-
1
-
-
80054767730
-
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling
-
Adam J, Hatipoglu E, O'Flaherty L, Ternette N, Sahgal N, Lockstone H, Baban D, Nye E, Stamp GW, Wolhuter K, Stevens M, Fischer R, Carmeliet P, Maxwell PH, Pugh CW, Frizzell N, Soga T, Kessler BM, El-Bahrawy M, Ratcliffe PJ & Pollard PJ. (2011). Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer Cell 20, 524-537.
-
(2011)
Cancer Cell
, vol.20
, pp. 524-537
-
-
Adam, J.1
Hatipoglu, E.2
O'Flaherty, L.3
Ternette, N.4
Sahgal, N.5
Lockstone, H.6
Baban, D.7
Nye, E.8
Stamp, G.W.9
Wolhuter, K.10
Stevens, M.11
Fischer, R.12
Carmeliet, P.13
Maxwell, P.H.14
Pugh, C.W.15
Frizzell, N.16
Soga, T.17
Kessler, B.M.18
El-Bahrawy, M.19
Ratcliffe, P.J.20
Pollard, P.J.21
more..
-
2
-
-
18744373593
-
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia
-
Ang SO, Chen H, Hirota K, Gordeuk VR, Jelinek J, Guan Y, Liu E, Sergueeva AI, Miasnikova GY, Mole D, Maxwell PH, Stockton DW, Semenza GL & Prchal JT (2002). Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia. Nat Genet 32, 614-621.
-
(2002)
Nat Genet
, vol.32
, pp. 614-621
-
-
Ang, S.O.1
Chen, H.2
Hirota, K.3
Gordeuk, V.R.4
Jelinek, J.5
Guan, Y.6
Liu, E.7
Sergueeva, A.I.8
Miasnikova, G.Y.9
Mole, D.10
Maxwell, P.H.11
Stockton, D.W.12
Semenza, G.L.13
Prchal, J.T.14
-
3
-
-
4644318828
-
Differential function of the prolyl hydroxylases PHD1, PHD2 and PHD3 in the regulation of hypoxia-inducible factor
-
Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ & Gleadle JM (2004). Differential function of the prolyl hydroxylases PHD1, PHD2 and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem 279, 38458-38465.
-
(2004)
J Biol Chem
, vol.279
, pp. 38458-38465
-
-
Appelhoff, R.J.1
Tian, Y.M.2
Raval, R.R.3
Turley, H.4
Harris, A.L.5
Pugh, C.W.6
Ratcliffe, P.J.7
Gleadle, J.M.8
-
4
-
-
38649143118
-
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
-
Aragones J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P & Carmeliet P (2008). Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet 40, 170-180.
-
(2008)
Nat Genet
, vol.40
, pp. 170-180
-
-
Aragones, J.1
Schneider, M.2
Van Geyte, K.3
Fraisl, P.4
Dresselaers, T.5
Mazzone, M.6
Dirkx, R.7
Zacchigna, S.8
Lemieux, H.9
Jeoung, N.H.10
Lambrechts, D.11
Bishop, T.12
Lafuste, P.13
Diez-Juan, A.14
Harten, S.K.15
Van Noten, P.16
De Bock, K.17
Willam, C.18
Tjwa, M.19
Grosfeld, A.20
Navet, R.21
Moons, L.22
Vandendriessche, T.23
Deroose, C.24
Wijeyekoon, B.25
Nuyts, J.26
Jordan, B.27
Silasi-Mansat, R.28
Lupu, F.29
Dewerchin, M.30
Pugh, C.31
Salmon, P.32
Mortelmans, L.33
Gallez, B.34
Gorus, F.35
Buyse, J.36
Sluse, F.37
Harris, R.A.38
Gnaiger, E.39
Hespel, P.40
Van Hecke, P.41
Schuit, F.42
Van Veldhoven, P.43
Ratcliffe, P.44
Baes, M.45
Maxwell, P.46
Carmeliet, P.47
more..
