-
1
-
-
30644458052
-
Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine
-
Bagley E.E., Chieng B.C.H., Christie M.J., Connor M. Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine. Br. J. Pharmacol. 2005, 146:68-76.
-
(2005)
Br. J. Pharmacol.
, vol.146
, pp. 68-76
-
-
Bagley, E.E.1
Chieng, B.C.H.2
Christie, M.J.3
Connor, M.4
-
2
-
-
12344316960
-
GABA transporter currents activated by protein kinase A excite midbrain neurons during opioid withdrawal
-
Bagley E.E., Gerke M.B., Vaughan C.W., Hack S.P., Christie M.J. GABA transporter currents activated by protein kinase A excite midbrain neurons during opioid withdrawal. Neuron 2005, 45:433-445.
-
(2005)
Neuron
, vol.45
, pp. 433-445
-
-
Bagley, E.E.1
Gerke, M.B.2
Vaughan, C.W.3
Hack, S.P.4
Christie, M.J.5
-
3
-
-
9144233475
-
Agonist-independent modulation of N-type calcium channels by ORL1 receptors
-
Beedle A.M., McRory J.E., Poirot O., Doering C.J., Altier C., Barrere C., Hamid J., Nargeot J., Bourinet E., Zamponi G.W. Agonist-independent modulation of N-type calcium channels by ORL1 receptors. Nat. Neurosci. 2004, 7:118-125.
-
(2004)
Nat. Neurosci.
, vol.7
, pp. 118-125
-
-
Beedle, A.M.1
McRory, J.E.2
Poirot, O.3
Doering, C.J.4
Altier, C.5
Barrere, C.6
Hamid, J.7
Nargeot, J.8
Bourinet, E.9
Zamponi, G.W.10
-
4
-
-
0035476877
-
Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganglion neurons in mouse
-
Borgland S.L., Connor M., Christie M.J. Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganglion neurons in mouse. J. Physiol. 2001, 536:35-47.
-
(2001)
J. Physiol.
, vol.536
, pp. 35-47
-
-
Borgland, S.L.1
Connor, M.2
Christie, M.J.3
-
5
-
-
9044238837
-
Determinants of the G protein-dependent opioid modulation of neuronal calcium channels
-
Bourinet E., Soong T.W., Stea A., Snutch T.P. Determinants of the G protein-dependent opioid modulation of neuronal calcium channels. Proc. Natl. Acad. Sci. USA. 2001, 93:1486-1491.
-
(2001)
Proc. Natl. Acad. Sci. USA.
, vol.93
, pp. 1486-1491
-
-
Bourinet, E.1
Soong, T.W.2
Stea, A.3
Snutch, T.P.4
-
6
-
-
2542492116
-
Cannabinoid signaling in rat cerebellar granule cells: G-protein activation, inhibition of glutamate release and endogenous cannabinoids
-
Breivogel C.S., Walker J.M., Huang S.M., Roy M.B., Childers S.R. Cannabinoid signaling in rat cerebellar granule cells: G-protein activation, inhibition of glutamate release and endogenous cannabinoids. Neuropharmacology 2004, 47:81-91.
-
(2004)
Neuropharmacology
, vol.47
, pp. 81-91
-
-
Breivogel, C.S.1
Walker, J.M.2
Huang, S.M.3
Roy, M.B.4
Childers, S.R.5
-
7
-
-
2642536906
-
Enhanced spontaneous activity of the mu opioid receptor by cysteine mutations: Characterization of a tool for inverse agonist screening
-
Brillet K., Kieffer B.L., Massotte D. Enhanced spontaneous activity of the mu opioid receptor by cysteine mutations: Characterization of a tool for inverse agonist screening. BMC Pharmacol. 2003, 3:14.
-
(2003)
BMC Pharmacol.
, vol.3
, pp. 14
-
-
Brillet, K.1
Kieffer, B.L.2
Massotte, D.3
-
9
-
-
0021193681
-
The mammalian β2-adrenergic receptor: Reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system
-
Cerione R.A., Codina J., Benovic J.L., Lefkowitz R.J., Birnbaumer L., Caron M.G. The mammalian β2-adrenergic receptor: Reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system. Biochemistry 1984, 23:4519-4525.
