-
1
-
-
43249110200
-
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
-
Li J-Y, Englund E, Holton JL, Soulet D, Hagell P, Lees AJ, Lashley T, Quinn NP, Rehncrona S, Björklund A, Widner H, Revesz T, Lindvall O, Brundin P. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med 2008; 14: 501-3.
-
(2008)
Nat Med
, vol.14
, pp. 501-503
-
-
Li, J.-Y.1
Englund, E.2
Holton, J.L.3
Soulet, D.4
Hagell, P.5
Lees, A.J.6
Lashley, T.7
Quinn, N.P.8
Rehncrona, S.9
Björklund, A.10
Widner, H.11
Revesz, T.12
Lindvall, O.13
Brundin, P.14
-
2
-
-
52449117926
-
Research in motion: the enigma of Parkinson's disease pathology spread
-
Brundin P, Li J-Y, Holton JL, Lindvall O, Revesz T. Research in motion: the enigma of Parkinson's disease pathology spread. Nat Rev Neurosci 2008; 9: 741-5.
-
(2008)
Nat Rev Neurosci
, vol.9
, pp. 741-745
-
-
Brundin, P.1
Li, J.-Y.2
Holton, J.L.3
Lindvall, O.4
Revesz, T.5
-
4
-
-
84977863366
-
Prion-like mechanisms in neurodegenerative diseases
-
Frost B, Diamond MI. Prion-like mechanisms in neurodegenerative diseases. Nat Rev Neurosci 2009; 17: 357-368.
-
(2009)
Nat Rev Neurosci
, vol.17
, pp. 357-368
-
-
Frost, B.1
Diamond, M.I.2
-
5
-
-
71849117852
-
Dissecting the potential molecular mechanisms underlying alpha-synuclein cell-to-cell transfer in Parkinson's disease
-
Angot E, Brundin P. Dissecting the potential molecular mechanisms underlying alpha-synuclein cell-to-cell transfer in Parkinson's disease. Parkinsonism Relat Disord 2009; 15: S143-S147.
-
(2009)
Parkinsonism Relat Disord
, vol.15
, pp. S143-S147
-
-
Angot, E.1
Brundin, P.2
-
6
-
-
0037333666
-
Staging of brain pathology related to sporadic Parkinson's disease
-
Braak H, del Tredici K, Rüb U, de Vos RA, Jansen Steur ENH, Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003; 24: 197-211.
-
(2003)
Neurobiol Aging
, vol.24
, pp. 197-211
-
-
Braak, H.1
del Tredici, K.2
Rüb, U.3
de Vos, R.A.4
Jansen Steur, E.N.H.5
Braak, E.6
-
7
-
-
0038748401
-
Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
-
Braak H, Rub U, Gai WP, Del Tredici K. Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J Neural Transm 2003; 110: 517-36.
-
(2003)
J Neural Transm
, vol.110
, pp. 517-536
-
-
Braak, H.1
Rub, U.2
Gai, W.P.3
Del Tredici, K.4
-
8
-
-
5444255434
-
Stages in the development of Parkinson's disease-related pathology
-
Braak H, Ghebremedhin E, Rüb U, Bratzke H, del Tredici K. Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res 2004; 318: 121-34.
-
(2004)
Cell Tissue Res
, vol.318
, pp. 121-134
-
-
Braak, H.1
Ghebremedhin, E.2
Rüb, U.3
Bratzke, H.4
del Tredici, K.5
-
9
-
-
84876057762
-
Prion-like spreading of pathological α-synuclein in brain
-
Masuda-Suzukake M, Nonaka T, Hosokawa M, Oikawa T, Arai T, Akiyama H, Mann DMA, Hasegawa M. Prion-like spreading of pathological α-synuclein in brain. Brain 2013; 136: 1128-38.
-
(2013)
Brain
, vol.136
, pp. 1128-1138
-
-
Masuda-Suzukake, M.1
Nonaka, T.2
Hosokawa, M.3
Oikawa, T.4
Arai, T.5
Akiyama, H.6
Mann, D.M.A.7
Hasegawa, M.8
-
10
-
-
84892538035
-
Alpha-synuclein transfers from neurons to oligodendrocytes
-
Reyes JF, Rey NL, Bousset L, Melki R, Brundin P, Angot E. Alpha-synuclein transfers from neurons to oligodendrocytes. Glia 2013; 62: 387-98.
-
(2013)
Glia
, vol.62
, pp. 387-398
-
-
Reyes, J.F.1
Rey, N.L.2
Bousset, L.3
Melki, R.4
Brundin, P.5
Angot, E.6
-
11
-
-
84867498658
-
Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies
-
Kisos H, Pukaß K, Ben-Hur T, Richter-Landsberg C, Sharon R. Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies. PLoS One 2012; 7: e46817.
-
(2012)
PLoS One
, vol.7
, pp. e46817
-
-
Kisos, H.1
Pukaß, K.2
Ben-Hur, T.3
Richter-Landsberg, C.4
Sharon, R.5
-
12
-
-
84864915936
-
Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy
-
Konno M, Hasegawa T, Baba T, Miura E, Sugeno N, Kikuchi A, Fiesel FC, Sasaki T, Aoki M, Itoyama Y, Takeda A. Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy. Mol Neurodegener 2012; 7: 38.
-
(2012)
Mol Neurodegener
, vol.7
, pp. 38
-
-
Konno, M.1
Hasegawa, T.2
Baba, T.3
Miura, E.4
Sugeno, N.5
Kikuchi, A.6
Fiesel, F.C.7
Sasaki, T.8
Aoki, M.9
Itoyama, Y.10
Takeda, A.11
-
13
-
-
33144489150
-
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium
-
Consortium on DLB
-
McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VMY, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M, Consortium on DLB. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 2005; 65: 1863-72.
-
(2005)
Neurology
, vol.65
, pp. 1863-1872
-
-
McKeith, I.G.1
Dickson, D.W.2
Lowe, J.3
Emre, M.4
O'Brien, J.T.5
Feldman, H.6
Cummings, J.7
Duda, J.E.8
Lippa, C.9
Perry, E.K.10
Aarsland, D.11
Arai, H.12
Ballard, C.G.13
Boeve, B.14
Burn, D.J.15
Costa, D.16
Del Ser, T.17
Dubois, B.18
Galasko, D.19
Gauthier, S.20
Goetz, C.G.21
Gomez-Tortosa, E.22
Halliday, G.23
Hansen, L.A.24
Hardy, J.25
Iwatsubo, T.26
Kalaria, R.N.27
Kaufer, D.28
Kenny, R.A.29
Korczyn, A.30
Kosaka, K.31
Lee, V.M.Y.32
Lees, A.33
Litvan, I.34
Londos, E.35
Lopez, O.L.36
Minoshima, S.37
Mizuno, Y.38
Molina, J.A.39
Mukaetova-Ladinska, E.B.40
Pasquier, F.41
Perry, R.H.42
Schulz, J.B.43
Trojanowski, J.Q.44
Yamada, M.45
more..
-
14
-
-
68749116710
-
A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders
-
Jellinger KA. A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders. Biochim Biophys Acta 2009; 1792: 730-40.
-
(2009)
Biochim Biophys Acta
, vol.1792
, pp. 730-740
-
-
Jellinger, K.A.1
-
15
-
-
79960842310
-
Neuropathology underlying clinical variability in patients with synucleinopathies
-
Halliday GM, Holton JL, Revesz T, Dickson DW. Neuropathology underlying clinical variability in patients with synucleinopathies. Acta Neuropathol 2011; 122: 187-204.
-
(2011)
Acta Neuropathol
, vol.122
, pp. 187-204
-
-
Halliday, G.M.1
Holton, J.L.2
Revesz, T.3
Dickson, D.W.4
-
16
-
-
0032692501
-
Alpha-synuclein immunoisolation of glial inclusions from multiple system atrophy brain tissue reveals multiprotein components
-
Gai WP, Power JH, Blumbergs PC, Culvenor JG, Jensen PH. Alpha-synuclein immunoisolation of glial inclusions from multiple system atrophy brain tissue reveals multiprotein components. J Neurochem 1999; 73: 2093-100.
-
(1999)
J Neurochem
, vol.73
, pp. 2093-2100
-
-
Gai, W.P.1
Power, J.H.2
Blumbergs, P.C.3
Culvenor, J.G.4
Jensen, P.H.5
-
17
-
-
82455205801
-
Multiple system atrophy: a clinical and neuropathological perspective
-
Ubhi K, Low P, Masliah E. Multiple system atrophy: a clinical and neuropathological perspective. Trends Neurosci 2011; 34: 581-90.
-
(2011)
Trends Neurosci
, vol.34
, pp. 581-590
-
-
Ubhi, K.1
Low, P.2
Masliah, E.3
-
18
-
-
0034602296
-
Alpha-synuclein membrane interactions and lipid specificity
-
Jo E, McLaurin J, Yip CM, St George-Hyslop P, Fraser PE. Alpha-synuclein membrane interactions and lipid specificity. J Biol Chem 2000; 275: 34328-34.
-
(2000)
J Biol Chem
, vol.275
, pp. 34328-34334
-
-
Jo, E.1
McLaurin, J.2
Yip, C.M.3
St George-Hyslop, P.4
Fraser, P.E.5
-
19
-
-
0033850190
-
Review: formation and Properties of Amyloid-like Fibrils Derived from α-Synuclein and Related Proteins
-
El-Agnaf OMA, Irvine GB. Review: formation and Properties of Amyloid-like Fibrils Derived from α-Synuclein and Related Proteins. J Struct Biol 2000; 130: 300-9.
-
(2000)
J Struct Biol
, vol.130
, pp. 300-309
-
-
El-Agnaf, O.M.A.1
Irvine, G.B.2
-
20
-
-
67949112595
-
Controlling aggregation propensity in A53T mutant of alpha-synuclein causing Parkinson's disease.