-
5
-
-
84888338062
-
A knockin mouse model of human PHD2-associated erythrocytosis establishes a haploinsufficiency mechanism
-
Arsenault PR, Pei F, Lee R, Kerestes H, Percy MJ, Keith B, Simon MC, Lappin TR, Khurana TS & Lee FS (2013). A knockin mouse model of human PHD2-associated erythrocytosis establishes a haploinsufficiency mechanism. J Biol Chem 288, 33571-33581.
-
(2013)
J Biol Chem
, vol.288
, pp. 33571-33581
-
-
Arsenault, P.R.1
Pei, F.2
Lee, R.3
Kerestes, H.4
Percy, M.J.5
Keith, B.6
Simon, M.C.7
Lappin, T.R.8
Khurana, T.S.9
Lee, F.S.10
-
6
-
-
33847703664
-
A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice
-
Balbir A, Lee H, Okumura M, Biswal S, Fitzgerald RS & Shirahata M (2007). A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice. Am J Physiol Lung Cell Mol Physiol 292, L704-715.
-
(2007)
Am J Physiol Lung Cell Mol Physiol
, vol.292
, pp. L704-L715
-
-
Balbir, A.1
Lee, H.2
Okumura, M.3
Biswal, S.4
Fitzgerald, R.S.5
Shirahata, M.6
-
7
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
-
Berra E, Benizri E, Ginouves A, Volmat V, Roux D & Pouyssegur J (2003). HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia. EMBO J 22, 4082-4090.
-
(2003)
EMBO J
, vol.22
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouves, A.3
Volmat, V.4
Roux, D.5
Pouyssegur, J.6
-
8
-
-
43249108443
-
-/- mice
-
-/- mice. Mol Cell Biol 28, 3386-3400.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 3386-3400
-
-
Bishop, T.1
Gallagher, D.2
Pascual, A.3
Lygate, C.A.4
de Bono, J.P.5
Nicholls, L.G.6
Ortega-Saenz, P.7
Oster, H.8
Wijeyekoon, B.9
Sutherland, A.I.10
Grosfeld, A.11
Aragones, J.12
Schneider, M.13
van Geyte, K.14
Teixeira, D.15
Diez-Juan, A.16
Lopez-Barneo, J.17
Channon, K.M.18
Maxwell, P.H.19
Pugh, C.W.20
Davies, A.M.21
Carmeliet, P.22
Ratcliffe, P.J.23
more..
-
9
-
-
84880723562
-
Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2
-
Bishop T, Talbot NP, Turner PJ, Nicholls LG, Pascual A, Hodson EJ, Douglas G, Fielding JW, Smith TG, Demetriades M, Schofield CJ, Robbins PA, Pugh CW, Buckler KJ & Ratcliffe PJ (2013). Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2. J Physiol 591, 3565-3577.
-
(2013)
J Physiol
, vol.591
, pp. 3565-3577
-
-
Bishop, T.1
Talbot, N.P.2
Turner, P.J.3
Nicholls, L.G.4
Pascual, A.5
Hodson, E.J.6
Douglas, G.7
Fielding, J.W.8
Smith, T.G.9
Demetriades, M.10
Schofield, C.J.11
Robbins, P.A.12
Pugh, C.W.13
Buckler, K.J.14
Ratcliffe, P.J.15
-
10
-
-
85047691081
-
Heterozygous deficiency of hypoxia-inducible factor-2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
-
Brusselmans K, Compernolle V, Tjwa M, Wiesener MS, Maxwell PH, Collen D & Carmeliet P (2003). Heterozygous deficiency of hypoxia-inducible factor-2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest 111, 1519-1527.
-
(2003)
J Clin Invest
, vol.111
, pp. 1519-1527
-
-
Brusselmans, K.1
Compernolle, V.2
Tjwa, M.3
Wiesener, M.S.4
Maxwell, P.H.5
Collen, D.6
Carmeliet, P.7
-
11
-
-
0032581277
-
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet P, Dor Y, Herbert J-M, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell PH, Koch CJ, Ratcliffe PJ, Moons L, Jain RK, Collen D & Keshert E (1998). Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394, 485-490.
