Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

Nature

Volumn 519, Issue 7542, 2015, Pages 237-241

  McNeil, Benjamin D ^a   Pundir, Priyanka ^b   Meeker, Sonya ^a   Han, Liang ^a   Undem, Bradley J ^a   Kulka, Marianna ^b,c   Dong, Xinzhong ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ATRACURIUM BESILATE; BETA N ACETYLHEXOSAMINIDASE; CETRORELIX; CIPROFLOXACIN; COMPOUND 48-80; G PROTEIN COUPLED RECEPTOR; HISTAMINE; ICATIBANT; IMMUNOGLOBULIN E ANTIBODY; INSULIN; LEUPRORELIN; OCTREOTIDE; PROSTAGLANDIN D2; QUINOLONE DERIVATIVE; SERMORELIN; TUMOR NECROSIS FACTOR; MRGPRB2 PROTEIN, MOUSE; MRGPRX2 PROTEIN, HUMAN; NERVE PROTEIN; NEUROPEPTIDE RECEPTOR;

ANAPHYLAXIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; CELL ACTIVATION; CELL SURVIVAL; DRUG HYPERSENSITIVITY; FOOD AND DRUG ADMINISTRATION; HEK293 CELL LINE; HISTAMINE RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INJECTION SITE INFLAMMATION; MOUSE; NONHUMAN; PERITONEUM MAST CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; FEMALE; GENETICS; IMMUNOLOGY; INFLAMMATION; KNOCKOUT MOUSE; MALE; MAST CELL; METABOLISM;

ANIMALS; DISEASE MODELS, ANIMAL; DRUG HYPERSENSITIVITY; FEMALE; HEK293 CELLS; HISTAMINE RELEASE; HUMANS; INFLAMMATION; MALE; MAST CELLS; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE;

EID: 84925521365     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14022     Document Type: Article

References (34)