-
Kumar S, Sarkar A, Sundar D. Controlling aggregation propensity in A53T mutant of alpha-synuclein causing Parkinson's disease. Biochem Biophys Res Commun 2009; 387: 305-9.
-
(2009)
Biochem Biophys Res Commun
, vol.387
, pp. 305-309
-
-
Kumar, S.1
Sarkar, A.2
Sundar, D.3
-
21
-
-
84879804769
-
Wildtype and A30P mutant alpha-synuclein form different fibril structures
-
Nielsen SB, Macchi F, Raccosta S, Langkilde AE, Giehm L, Kyrsting A, Svane ASP, Manno M, Christiansen G, Nielsen NC, Oddershede L, Vestergaard B, Otzen DE. Wildtype and A30P mutant alpha-synuclein form different fibril structures. PLoS One 2013; 8: e67713.
-
(2013)
PLoS One
, vol.8
, pp. e67713
-
-
Nielsen, S.B.1
Macchi, F.2
Raccosta, S.3
Langkilde, A.E.4
Giehm, L.5
Kyrsting, A.6
Svane, A.S.P.7
Manno, M.8
Christiansen, G.9
Nielsen, N.C.10
Oddershede, L.11
Vestergaard, B.12
Otzen, D.E.13
-
22
-
-
84876945450
-
The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration
-
Costanzo M, Zurzolo C. The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration. Biochem J 2013; 452: 1-17.
-
(2013)
Biochem J
, vol.452
, pp. 1-17
-
-
Costanzo, M.1
Zurzolo, C.2
-
23
-
-
0034712918
-
Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation
-
Serpell LC, Berriman J, Jakes R, Goedert M, Crowther RA. Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation. Proc Natl Acad Sci USA 2000; 97: 4897-902.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 4897-4902
-
-
Serpell, L.C.1
Berriman, J.2
Jakes, R.3
Goedert, M.4
Crowther, R.A.5
-
24
-
-
70349503591
-
Biophysics of Parkinson's Disease: structure and Aggregation of alpha-synuclein
-
Uversky VN, Eliezer D. Biophysics of Parkinson's Disease: structure and Aggregation of alpha-synuclein. Curr Protein Pept Sci 2009; 10: 483-99.
-
(2009)
Curr Protein Pept Sci
, vol.10
, pp. 483-499
-
-
Uversky, V.N.1
Eliezer, D.2
-
25
-
-
84942522975
-
Structure of the toxic core of α-synuclein from invisible crystals
-
Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS. Structure of the toxic core of α-synuclein from invisible crystals. Nature 2015; 525: 486-90.
-
(2015)
Nature
, vol.525
, pp. 486-490
-
-
Rodriguez, J.A.1
Ivanova, M.I.2
Sawaya, M.R.3
Cascio, D.4
Reyes, F.E.5
Shi, D.6
Sangwan, S.7
Guenther, E.L.8
Johnson, L.M.9
Zhang, M.10
Jiang, L.11
Arbing, M.A.12
Nannenga, B.L.13
Hattne, J.14
Whitelegge, J.15
Brewster, A.S.16
Messerschmidt, M.17
Boutet, S.18
Sauter, N.K.19
Gonen, T.20
Eisenberg, D.S.21
more..
-
26
-
-
77950021983
-
Accelerated formation of α-synuclein oligomers by concerted action of the 20S proteasome and familial Parkinson mutations
-
Lewis KA, Yaeger A, DeMartino GN, Thomas PJ. Accelerated formation of α-synuclein oligomers by concerted action of the 20S proteasome and familial Parkinson mutations. J Bioenerg Biomembr 2010; 42: 85-95.
-
(2010)
J Bioenerg Biomembr
, vol.42
, pp. 85-95
-
-
Lewis, K.A.1
Yaeger, A.2
DeMartino, G.N.3
Thomas, P.J.4
-
27
-
-
84939506533
-
Alzheimer's and Parkinson's diseases: the prion concept in relation to assembled Aβ, tau, and α synuclein
-
Goedert M. Alzheimer's and Parkinson's diseases: the prion concept in relation to assembled Aβ, tau, and α synuclein. Science 2015; 349: 1255555.
-
(2015)
Science
, vol.349
, pp. 1255555
-
-
Goedert, M.1
-
28
-
-
66449097646
-
Detecting morphologically distinct oligomeric forms of alpha-synuclein
-
Emadi S, Kasturirangan S, Wang MS, Schulz P, Sierks MR. Detecting morphologically distinct oligomeric forms of alpha-synuclein. J Biol Chem 2009; 284: 11048-58.
-
(2009)
J Biol Chem
, vol.284
, pp. 11048-11058
-
-
Emadi, S.1
Kasturirangan, S.2
Wang, M.S.3
Schulz, P.4
Sierks, M.R.5
-
29
-
-
84871414210
-
The many faces of α-synuclein: from structure and toxicity to therapeutic target
-
Lashuel HA, Overk CR, Oueslati A, Masliah E. The many faces of α-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci 2012; 14: 38-48.
-
(2012)
Nat Rev Neurosci
, vol.14
, pp. 38-48
-
-
Lashuel, H.A.1
Overk, C.R.2
Oueslati, A.3
Masliah, E.4
-
30
-
-
0037551741
-
Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders
-
Caughey B, Lansbury PT. Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu Rev Neurosci 2003; 26: 267-98.
-
(2003)
Annu Rev Neurosci
, vol.26
, pp. 267-298
-
-
Caughey, B.1
Lansbury, P.T.2
-
32
-
-
33846419768
-
Stanley Fahn Lecture 2005: the staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered
-
Braak H, Bohl JRR, Müller CM, Rüb U, de Vos RA, del Tredici K. Stanley Fahn Lecture 2005: the staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered. Mov Disord 2006; 21: 2042-51.
-
(2006)
Mov Disord
, vol.21
, pp. 2042-2051
-
-
Braak, H.1
Bohl, J.R.R.2
Müller, C.M.3
Rüb, U.4
de Vos, R.A.5
del Tredici, K.6
-
33
-
-
33645755812
-
The parkinson's complex: Parkinsonism is just the tip of the iceberg
-
Langston JW. The parkinson's complex: Parkinsonism is just the tip of the iceberg. Ann Neurol 2006; 59: 591-6.
-
(2006)
Ann Neurol
, vol.59
, pp. 591-596
-
-
Langston, J.W.1
-
35
-
-
84942990024
-
Neuropathobiology of non-motor symptoms in Parkinson disease
-
Jellinger KA. Neuropathobiology of non-motor symptoms in Parkinson disease. J Neural Transm 2015; 122: 1429-40.
-
(2015)
J Neural Transm
, vol.122
, pp. 1429-1440
-
-
Jellinger, K.A.1
-
37
-
-
0346850964
-
Poor and protracted myelination as a contributory factor to neurodegenerative disorders
-
Braak H, del Tredici K. Poor and protracted myelination as a contributory factor to neurodegenerative disorders. Neurobiol Aging 2004; 25: 19-23.
-
(2004)
Neurobiol Aging
, vol.25
, pp. 19-23
-
-
Braak, H.1
del Tredici, K.2
-
39
-
-
68649095434
-
Parkinson's disease: the dual hit theory revisited
-
Hawkes CH, del Tredici K, Braak H. Parkinson's disease: the dual hit theory revisited. Ann N Y Acad Sci 2009; 1170: 615-22.
-
(2009)
Ann N Y Acad Sci
, vol.1170
, pp. 615-622
-
-
Hawkes, C.H.1
del Tredici, K.2
Braak, H.3
-
40
-
-
42549125030
-
The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease: a critical analysis of α-synuclein staging
-
Kalaitzakis ME, Graeber MB, Gentleman SM, Pearce RKB. The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease: a critical analysis of α-synuclein staging. Neuropathol Appl Neurobiol 2008; 34: 284-95.
-
(2008)
Neuropathol Appl Neurobiol
, vol.34
, pp. 284-295
-
-
Kalaitzakis, M.E.1
Graeber, M.B.2
Gentleman, S.M.3
Pearce, R.K.B.4
-
41
-
-
57749095477
-
A critical evaluation of the Braak staging scheme for Parkinson's disease
-
Burke RE, Dauer WT, Vonsattel JPG. A critical evaluation of the Braak staging scheme for Parkinson's disease. Ann Neurol 2008; 64: 485-91.
-
(2008)
Ann Neurol
, vol.64
, pp. 485-491
-
-
Burke, R.E.1
Dauer, W.T.2
Vonsattel, J.P.G.3
-
43
-
-
41149141259
-
Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance
-
Parkkinen L, Pirttilä T, Alafuzoff I. Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance. Acta Neuropathol 2008; 115: 399-407.
-
(2008)
Acta Neuropathol
, vol.115
, pp. 399-407
-
-
Parkkinen, L.1
Pirttilä, T.2
Alafuzoff, I.3
-
44
-
-
84879122389
-
The Lewy Body in Parkinson's Disease and Related Neurodegenerative Disorders
-
Wakabayashi K, Tanji K, Odagiri S, Miki Y, Mori F, Takahashi H. The Lewy Body in Parkinson's Disease and Related Neurodegenerative Disorders. Mol Neurobiol 2012; 47: 495-508.
-
(2012)
Mol Neurobiol
, vol.47
, pp. 495-508
-
-
Wakabayashi, K.1
Tanji, K.2
Odagiri, S.3
Miki, Y.4
Mori, F.5
Takahashi, H.6
-
45
-
-
84855972240
-
Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts
-
Jellinger KA. Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts. Mov Disord 2011; 27: 8-30.
-
(2011)
Mov Disord
, vol.27
, pp. 8-30
-
-
Jellinger, K.A.1
-
46
-
-
77951707225
-
Critical evaluation of the Braak staging scheme for Parkinson's disease
-
Jellinger KA. Critical evaluation of the Braak staging scheme for Parkinson's disease. Ann Neurol 2009; 67: 550.