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.-M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.H.10
Koch, C.J.11
Ratcliffe, P.J.12
Moons, L.13
Jain, R.K.14
Collen, D.15
Keshert, E.16
-
12
-
-
0035983324
-
Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
-
Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, Plaisance S, Dor Y, Keshet E, Lupu F, Nemery B, Dewerchin M, Van Veldhoven P, Plate K, Moons L, Collen D & Carmeliet P (2002). Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med 8, 702-710.
-
(2002)
Nat Med
, vol.8
, pp. 702-710
-
-
Compernolle, V.1
Brusselmans, K.2
Acker, T.3
Hoet, P.4
Tjwa, M.5
Beck, H.6
Plaisance, S.7
Dor, Y.8
Keshet, E.9
Lupu, F.10
Nemery, B.11
Dewerchin, M.12
Van Veldhoven, P.13
Plate, K.14
Moons, L.15
Collen, D.16
Carmeliet, P.17
-
13
-
-
0345490692
-
Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1α
-
Compernolle V, Brusselmans K, Franco D, Moorman A, Dewerchin M, Collen D & Carmeliet P (2003). Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1α. Cardiovasc Res 60, 569-579.
-
(2003)
Cardiovasc Res
, vol.60
, pp. 569-579
-
-
Compernolle, V.1
Brusselmans, K.2
Franco, D.3
Moorman, A.4
Dewerchin, M.5
Collen, D.6
Carmeliet, P.7
-
14
-
-
0037423948
-
HIF-1α is essential for myeloid cell-mediated inflammation
-
Cramer T, Yamanishi Y, Clausen BE, Forster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber H-P, Ferrara N & Johnson RS (2003). HIF-1α is essential for myeloid cell-mediated inflammation. Cell 112, 645-657.
-
(2003)
Cell
, vol.112
, pp. 645-657
-
-
Cramer, T.1
Yamanishi, Y.2
Clausen, B.E.3
Forster, I.4
Pawlinski, R.5
Mackman, N.6
Haase, V.H.7
Jaenisch, R.8
Corr, M.9
Nizet, V.10
Firestein, G.S.11
Gerber, H.-P.12
Ferrara, N.13
Johnson, R.S.14
-
15
-
-
84874351409
-
HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis
-
Franke K, Kalucka J, Mamlouk S, Singh RP, Muschter A, Weidemann A, Iyengar V, Jahn S, Wieczorek K, Geiger K, Muders M, Sykes AM, Poitz DM, Ripich T, Otto T, Bergmann S, Breier G, Baretton G, Fong GH, Greaves DR, Bornstein S, Chavakis T, Fandrey J, Gassmann M & Wielockx B (2013). HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis. Blood 121, 1436-1445.
-
(2013)
Blood
, vol.121
, pp. 1436-1445
-
-
Franke, K.1
Kalucka, J.2
Mamlouk, S.3
Singh, R.P.4
Muschter, A.5
Weidemann, A.6
Iyengar, V.7
Jahn, S.8
Wieczorek, K.9
Geiger, K.10
Muders, M.11
Sykes, A.M.12
Poitz, D.M.13
Ripich, T.14
Otto, T.15
Bergmann, S.16
Breier, G.17
Baretton, G.18
Fong, G.H.19
Greaves, D.R.20
Bornstein, S.21
Chavakis, T.22
Fandrey, J.23
Gassmann, M.24
Wielockx, B.25
more..
-
16
-
-
33847796951
-
Acute postnatal ablation of Hif-2α results in anemia
-
Gruber M, Hu CJ, Johnson RS, Brown EJ, Keith B & Simon MC (2007). Acute postnatal ablation of Hif-2α results in anemia. Proc Natl Acad Sci USA 104, 2301-2306.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 2301-2306
-
-
Gruber, M.1
Hu, C.J.2
Johnson, R.S.3
Brown, E.J.4
Keith, B.5
Simon, M.C.6
-
17
-
-
84931395849
-
Principles and standards for reporting animal experiments in The J Physiol and Experimental Physiology
-
Grundy D (2015). Principles and standards for reporting animal experiments in The J Physiol and Experimental Physiology. J Physiol 593, 2547-2549.
