Neutrophil elastase activates protease-activated receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to cause inflammation and pain

Journal of Biological Chemistry

Volumn 290, Issue 22, 2015, Pages 13875-13887

  Zhao, Peishen ^a   Lieu, TinaMarie ^a   Barlow, Nicholas ^a   Sostegni, Silvia ^b   Haerteis, Silke ^b   Korbmacher, Christoph ^b   Liedtke, Wolfgang ^c   Jimenez Vargas, Nestor N ^d   Vanner, Stephen J ^d   Bunnett, Nigel W ^a,e  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d QUEEN S UNIVERSITY   (Canada)

^e UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CHEMICAL ACTIVATION; ENZYME ACTIVITY; ENZYMES; HEALTH; MAMMALS; MOLECULAR BIOLOGY; PROTEINS;

G PROTEIN-COUPLED RECEPTOR KINASE; PROTEASE ACTIVATED RECEPTORS; PROTEIN KINASE A; RECEPTOR ENDOCYTOSIS; SIGNALING CASCADES; TRANSIENT RECEPTOR POTENTIAL VANILLOID; TRANSIENT RECEPTOR POTENTIALS; XENOPUS LAEVIS OOCYTES;

PATHOLOGY;

ADENYLATE CYCLASE; BETA ARRESTIN; CALCIUM ION; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 6; LEUKOCYTE ELASTASE; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEINASE ACTIVATED RECEPTOR 2; VANILLOID RECEPTOR 4; CALCIUM; GUANINE NUCLEOTIDE BINDING PROTEIN; PEPTIDE HYDROLASE; TRPV4 PROTEIN, HUMAN; TRPV4 PROTEIN, MOUSE; VANILLOID RECEPTOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CELL LINE; CONTROLLED STUDY; ENDOCYTOSIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYPERALGESIA; INFLAMMATION; MALE; MOUSE; NOCICEPTION; NONHUMAN; OOCYTE; PAIN; PAIN RECEPTOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; REGULATORY MECHANISM; XENOPUS LAEVIS; ANIMAL; C57BL MOUSE; CELL MEMBRANE; CYTOLOGY; EDEMA; HEK293 CELL LINE; METABOLISM; NERVE CELL; PATCH CLAMP TECHNIQUE; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; SPINAL GANGLION;

MUS; XENOPUS LAEVIS;

ANIMALS; CALCIUM; CELL MEMBRANE; CYCLIC AMP; EDEMA; GANGLIA, SPINAL; GTP-BINDING PROTEINS; HEK293 CELLS; HUMANS; INFLAMMATION; LEUKOCYTE ELASTASE; MALE; MICE; MICE, INBRED C57BL; NEURONS; NOCICEPTION; OOCYTES; PAIN; PATCH-CLAMP TECHNIQUES; PEPTIDE HYDROLASES; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, PAR-2; SIGNAL TRANSDUCTION; TRPV CATION CHANNELS; XENOPUS LAEVIS;

EID: 84930619167     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.642736     Document Type: Article

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