-
(2009)
Ann Neurol
, vol.67
, pp. 550
-
-
Jellinger, K.A.1
-
47
-
-
0042974099
-
Alpha-synuclein pathology in Parkinson's and Alzheimer's disease brain: incidence and topographic distribution-a pilot study
-
Jellinger KA. Alpha-synuclein pathology in Parkinson's and Alzheimer's disease brain: incidence and topographic distribution-a pilot study. Acta Neuropathol 2003; 106: 191-201.
-
(2003)
Acta Neuropathol
, vol.106
, pp. 191-201
-
-
Jellinger, K.A.1
-
48
-
-
41149115508
-
Evidence that incidential Lewy body disease is pre-symptomatic parkinson's disease
-
Dickson DW, Fujishiro H, DelleDonne A, Menke J, Ahmed Z, Klos KJ, Josephs KA, Frigerio R, Burnett M, Parisi JE, Ahlskog JE. Evidence that incidential Lewy body disease is pre-symptomatic parkinson's disease. Acta Neuropathol 2008; 115: 437-44.
-
(2008)
Acta Neuropathol
, vol.115
, pp. 437-444
-
-
Dickson, D.W.1
Fujishiro, H.2
DelleDonne, A.3
Menke, J.4
Ahmed, Z.5
Klos, K.J.6
Josephs, K.A.7
Frigerio, R.8
Burnett, M.9
Parisi, J.E.10
Ahlskog, J.E.11
-
49
-
-
79954602288
-
Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies?
-
Frigerio R, Fujishiro H, Ahn T-B, Josephs KA, Maraganore DM, DelleDonne A, Parisi JE, Klos KJ, Boeve BF, Dickson DW, Ahlskog JE. Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies? Neurobiol Aging 2011; 32: 857-63.
-
(2011)
Neurobiol Aging
, vol.32
, pp. 857-863
-
-
Frigerio, R.1
Fujishiro, H.2
Ahn, T.-B.3
Josephs, K.A.4
Maraganore, D.M.5
DelleDonne, A.6
Parisi, J.E.7
Klos, K.J.8
Boeve, B.F.9
Dickson, D.W.10
Ahlskog, J.E.11
-
50
-
-
84861739631
-
Evaluation of the Braak hypothesis: how far can it explain the pathogenesis of Parkinson's disease?
-
Halliday G, McCann H, Shepherd C. Evaluation of the Braak hypothesis: how far can it explain the pathogenesis of Parkinson's disease? Expert Rev Neurother 2012; 12: 673-86.
-
(2012)
Expert Rev Neurother
, vol.12
, pp. 673-686
-
-
Halliday, G.1
McCann, H.2
Shepherd, C.3
-
51
-
-
0037604508
-
Accumulation of phosphorylated alpha-synuclein in aging human brain
-
Saito Y, Kawashima A, Ruberu NN, Fujiwara H, Koyama S, Sawabe M, Arai T, Nagura H, Yamanouchi H, Hasegawa M, Iwatsubo T, Murayama S. Accumulation of phosphorylated alpha-synuclein in aging human brain. J Neuropathol Exp Neurol 2003; 62: 1-11.
-
(2003)
J Neuropathol Exp Neurol
, vol.62
, pp. 1-11
-
-
Saito, Y.1
Kawashima, A.2
Ruberu, N.N.3
Fujiwara, H.4
Koyama, S.5
Sawabe, M.6
Arai, T.7
Nagura, H.8
Yamanouchi, H.9
Hasegawa, M.10
Iwatsubo, T.11
Murayama, S.12
-
52
-
-
84894244854
-
α-synuclein imaging: a critical need for Parkinson's disease research
-
Eberling JL, Dave KD, Frasier MA. α-synuclein imaging: a critical need for Parkinson's disease research. J Parkinsons Dis 2013; 3: 565-7.
-
(2013)
J Parkinsons Dis
, vol.3
, pp. 565-567
-
-
Eberling, J.L.1
Dave, K.D.2
Frasier, M.A.3
-
53
-
-
84942366331
-
Vagotomy and subsequent risk of Parkinson's disease
-
Svensson E, Horváth-Puhó E, Thomsen RW, Djurhuus JC, Pedersen L, Borghammer P, Sørensen HT. Vagotomy and subsequent risk of Parkinson's disease. Ann Neurol 2015; 78: 522-9.
-
(2015)
Ann Neurol
, vol.78
, pp. 522-529
-
-
Svensson, E.1
Horváth-Puhó, E.2
Thomsen, R.W.3
Djurhuus, J.C.4
Pedersen, L.5
Borghammer, P.6
Sørensen, H.T.7
-
54
-
-
84941042496
-
Appendectomy may delay Parkinson's disease Onset
-
Mendes A, Gonçalves A, Vila-Chã N, Moreira I, Fernandes J, Damásio J, Teixeira-Pinto A, Taipa R, Lima AB, Cavaco S. Appendectomy may delay Parkinson's disease Onset. Mov Disord 2015; 30: 1404-7.
-
(2015)
Mov Disord
, vol.30
, pp. 1404-1407
-
-
Mendes, A.1
Gonçalves, A.2
Vila-Chã, N.3
Moreira, I.4
Fernandes, J.5
Damásio, J.6
Teixeira-Pinto, A.7
Taipa, R.8
Lima, A.B.9
Cavaco, S.10
-
55
-
-
0031941058
-
Aggregation of alpha-synuclein in Lewy Bodies of sporadic Parkinson's disease and dementia with Lewy bodies
-
Baba M, Nakajo S, Tu P-H, Tomita T, Nakaya K, Lee VMY, Trojanowski JQ, Iwatsubo T. Aggregation of alpha-synuclein in Lewy Bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 1998; 152: 879-84.
-
(1998)
Am J Pathol
, vol.152
, pp. 879-884
-
-
Baba, M.1
Nakajo, S.2
Tu, P.-H.3
Tomita, T.4
Nakaya, K.5
Lee, V.M.Y.6
Trojanowski, J.Q.7
Iwatsubo, T.8
-
56
-
-
0032589409
-
Non-Aβ component of Alzheimer's Disease Amyloid (NAC) revisited
-
Culvenor JG, McLean CA, Cutt S, Campbell BCV, Maher F, Jäkälä P, Hartmann T, Beyreuther K, Masters CL, Li Q-X. Non-Aβ component of Alzheimer's Disease Amyloid (NAC) revisited. Am J Pathol 1999; 155: 1-9.
-
(1999)
Am J Pathol
, vol.155
, pp. 1-9
-
-
Culvenor, J.G.1
McLean, C.A.2
Cutt, S.3
Campbell, B.C.V.4
Maher, F.5
Jäkälä, P.6
Hartmann, T.7
Beyreuther, K.8
Masters, C.L.9
Li, Q.-X.10
-
57
-
-
34047223232
-
DLB and PDD boundary issues; diagnosis, treatment, molecular pathology, and biomarkers
-
Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, Brooks DJ, Dickson DW, Dubois B, Emre M, Fahn S, Farmer JM, Galasko D, Galvin JE, Goetz CG, Growdon JH, Gwinn-Hardy KA, Hardy J, Heutink P, Iwatsubo T, Kosaka K, Lee VM, Leverenz JB, Masliah E, McKeith IG, Nussbaum RL, Olanow CW, Ravina BM, Singleton AB, Tanner CM, Trojanowski JQ, Wszolek ZK. DLB and PDD boundary issues; diagnosis, treatment, molecular pathology, and biomarkers. Neurology 2007; 68: 812-9.
-
(2007)
Neurology
, vol.68
, pp. 812-819
-
-
Lippa, C.F.1
Duda, J.E.2
Grossman, M.3
Hurtig, H.I.4
Aarsland, D.5
Boeve, B.F.6
Brooks, D.J.7
Dickson, D.W.8
Dubois, B.9
Emre, M.10
Fahn, S.11
Farmer, J.M.12
Galasko, D.13
Galvin, J.E.14
Goetz, C.G.15
Growdon, J.H.16
Gwinn-Hardy, K.A.17
Hardy, J.18
Heutink, P.19
Iwatsubo, T.20
Kosaka, K.21
Lee, V.M.22
Leverenz, J.B.23
Masliah, E.24
McKeith, I.G.25
Nussbaum, R.L.26
Olanow, C.W.27
Ravina, B.M.28
Singleton, A.B.29
Tanner, C.M.30
Trojanowski, J.Q.31
Wszolek, Z.K.32
more..
-
58
-
-
0021636665
-
Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree-a new disease?
-
Kosaka K, Yoshimura M, Ikeda K, Budka H. Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree-a new disease? Clin Neuropathol 1984; 3: 185-92.
-
(1984)
Clin Neuropathol
, vol.3
, pp. 185-192
-
-
Kosaka, K.1
Yoshimura, M.2
Ikeda, K.3
Budka, H.4
-
59
-
-
0006164301
-
Consensus guidelines for the clinical and pathological diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop
-
McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, Salmon DP, Lowe J, Mirra SS, Byrne EJ, Lennox G, P QN, Edwardson JA, Ince PG, Bergeron C, Burns A, Miller BL, Lovestone S, Collerton D, Jansen EN, Ballard C, De Vos RA, Wilcock GK, Jellinger KA, Perry RH. Consensus guidelines for the clinical and pathological diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 1996; 47: 1113-24.
-
(1996)
Neurology
, vol.47
, pp. 1113-1124
-
-
McKeith, I.G.1
Galasko, D.2
Kosaka, K.3
Perry, E.K.4
Dickson, D.W.5
Hansen, L.A.6
Salmon, D.P.7
Lowe, J.8
Mirra, S.S.9
Byrne, E.J.10
Lennox, G.P.Q.N.11
Edwardson, J.A.12
Ince, P.G.13
Bergeron, C.14
Burns, A.15
Miller, B.L.16
Lovestone, S.17
Collerton, D.18
Jansen, E.N.19
Ballard, C.20
De Vos, R.A.21
Wilcock, G.K.22
Jellinger, K.A.23
Perry, R.H.24
more..