-
(2015)
J Physiol
, vol.593
, pp. 2547-2549
-
-
Grundy, D.1
-
18
-
-
0036089788
-
Periodic breathing in the mouse
-
Han F, Subramanian S, Price ER, Nadeau J & Strohl KP (2002). Periodic breathing in the mouse. J Appl Physiol (1985) 92, 1133-1140.
-
(2002)
J Appl Physiol (1985)
, vol.92
, pp. 1133-1140
-
-
Han, F.1
Subramanian, S.2
Price, E.R.3
Nadeau, J.4
Strohl, K.P.5
-
19
-
-
77949725833
-
The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice
-
Hickey MM, Richardson T, Wang T, Mosqueira M, Arguiri E, Yu H, Yu QC, Solomides CC, Morrisey EE, Khurana TS, Christofidou-Solomidou M & Simon MC (2010). The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice. J Clin Invest 120, 827-839.
-
(2010)
J Clin Invest
, vol.120
, pp. 827-839
-
-
Hickey, M.M.1
Richardson, T.2
Wang, T.3
Mosqueira, M.4
Arguiri, E.5
Yu, H.6
Yu, Q.C.7
Solomides, C.C.8
Morrisey, E.E.9
Khurana, T.S.10
Christofidou-Solomidou, M.11
Simon, M.C.12
-
20
-
-
8644229386
-
Hypoxic induction of Ctgf is directly mediated by Hif-1
-
Higgins DF, Biju MP, Akai Y, Wutz A, Johnson RS & Haase VH (2004). Hypoxic induction of Ctgf is directly mediated by Hif-1. Am J Physiol Renal Physiol 287, F1223-1232.
-
(2004)
Am J Physiol Renal Physiol
, vol.287
, pp. F1223-F1232
-
-
Higgins, D.F.1
Biju, M.P.2
Akai, Y.3
Wutz, A.4
Johnson, R.S.5
Haase, V.H.6
-
21
-
-
0028956496
-
Ventilatory response to 8 h of isocapnic and poikilocapnic hypoxia in humans
-
Howard LS & Robbins PA (1995). Ventilatory response to 8 h of isocapnic and poikilocapnic hypoxia in humans. J Appl Physiol (1985) 78, 1092-1097.
-
(1995)
J Appl Physiol (1985)
, vol.78
, pp. 1092-1097
-
-
Howard, L.S.1
Robbins, P.A.2
-
22
-
-
33751081248
-
Impaired ventilation and metabolism response to hypoxia in histamine H1 receptor-knockout mice
-
Ishiguro T, Iwase M, Kanamaru M, Izumizaki M, Ohshima Y & Homma I (2006). Impaired ventilation and metabolism response to hypoxia in histamine H1 receptor-knockout mice. Respir Physiol Neurobiol 154, 331-341.
-
(2006)
Respir Physiol Neurobiol
, vol.154
, pp. 331-341
-
-
Ishiguro, T.1
Iwase, M.2
Kanamaru, M.3
Izumizaki, M.4
Ohshima, Y.5
Homma, I.6
-
23
-
-
15444342958
-
2 homeostasis by hypoxia-inducible factor 1α
-
2 homeostasis by hypoxia-inducible factor 1α. Genes Dev 12, 149-162.
-
(1998)
Genes Dev
, vol.12
, pp. 149-162
-
-
Iyer, N.V.1
Kotch, L.E.2
Agani, F.3
Leung, S.W.4
Laughner, E.5
Wenger, R.H.6
Gassmann, M.7
Gearhart, J.D.8
Lawler, A.M.9
Yu, A.Y.10
Semenza, G.L.11
-
24
-
-
43649093915
-
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
-
Kaelin WGJ & Ratcliffe PJ (2008). Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 30, 393-402.