-
(1984)
Biochemistry
, vol.23
, pp. 4519-4525
-
-
Cerione, R.A.1
Codina, J.2
Benovic, J.L.3
Lefkowitz, R.J.4
Birnbaumer, L.5
Caron, M.G.6
-
11
-
-
17644428076
-
+ channels in dendrites of hippocampal CA1 pyramidal neurons
-
+ channels in dendrites of hippocampal CA1 pyramidal neurons. J. Neurosci. 2005, 25:3787-3792.
-
(2005)
J. Neurosci.
, vol.25
, pp. 3787-3792
-
-
Chen, X.1
Johnston, D.2
-
12
-
-
0029822432
-
Local opioid withdrawal in rat single periaqueductal gray neurons in vitro
-
Chieng B., Christie M.J. Local opioid withdrawal in rat single periaqueductal gray neurons in vitro. J. Neurosci. 1996, 16:7128-7136.
-
(1996)
J. Neurosci.
, vol.16
, pp. 7128-7136
-
-
Chieng, B.1
Christie, M.J.2
-
13
-
-
0023510867
-
Cellular mechanisms of opioid tolerance: Studies in single brain neurons
-
Christie M.J., Williams J.T., North R.A. Cellular mechanisms of opioid tolerance: Studies in single brain neurons. Mol. Pharmacol. 1987, 32:633-638.
-
(1987)
Mol. Pharmacol.
, vol.32
, pp. 633-638
-
-
Christie, M.J.1
Williams, J.T.2
North, R.A.3
-
14
-
-
4344691146
-
Assays for G-protein-coupled receptor signaling using RGS-insensitive Galpha subunits
-
Clark M.J., Traynor J.R. Assays for G-protein-coupled receptor signaling using RGS-insensitive Galpha subunits. Meth. Enzymol. 2004, 389:155-169.
-
(2004)
Meth. Enzymol.
, vol.389
, pp. 155-169
-
-
Clark, M.J.1
Traynor, J.R.2
-
15
-
-
0035866075
-
G-protein inhibition of N- and P/Q-type calcium channels: Distinctive elementary mechanisms and their functional impact
-
Colecraft H.M., Brody D.L., Yue D.T. G-protein inhibition of N- and P/Q-type calcium channels: Distinctive elementary mechanisms and their functional impact. J. Neurosci. 2001, 21:1137-1147.
-
(2001)
J. Neurosci.
, vol.21
, pp. 1137-1147
-
-
Colecraft, H.M.1
Brody, D.L.2
Yue, D.T.3
-
16
-
-
67650693034
-
Shadows across μ-star? Constitutively active μ-opioid receptors revisited
-
Connor M. Shadows across μ-star? Constitutively active μ-opioid receptors revisited. Br. J. Pharmacol. 2009, 156:1041-1043.
-
(2009)
Br. J. Pharmacol.
, vol.156
, pp. 1041-1043
-
-
Connor, M.1
-
17
-
-
0032704860
-
Continued morphine modulation of calcium channel currents in acutely isolated locus coeruleus neurons from morphine-dependent rats
-
Connor M., Borgland S.L., Christie M.J. Continued morphine modulation of calcium channel currents in acutely isolated locus coeruleus neurons from morphine-dependent rats. Br. J. Pharmacol. 1999, 128:1561-1569.
-
(1999)
Br. J. Pharmacol.
, vol.128
, pp. 1561-1569
-
-
Connor, M.1
Borgland, S.L.2
Christie, M.J.3
-
18
-
-
0032523741
-
Modulation of calcium channel currents of acutely dissociated rat periaqueductal grey neurons
-
Connor M., Christie M.J. Modulation of calcium channel currents of acutely dissociated rat periaqueductal grey neurons. J. Physiol. 1998, 509:47-58.
-
(1998)
J. Physiol.
, vol.509
, pp. 47-58
-
-
Connor, M.1
Christie, M.J.2
-
19
-
-
0001169515
-
Antagonists with negative intrinsic activity at δ opioid receptors coupled to GTP-binding proteins
-
Costa T., Herz A. Antagonists with negative intrinsic activity at δ opioid receptors coupled to GTP-binding proteins. Proc. Natl. Acad. Sci. USA 1989, 86:7321-7325.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 7321-7325
-
-
Costa, T.1
Herz, A.2
-
20
-
-
0035511611
-
Ion-channel regulation by G proteins
-
Dascal N. Ion-channel regulation by G proteins. Trends Endocrinol. Metab. 2001, 12:391-398.