-
61
-
-
41149138514
-
Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient
-
Leverenz JB, Hamilton R, Tsuang DW, Schantz A, Vavrek D, Larson EB, Kukull WA, Lopez O, Galasko D, Masliah E, Kaye J, Woltjer R, Clark C, Trojanowski JQ, Montine TJ. Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient. Brain Pathol 2008; 18: 220-4.
-
(2008)
Brain Pathol
, vol.18
, pp. 220-224
-
-
Leverenz, J.B.1
Hamilton, R.2
Tsuang, D.W.3
Schantz, A.4
Vavrek, D.5
Larson, E.B.6
Kukull, W.A.7
Lopez, O.8
Galasko, D.9
Masliah, E.10
Kaye, J.11
Woltjer, R.12
Clark, C.13
Trojanowski, J.Q.14
Montine, T.J.15
-
62
-
-
67349131839
-
Staging/typing of Lewy body related α-synuclein pathology: a study of the BrainNet Europe Consortium
-
Alafuzoff I, Ince PG, Arzberger T, Al-Sarraj S, Bell J, Bodi I, Bogdanovic N, Bugiani O, Ferrer I, Gelpi E, Gentleman S, Giaccone G, Ironside JW, Kavantzas N, King A, Korkolopoulou P, Kovacs GG, Meyronet D, Monoranu C, Parchi P, Parkkinen L, Patsouris E, Roggendorf W, Rozemuller A, Stadelmann-Nessler C, Streichenberger N, Thal DR, Kretzschmar H. Staging/typing of Lewy body related α-synuclein pathology: a study of the BrainNet Europe Consortium. Acta Neuropathol 2009; 117: 635-52.
-
(2009)
Acta Neuropathol
, vol.117
, pp. 635-652
-
-
Alafuzoff, I.1
Ince, P.G.2
Arzberger, T.3
Al-Sarraj, S.4
Bell, J.5
Bodi, I.6
Bogdanovic, N.7
Bugiani, O.8
Ferrer, I.9
Gelpi, E.10
Gentleman, S.11
Giaccone, G.12
Ironside, J.W.13
Kavantzas, N.14
King, A.15
Korkolopoulou, P.16
Kovacs, G.G.17
Meyronet, D.18
Monoranu, C.19
Parchi, P.20
Parkkinen, L.21
Patsouris, E.22
Roggendorf, W.23
Rozemuller, A.24
Stadelmann-Nessler, C.25
Streichenberger, N.26
Thal, D.R.27
Kretzschmar, H.28
more..
-
63
-
-
67349279396
-
Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
-
Beach TG, Adler CH, Lue L, Sue LI, Bachalakuri J, Henry-Watson J, Sasse J, Boyer S, Shirohi S, Brooks R, Eschbacher J, White CL, Akiyama H, Caviness J, Shill HA, Connor DJ, Sabbagh MN, Walker DG. Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction. Acta Neuropathol 2009; 117: 613-34.
-
(2009)
Acta Neuropathol
, vol.117
, pp. 613-634
-
-
Beach, T.G.1
Adler, C.H.2
Lue, L.3
Sue, L.I.4
Bachalakuri, J.5
Henry-Watson, J.6
Sasse, J.7
Boyer, S.8
Shirohi, S.9
Brooks, R.10
Eschbacher, J.11
White, C.L.12
Akiyama, H.13
Caviness, J.14
Shill, H.A.15
Connor, D.J.16
Sabbagh, M.N.17
Walker, D.G.18
-
64
-
-
58149252527
-
Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb
-
Sengoku R, Saito Y, Ikemura M, Hatsuta H, Sakiyama Y, Kanemaru K, Arai T, Sawabe M, Tanaka N, Mochizuki H, Inoue K, Murayama S. Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb. J Neuropathol Exp Neurol 2008; 67: 1072-83.
-
(2008)
J Neuropathol Exp Neurol
, vol.67
, pp. 1072-1083
-
-
Sengoku, R.1
Saito, Y.2
Ikemura, M.3
Hatsuta, H.4
Sakiyama, Y.5
Kanemaru, K.6
Arai, T.7
Sawabe, M.8
Tanaka, N.9
Mochizuki, H.10
Inoue, K.11
Murayama, S.12
-
65
-
-
84873257019
-
Neuropathologic analysis of Lewy-related α-synucleinopathy in olfactory mucosa
-
Funabe S, Takao M, Saito Y, Hatsuta H, Sugiyama M, Ito S, Kanemaru K, Sawabe M, Arai T, Mochizuki H, Hattori N, Murayama S. Neuropathologic analysis of Lewy-related α-synucleinopathy in olfactory mucosa. Neuropathology 2012; 33: 47-58.
-
(2012)
Neuropathology
, vol.33
, pp. 47-58
-
-
Funabe, S.1
Takao, M.2
Saito, Y.3
Hatsuta, H.4
Sugiyama, M.5
Ito, S.6
Kanemaru, K.7
Sawabe, M.8
Arai, T.9
Mochizuki, H.10
Hattori, N.11
Murayama, S.12
-
66
-
-
84899567470
-
Alpha-synuclein immunohistochemistry of gastrointestinal and biliary surgical specimens for diagnosis of Lewy body disease
-
Ito S, Takao M, Hatsuta H, Kanemaru K, Arai T, Saito Y, Fukayama M, Murayama S. Alpha-synuclein immunohistochemistry of gastrointestinal and biliary surgical specimens for diagnosis of Lewy body disease. Int J Clin Exp Pathol 2014; 7: 1714-23.
-
(2014)
Int J Clin Exp Pathol
, vol.7
, pp. 1714-1723
-
-
Ito, S.1
Takao, M.2
Hatsuta, H.3
Kanemaru, K.4
Arai, T.5
Saito, Y.6
Fukayama, M.7
Murayama, S.8
-
67
-
-
54449089153
-
Lewy body pathology involves cutaneous nerves
-
Ikemura M, Saito Y, Sengoku R, Sakiyama Y, Hatsuta H, Kanemaru K, Sawabe M, Arai T, Ito G, Iwatsubo T, Fukayama M, Murayama S. Lewy body pathology involves cutaneous nerves. J Neuropathol Exp Neurol 2008; 67: 945-53.
-
(2008)
J Neuropathol Exp Neurol
, vol.67
, pp. 945-953
-
-
Ikemura, M.1
Saito, Y.2
Sengoku, R.3
Sakiyama, Y.4
Hatsuta, H.5
Kanemaru, K.6
Sawabe, M.7
Arai, T.8
Ito, G.9
Iwatsubo, T.10
Fukayama, M.11
Murayama, S.12
-
68
-
-
1842789766
-
Accumulation of phosphorylated α-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy
-
Nishie M, Mori F, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K. Accumulation of phosphorylated α-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy. Acta Neuropathol 2004; 107: 292-8.
-
(2004)
Acta Neuropathol
, vol.107
, pp. 292-298
-
-
Nishie, M.1
Mori, F.2
Fujiwara, H.3
Hasegawa, M.4
Yoshimoto, M.5
Iwatsubo, T.6
Takahashi, H.7
Wakabayashi, K.8
-
69
-
-
0032568534
-
Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
-
Spillantini MG, Goedert M, Hasegawa M. Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci U S A 1998; 95: 6469-73.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 6469-6473
-
-
Spillantini, M.G.1
Goedert, M.2
Hasegawa, M.3
-
70
-
-
16344362746
-
The role of alpha-synuclein in the pathogenesis of multiple system atrophy
-
Wenning GK, Jellinger KA. The role of alpha-synuclein in the pathogenesis of multiple system atrophy. Acta Neuropathol 2005; 109: 129-40.
-
(2005)
Acta Neuropathol
, vol.109
, pp. 129-140
-
-
Wenning, G.K.1
Jellinger, K.A.2
-
71
-
-
38849122015
-
Effects of disease duration on the clinical features and brain glucose metabolism in patients with mixed type multiple system atrophy
-
Lyoo CH, Jeong Y, Ryu YH, Lee SY, Song TJ, Lee JH, Rinne JO, Lee MS. Effects of disease duration on the clinical features and brain glucose metabolism in patients with mixed type multiple system atrophy. Brain 2008; 131: 438-46.
-
(2008)
Brain
, vol.131
, pp. 438-446
-
-
Lyoo, C.H.1
Jeong, Y.2
Ryu, Y.H.3
Lee, S.Y.4
Song, T.J.5
Lee, J.H.6
Rinne, J.O.7
Lee, M.S.8
-
72
-
-
47749128106
-
Clinical, neuropathological and genotypic variability in SNCA A53T familial Parkinson's disease
-
Markopoulou K, Dickson DW, McComb RD, Wszolek ZK, Katechalidou L, Avery L, Stansbury MS, Chase BA. Clinical, neuropathological and genotypic variability in SNCA A53T familial Parkinson's disease. Acta Neuropathol 2008; 116: 25-35.
-
(2008)
Acta Neuropathol
, vol.116
, pp. 25-35
-
-
Markopoulou, K.1
Dickson, D.W.2
McComb, R.D.3
Wszolek, Z.K.4
Katechalidou, L.5
Avery, L.6
Stansbury, M.S.7
Chase, B.A.8
-
73
-
-
84899811573
-
Genetic variants and animal models in SNCA and Parkinson disease
-
Deng H, Yuan L. Genetic variants and animal models in SNCA and Parkinson disease. Ageing Res Rev 2014; 15: 161-76.
-
(2014)
Ageing Res Rev
, vol.15
, pp. 161-176
-
-
Deng, H.1
Yuan, L.2
-
74
-
-
0034069848
-
Distinctive neuropathology revealed by alpha-synuclein antibodies in hereditary parkinsonism and dementia linked to chromosome 4p
-
Gwinn-Hardy K, Mehta ND, Farrer M, Maraganore D, Muenter M, Yen SH, Hardy J, Dickson DW. Distinctive neuropathology revealed by alpha-synuclein antibodies in hereditary parkinsonism and dementia linked to chromosome 4p. Acta Neuropathol 2000; 99: 663-72.
