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Volumn 594, Issue 5, 2016, Pages 1179-1195

Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE; TAMOXIFEN; TRANSCRIPTION FACTOR; EGLN1 PROTEIN, MOUSE; HIF-2 PROTEIN, MOUSE; HIF1A PROTEIN, MOUSE;

EID: 84959311501     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/JP271050     Document Type: Article
Times cited : (68)

References (57)
  • 6
    • 33847703664 scopus 로고    scopus 로고
    • A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice
    • Balbir A, Lee H, Okumura M, Biswal S, Fitzgerald RS & Shirahata M (2007). A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice. Am J Physiol Lung Cell Mol Physiol 292, L704-715.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292 , pp. L704-L715
    • Balbir, A.1    Lee, H.2    Okumura, M.3    Biswal, S.4    Fitzgerald, R.S.5    Shirahata, M.6
  • 7
    • 0041465022 scopus 로고    scopus 로고
    • HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
    • Berra E, Benizri E, Ginouves A, Volmat V, Roux D & Pouyssegur J (2003). HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia. EMBO J 22, 4082-4090.
    • (2003) EMBO J , vol.22 , pp. 4082-4090
    • Berra, E.1    Benizri, E.2    Ginouves, A.3    Volmat, V.4    Roux, D.5    Pouyssegur, J.6
  • 10
    • 85047691081 scopus 로고    scopus 로고
    • Heterozygous deficiency of hypoxia-inducible factor-2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
    • Brusselmans K, Compernolle V, Tjwa M, Wiesener MS, Maxwell PH, Collen D & Carmeliet P (2003). Heterozygous deficiency of hypoxia-inducible factor-2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest 111, 1519-1527.
    • (2003) J Clin Invest , vol.111 , pp. 1519-1527
    • Brusselmans, K.1    Compernolle, V.2    Tjwa, M.3    Wiesener, M.S.4    Maxwell, P.H.5    Collen, D.6    Carmeliet, P.7
  • 13
    • 0345490692 scopus 로고    scopus 로고
    • Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1α
    • Compernolle V, Brusselmans K, Franco D, Moorman A, Dewerchin M, Collen D & Carmeliet P (2003). Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1α. Cardiovasc Res 60, 569-579.
    • (2003) Cardiovasc Res , vol.60 , pp. 569-579
    • Compernolle, V.1    Brusselmans, K.2    Franco, D.3    Moorman, A.4    Dewerchin, M.5    Collen, D.6    Carmeliet, P.7
  • 17
    • 84931395849 scopus 로고    scopus 로고
    • Principles and standards for reporting animal experiments in The J Physiol and Experimental Physiology
    • Grundy D (2015). Principles and standards for reporting animal experiments in The J Physiol and Experimental Physiology. J Physiol 593, 2547-2549.
    • (2015) J Physiol , vol.593 , pp. 2547-2549
    • Grundy, D.1
  • 21
    • 0028956496 scopus 로고
    • Ventilatory response to 8 h of isocapnic and poikilocapnic hypoxia in humans
    • Howard LS & Robbins PA (1995). Ventilatory response to 8 h of isocapnic and poikilocapnic hypoxia in humans. J Appl Physiol (1985) 78, 1092-1097.
    • (1995) J Appl Physiol (1985) , vol.78 , pp. 1092-1097
    • Howard, L.S.1    Robbins, P.A.2
  • 24
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
    • Kaelin WGJ & Ratcliffe PJ (2008). Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 30, 393-402.
    • (2008) Mol. Cell , vol.30 , pp. 393-402
    • Kaelin, W.G.J.1    Ratcliffe, P.J.2
  • 26
    • 84655161946 scopus 로고    scopus 로고
    • HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
    • Keith B, Johnson RS & Simon MC (2012). HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 12, 9-22.
    • (2012) Nat Rev Cancer , vol.12 , pp. 9-22
    • Keith, B.1    Johnson, R.S.2    Simon, M.C.3
  • 27
    • 84904760921 scopus 로고    scopus 로고
    • Vulnerability of the developing heart to oxygen deprivation as a cause of congenital heart defects
    • Kenchegowda D, Liu H, Thompson K, Luo L, Martin SS & Fisher SA (2014). Vulnerability of the developing heart to oxygen deprivation as a cause of congenital heart defects. J Am Heart Assoc 3, e000841.