-
(2001)
Trends Endocrinol. Metab.
, vol.12
, pp. 391-398
-
-
Dascal, N.1
-
21
-
-
3242792519
-
35 S]GTPγS scintillation proximity assay: A powerful emerging technique for analysis of GPCR pharmacology
-
35 S]GTPγS scintillation proximity assay: A powerful emerging technique for analysis of GPCR pharmacology. Trends Pharmacol. Sci. 2004, 25:400-401.
-
(2004)
Trends Pharmacol. Sci.
, vol.25
, pp. 400-401
-
-
DeLapp, N.W.1
-
22
-
-
67650653732
-
Neutral antagonist activity of naltrexone and 6β-naltrexol in naive and opioid-dependent C6 cells expressing a μ-opioid receptor
-
Divin M.F., Bradbury F.A., Carroll F.I., Traynor J.R. Neutral antagonist activity of naltrexone and 6β-naltrexol in naive and opioid-dependent C6 cells expressing a μ-opioid receptor. Br. J. Pharmacol. 2009, 156:1044-1053.
-
(2009)
Br. J. Pharmacol.
, vol.156
, pp. 1044-1053
-
-
Divin, M.F.1
Bradbury, F.A.2
Carroll, F.I.3
Traynor, J.R.4
-
23
-
-
33644875185
-
The G protein-gated potassium current IK, ACH is constitutively active in patients with chronic atrial fibrillation
-
Dobrev D., Friedrich A., Voight N., Jost N., Wettwer E., Christ T., Knaut M., Ravens U. The G protein-gated potassium current IK, ACH is constitutively active in patients with chronic atrial fibrillation. Circulation 2005, 112:3697-3706.
-
(2005)
Circulation
, vol.112
, pp. 3697-3706
-
-
Dobrev, D.1
Friedrich, A.2
Voight, N.3
Jost, N.4
Wettwer, E.5
Christ, T.6
Knaut, M.7
Ravens, U.8
-
24
-
-
0029670997
-
2+ current in excitable cells
-
2+ current in excitable cells. Trends Neurosci. 1996, 19:35-43.
-
(1996)
Trends Neurosci.
, vol.19
, pp. 35-43
-
-
Dolphin, A.C.1
-
26
-
-
1342265789
-
Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons
-
Guo J., Ikeda S.R. Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons. Mol. Pharmacol. 2004, 65:665-674.
-
(2004)
Mol. Pharmacol.
, vol.65
, pp. 665-674
-
-
Guo, J.1
Ikeda, S.R.2
-
27
-
-
0242552831
-
35 S]GTPgammaS binding assay: Approaches and applications in pharmacology
-
35 S]GTPgammaS binding assay: Approaches and applications in pharmacology. Life Sci. 2003, 74:489-508.
-
(2003)
Life Sci.
, vol.74
, pp. 489-508
-
-
Harrison, C.1
Traynor, J.R.2
-
29
-
-
35648985647
-
PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats
-
Horswill J.G., Bali U., Shaaban S., Kelly J.F., Jeevaratnam P., Babbs A.J., Reynet A.J., In P.W.K. PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. Br. J. Pharmacol. 2007, 152:805-814.
-
(2007)
Br. J. Pharmacol.
, vol.152
, pp. 805-814
-
-
Horswill, J.G.1
Bali, U.2
Shaaban, S.3
Kelly, J.F.4
Jeevaratnam, P.5
Babbs, A.J.6
Reynet, A.J.7
In, P.W.K.8
-
30
-
-
4444348830
-
Efficacy in CB1 receptor-mediated signal transduction
-
Howlett A.C. Efficacy in CB1 receptor-mediated signal transduction. Br. J. Pharmacol. 2004, 142:1209-1218.
-
(2004)
Br. J. Pharmacol.
, vol.142
, pp. 1209-1218
-
-
Howlett, A.C.1
-
31
-
-
0035856560
-
Functional role of a conserved motif in TM6 of the rat mu opioid receptor: Constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp
-
Huang P., Li J., Chen C., Visiers I., Weinstein H., Liu-Chen L.Y. Functional role of a conserved motif in TM6 of the rat mu opioid receptor: Constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp. Biochemistry 2001, 40:13501-13509.