-
(2008)
Mol. Cell
, vol.30
, pp. 393-402
-
-
Kaelin, W.G.J.1
Ratcliffe, P.J.2
-
26
-
-
84655161946
-
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
-
Keith B, Johnson RS & Simon MC (2012). HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 12, 9-22.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 9-22
-
-
Keith, B.1
Johnson, R.S.2
Simon, M.C.3
-
27
-
-
84904760921
-
Vulnerability of the developing heart to oxygen deprivation as a cause of congenital heart defects
-
Kenchegowda D, Liu H, Thompson K, Luo L, Martin SS & Fisher SA (2014). Vulnerability of the developing heart to oxygen deprivation as a cause of congenital heart defects. J Am Heart Assoc 3, e000841.
-
(2014)
J Am Heart Assoc
, vol.3
, pp. e000841
-
-
Kenchegowda, D.1
Liu, H.2
Thompson, K.3
Luo, L.4
Martin, S.S.5
Fisher, S.A.6
-
28
-
-
0037154262
-
Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
-
Kline DD, Peng Y-J, Manola DJ, Semenza GL & Prabhakar NR (2002). Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α. Proc Natl Acad Sci USA 99, 821-826.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 821-826
-
-
Kline, D.D.1
Peng, Y.-J.2
Manola, D.J.3
Semenza, G.L.4
Prabhakar, N.R.5
-
29
-
-
0033562569
-
Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
-
Kotch LE, Iyer NV, Laughner E & Semenza GL (1999). Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev Biol 209, 254-267.
-
(1999)
Dev Biol
, vol.209
, pp. 254-267
-
-
Kotch, L.E.1
Iyer, N.V.2
Laughner, E.3
Semenza, G.L.4
-
30
-
-
78650887484
-
The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens
-
Loenarz C, Coleman ML, Boleininger A, Schierwater B, Holland PW, Ratcliffe PJ & Schofield CJ (2010). The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens. EMBO Rep 12, 63-70.
-
(2010)
EMBO Rep
, vol.12
, pp. 63-70
-
-
Loenarz, C.1
Coleman, M.L.2
Boleininger, A.3
Schierwater, B.4
Holland, P.W.5
Ratcliffe, P.J.6
Schofield, C.J.7
-
31
-
-
84918566655
-
Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia
-
Macias D, Fernandez-Aguera MC, Bonilla-Henao V & Lopez-Barneo J (2014). Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia. EMBO Mol Med 6, 1577-1592.
-
(2014)
EMBO Mol Med
, vol.6
, pp. 1577-1592
-
-
Macias, D.1
Fernandez-Aguera, M.C.2
Bonilla-Henao, V.3
Lopez-Barneo, J.4
-
32
-
-
59649117924
-
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
-
Mazzone M, Dettori D, Leite de Oliveira R, Loges S, Schmidt T, Jonckx B, Tian YM, Lanahan AA, Pollard P, Ruiz de Almodovar C, De Smet F, Vinckier S, Aragones J, Debackere K, Luttun A, Wyns S, Jordan B, Pisacane A, Gallez B, Lampugnani MG, Dejana E, Simons M, Ratcliffe P, Maxwell P & Carmeliet P (2009). Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 136, 839-851.
-
(2009)
Cell
, vol.136
, pp. 839-851
-
-
Mazzone, M.1
Dettori, D.2
Leite de Oliveira, R.3
Loges, S.4
Schmidt, T.5
Jonckx, B.6
Tian, Y.M.7
Lanahan, A.A.8
Pollard, P.9
Ruiz de Almodovar, C.10
De Smet, F.11
Vinckier, S.12
Aragones, J.13
Debackere, K.14
Luttun, A.15
Wyns, S.16
Jordan, B.17
Pisacane, A.18
Gallez, B.19
Lampugnani, M.G.20
Dejana, E.21
Simons, M.22
Ratcliffe, P.23
Maxwell, P.24
Carmeliet, P.25
more..
-
34
-
-
42449163874
-
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure
-
Minamishima YA, Moslehi J, Bardeesy N, Cullen D, Bronson RT & Kaelin WG, Jr (2008). Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood 111, 3236-3244.