    • (2014) J Am Heart Assoc , vol.3 , pp. e000841
    • Kenchegowda, D.1    Liu, H.2    Thompson, K.3    Luo, L.4    Martin, S.S.5    Fisher, S.A.6
  • 28
    • 0037154262 scopus 로고    scopus 로고
    • Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
    • Kline DD, Peng Y-J, Manola DJ, Semenza GL & Prabhakar NR (2002). Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α. Proc Natl Acad Sci USA 99, 821-826.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 821-826
    • Kline, D.D.1    Peng, Y.-J.2    Manola, D.J.3    Semenza, G.L.4    Prabhakar, N.R.5
  • 29
    • 0033562569 scopus 로고    scopus 로고
    • Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
    • Kotch LE, Iyer NV, Laughner E & Semenza GL (1999). Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev Biol 209, 254-267.
    • (1999) Dev Biol , vol.209 , pp. 254-267
    • Kotch, L.E.1    Iyer, N.V.2    Laughner, E.3    Semenza, G.L.4
  • 31
    • 84918566655 scopus 로고    scopus 로고
    • Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia
    • Macias D, Fernandez-Aguera MC, Bonilla-Henao V & Lopez-Barneo J (2014). Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia. EMBO Mol Med 6, 1577-1592.
    • (2014) EMBO Mol Med , vol.6 , pp. 1577-1592
    • Macias, D.1    Fernandez-Aguera, M.C.2    Bonilla-Henao, V.3    Lopez-Barneo, J.4
  • 34
    • 42449163874 scopus 로고    scopus 로고
    • Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure
    • Minamishima YA, Moslehi J, Bardeesy N, Cullen D, Bronson RT & Kaelin WG, Jr (2008). Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood 111, 3236-3244.
    • (2008) Blood , vol.111 , pp. 3236-3244
    • Minamishima, Y.A.1    Moslehi, J.2    Bardeesy, N.3    Cullen, D.4    Bronson, R.T.5    Kaelin, W.G.6
  • 35
    • 67650531089 scopus 로고    scopus 로고
    • Genome-wide association of hypoxia-inducible factor (HIF)-1α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts
    • Mole DR, Blancher C, Copley RR, Pollard PJ, Gleadle JM, Ragoussis J & Ratcliffe PJ (2009). Genome-wide association of hypoxia-inducible factor (HIF)-1α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts. J Biol Chem 284, 16767-16775.
    • (2009) J Biol Chem , vol.284 , pp. 16767-16775
    • Mole, D.R.1    Blancher, C.2    Copley, R.R.3    Pollard, P.J.4    Gleadle, J.M.5    Ragoussis, J.6    Ratcliffe, P.J.7
  • 36
    • 84870405372 scopus 로고    scopus 로고
    • Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase W22;1(PHD-1) deficient mice
    • In, ed. Nurse CA, Gonzalez C, Peers C & Prabhakar N, Springer, Berlin.
    • Pan J, Yeger H, Ratcliffe P, Bishop T & Cutz E (2012). Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase W22;1(PHD-1) deficient mice. In Arterial Chemoreception, ed. Nurse CA, Gonzalez C, Peers C & Prabhakar N, pp. 149-155. Springer, Berlin.
    • (2012) Arterial Chemoreception , pp. 149-155
    • Pan, J.1    Yeger, H.2    Ratcliffe, P.3    Bishop, T.4    Cutz, E.5
  • 37
    • 35348906206 scopus 로고    scopus 로고
    • Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body
    • Pardal R, Ortega-Saenz P, Duran R & Lopez-Barneo J (2007). Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body. Cell 131, 364-377.