-
(2001)
Biochemistry
, vol.40
, pp. 13501-13509
-
-
Huang, P.1
Li, J.2
Chen, C.3
Visiers, I.4
Weinstein, H.5
Liu-Chen, L.Y.6
-
32
-
-
0029921401
-
Voltage-dependent modulation of N-type calcium channels by G-protein βγ subunits
-
Ikeda S.R. Voltage-dependent modulation of N-type calcium channels by G-protein βγ subunits. Nature 1996, 380:255-258.
-
(1996)
Nature
, vol.380
, pp. 255-258
-
-
Ikeda, S.R.1
-
33
-
-
33746265800
-
Agonist-selective mechanisms of μ-opioid receptor desensitization in human embryonic kidney 293 cells
-
Johnson E.A., Oldfield S., Brakstor E., Gonzalez-Cuello A., Couch D., Hall K.J., Mundell S.J., Bailey C.P., Kelly E., Henderson G. Agonist-selective mechanisms of μ-opioid receptor desensitization in human embryonic kidney 293 cells. Mol. Pharmacol. 2006, 70:676-685.
-
(2006)
Mol. Pharmacol.
, vol.70
, pp. 676-685
-
-
Johnson, E.A.1
Oldfield, S.2
Brakstor, E.3
Gonzalez-Cuello, A.4
Couch, D.5
Hall, K.J.6
Mundell, S.J.7
Bailey, C.P.8
Kelly, E.9
Henderson, G.10
-
34
-
-
84886326028
-
Use of the [35S]GTPγS binding assay to determine ligand efficacy at G-protein coupled receptors
-
Wiley-VCH, D. Poyner, M.G. Wheatley (Eds.)
-
Kara E., Strange P. Use of the [35S]GTPγS binding assay to determine ligand efficacy at G-protein coupled receptors. Protein-Coupled Receptors: Essential Methods 2010, Wiley-VCH. D. Poyner, M.G. Wheatley (Eds.).
-
(2010)
Protein-Coupled Receptors: Essential Methods
-
-
Kara, E.1
Strange, P.2
-
35
-
-
1642495639
-
Efficacy as a vector: The relative prevalence and paucity of inverse agonism
-
Kenakin T. Efficacy as a vector: The relative prevalence and paucity of inverse agonism. Mol. Pharmacol. 2004, 65:2-11.
-
(2004)
Mol. Pharmacol.
, vol.65
, pp. 2-11
-
-
Kenakin, T.1
-
36
-
-
0036591660
-
The ligand paradox between affinity and efficacy: Can you be there and not make a difference?
-
Kenakin T., Onaran O. The ligand paradox between affinity and efficacy: Can you be there and not make a difference?. Trends Pharmacol. Sci. 2002, 23:275-280.
-
(2002)
Trends Pharmacol. Sci.
, vol.23
, pp. 275-280
-
-
Kenakin, T.1
Onaran, O.2
-
37
-
-
0026648286
-
Chronic exposure to morphine does not induce dependence at the level of the calcium current in human SH-SY5Y cells
-
Kennedy C., Henderson G. Chronic exposure to morphine does not induce dependence at the level of the calcium current in human SH-SY5Y cells. Neuroscience 1992, 49:937-944.
-
(1992)
Neuroscience
, vol.49
, pp. 937-944
-
-
Kennedy, C.1
Henderson, G.2
-
38
-
-
70350381113
-
Purification and functional reconstitution of monomeric mu-opioid receptors: Allosteric modulation of agonist binding by Gi2
-
Kuszak A.J., Pitchiaya S., Anand J.P., Mosberg H.I., Walter N.G., Sunahara R.K. Purification and functional reconstitution of monomeric mu-opioid receptors: Allosteric modulation of agonist binding by Gi2. J. Biol. Chem. 2009, 284:26732-26741.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 26732-26741
-
-
Kuszak, A.J.1
Pitchiaya, S.2
Anand, J.P.3
Mosberg, H.I.4
Walter, N.G.5
Sunahara, R.K.6
-
39
-
-
67650394865
-
A time-resolved fluorescent lanthanide (Eu)-GTP binding assay for chemokine receptors as targets in drug discovery
-
Labrecque J., Wong R.S., Fricker S.P. A time-resolved fluorescent lanthanide (Eu)-GTP binding assay for chemokine receptors as targets in drug discovery. Meth. Mol. Biol. 2009, 552:153-169.