-
(2000)
Acta Neuropathol
, vol.99
, pp. 663-672
-
-
Gwinn-Hardy, K.1
Mehta, N.D.2
Farrer, M.3
Maraganore, D.4
Muenter, M.5
Yen, S.H.6
Hardy, J.7
Dickson, D.W.8
-
75
-
-
84885461450
-
α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?
-
Kiely AP, Asi YT, Kara E, Limousin P, Ling H, Lewis P, Proukakis C, Quinn N, Lees AJ, Hardy J, Revesz T, Houlden H, Holton JL. α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy? Acta Neuropathol 2013; 125: 753-69.
-
(2013)
Acta Neuropathol
, vol.125
, pp. 753-769
-
-
Kiely, A.P.1
Asi, Y.T.2
Kara, E.3
Limousin, P.4
Ling, H.5
Lewis, P.6
Proukakis, C.7
Quinn, N.8
Lees, A.J.9
Hardy, J.10
Revesz, T.11
Houlden, H.12
Holton, J.L.13
-
76
-
-
84902118984
-
A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology
-
Pasanen P, Myllykangas L, Siitonen M, Raunio A, Kaakkola S, Lyytinen J, Tienari PJ, Pöyhönen M, Paetau A. A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology. Neurobiol Aging 2014; 35: 2180.e1-5.
-
(2014)
Neurobiol Aging
, vol.35
, pp. 2180e1-2180e5
-
-
Pasanen, P.1
Myllykangas, L.2
Siitonen, M.3
Raunio, A.4
Kaakkola, S.5
Lyytinen, J.6
Tienari, P.J.7
Pöyhönen, M.8
Paetau, A.9
-
77
-
-
84923460328
-
The link between the SNCA gene and parkinsonism
-
Xu W, Tan L, Yu J-T. The link between the SNCA gene and parkinsonism. Neurobiol Aging 2015; 36: 1505-18.
-
(2015)
Neurobiol Aging
, vol.36
, pp. 1505-1518
-
-
Xu, W.1
Tan, L.2
Yu, J.-T.3
-
78
-
-
27744455451
-
Absence of α-synuclein mRNA expression in normal and multiple system atrophy oligodendroglia
-
Miller DW, Johnson JM, Solano SM, Hollingsworth ZR, Standaert DG, Young AB. Absence of α-synuclein mRNA expression in normal and multiple system atrophy oligodendroglia. J Neural Transm 2005; 112: 1613-24.
-
(2005)
J Neural Transm
, vol.112
, pp. 1613-1624
-
-
Miller, D.W.1
Johnson, J.M.2
Solano, S.M.3
Hollingsworth, Z.R.4
Standaert, D.G.5
Young, A.B.6
-
79
-
-
84898046790
-
Alpha-synuclein mRNA expression in oligodendrocytes in MSA
-
Asi YT, Simpson JE, Heath PR, Wharton SB, Lees AJ, Revesz T, Houlden H, Holton JL. Alpha-synuclein mRNA expression in oligodendrocytes in MSA. Glia 2014; 62: 964-70.
-
(2014)
Glia
, vol.62
, pp. 964-970
-
-
Asi, Y.T.1
Simpson, J.E.2
Heath, P.R.3
Wharton, S.B.4
Lees, A.J.5
Revesz, T.6
Houlden, H.7
Holton, J.L.8
-
80
-
-
84954168300
-
Alpha-synuclein expression in the oligodendrocyte lineage: an in vitro and in vivo study using rodent and human models
-
Djelloul M, Holmqvist S, Boza-Serrano A, Azevedo C, Yeung MS, Goldwurm S, Frisén J, Deierborg T, Roybon L. Alpha-synuclein expression in the oligodendrocyte lineage: an in vitro and in vivo study using rodent and human models. Stem Cell Reports 2015; 5: 174-84.
-
(2015)
Stem Cell Reports
, vol.5
, pp. 174-184
-
-
Djelloul, M.1
Holmqvist, S.2
Boza-Serrano, A.3
Azevedo, C.4
Yeung, M.S.5
Goldwurm, S.6
Frisén, J.7
Deierborg, T.8
Roybon, L.9
-
81
-
-
79958227103
-
Signs of degeneration in 12-22 years old grafts of mesencephalic dopamine neurons in patients with Parkinson's disease
-
Kurowska Z, Englund E, Widner H, Lindvall O, Li J-Y, Brundin P. Signs of degeneration in 12-22 years old grafts of mesencephalic dopamine neurons in patients with Parkinson's disease. J Parkinsons Dis 2011; 1: 83-92.
-
(2011)
J Parkinsons Dis
, vol.1
, pp. 83-92
-
-
Kurowska, Z.1
Englund, E.2
Widner, H.3
Lindvall, O.4
Li, J.-Y.5
Brundin, P.6
-
82
-
-
77949820437
-
Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
-
Li J-Y, Englund E, Widner H, Rehncrona S, Björklund A, Lindvall O, Brundin P. Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease. Mov Disord 2010; 25: 1091-6.
-
(2010)
Mov Disord
, vol.25
, pp. 1091-1096
-
-
Li, J.-Y.1
Englund, E.2
Widner, H.3
Rehncrona, S.4
Björklund, A.5
Lindvall, O.6
Brundin, P.7
-
83
-
-
43249114934
-
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
-
Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 2008; 14: 504-6.
-
(2008)
Nat Med
, vol.14
, pp. 504-506
-
-
Kordower, J.H.1
Chu, Y.2
Hauser, R.A.3
Freeman, T.B.4
Olanow, C.W.5
-
84
-
-
69149089854
-
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
-
Desplats P, Lee H-J, Bae E-J, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee S-J. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein. Proc Natl Acad Sci U S A 2009; 106: 13010-5.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 13010-13015
-
-
Desplats, P.1
Lee, H.-J.2
Bae, E.-J.3
Patrick, C.4
Rockenstein, E.5
Crews, L.6
Spencer, B.7
Masliah, E.8
Lee, S.-J.9
-
85
-
-
79960285197
-
Transfer of host-derived alpha-synuclein to grafted dopaminergic neurons in rat
-
Kordower JH, Dodiya HB, Kordower AM, Terpstra B, Paumier K, Madhavan L, Sortwell C, Steece-Collier K, Collier TJ. Transfer of host-derived alpha-synuclein to grafted dopaminergic neurons in rat. Neurobiol Dis 2011; 43: 552-7.
-
(2011)
Neurobiol Dis
, vol.43
, pp. 552-557
-
-
Kordower, J.H.1
Dodiya, H.B.2
Kordower, A.M.3
Terpstra, B.4
Paumier, K.5
Madhavan, L.6
Sortwell, C.7
Steece-Collier, K.8
Collier, T.J.9
-
86
-
-
84862680670
-
Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo
-
Angot E, Steiner JA, Lema Tomé CM, Ekström P, Mattsson B, Björklund A, Björklund A, Brundin P. Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo. PLoS One 2012; 7: e39465.
-
(2012)
PLoS One
, vol.7
, pp. e39465
-
-
Angot, E.1
Steiner, J.A.2
Lema Tomé, C.M.3
Ekström, P.4
Mattsson, B.5
Björklund, A.6
Björklund, A.7
Brundin, P.8
-
87
-
-
79551519276
-
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
-
Hansen C, Angot E, Bergström A-L, Steiner JA, Pieri L, Paul G, Outeiro TF, Melki R, Kallunki P, Fog K, Li J-Y, Brundin P. α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. J Clin Invest 2011; 121: 715-25.
-
(2011)
J Clin Invest
, vol.121
, pp. 715-725
-
-
Hansen, C.1
Angot, E.2
Bergström, A.-L.3
Steiner, J.A.4
Pieri, L.5
Paul, G.6
Outeiro, T.F.7
Melki, R.8
Kallunki, P.9
Fog, K.10
Li, J.-Y.11
Brundin, P.12
-
88
-
-
84883688262
-
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
-
Jucker M, Walker LC. Self-propagation of pathogenic protein aggregates in neurodegenerative diseases. Nature 2013; 501: 45-51.
-
(2013)
Nature
, vol.501
, pp. 45-51
-
-
Jucker, M.1
Walker, L.C.2
-
89
-
-
84923011766
-
Invited review: Animal models of tauopathies and their implications for research/translation into the clinic
-
Dujardin S, Colin M, Buee L. Invited review: Animal models of tauopathies and their implications for research/translation into the clinic. Neuropathol Appl Neurobiol 2015; 41: 59-80.
-
(2015)
Neuropathol Appl Neurobiol
, vol.41
, pp. 59-80
-
-
Dujardin, S.1
Colin, M.2
Buee, L.3
-
90
-
-
2942620539
-
Propagating prions in fungi and mammals
-
Tuite MF, Koloteva-Levin N. Propagating prions in fungi and mammals. Mol Cell 2004; 14: 541-52.
-
(2004)
Mol Cell
, vol.14
, pp. 541-552
-
-
Tuite, M.F.1
Koloteva-Levin, N.2
-
91
-
-
84885470591
-
Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice
-
Rey NL, Petit GH, Bousset L, Melki R, Brundin P. Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice. Acta Neuropathol 2013; 126: 555-73.
-
(2013)
Acta Neuropathol
, vol.126
, pp. 555-573
-
-
Rey, N.L.1
Petit, G.H.2
Bousset, L.3
Melki, R.4
Brundin, P.5
-
92
-
-
84922092995
-
Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
-
Holmqvist S, Chutna O, Bousset L, Aldrin-Kirk P, Li W, Björklund T, Wang Z-Y, Roybon L, Melki R, Li J-Y. Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats. Acta Neuropathol 2014; 128: 805-20.
-
(2014)
Acta Neuropathol
, vol.128
, pp. 805-820
-
-
Holmqvist, S.1
Chutna, O.2
Bousset, L.3
Aldrin-Kirk, P.4
Li, W.5
Björklund, T.6
Wang, Z.-Y.7
Roybon, L.8
Melki, R.9
Li, J.-Y.10
-
93
-
-
84860686110
-
Can Parkinson's disease pathology be propagated from one neuron to another?