-
(2008)
Blood
, vol.111
, pp. 3236-3244
-
-
Minamishima, Y.A.1
Moslehi, J.2
Bardeesy, N.3
Cullen, D.4
Bronson, R.T.5
Kaelin, W.G.6
-
35
-
-
67650531089
-
Genome-wide association of hypoxia-inducible factor (HIF)-1α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts
-
Mole DR, Blancher C, Copley RR, Pollard PJ, Gleadle JM, Ragoussis J & Ratcliffe PJ (2009). Genome-wide association of hypoxia-inducible factor (HIF)-1α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts. J Biol Chem 284, 16767-16775.
-
(2009)
J Biol Chem
, vol.284
, pp. 16767-16775
-
-
Mole, D.R.1
Blancher, C.2
Copley, R.R.3
Pollard, P.J.4
Gleadle, J.M.5
Ragoussis, J.6
Ratcliffe, P.J.7
-
36
-
-
84870405372
-
Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase W22;1(PHD-1) deficient mice
-
In, ed. Nurse CA, Gonzalez C, Peers C & Prabhakar N, Springer, Berlin.
-
Pan J, Yeger H, Ratcliffe P, Bishop T & Cutz E (2012). Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase W22;1(PHD-1) deficient mice. In Arterial Chemoreception, ed. Nurse CA, Gonzalez C, Peers C & Prabhakar N, pp. 149-155. Springer, Berlin.
-
(2012)
Arterial Chemoreception
, pp. 149-155
-
-
Pan, J.1
Yeger, H.2
Ratcliffe, P.3
Bishop, T.4
Cutz, E.5
-
37
-
-
35348906206
-
Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body
-
Pardal R, Ortega-Saenz P, Duran R & Lopez-Barneo J (2007). Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body. Cell 131, 364-377.
-
(2007)
Cell
, vol.131
, pp. 364-377
-
-
Pardal, R.1
Ortega-Saenz, P.2
Duran, R.3
Lopez-Barneo, J.4
-
38
-
-
0034682513
-
The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling
-
Peng J, Zhang L, Drysdale L & Fong GH (2000). The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling. Proc Natl Acad Sci USA 97, 8386-8391.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 8386-8391
-
-
Peng, J.1
Zhang, L.2
Drysdale, L.3
Fong, G.H.4
-
39
-
-
79952609061
-
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
-
Peng YJ, Nanduri J, Khan SA, Yuan G, Wang N, Kinsman B, Vaddi DR, Kumar GK, Garcia JA, Semenza GL & Prabhakar NR (2011). Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc Natl Acad Sci USA 108, 3065-3070.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 3065-3070
-
-
Peng, Y.J.1
Nanduri, J.2
Khan, S.A.3
Yuan, G.4
Wang, N.5
Kinsman, B.6
Vaddi, D.R.7
Kumar, G.K.8
Garcia, J.A.9
Semenza, G.L.10
Prabhakar, N.R.11
-
40
-
-
33751329032
-
Heterozygous HIF-1α deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia
-
Peng YJ, Yuan G, Ramakrishnan D, Sharma SD, Bosch-Marce M, Kumar GK, Semenza GL & Prabhakar NR (2006). Heterozygous HIF-1α deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J Physiol 577, 705-716.
-
(2006)
J Physiol
, vol.577
, pp. 705-716
-
-
Peng, Y.J.1
Yuan, G.2
Ramakrishnan, D.3
Sharma, S.D.4
Bosch-Marce, M.5
Kumar, G.K.6
Semenza, G.L.7
Prabhakar, N.R.8
-
41
-
-
84892688467
-
2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hypoxia
-
2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hypoxia. Cell 156, 291-303.
-
(2014)
Cell
, vol.156
, pp. 291-303
-
-
Platero-Luengo, A.1
Gonzalez-Granero, S.2
Duran, R.3
Diaz-Castro, B.4
Piruat, J.I.5
Garcia-Verdugo, J.M.6
Pardal, R.7
Lopez-Barneo, J.8
-
42
-
-
84864131464
-
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2
-
Prabhakar NR & Semenza GL (2012). Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev 92, 967-1003.