-
(2009)
Meth. Mol. Biol.
, vol.552
, pp. 153-169
-
-
Labrecque, J.1
Wong, R.S.2
Fricker, S.P.3
-
40
-
-
69249115724
-
Differential effect of membrane cholesterol removal on mu- and delta-opioid receptors: A parallel comparison of acute and chronic signaling to adenylyl cyclase
-
Levitt E.S., Clark M.J., Jenkins P.M., Martens J.R., Traynor J.R. Differential effect of membrane cholesterol removal on mu- and delta-opioid receptors: A parallel comparison of acute and chronic signaling to adenylyl cyclase. J. Biol. Chem. 2009, 284:22108-22122.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 22108-22122
-
-
Levitt, E.S.1
Clark, M.J.2
Jenkins, P.M.3
Martens, J.R.4
Traynor, J.R.5
-
41
-
-
0034763966
-
Inverse agonist up-regulates the constitutively active D3.49(164)Q mutant of the rat μ-opioid receptor by stabilizing the structure and blocking constitutive internalization and down-regulation
-
Li J., Chen C., Huang P., Liu-Chen L.-Y. Inverse agonist up-regulates the constitutively active D3.49(164)Q mutant of the rat μ-opioid receptor by stabilizing the structure and blocking constitutive internalization and down-regulation. Mol. Pharmacol. 2001, 60:1064-1075.
-
(2001)
Mol. Pharmacol.
, vol.60
, pp. 1064-1075
-
-
Li, J.1
Chen, C.2
Huang, P.3
Liu-Chen, L.-Y.4
-
42
-
-
0035834092
-
Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression
-
Li J., Huang P., Chen C., de Reil J.K., Weinstein H., Liu-Chen L.-Y. Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression. Biochemistry 2001, 40:12039-12050.
-
(2001)
Biochemistry
, vol.40
, pp. 12039-12050
-
-
Li, J.1
Huang, P.2
Chen, C.3
de Reil, J.K.4
Weinstein, H.5
Liu-Chen, L.-Y.6
-
43
-
-
33749027768
-
Assays for enhanced activity of low efficacy partial agonists at the D(2) dopamine receptor
-
Lin H., Saisch S.G., Strange P.G. Assays for enhanced activity of low efficacy partial agonists at the D(2) dopamine receptor. Br. J. Pharmacol. 2006, 149:291-299.
-
(2006)
Br. J. Pharmacol.
, vol.149
, pp. 291-299
-
-
Lin, H.1
Saisch, S.G.2
Strange, P.G.3
-
44
-
-
0034955327
-
Chronic exposure to μ-opioid agonists produces constitutive activation of the μ-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment
-
Liu J.-G., Prather P.L. Chronic exposure to μ-opioid agonists produces constitutive activation of the μ-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment. Mol. Pharmacol. 2001, 60:53-62.
-
(2001)
Mol. Pharmacol.
, vol.60
, pp. 53-62
-
-
Liu, J.-G.1
Prather, P.L.2
-
45
-
-
0035851139
-
Constitutively active μ-opioid receptors inhibit adenylyl cyclase activity in intact cells and activate G-proteins differently than the agonist [D-Ala2, N-MePhe4, Gly-ol5]enkephalin
-
Liu J.G., Ruckle M.B., Prather P.L. Constitutively active μ-opioid receptors inhibit adenylyl cyclase activity in intact cells and activate G-proteins differently than the agonist [D-Ala2, N-MePhe4, Gly-ol5]enkephalin. J. Biol. Chem. 2001, 276:37779-37786.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37779-37786
-
-
Liu, J.G.1
Ruckle, M.B.2
Prather, P.L.3
-
47
-
-
0032749031
-
Constitutive activity of the δ-opioid receptor expressed in C6 glioma cells: Identification of non-peptide δ-inverse agonists
-
Neilan C.L., Akil H., Woods J.H., Traynor J.R. Constitutive activity of the δ-opioid receptor expressed in C6 glioma cells: Identification of non-peptide δ-inverse agonists. Br. J. Pharmacol. 1999, 128:556-562.
-
(1999)
Br. J. Pharmacol.
