Endogenous regulation of visceral pain via production of opioids by colitogenic CD4+ T cells in mice

Gastroenterology

Volumn 146, Issue 1, 2014, Pages 166-175

  Boué, Jérôme ^a,b   Basso, Lilian ^a,b   Cenac, Nicolas ^a,b   Blanpied, Catherine ^a,b   Rolli Derkinderen, Malvyne ^c,d   Neunlist, Michel ^c,d   Vergnolle, Nathalie ^a,b,e   Dietrich, Gilles ^a,b  

^a University of Toulouse III   (France)

^b CNRS   (France)

^c INSERM   (France)

^d UNIVERSITÉ DE NANTES   (France)

^e UNIVERSITY OF CALGARY   (Canada)

Author keywords

Mouse Model; Mucosal Immunity; UC; Visceral Sensitivity

Indexed keywords

DEXTRAN SULFATE; ENDORPHIN; ENKEPHALIN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; METENKEPHALIN; OPIATE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; COLITIS; CONTROLLED STUDY; CYTOFLUOROMETRY; CYTOKINE RELEASE; EPITHELIUM CELL; HYPERSENSITIVITY; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LAMINA PROPRIA; MACROPHAGE; MONONUCLEAR CELL; MOUSE; MYENTERIC PLEXUS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL; TH1 CELL; TH17 CELL; VISCERAL PAIN;

EID: 84890596350     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.09.020     Document Type: Article

References (16)

1. C. Stein, and H. Machelska Modulation of peripheral sensory neurons by the immune system: implications for pain therapy Pharmacol Rev 63 2011 860 881
2. J. Boue, C. Blanpied, and P. Brousset Endogenous opioid-mediated analgesia is dependent on adaptive T cell response in mice J Immunol 186 2011 5078 5084
3. + T effector-induced opioid release and analgesia Pain 153 2012 485 493
4. S. Brand Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease Gut 58 2009 1152 1167
5. B. Gomes, M. Savignac, and M.D. Cabral The cGMP/protein kinase G pathway contributes to dihydropyridine-sensitive calcium response and cytokine production in TH2 lymphocytes J Biol Chem 281 2006 12421 12427
6. L. Martin, C. Auge, and J. Boue Thrombin receptor: an endogenous inhibitor of inflammatory pain, activating opioid pathways Pain 146 2009 121 129
7. A. Benard, P. Cavailles, and J. Boue mu-Opioid receptor is induced by IL-13 within lymph nodes from patients with Sezary syndrome J Invest Dermatol 130 2010 1337 1344
8. D. Philippe, L. Dubuquoy, and H. Groux Anti-inflammatory properties of the mu-opioid receptor support its use in the treatment of colon inflammation J Clin Invest 111 2003 1329 1338
9. S. Hook, M. Prout, and M. Camberis Th2-dependent airway eosinophilia is regulated by preproenkephalin J Neuroimmunol 107 2000 59 65
10. M. Verma-Gandhu, P. Bercik, and Y. Motomura CD4+ T-cell modulation of visceral nociception in mice Gastroenterology 130 2006 1721 1728
11. M. Verma-Gandhu, E.F. Verdu, and D. Cohen-Lyons Lymphocyte-mediated regulation of beta-endorphin in the myenteric plexus Am J Physiol Gastrointest Liver Physiol 292 2007 G344 G348
12. E. Valdez-Morales, R. Guerrero-Alba, and F. Ochoa-Cortes Release of endogenous opioids during a chronic IBD model suppresses the excitability of colonic DRG neurons Neurogastroenterol Motil 25 2012 39-e4
13. C.A. Siegel, and R.P. MacDermott Is chronic pain an extraintestinal manifestation of IBD? Inflamm Bowel Dis 15 2009 769 771
14. A.I. Srinath, C. Walter, and M.C. Newara Pain management in patients with inflammatory bowel disease: insights for the clinician Therap Adv Gastroenterol 5 2012 339 357
15. M.J. Docherty, R.C. Jones III, and M.S. Wallace Managing pain in inflammatory bowel disease Gastroenterol Hepatol (N Y) 7 2011 592 601
16. J.P. Motta, L.G. Bermudez-Humaran, and C. Deraison Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis Sci Transl Med 4 2012 158ra144