    • (2007) Cell , vol.131 , pp. 364-377
    • Pardal, R.1    Ortega-Saenz, P.2    Duran, R.3    Lopez-Barneo, J.4
  • 38
    • 0034682513 scopus 로고    scopus 로고
    • The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling
    • Peng J, Zhang L, Drysdale L & Fong GH (2000). The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling. Proc Natl Acad Sci USA 97, 8386-8391.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 8386-8391
    • Peng, J.1    Zhang, L.2    Drysdale, L.3    Fong, G.H.4
  • 40
    • 33751329032 scopus 로고    scopus 로고
    • Heterozygous HIF-1α deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia
    • Peng YJ, Yuan G, Ramakrishnan D, Sharma SD, Bosch-Marce M, Kumar GK, Semenza GL & Prabhakar NR (2006). Heterozygous HIF-1α deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J Physiol 577, 705-716.
    • (2006) J Physiol , vol.577 , pp. 705-716
    • Peng, Y.J.1    Yuan, G.2    Ramakrishnan, D.3    Sharma, S.D.4    Bosch-Marce, M.5    Kumar, G.K.6    Semenza, G.L.7    Prabhakar, N.R.8
  • 42
    • 84864131464 scopus 로고    scopus 로고
    • Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2
    • Prabhakar NR & Semenza GL (2012). Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev 92, 967-1003.
    • (2012) Physiol Rev , vol.92 , pp. 967-1003
    • Prabhakar, N.R.1    Semenza, G.L.2
  • 43
    • 84876325985 scopus 로고    scopus 로고
    • Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer
    • Ratcliffe PJ (2013). Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer. J Physiol 591, 2027-2042.
    • (2013) J Physiol , vol.591 , pp. 2027-2042
    • Ratcliffe, P.J.1
  • 44
    • 34548691285 scopus 로고    scopus 로고
    • Role of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude
    • Robbins PA (2007). Role of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude. Respir Physiol Neurobiol 158, 237-242.
    • (2007) Respir Physiol Neurobiol , vol.158 , pp. 237-242
    • Robbins, P.A.1
  • 47
    • 84901218507 scopus 로고    scopus 로고
    • The von Hippel-Lindau Chuvash mutation in mice causes carotid-body hyperplasia and enhanced ventilatory sensitivity to hypoxia
    • Slingo ME, Turner PJ, Christian HC, Buckler KJ & Robbins PA (2014). The von Hippel-Lindau Chuvash mutation in mice causes carotid-body hyperplasia and enhanced ventilatory sensitivity to hypoxia. J Appl Physiol (1985) 116, 885-892.
    • (2014) J Appl Physiol (1985) , vol.116 , pp. 885-892
    • Slingo, M.E.1    Turner, P.J.2    Christian, H.C.3    Buckler, K.J.4    Robbins, P.A.5
  • 51
    • 34547905406 scopus 로고    scopus 로고
    • Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system
    • Takeda K, Cowan A & Fong GH (2007). Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation 116, 774-781.
    • (2007) Circulation , vol.116 , pp. 774-781
    • Takeda, K.1    Cowan, A.2    Fong, G.H.3
  • 52
    • 33750976389 scopus 로고    scopus 로고
    • Placental but not heart defect is associated with elevated HIFα levels in mice lacking prolyl hydroxylase domain protein 2
    • Takeda K, Ho V, Takeda H, Duan LJ, Nagy A & Fong GH (2006). Placental but not heart defect is associated with elevated HIFα levels in mice lacking prolyl hydroxylase domain protein 2. Mol Cell Biol 26, 8336-8346.
    • (2006) Mol Cell Biol , vol.26 , pp. 8336-8346
    • Takeda, K.1    Ho, V.2    Takeda, H.3    Duan, L.J.4    Nagy, A.5    Fong, G.H.6
  • 54
    • 0032213236 scopus 로고    scopus 로고
    • The hypoxia responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
    • Tian H, Hammer RE, Matsumoto AM, Russell DW & McKnight SL (1998). The hypoxia responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev 12, 3320-3324.
    • (1998) Genes Dev , vol.12 , pp. 3320-3324
    • Tian, H.1    Hammer, R.E.2    Matsumoto, A.M.3    Russell, D.W.4    McKnight, S.L.5
  • 55
    • 0035029433 scopus 로고    scopus 로고
    • A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent
    • Vooijs M, Jonkers J & Berns A (2001). A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. EMBO J 2, 292-297.
    • (2001) EMBO J , vol.2 , pp. 292-297
    • Vooijs, M.1    Jonkers, J.2    Berns, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.