-
(2012)
Physiol Rev
, vol.92
, pp. 967-1003
-
-
Prabhakar, N.R.1
Semenza, G.L.2
-
43
-
-
84876325985
-
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer
-
Ratcliffe PJ (2013). Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer. J Physiol 591, 2027-2042.
-
(2013)
J Physiol
, vol.591
, pp. 2027-2042
-
-
Ratcliffe, P.J.1
-
44
-
-
34548691285
-
Role of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude
-
Robbins PA (2007). Role of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude. Respir Physiol Neurobiol 158, 237-242.
-
(2007)
Respir Physiol Neurobiol
, vol.158
, pp. 237-242
-
-
Robbins, P.A.1
-
45
-
-
79959450883
-
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
-
Schödel J, Oikonomopoulos S, Ragoussis J, Pugh CW, Ratcliffe PJ & Mole DR (2012). High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. Blood 117, e207-217.
-
(2012)
Blood
, vol.117
, pp. e207-e217
-
-
Schödel, J.1
Oikonomopoulos, S.2
Ragoussis, J.3
Pugh, C.W.4
Ratcliffe, P.J.5
Mole, D.R.6
-
46
-
-
0344826529
-
-/- mice
-
-/- mice. Nat Genet 35, 331-340.
-
(2003)
Nat Genet
, vol.35
, pp. 331-340
-
-
Scortegagna, M.1
Ding, K.2
Oktay, Y.3
Gaur, A.4
Thurmond, F.5
Yan, L.-J.6
Marck, B.T.7
Matsumoto, A.M.8
Shelton, J.M.9
Richardson, J.A.10
Bennett, M.J.11
Garcia, J.A.12
-
47
-
-
84901218507
-
The von Hippel-Lindau Chuvash mutation in mice causes carotid-body hyperplasia and enhanced ventilatory sensitivity to hypoxia
-
Slingo ME, Turner PJ, Christian HC, Buckler KJ & Robbins PA (2014). The von Hippel-Lindau Chuvash mutation in mice causes carotid-body hyperplasia and enhanced ventilatory sensitivity to hypoxia. J Appl Physiol (1985) 116, 885-892.
-
(2014)
J Appl Physiol (1985)
, vol.116
, pp. 885-892
-
-
Slingo, M.E.1
Turner, P.J.2
Christian, H.C.3
Buckler, K.J.4
Robbins, P.A.5
-
48
-
-
33746398489
-
Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology
-
Smith TG, Brooks JT, Balanos GM, Lappin TR, Layton DM, Leedham DL, Liu C, Maxwell PH, McMullin MF, McNamara CJ, Percy MJ, Pugh CW, Ratcliffe PJ, Talbot NP, Treacy M & Robbins PA (2006). Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. PLoS Med 3, e290.
-
(2006)
PLoS Med
, vol.3
, pp. e290
-
-
Smith, T.G.1
Brooks, J.T.2
Balanos, G.M.3
Lappin, T.R.4
Layton, D.M.5
Leedham, D.L.6
Liu, C.7
Maxwell, P.H.8
McMullin, M.F.9
McNamara, C.J.10
Percy, M.J.11
Pugh, C.W.12
Ratcliffe, P.J.13
Talbot, N.P.14
Treacy, M.15
Robbins, P.A.16
-
49
-
-
80052960971
-
2
-
2. Nature Chem Biol 7, 701-711.
-
(2011)
Nature Chem Biol
, vol.7
, pp. 701-711
-
-
Takahashi, N.1
Kuwaki, T.2
Kiyonaka, S.3
Numata, T.4
Kozai, D.5
Mizuno, Y.6
Yamamoto, S.7
Naito, S.8
Knevels, E.9
Carmeliet, P.10
Oga, T.11
Kaneko, S.12
Suga, S.13
Nokami, T.14
Yoshida, J.15
Mori, Y.16
-
50
-
-
40949090791
-
Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins
-
Takeda K, Aguila HL, Parikh NS, Li X, Lamothe K, Duan LJ, Takeda H, Lee FS & Fong GH (2008). Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins. Blood 111, 3229-3235.
