganglion neurons. Eur. J. Neurosci. 18 (2003) 1572-1583
    • (2003) Eur. J. Neurosci. , vol.18 , pp. 1572-1583
    • Powell, K.J.1    Quirion, R.2    Jhamandas, K.3
  • 45
    • 37349079240 scopus 로고    scopus 로고
    • An emerging role for the delta opioid receptor in the regulation of mu opioid receptor function
    • Rozenfeld R., Abul-Husn N.S., Gomez I., and Devi L.A. An emerging role for the delta opioid receptor in the regulation of mu opioid receptor function. ScientificWorldJournal 7 (2007) 64-73
    • (2007) ScientificWorldJournal , vol.7 , pp. 64-73
    • Rozenfeld, R.1    Abul-Husn, N.S.2    Gomez, I.3    Devi, L.A.4
  • 46
    • 2342567029 scopus 로고    scopus 로고
    • The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice
    • Scherrer G., Befort K., Contet C., Becker J., Matifas A., and Kieffer B.L. The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice. Eur. J. Neurosci. 19 (2004) 2239-2248
    • (2004) Eur. J. Neurosci. , vol.19 , pp. 2239-2248
    • Scherrer, G.1    Befort, K.2    Contet, C.3    Becker, J.4    Matifas, A.5    Kieffer, B.L.6
  • 48
    • 0142148212 scopus 로고    scopus 로고
    • Spared nerve injury model of neuropathic pain in the mouse: a behavioral and anatomic analysis
    • Shields S.D., Eckert III W.A., and Basbaum A.I. Spared nerve injury model of neuropathic pain in the mouse: a behavioral and anatomic analysis. J. Pain 4 (2003) 465-470
    • (2003) J. Pain , vol.4 , pp. 465-470
    • Shields, S.D.1    Eckert III, W.A.2    Basbaum, A.I.3
  • 49
    • 0030949768 scopus 로고    scopus 로고
    • The mu-opioid receptor is necessary for [D-Pen2,D-Pen5]enkephalin-induced analgesia
    • Sora I., Funada M., and Uhl G.R. The mu-opioid receptor is necessary for [D-Pen2,D-Pen5]enkephalin-induced analgesia. Eur. J. Pharmacol. 324 (1997) R1-R2
    • (1997) Eur. J. Pharmacol. , vol.324
    • Sora, I.1    Funada, M.2    Uhl, G.R.3
  • 50
  • 51
    • 0035252359 scopus 로고    scopus 로고
    • Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections
    • Sun H., Ren K., Zhong C.M., Ossipov M.H., Malan T.P., Lai J., and Porreca F. Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections. Pain 90 (2001) 105-111
    • (2001) Pain , vol.90 , pp. 105-111
    • Sun, H.1    Ren, K.2    Zhong, C.M.3    Ossipov, M.H.4    Malan, T.P.5    Lai, J.6    Porreca, F.7
  • 52
    • 0028792544 scopus 로고
    • Selective opioid inhibition of small nociceptive neurons
    • Taddese A., Nah S.Y., and McCleskey E.W. Selective opioid inhibition of small nociceptive neurons. Science 270 (1995) 1366-1369
    • (1995) Science , vol.270 , pp. 1366-1369
    • Taddese, A.1    Nah, S.Y.2    McCleskey, E.W.3
  • 53
    • 0034555126 scopus 로고    scopus 로고
    • Postsynaptic signaling via the [mu]-opioid receptor: responses of dorsal horn neurons to exogenous opioids and noxious stimulation
    • Trafton J.A., Abbadie C., Marek K., and Basbaum A.I. Postsynaptic signaling via the [mu]-opioid receptor: responses of dorsal horn neurons to exogenous opioids and noxious stimulation. J. Neurosci. 20 (2000) 8578-8584
    • (2000) J. Neurosci. , vol.20 , pp. 8578-8584
    • Trafton, J.A.1    Abbadie, C.2    Marek, K.3    Basbaum, A.I.4
  • 54
    • 27844524967 scopus 로고    scopus 로고
    • Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons
    • Walwyn W., Maidment N.T., Sanders M., Evans C.J., Kieffer B.L., and Hales T.G. Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons. Mol. Pharmacol. 68 (2005) 1688-1698
    • (2005) Mol. Pharmacol. , vol.68 , pp. 1688-1698
    • Walwyn, W.1    Maidment, N.T.2    Sanders, M.3    Evans, C.J.4    Kieffer, B.L.5    Hales, T.G.6
  • 55
    • 0030933655 scopus 로고    scopus 로고
    • A potent and selective endogenous agonist for the mu-opiate receptor
    • Zadina J.E., Hackler L., Ge L.J., and Kastin A.J. A potent and selective endogenous agonist for the mu-opiate receptor. Nature 386 (1997) 499-502
    • (1997) Nature , vol.386 , pp. 499-502
    • Zadina, J.E.1    Hackler, L.2    Ge, L.J.3    Kastin, A.J.4
  • 56
    • 0343144796 scopus 로고    scopus 로고
    • Localization and regulation of the delta-opioid receptor in dorsal root ganglia and spinal cord of the rat and monkey: evidence for association with the membrane of large dense-core vesicles
    • Zhang X., Bao L., Arvidsson U., Elde R., and Hökfelt T. Localization and regulation of the delta-opioid receptor in dorsal root ganglia and spinal cord of the rat and monkey: evidence for association with the membrane of large dense-core vesicles. Neuroscience 82 (1998) 1225-1242
    • (1998) Neuroscience , vol.82 , pp. 1225-1242
    • Zhang, X.1    Bao, L.2    Arvidsson, U.3    Elde, R.4    Hökfelt, T.5
  • 57
    • 33746932103 scopus 로고    scopus 로고
    • Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance
    • Zhang X., Bao L., and Guan J.S. Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance. Trends Pharmacol. Sci. 27 (2006) 324-329
    • (2006) Trends Pharmacol. Sci. , vol.27 , pp. 324-329
    • Zhang, X.1    Bao, L.2    Guan, J.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.