1. Metcalfe, D. D., Baram, D. & Mekori, Y. A. Mast cells. Physiol. Rev. 77, 1033-1079 (1997).
2. Galli, S. J., Nakae, S. & Tsai, M. Mast cells in the development of adaptive immune responses. Nature Immunol. 6, 135-142 (2005).
3. Lagunoff, D.,Martin, T. W.&Read, G. Agents that release histamine frommast cells. Annu. Rev. Pharmacol. Toxicol. 23, 331-351 (1983).
4. Halpern, B. N.& Wood, D. R. The action of promethazine (phenergan) in protecting mice against death due to histamine. Br. J. Pharmacol. Chemother. 5, 510-516 (1950).
5. Taneike, T., Miyazaki, H., Oikawa, S.&Ohga, A. Compound 48/80 elicits cholinergic contraction through histamine release in the chick oesophagus. Gen. Pharmacol. 19, 689-695 (1988).
6. Ferry, X., Brehin, S., Kamel, R. & Landry, Y. G protein-dependent activation of mast cell by peptides and basic secretagogues. Peptides 23, 1507-1515 (2002).
7. Purcell, W. M., Doyle, K. M., Westgate, C. & Atterwill, C. K. Characterisation of a functional polyamine site on rat mast cells: association with a NMDA receptor macrocomplex. J. Neuroimmunol. 65, 49-53 (1996).
8. Tatemoto, K. et al. Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptors. Biochem. Biophys. Res. Commun. 349, 1322-1328 (2006).
9. Sick, E., Niederhoffer, N., Takeda, K., Landry, Y. & Gies, J. P. Activation of CD47 receptors causes histamine secretion from mast cells. Cell. Mol. Life Sci. 66, 1271-1282 (2009).
10. Robas, N., Mead, E. & Fidock, M. MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. J. Biol. Chem. 278, 44400-44404 (2003).
11. Subramanian, H.,Gupta, K., Guo, Q., Price, R.& Ali, H.Mas-related gene X2 (MrgX2) is a novelGprotein-coupled receptor for the antimicrobial peptide LL-37 inhuman mast cells: resistance to receptor phosphorylation, desensitization, and internalization. J. Biol. Chem. 286, 44739-44749 (2011).
12. Kashem, S. W. et al. G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: roles of Mas-related genes MrgX1 and MrgX2. Eur. J. Pharmacol. 668, 299-304 (2011).
13. Subramanian, H. et al. β-Defensins activate humanmast cells via Mas-related gene X2. J. Immunol. 191, 345-352 (2013).
14. Kamohara, M. et al. Identification ofMrgX2as ahumanG-protein-coupledreceptor for proadrenomedullin N-terminal peptides. Biochem. Biophys. Res.Commun. 330, 1146-1152 (2005).
15. Liu, Q. et al. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell 139, 1353-1365 (2009).
16. Mousli, M., Hugli, T. E., Landry, Y. & Bronner, C. Peptidergic pathway in human skin and rat peritoneal mast cell activation. Immunopharmacology 27, 1-11 (1994).
17. Pundir, P. & Kulka, M. The role of G protein-coupled receptors in mast cell activation by antimicrobial peptides: is there a connection? Immunol. Cell Biol. 88, 632-640 (2010).
18. Hausmann, O., Schnyder, B. & Pichler, W. J. Etiology and pathogenesis of adverse drug reactions. Chem. Immunol. Allergy 97, 32-46 (2012).
19. Lumry, W. R. et al. Randomized placebo-controlled trial of the bradykinin B2receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema: theFAST-3trial. Ann. Allergy AsthmaImmunol. 107, 529-537(2011).
20. Nel, L. & Eren, E. Peri-operative anaphylaxis. Br. J. Clin. Pharmacol. 71, 647-658 (2011).
21. Read, G. W. Compound 48-80. Structure-activity relations and poly-THIQ, a new, more potent analog. J. Med. Chem. 16, 1292-1295 (1973).
22. Mertes, P. M., Alla, F., Trechot, P., Auroy, Y. & Jougla, E. Anaphylaxis during anesthesia in France: an 8-year national survey. J. Allergy Clin. Immunol. 128, 366-373 (2011).
23. Koppert, W. et al. Different patterns of mast cell activation by muscle relaxants in human skin. Anesthesiology 95, 659-667 (2001).
24. Kelesidis, T., Fleisher, J. & Tsiodras, S. Anaphylactoid reaction considered ciprofloxacin related: a case report and literature review. Clin. Ther. 32, 515-526 (2010).
25. Blanca-Lopez, N. et al. Hypersensitivity reactions to fluoroquinolones: analysis of the factors involved. Clin. Exp. Allergy 43, 560-567 (2013).
26. Mori, K., Maru, C. & Takasuna, K. Characterization of histamine release induced by fluoroquinolone antibacterial agents in-vivo and in-vitro. J. Pharm. Pharmacol. 52, 577-584 (2000).
27. Mori, K., Maru, C., Takasuna, K. & Furuhama, K. Mechanism of histamine release induced by levofloxacin, a fluoroquinolone antibacterial agent. Eur. J. Pharmacol. 394, 51-55 (2000).
28. Doyle, E., Trosien, J. & Metz, M. Protocols for the induction and evaluation of systemic anaphylaxis in mice. Methods Mol. Biol. 1032, 133-138 (2013).
29. Bergman, R. K. & Munoz, J. Efficacy of β-adrenergic blocking agents in inducing histamine sensitivity in mice. Nature 217, 1173-1174 (1968).
30. Matsumura, Y., Tan, E. M. & Vaughan, J. H. Hypersensitivity to histamine and systemic anaphylaxis in mice with pharmacologic β adrenergic blockade: protection by nucleotides. J. Allergy Clin. Immunol. 58, 387-394 (1976).
31. Han, L. et al. A subpopulation of nociceptors specifically linked to itch. Nature Neurosci. 16, 174-182 (2013).
32. Siraganian, R. P. An automated continuous-flow system for the extraction and fluorometric analysis of histamine. Anal. Biochem. 57, 383-394 (1974).
33. Weigand, L. A., Myers, A. C., Meeker, S. & Undem, B. J. Mast cell-cholinergic nerve interaction in mouse airways. J. Physiol. (Lond.) 587, 3355-3362 (2009).
34. Maurer, M. et al. Mast cells promote homeostasis by limiting endothelin-1- induced toxicity. Nature 432, 512-516 (2004).