, vol.128
, pp. 556-562
-
-
Neilan, C.L.1
Akil, H.2
Woods, J.H.3
Traynor, J.R.4
-
48
-
-
0032407482
-
2+ currents by reversal of tonic CB1 cannabinoid receptor activity
-
2+ currents by reversal of tonic CB1 cannabinoid receptor activity. Mol. Pharmacol. 1998, 54:1064-1072.
-
(1998)
Mol. Pharmacol.
, vol.54
, pp. 1064-1072
-
-
Pan, X.1
Ikeda, S.R.2
Lewis, D.L.3
-
49
-
-
19444361830
-
In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice
-
Raehal K.M., Lowery J.J., Bhamidipati C.M., Paolino R.M., Blair J.R., Wang D., Sadee W., Bilsky E.J. In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice. J. Pharmacol. Exp. Ther. 2005, 313:1150-1162.
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.313
, pp. 1150-1162
-
-
Raehal, K.M.1
Lowery, J.J.2
Bhamidipati, C.M.3
Paolino, R.M.4
Blair, J.R.5
Wang, D.6
Sadee, W.7
Bilsky, E.J.8
-
50
-
-
1642382773
-
High-throughput real-time monitoring of Gs-coupled receptor activation in intact cells using cyclic-nucleotide gated channels
-
Reinsheid R.K., Kim J., Zeng J., Civelli O. High-throughput real-time monitoring of Gs-coupled receptor activation in intact cells using cyclic-nucleotide gated channels. Eur. J. Pharmacol. 2003, 478:27-34.
-
(2003)
Eur. J. Pharmacol.
, vol.478
, pp. 27-34
-
-
Reinsheid, R.K.1
Kim, J.2
Zeng, J.3
Civelli, O.4
-
51
-
-
18744362461
-
Mechanisms of inverse agonist action at D2 dopamine receptors
-
Roberts D.J., Strange P.G. Mechanisms of inverse agonist action at D2 dopamine receptors. Br. J. Pharmacol. 2005, 145:34-42.
-
(2005)
Br. J. Pharmacol.
, vol.145
, pp. 34-42
-
-
Roberts, D.J.1
Strange, P.G.2
-
52
-
-
66249144426
-
The structure and function of G-protein-coupled receptors
-
Rosenbaum D.M., Rasmussen S.G., Kobilka B.K. The structure and function of G-protein-coupled receptors. Nature 2009, 459:356-363.
-
(2009)
Nature
, vol.459
, pp. 356-363
-
-
Rosenbaum, D.M.1
Rasmussen, S.G.2
Kobilka, B.K.3
-
53
-
-
0032535753
-
+ channels in adult rat sympathetic neurons
-
+ channels in adult rat sympathetic neurons. J. Physiol. 1998, 513:761-773.
-
(1998)
J. Physiol.
, vol.513
, pp. 761-773
-
-
Ruiz-Velasco, V.1
Ikeda, S.R.2
-
54
-
-
54249153754
-
Physiological roles for G protein-regulated adenylyl cyclase isoforms: Insights from knockout and overexpression studies
-
Sadana R., Dessauer C.W. Physiological roles for G protein-regulated adenylyl cyclase isoforms: Insights from knockout and overexpression studies. Neurosignals 2009, 17:5-22.
-
(2009)
Neurosignals
, vol.17
, pp. 5-22
-
-
Sadana, R.1
Dessauer, C.W.2
-
55
-
-
12844281159
-
Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities
-
Sadee W., Wang D., Bilsky E.J. Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities. Life Sci. 2005, 76:1427-1437.
-
(2005)
Life Sci.
, vol.76
, pp. 1427-1437
-
-
Sadee, W.1
Wang, D.2
Bilsky, E.J.3
-
56
-
-
0036667344
-
Graded contribution of the Gβγ binding domains to GIRK channel function
-
Sadja R., Alagem N., Reuveny E. Graded contribution of the Gβγ binding domains to GIRK channel function. Proc. Natl. Acad. Sci. USA 2002, 99:10783-10788.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 10783-10788
-
-
Sadja, R.1
Alagem, N.2
Reuveny, E.3
-
57
-
-
73449114609
-
Identification of a novel "almost neutral" μ-opioid receptor antagonist in CHO cells expressing the cloned μ-opioid receptor
-
Sally E.J., Xu H., Dersch C.M., Hsin L.-W., Chang L.-T., Prisinzano T.E., Simpson D.S., Giuvelis D., Rice K.C., Jacobson A.E., Cheng K., Bilsky E.J., et al. Identification of a novel "almost neutral" μ-opioid receptor antagonist in CHO cells expressing the cloned μ-opioid receptor. Synapse 2010, 64:280-288.
