Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes

Journal of Biological Chemistry

Volumn 284, Issue 29, 2009, Pages 19361-19370

  Hislop, James N ^a,d   Henry, Anastasia G ^b   Marchese, Adriano ^c   von Zastrow, Mark ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COVALENT MODIFICATIONS; DEUBIQUITINATING ENZYMES; DOWN-REGULATION; ENDOCYTIC SORTING; G PROTEIN COUPLED RECEPTORS; HYDROPHOBIC CORE; LYSINE RESIDUES; OPIOID RECEPTORS; PROTEOLYTIC PROCESSING; RADIOLIGAND BINDING; TRANSMEMBRANE HELICES; UBIQUITIN LIGASE; UBIQUITINATION; WILD TYPES;

AMINO ACIDS; ENZYMES; PROTEINS;

ENZYME ACTIVITY;

DELTA OPIATE RECEPTOR; G PROTEIN COUPLED RECEPTOR; LYSINE; PROTEIN AIP4; PROTEIN AMSH; PROTEIN UBPY; RADIOLIGAND; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; BIOTINYLATION; CELL STRAIN HEK293; CONTROLLED STUDY; DOWN REGULATION; ENDOCYTOSIS; ENDOSOME; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOBLOTTING; LIGAND BINDING; LYSOSOME; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN MODIFICATION; RECEPTOR BLOCKING; REGULATORY MECHANISM; UBIQUITINATION; WILD TYPE;

BINDING, COMPETITIVE; BIOTINYLATION; CELL LINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOSOMES; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOBLOTTING; LYSOSOMES; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MUTATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; RADIOLIGAND ASSAY; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT FUSION PROTEINS; TRANSFECTION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

MURINAE;

EID: 67749127754     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.001644     Document Type: Article

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