-
Dunning CJR, Reyes JF, Steiner JA, Brundin P. Can Parkinson's disease pathology be propagated from one neuron to another? Prog Neurobiol 2012; 97: 205-19.
-
(2012)
Prog Neurobiol
, vol.97
, pp. 205-219
-
-
Dunning, C.J.R.1
Reyes, J.F.2
Steiner, J.A.3
Brundin, P.4
-
94
-
-
84868148328
-
Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport
-
Freundt EC, Maynard N, Clancy EK, Roy S, Bousset L, Sourigues Y, Covert M, Melki R, Kirkegaard K, Brahic M. Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport. Ann Neurol 2012; 72: 517-24.
-
(2012)
Ann Neurol
, vol.72
, pp. 517-524
-
-
Freundt, E.C.1
Maynard, N.2
Clancy, E.K.3
Roy, S.4
Bousset, L.5
Sourigues, Y.6
Covert, M.7
Melki, R.8
Kirkegaard, K.9
Brahic, M.10
-
95
-
-
84919424987
-
Alpha-synuclein spreading in Parkinson's disease
-
Recasens A, Dehay B. Alpha-synuclein spreading in Parkinson's disease. Front Neuroanat 2014; 8: 159.
-
(2014)
Front Neuroanat
, vol.8
, pp. 159
-
-
Recasens, A.1
Dehay, B.2
-
96
-
-
84880025984
-
Caudo-rostral brain spreading of α-synuclein through vagal connections
-
Ulusoy A, Rusconi R, Pérez-Revuelta BI, Musgrove RE, Helwig M, Winzen-Reichert B, et al. Caudo-rostral brain spreading of α-synuclein through vagal connections. EMBO Mol Med 2013; 5: 1119-27.
-
(2013)
EMBO Mol Med
, vol.5
, pp. 1119-1127
-
-
Ulusoy, A.1
Rusconi, R.2
Pérez-Revuelta, B.I.3
Musgrove, R.E.4
Helwig, M.5
Winzen-Reichert, B.6
-
97
-
-
85018196378
-
Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury
-
Ulusoy A, Musgrove RE, Rusconi R, Klinkenberg M, Helwig M, Schneider A, Di Monte DA. Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury. Acta Neuropathol Commun 2015; 3: 13.
-
(2015)
Acta Neuropathol Commun
, vol.3
, pp. 13
-
-
Ulusoy, A.1
Musgrove, R.E.2
Rusconi, R.3
Klinkenberg, M.4
Helwig, M.5
Schneider, A.6
Di Monte, D.A.7
-
98
-
-
84863433677
-
Prion-like acceleration of a synucleinopathy in a transgenic mouse model
-
Mougenot A-L, Nicot S, Bencsik A, Morignat E, Verchère J, Lakhdar L, Legastelois S, Baron T. Prion-like acceleration of a synucleinopathy in a transgenic mouse model. Neurobiol Aging 2012; 33: 2225-8.
-
(2012)
Neurobiol Aging
, vol.33
, pp. 2225-2228
-
-
Mougenot, A.-L.1
Nicot, S.2
Bencsik, A.3
Morignat, E.4
Verchère, J.5
Lakhdar, L.6
Legastelois, S.7
Baron, T.8
-
99
-
-
84862609075
-
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
-
Luk KC, Kehm VM, Zhang B, O'Brien P, Trojanowski JQ, Lee VMY. Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. J Exp Med 2012; 209: 975-86.
-
(2012)
J Exp Med
, vol.209
, pp. 975-986
-
-
Luk, K.C.1
Kehm, V.M.2
Zhang, B.3
O'Brien, P.4
Trojanowski, J.Q.5
Lee, V.M.Y.6
-
100
-
-
84904636970
-
Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice
-
Sacino AN, Brooks M, Thomas MA, McKinney AB, Lee S, Regenhardt RW, McGarvey NH, Ayers JI, Notterpek L, Borchelt DR, Golde TE, Giasson BI. Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proc Natl Acad Sci 2014; 111: 10732-7.
-
(2014)
Proc Natl Acad Sci
, vol.111
, pp. 10732-10737
-
-
Sacino, A.N.1
Brooks, M.2
Thomas, M.A.3
McKinney, A.B.4
Lee, S.5
Regenhardt, R.W.6
McGarvey, N.H.7
Ayers, J.I.8
Notterpek, L.9
Borchelt, D.R.10
Golde, T.E.11
Giasson, B.I.12
-
101
-
-
85005777549
-
Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
-
Sacino AN, Brooks M, McGarvey NH, McKinney AB, Thomas MA, Levites Y, Ran Y, Golde TE, Giasson BI. Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein. Acta Neuropathol Commun 2013; 1: 38.
-
(2013)
Acta Neuropathol Commun
, vol.1
, pp. 38
-
-
Sacino, A.N.1
Brooks, M.2
McGarvey, N.H.3
McKinney, A.B.4
Thomas, M.A.5
Levites, Y.6
Ran, Y.7
Golde, T.E.8
Giasson, B.I.9
-
102
-
-
84899896344
-
Amyloidogenic a-synuclein seeds do not invariably induce rapid, widespread pathology in mice
-
Sacino AN, Brooks M, Thomas MA, McKinney AB, McGarvey NH, Rutherford NJ, Ceballos-Diaz C, Robertson J, Golde TE, Giasson BI. Amyloidogenic a-synuclein seeds do not invariably induce rapid, widespread pathology in mice. Acta Neuropathol 2014; 127: 645-65.
-
(2014)
Acta Neuropathol
, vol.127
, pp. 645-665
-
-
Sacino, A.N.1
Brooks, M.2
Thomas, M.A.3
McKinney, A.B.4
McGarvey, N.H.5
Rutherford, N.J.6
Ceballos-Diaz, C.7
Robertson, J.8
Golde, T.E.9
Giasson, B.I.10
-
103
-
-
84964853990
-
Prion-like propagation of humanbrain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein
-
Bernis ME, Babila JT, Breid S, Wüsten KA, Wüllner U, Tamgüney G. Prion-like propagation of humanbrain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein. Acta Neuropathol Commun 2015; 3: 75.
-
(2015)
Acta Neuropathol Commun
, vol.3
, pp. 75
-
-
Bernis, M.E.1
Babila, J.T.2
Breid, S.3
Wüsten, K.A.4
Wüllner, U.5
Tamgüney, G.6
-
104
-
-
84947997820
-
Transmission of Soluble and Insoluble α-Synuclein to Mice
-
Jones DR, Delenclos M, Baine AT, DeTure M, Murray ME, Dickson DW, McLean PJ. Transmission of Soluble and Insoluble α-Synuclein to Mice. J Neuropathol Exp Neurol 2015; 74: 1158-69.
-
(2015)
J Neuropathol Exp Neurol
, vol.74
, pp. 1158-1169
-
-
Jones, D.R.1
Delenclos, M.2
Baine, A.T.3
DeTure, M.4
Murray, M.E.5
Dickson, D.W.6
McLean, P.J.7
-
106
-
-
84869109864
-
Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
-
Luk KC, Kehm V, Carroll J, Zhang B, O'Brien P, Trojanowski JQ, Lee VMY. Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 2012; 338: 949-53.
-
(2012)
Science
, vol.338
, pp. 949-953
-
-
Luk, K.C.1
Kehm, V.2
Carroll, J.3
Zhang, B.4
O'Brien, P.5
Trojanowski, J.Q.6
Lee, V.M.Y.7
-
107
-
-
85048243758
-
Pathological alpha-synuclein propagates through neural networks
-
Masuda-Suzukake M, Nonaka T, Hosokawa M, Kubo M, Shimozawa A, Akiyama H, Hasegawa M. Pathological alpha-synuclein propagates through neural networks. Acta Neuropathol Commun 2014; 2: 88.
-
(2014)
Acta Neuropathol Commun
, vol.2
, pp. 88
-
-
Masuda-Suzukake, M.1
Nonaka, T.2
Hosokawa, M.3
Kubo, M.4
Shimozawa, A.5
Akiyama, H.6
Hasegawa, M.7
-
108
-
-
84907033533
-
Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates
-
Volpicelli-Daley LA, Luk KC, Lee VMY. Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates. Nat Protoc 2014; 9: 2135-46.
-
(2014)
Nat Protoc
, vol.9
, pp. 2135-2146
-
-
Volpicelli-Daley, L.A.1
Luk, K.C.2
Lee, V.M.Y.3
-
109
-
-
84934983329
-
α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
-
Peelaerts W, Bousset L, Van der Perren A, Moskalyuk A, Pulizzi R, Giugliano M, Van den Haute C, Melki R, Baekelandt V. α-Synuclein strains cause distinct synucleinopathies after local and systemic administration. Nature 2015; 522: 340-4.
-
(2015)
Nature
, vol.522
, pp. 340-344
-
-
Peelaerts, W.1
Bousset, L.2
Van der Perren, A.3
Moskalyuk, A.4
Pulizzi, R.5
Giugliano, M.6
Van den Haute, C.7
Melki, R.8
Baekelandt, V.9
-
110
-
-
84897977607
-
Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys
-
Recasens A, Dehay B, Bové J, Carballo-Carbajal I, Dovero S, Pérez-Villalba A, Fernagut P-O, Blesa J, Parent A, Perier C, Fariñas I, Obeso JA, Bézard E, Vila M. Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys. Ann Neurol 2014; 75: 351-62.
-
(2014)
Ann Neurol
, vol.75
, pp. 351-362
-
-
Recasens, A.1
Dehay, B.2
Bové, J.3
Carballo-Carbajal, I.4
Dovero, S.5
Pérez-Villalba, A.6
Fernagut, P.-O.7
Blesa, J.8
Parent, A.9
Perier, C.10
Fariñas, I.11
Obeso, J.A.12
Bézard, E.13
Vila, M.14
-
111
-
-
0035409575
-
Alpha-synuclein and neurodegenerative diseases
-
Goedert M. Alpha-synuclein and neurodegenerative diseases. Nat Rev Neurosci 2001; 2: 492-501.