-
(2010)
Synapse
, vol.64
, pp. 280-288
-
-
Sally, E.J.1
Xu, H.2
Dersch, C.M.3
Hsin, L.-W.4
Chang, L.-T.5
Prisinzano, T.E.6
Simpson, D.S.7
Giuvelis, D.8
Rice, K.C.9
Jacobson, A.E.10
Cheng, K.11
Bilsky, E.J.12
-
58
-
-
0031019660
-
Opioid receptor-coupled G proteins in rat locus coeruleus membranes: Decrease in activity after chronic morphine treatment
-
Selley D.E., Nestler E.J., Brievogel C.S., Childers S.R. Opioid receptor-coupled G proteins in rat locus coeruleus membranes: Decrease in activity after chronic morphine treatment. Brain Res. 1997, 746:10-18.
-
(1997)
Brain Res.
, vol.746
, pp. 10-18
-
-
Selley, D.E.1
Nestler, E.J.2
Brievogel, C.S.3
Childers, S.R.4
-
60
-
-
33847081648
-
Pharmacogenomic and structural analysis of constitutive G protein-coupled receptor activity
-
Smit M.J., Vischer H.F., Bakker R.A., Jongejan A., Timmerman H., Pardo L., Leurs R. Pharmacogenomic and structural analysis of constitutive G protein-coupled receptor activity. Annu. Rev. Pharmacol. Toxicol. 2007, 47:53-87.
-
(2007)
Annu. Rev. Pharmacol. Toxicol.
, vol.47
, pp. 53-87
-
-
Smit, M.J.1
Vischer, H.F.2
Bakker, R.A.3
Jongejan, A.4
Timmerman, H.5
Pardo, L.6
Leurs, R.7
-
61
-
-
0021748090
-
Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain
-
Sternweis P.C., Robishaw J.D. Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain. J. Biol. Chem. 1984, 259:13806-13813.
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 13806-13813
-
-
Sternweis, P.C.1
Robishaw, J.D.2
-
62
-
-
0031456986
-
Delta opioid modulation of the binding of guanosine-5'-O-(3-[35S]thio)triphosphate to NG108-15 cell membranes: Characterization of agonist and inverse agonist effects
-
Szekeres P.G., Traynor J.R. Delta opioid modulation of the binding of guanosine-5'-O-(3-[35S]thio)triphosphate to NG108-15 cell membranes: Characterization of agonist and inverse agonist effects. J. Pharmacol. Exp. Ther. 1997, 283:1276-1284.
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.283
, pp. 1276-1284
-
-
Szekeres, P.G.1
Traynor, J.R.2
-
63
-
-
0028986870
-
35 S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells
-
35 S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells. Mol. Pharmacol. 1995, 47:848-854.
-
(1995)
Mol. Pharmacol.
, vol.47
, pp. 848-854
-
-
Traynor, J.R.1
Nahorski, S.R.2
-
64
-
-
57049115401
-
Real-time monitoring of cyclic nucleotide signalling in neurons using genetically encoded FRET probes
-
Vincent P., Gervasi N., Zhang J. Real-time monitoring of cyclic nucleotide signalling in neurons using genetically encoded FRET probes. Brain Cell Biol. 2008, 36:3-17.
-
(2008)
Brain Cell Biol.
, vol.36
, pp. 3-17
-
-
Vincent, P.1
Gervasi, N.2
Zhang, J.3
-
65
-
-
34248382512
-
β-Arrestin and c-Src regulate the constitutive activity and recycling of μ-opioid receptors in dorsal root ganglion neurons
-
Walwyn W., Evans C.J., Hales T.G. β-Arrestin and c-Src regulate the constitutive activity and recycling of μ-opioid receptors in dorsal root ganglion neurons. J. Neurosci. 2007, 27:5092-5104.