-
(2008)
Blood
, vol.111
, pp. 3229-3235
-
-
Takeda, K.1
Aguila, H.L.2
Parikh, N.S.3
Li, X.4
Lamothe, K.5
Duan, L.J.6
Takeda, H.7
Lee, F.S.8
Fong, G.H.9
-
51
-
-
34547905406
-
Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system
-
Takeda K, Cowan A & Fong GH (2007). Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation 116, 774-781.
-
(2007)
Circulation
, vol.116
, pp. 774-781
-
-
Takeda, K.1
Cowan, A.2
Fong, G.H.3
-
52
-
-
33750976389
-
Placental but not heart defect is associated with elevated HIFα levels in mice lacking prolyl hydroxylase domain protein 2
-
Takeda K, Ho V, Takeda H, Duan LJ, Nagy A & Fong GH (2006). Placental but not heart defect is associated with elevated HIFα levels in mice lacking prolyl hydroxylase domain protein 2. Mol Cell Biol 26, 8336-8346.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 8336-8346
-
-
Takeda, K.1
Ho, V.2
Takeda, H.3
Duan, L.J.4
Nagy, A.5
Fong, G.H.6
-
53
-
-
84879037862
-
Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation
-
Tan Q, Kerestes H, Percy MJ, Pietrofesa R, Chen L, Khurana TS, Christofidou-Solomidou M, Lappin TR & Lee FS (2013). Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation. J Biol Chem 288, 17134-17144.
-
(2013)
J Biol Chem
, vol.288
, pp. 17134-17144
-
-
Tan, Q.1
Kerestes, H.2
Percy, M.J.3
Pietrofesa, R.4
Chen, L.5
Khurana, T.S.6
Christofidou-Solomidou, M.7
Lappin, T.R.8
Lee, F.S.9
-
54
-
-
0032213236
-
The hypoxia responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
-
Tian H, Hammer RE, Matsumoto AM, Russell DW & McKnight SL (1998). The hypoxia responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev 12, 3320-3324.
-
(1998)
Genes Dev
, vol.12
, pp. 3320-3324
-
-
Tian, H.1
Hammer, R.E.2
Matsumoto, A.M.3
Russell, D.W.4
McKnight, S.L.5
-
55
-
-
0035029433
-
A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent
-
Vooijs M, Jonkers J & Berns A (2001). A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. EMBO J 2, 292-297.
-
(2001)
EMBO J
, vol.2
, pp. 292-297
-
-
Vooijs, M.1
Jonkers, J.2
Berns, A.3
-
56
-
-
0033104847
-
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
-
Yu AY, Shimoda LA, Iyer NV, Huso DL, Sun X, McWilliams R, Beaty T, Sham JSK, Wiener CM, Sylvester JT & Semenza GL (1999). Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α. J Clin Invest 103, 691-696.
-
(1999)
J Clin Invest
, vol.103
, pp. 691-696
-
-
Yu, A.Y.1
Shimoda, L.A.2
Iyer, N.V.3
Huso, D.L.4
Sun, X.5
McWilliams, R.6
Beaty, T.7
Sham, J.S.K.8
Wiener, C.M.9
Sylvester, J.T.10
Semenza, G.L.11
-
57
-
-
84877347155
-
Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis
-
Yuan G, Peng YJ, Reddy VD, Makarenko VV, Nanduri J, Khan SA, Garcia JA, Kumar GK, Semenza GL & Prabhakar NR (2013). Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis. Proc Natl Acad Sci USA 110, E1788-1796.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. E1788-E1796
-
-
Yuan, G.1
Peng, Y.J.2
Reddy, V.D.3
Makarenko, V.V.4
Nanduri, J.5
Khan, S.A.6
Garcia, J.A.7
Kumar, G.K.8
Semenza, G.L.9
Prabhakar, N.R.10
|