-
(2001)
Nat Rev Neurosci
, vol.2
, pp. 492-501
-
-
Goedert, M.1
-
112
-
-
2642514788
-
Alpha-synuclein: normal function and role in neurodegenerative diseases
-
Norris EH, Giasson BI, Lee VM. Alpha-synuclein: normal function and role in neurodegenerative diseases. Curr Top Dev Biol 2004; 60: 17-54.
-
(2004)
Curr Top Dev Biol
, vol.60
, pp. 17-54
-
-
Norris, E.H.1
Giasson, B.I.2
Lee, V.M.3
-
113
-
-
18344417178
-
Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes
-
Lippa CF, Fujiwara H, Mann DM, Giasson B, Baba M, Schmidt ML, Nee LE, O'Connell B, Pollen DA, St George-Hyslop P, Ghetti B, Nochlin D, Bird TD, Cairns NJ, Lee VM, Iwatsubo T, Trojanowski JQ. Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. Am J Pathol 1998; 153: 1365-70.
-
(1998)
Am J Pathol
, vol.153
, pp. 1365-1370
-
-
Lippa, C.F.1
Fujiwara, H.2
Mann, D.M.3
Giasson, B.4
Baba, M.5
Schmidt, M.L.6
Nee, L.E.7
O'Connell, B.8
Pollen, D.A.9
St George-Hyslop, P.10
Ghetti, B.11
Nochlin, D.12
Bird, T.D.13
Cairns, N.J.14
Lee, V.M.15
Iwatsubo, T.16
Trojanowski, J.Q.17
-
114
-
-
14844292710
-
A mutant PSEN1 causes dementia with Lewy bodies and variant Alzheimer's disease
-
Ishikawa A, Piao Y-S, Kuwano R, Onodera O, Ohtake H, Suzuki M, Nishizawa M, Takahashi H. A mutant PSEN1 causes dementia with Lewy bodies and variant Alzheimer's disease. Ann Neurol 2005; 57: 429-34.
-
(2005)
Ann Neurol
, vol.57
, pp. 429-434
-
-
Ishikawa, A.1
Piao, Y.-S.2
Kuwano, R.3
Onodera, O.4
Ohtake, H.5
Suzuki, M.6
Nishizawa, M.7
Takahashi, H.8
-
115
-
-
84964313762
-
Alpha-synuclein and tau: teammates in neurodegeneration?
-
Moussaud S, Jones DR, Moussaud-Lamodière EL, Delenclos M, Ross OA, McLean PJ. Alpha-synuclein and tau: teammates in neurodegeneration? Mol Neurodegener 2014; 9: 43.
-
(2014)
Mol Neurodegener
, vol.9
, pp. 43
-
-
Moussaud, S.1
Jones, D.R.2
Moussaud-Lamodière, E.L.3
Delenclos, M.4
Ross, O.A.5
McLean, P.J.6
-
116
-
-
84940894409
-
Pathological interface between oligomeric alpha-synuclein and tau in synucleinopathies
-
Sengupta U, Guerreiro MJ, Castillo-Carranza DL, Lasagna-Reeves CA, Gerson JE, Paulucci-Holthauzen AA, Krishnamurthy S, Farhed M, Jackson GR, Kayed R. Pathological interface between oligomeric alpha-synuclein and tau in synucleinopathies. Biol Psychol 2015; 78: 672-83.
-
(2015)
Biol Psychol
, vol.78
, pp. 672-683
-
-
Sengupta, U.1
Guerreiro, M.J.2
Castillo-Carranza, D.L.3
Lasagna-Reeves, C.A.4
Gerson, J.E.5
Paulucci-Holthauzen, A.A.6
Krishnamurthy, S.7
Farhed, M.8
Jackson, G.R.9
Kayed, R.10
-
117
-
-
84959247911
-
Seeding and Cross-seeding in Amyloid Diseases
-
Ed M Jucker.: Springer (IPSEN book series), Berlin Heidelberg, Germany
-
Westermark P, Westermark GT. Seeding and Cross-seeding in Amyloid Diseases. In Proteopathic Seeds and Neurodegenerative Diseases. Ed M Jucker . 2013: Springer (IPSEN book series), Berlin Heidelberg, Germany; 47-60.
-
(2013)
Proteopathic Seeds and Neurodegenerative Diseases
, pp. 47-60
-
-
Westermark, P.1
Westermark, G.T.2
-
118
-
-
84893485687
-
Exogenous amyloidogenic proteins function as seeds in amyloid β-protein aggregation
-
Ono K, Takahashi R, Ikeda T, Mizuguchi M, Hamaguchi T, Yamada M. Exogenous amyloidogenic proteins function as seeds in amyloid β-protein aggregation. Biochim Biophys Acta 2014; 1842: 646-53.
-
(2014)
Biochim Biophys Acta
, vol.1842
, pp. 646-653
-
-
Ono, K.1
Takahashi, R.2
Ikeda, T.3
Mizuguchi, M.4
Hamaguchi, T.5
Yamada, M.6
-
119
-
-
77950633906
-
Molecular Cross Talk between Misfolded Proteins in Animal Models of Alzheimer's and Prion Diseases
-
Morales R, Estrada LD, Diaz-Espinoza R, Morales-Scheihing D, Jara MC, Castilla J, Soto C. Molecular Cross Talk between Misfolded Proteins in Animal Models of Alzheimer's and Prion Diseases. J Neurosci 2010; 30: 4528-35.
-
(2010)
J Neurosci
, vol.30
, pp. 4528-4535
-
-
Morales, R.1
Estrada, L.D.2
Diaz-Espinoza, R.3
Morales-Scheihing, D.4
Jara, M.C.5
Castilla, J.6
Soto, C.7
-
120
-
-
84884683227
-
Cross-seeding of misfolded proteins: implications for etiology and pathogenesis of protein misfolding diseases
-
Morales R, Moreno-Gonzalez I, Soto C. Cross-seeding of misfolded proteins: implications for etiology and pathogenesis of protein misfolding diseases. PLoS Pathog 2013; 9: e1003537.
-
(2013)
PLoS Pathog
, vol.9
, pp. e1003537
-
-
Morales, R.1
Moreno-Gonzalez, I.2
Soto, C.3
-
121
-
-
84879895467
-
Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons
-
Guo JL, Covell DJ, Daniels JP, Iba M, Stieber A, Zhang B, Riddle DM, Kwong LK, Xu Y, Trojanowski JQ, Lee VMY. Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons. Cell 2013; 154: 103-17.
-
(2013)
Cell
, vol.154
, pp. 103-117
-
-
Guo, J.L.1
Covell, D.J.2
Daniels, J.P.3
Iba, M.4
Stieber, A.5
Zhang, B.6
Riddle, D.M.7
Kwong, L.K.8
Xu, Y.9
Trojanowski, J.Q.10
Lee, V.M.Y.11
-
122
-
-
77649284470
-
Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice
-
Pan-Montojo F, Anichtchik O, Dening Y, Knels L, Pursche S, Jung R, Jackson S, Gille G, Spillantini MG, Reichmann H, Funk RHW. Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice. PLoS One 2010; 5: e8762.
-
(2010)
PLoS One
, vol.5
, pp. e8762
-
-
Pan-Montojo, F.1
Anichtchik, O.2
Dening, Y.3
Knels, L.4
Pursche, S.5
Jung, R.6
Jackson, S.7
Gille, G.8
Spillantini, M.G.9
Reichmann, H.10
Funk, R.H.W.11
-
123
-
-
84870769168
-
Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice
-
Pan-Montojo F, Schwarz M, Winkler C, Arnhold M, O'Sullivan GA, Pal A, Said J, Marsico G, Verbavatz J-M, Rodrigo-Angulo M, Gille G, Funk RHW, Reichmann H. Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice. Sci Rep 2012; 2: 898.
-
(2012)
Sci Rep
, vol.2
, pp. 898
-
-
Pan-Montojo, F.1
Schwarz, M.2
Winkler, C.3
Arnhold, M.4
O'Sullivan, G.A.5
Pal, A.6
Said, J.7
Marsico, G.8
Verbavatz, J.-M.9
Rodrigo-Angulo, M.10
Gille, G.11
Funk, R.H.W.12
Reichmann, H.13
-
124
-
-
84861563520
-
Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
-
Cremades N, Cohen SIA, Deas E, Abramov AY, Chen AY, Orte A, Sandal M, Clarke RW, Dunne P, Aprile FA, Bertoncini CW, Wood NW, Knowles TPJ, Dobson CM, Klenerman D. Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein. Cell 2012; 149: 1048-59.
-
(2012)
Cell
, vol.149
, pp. 1048-1059
-
-
Cremades, N.1
Cohen, S.I.A.2
Deas, E.3
Abramov, A.Y.4
Chen, A.Y.5
Orte, A.6
Sandal, M.7
Clarke, R.W.8
Dunne, P.9
Aprile, F.A.10
Bertoncini, C.W.11
Wood, N.W.12
Knowles, T.P.J.13
Dobson, C.M.14
Klenerman, D.15
-
125
-
-
58149277410
-
Concentration dependence of α-Synuclein fibril length assessed by quantitative atomic force microscopy and statistical-mechanical theory
-
van Raaij ME, van Gestel J, Segers-Nolten IMJ, de Leeuw SW, Subramaniam V. Concentration dependence of α-Synuclein fibril length assessed by quantitative atomic force microscopy and statistical-mechanical theory. Biophys J 2008; 95: 4871-8.