-
(2007)
J. Neurosci.
, vol.27
, pp. 5092-5104
-
-
Walwyn, W.1
Evans, C.J.2
Hales, T.G.3
-
66
-
-
0028299699
-
Constitutive μ opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence
-
Wang Z., Bilsky E.J., Porreca F., Sadee W. Constitutive μ opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence. Life Sci. 1994, 54:339-350.
-
(1994)
Life Sci.
, vol.54
, pp. 339-350
-
-
Wang, Z.1
Bilsky, E.J.2
Porreca, F.3
Sadee, W.4
-
67
-
-
0034972443
-
Inverse agonists and neutral antagonists at μ opioid receptor (MOR): Possible role of basal receptor signaling in narcotic tolerance
-
Wang D., Raehal K.M., Bilsky E.J., Sadee W. Inverse agonists and neutral antagonists at μ opioid receptor (MOR): Possible role of basal receptor signaling in narcotic tolerance. J. Neurochem. 2001, 77:1590-1600.
-
(2001)
J. Neurochem.
, vol.77
, pp. 1590-1600
-
-
Wang, D.1
Raehal, K.M.2
Bilsky, E.J.3
Sadee, W.4
-
68
-
-
1642579545
-
Basal signalling activity of μ opioid receptor in mouse brain: Role in narcotic dependence
-
Wang D., Raehal K.M., Lin E.T., Lowery J.J., Keiffer B.L., Bilsky E.J., Sadee W. Basal signalling activity of μ opioid receptor in mouse brain: Role in narcotic dependence. J. Pharmacol. Exp. Ther. 2004, 308:512-520.
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.308
, pp. 512-520
-
-
Wang, D.1
Raehal, K.M.2
Lin, E.T.3
Lowery, J.J.4
Keiffer, B.L.5
Bilsky, E.J.6
Sadee, W.7
-
69
-
-
34247234605
-
Different effects of opioid antagonists on μ-, δ-, and κ-opioid receptors with and without agonist pretreatment
-
Wang D., Sun X., Sadee W. Different effects of opioid antagonists on μ-, δ-, and κ-opioid receptors with and without agonist pretreatment. J. Pharmacol. Exp. Ther. 2007, 321:544-552.
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.321
, pp. 544-552
-
-
Wang, D.1
Sun, X.2
Sadee, W.3
-
70
-
-
19444378697
-
Sensitization of adenylate cyclase by Gαi/o-coupled receptors
-
Watts V.J., Neve K.A. Sensitization of adenylate cyclase by Gαi/o-coupled receptors. Pharmacol. Ther. 2005, 106:405-421.
-
(2005)
Pharmacol. Ther.
, vol.106
, pp. 405-421
-
-
Watts, V.J.1
Neve, K.A.2
-
71
-
-
0035138995
-
Cellular and synaptic adaptations mediating opioid withdrawal
-
Williams J.T., Christie M.J., Manzoni O. Cellular and synaptic adaptations mediating opioid withdrawal. Physiol. Rev. 2001, 81:299-343.
-
(2001)
Physiol. Rev.
, vol.81
, pp. 299-343
-
-
Williams, J.T.1
Christie, M.J.2
Manzoni, O.3
-
72
-
-
33846251929
-
A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) μ-opioid agonists on cellular markers related to opioid tolerance and dependence
-
Xu H., Partilla J.S., Wang X., Rutherford J.M., Tidgewell K., Prisinzano T.E., Bohn L.M., Rothman R.B. A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) μ-opioid agonists on cellular markers related to opioid tolerance and dependence. Synapse 2007, 61:166-175.
-
(2007)
Synapse
, vol.61
, pp. 166-175
-
-
Xu, H.1
Partilla, J.S.2
Wang, X.3
Rutherford, J.M.4
Tidgewell, K.5
Prisinzano, T.E.6
Bohn, L.M.7
Rothman, R.B.8
-
73
-
-
67249125561
-
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
-
Yao X.J., Velez Ruiz G., Whorton M.R., Rasmussen S.G.F., DeVree B.T., Deupi X., Sunahara R.K., Kobilka B. The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex. Proc. Natl. Acad. Sci. USA 2009, 106:9501-9506.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 9501-9506
-
-
Yao, X.J.1
Velez Ruiz, G.2
Whorton, M.R.3
Rasmussen, S.G.F.4
DeVree, B.T.5
Deupi, X.6
Sunahara, R.K.7
Kobilka, B.8
|