-
(2008)
Biophys J
, vol.95
, pp. 4871-4878
-
-
van Raaij, M.E.1
van Gestel, J.2
Segers-Nolten, I.M.J.3
de Leeuw, S.W.4
Subramaniam, V.5
-
126
-
-
48249141404
-
Tissue transglutaminase modulates α-synuclein oligomerization
-
Segers-Nolten IMJ, Wilhelmus MMM, Veldhuis G, van Rooijen BD, Drukarch B, Subramaniam V. Tissue transglutaminase modulates α-synuclein oligomerization. Protein Sci 2008; 17: 1395-402.
-
(2008)
Protein Sci
, vol.17
, pp. 1395-1402
-
-
Segers-Nolten, I.M.J.1
Wilhelmus, M.M.M.2
Veldhuis, G.3
van Rooijen, B.D.4
Drukarch, B.5
Subramaniam, V.6
-
127
-
-
0037177250
-
Molecular crowding accelerates fibrillization of α-synuclein: Could an increase in the cytoplasmic protein concentration induce Parkinson's disease?
-
Shtilerman MD, Ding TT, Lansbury PT. Molecular crowding accelerates fibrillization of α-synuclein: Could an increase in the cytoplasmic protein concentration induce Parkinson's disease? Biochemistry 2002; 41: 3855-60.
-
(2002)
Biochemistry
, vol.41
, pp. 3855-3860
-
-
Shtilerman, M.D.1
Ding, T.T.2
Lansbury, P.T.3
-
128
-
-
0033538541
-
α-Synuclein fibrillogenesis is nucleation-dependent
-
Wood SJ, Wypych J, Steavenson S, Louis J-C, Citron M, Biere AL. α-Synuclein fibrillogenesis is nucleation-dependent. J Biol Chem 1999; 274: 19509-12.
-
(1999)
J Biol Chem
, vol.274
, pp. 19509-19512
-
-
Wood, S.J.1
Wypych, J.2
Steavenson, S.3
Louis, J.-C.4
Citron, M.5
Biere, A.L.6
-
129
-
-
80052555139
-
Metastability of native proteins and the phenomenon of amyloid formation
-
Baldwin AJ, Knowles TPJ, Tartaglia GG, Fitzpatrick AW, Devlin GL, Shammas SL, Waudby CA, Mossuto MF, Meehan S, Gras SL, Christodoulou J, Anthony-Cahill SJ, Barker PD, Vendruscolo M, Dobson CM. Metastability of native proteins and the phenomenon of amyloid formation. J Am Chem Soc 2011; 133: 14160-3.
-
(2011)
J Am Chem Soc
, vol.133
, pp. 14160-14163
-
-
Baldwin, A.J.1
Knowles, T.P.J.2
Tartaglia, G.G.3
Fitzpatrick, A.W.4
Devlin, G.L.5
Shammas, S.L.6
Waudby, C.A.7
Mossuto, M.F.8
Meehan, S.9
Gras, S.L.10
Christodoulou, J.11
Anthony-Cahill, S.J.12
Barker, P.D.13
Vendruscolo, M.14
Dobson, C.M.15
-
130
-
-
0036415838
-
α-Synuclein, Especially the Parkinson's Disease-associated Mutants, Forms Pore-like Annular and Tubular Protofibrils
-
Lashuel HA, Petre BM, Wall J, Simon M, Nowak RJ, Walz T, Lansbury PT Jr. α-Synuclein, Especially the Parkinson's Disease-associated Mutants, Forms Pore-like Annular and Tubular Protofibrils. J Mol Biol 2002; 322: 1089-102.
-
(2002)
J Mol Biol
, vol.322
, pp. 1089-1102
-
-
Lashuel, H.A.1
Petre, B.M.2
Wall, J.3
Simon, M.4
Nowak, R.J.5
Walz, T.6
Lansbury, P.T.7
-
131
-
-
38849179462
-
Formation of a high affinity lipid-binding intermediate during the early aggregation phase of α-synuclein
-
Smith DP, Tew DJ, Hill AF, Bottomley SP, Masters CL, Barnham KJ, Cappai R. Formation of a high affinity lipid-binding intermediate during the early aggregation phase of α-synuclein. Biochemistry 2008; 47: 1425-34.
-
(2008)
Biochemistry
, vol.47
, pp. 1425-1434
-
-
Smith, D.P.1
Tew, D.J.2
Hill, A.F.3
Bottomley, S.P.4
Masters, C.L.5
Barnham, K.J.6
Cappai, R.7
-
132
-
-
84875553835
-
On-surface aggregation of α-synuclein at nanomolar concentrations results in two distinct growth mechanisms
-
Rabe M, Soragni A, Reynolds NP, Verdes D, Liverani E, Riek R, Seeger S. On-surface aggregation of α-synuclein at nanomolar concentrations results in two distinct growth mechanisms. ACS Chem Neurosci 2013; 4: 408-17.
-
(2013)
ACS Chem Neurosci
, vol.4
, pp. 408-417
-
-
Rabe, M.1
Soragni, A.2
Reynolds, N.P.3
Verdes, D.4
Liverani, E.5
Riek, R.6
Seeger, S.7
-
133
-
-
84901660540
-
Solution conditions determine the relative importance of nucleation and growth processes in -synuclein aggregation
-
Buell AK, Galvagnion C, Gaspar R, Sparr E, Vendruscolo M, Knowles TPJ, Linse S, Dobson CM. Solution conditions determine the relative importance of nucleation and growth processes in -synuclein aggregation. Proc Natl Acad Sci 2014; 111: 7671-6.
-
(2014)
Proc Natl Acad Sci
, vol.111
, pp. 7671-7676
-
-
Buell, A.K.1
Galvagnion, C.2
Gaspar, R.3
Sparr, E.4
Vendruscolo, M.5
Knowles, T.P.J.6
Linse, S.7
Dobson, C.M.8
-
134
-
-
85012094057
-
The Interplay between Alpha-Synuclein Clearance and Spreading
-
Fonseca T, Villar-Piqué A, Outeiro T. The Interplay between Alpha-Synuclein Clearance and Spreading. Biomolecules 2015; 5: 435-71.
-
(2015)
Biomolecules
, vol.5
, pp. 435-471
-
-
Fonseca, T.1
Villar-Piqué, A.2
Outeiro, T.3
-
135
-
-
70349705441
-
Prions: protein aggregation and infectious diseases
-
Aguzzi A, Calella AM. Prions: protein aggregation and infectious diseases. Physiol Rev 2009; 89: 1105-52.
-
(2009)
Physiol Rev
, vol.89
, pp. 1105-1152
-
-
Aguzzi, A.1
Calella, A.M.2
-
136
-
-
84926443335
-
Could α-Synuclein Amyloid-Like Aggregates Trigger a Prionic Neuronal Invasion?
-
Busquets MA, Espargaró A, Estelrich J, Sabate R. Could α-Synuclein Amyloid-Like Aggregates Trigger a Prionic Neuronal Invasion? Biomed Res Int 2015; 2015: 1-7.
-
(2015)
Biomed Res Int
, vol.2015
, pp. 1-7
-
-
Busquets, M.A.1
Espargaró, A.2
Estelrich, J.3
Sabate, R.4
-
137
-
-
15244339160
-
Neuromelanin in human dopamine neurons: comparison with peripheral melanins and relevance to Parkinson's disease
-
Fedorow H, Tribl F, Halliday G, Gerlach M, Riederer P, Double KL. Neuromelanin in human dopamine neurons: comparison with peripheral melanins and relevance to Parkinson's disease. Prog Neurobiol 2005; 75: 109-24.
-
(2005)
Prog Neurobiol
, vol.75
, pp. 109-124
-
-
Fedorow, H.1
Tribl, F.2
Halliday, G.3
Gerlach, M.4
Riederer, P.5
Double, K.L.6
-
138
-
-
85012094006
-
Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease
-
Xu S, Chan P. Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease. Biomolecules 2015; 5: 1122-42.
-
(2015)
Biomolecules
, vol.5
, pp. 1122-1142
-
-
Xu, S.1
Chan, P.2
-
139
-
-
41149084580
-
Relationship of phosphorylated α-synuclein and tau accumulation to Aβ deposition in the cerebral cortex of dementia with Lewy bodies
-
Obi K, Akiyama H, Kondo H, Shimomura Y, Hasegawa M, Iwatsubo T, Mizuno Y, Mochizuki H. Relationship of phosphorylated α-synuclein and tau accumulation to Aβ deposition in the cerebral cortex of dementia with Lewy bodies. Exp Neurol 2008; 210: 409-20.
-
(2008)
Exp Neurol
, vol.210
, pp. 409-420
-
-
Obi, K.1
Akiyama, H.2
Kondo, H.3
Shimomura, Y.4
Hasegawa, M.5
Iwatsubo, T.6
Mizuno, Y.7
Mochizuki, H.8
-
140
-
-
77953021942
-
Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders
-
Arizona Parkinson's Disease Consortium
-
Beach TG, adler CH, Sue LI, Vedders L, Lue L, White CLIII, Akiyama H, Caviness JN, Shill HA, Sabbagh MN, Walker DG, Arizona Parkinson's Disease Consortium. Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol 2010; 119: 689-702.
-
(2010)
Acta Neuropathol
, vol.119
, pp. 689-702
-
-
Beach, T.G.1
adler, C.H.2
Sue, L.I.3
Vedders, L.4
Lue, L.5
White, C.L.6
Akiyama, H.7
Caviness, J.N.8
Shill, H.A.9
Sabbagh, M.N.10
Walker, D.G.11
-
141
-
-
84871489685
-
Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains
-
Consortium APD
-
Walker DG, Lue L-F, adler CH, Shill HA, Caviness JN, Sabbagh MN, Akiyama H, Serrano GE, Sue LI, Beach TG, Consortium APD. Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains. Exp Neurol 2013; 240: 190-204.
-
(2013)
Exp Neurol
, vol.240
, pp. 190-204
-
-
Walker, D.G.1
Lue, L.-F.2
adler, C.H.3
Shill, H.A.4
Caviness, J.N.5
Sabbagh, M.N.6
Akiyama, H.7
Serrano, G.E.8
Sue, L.I.9
Beach, T.G.10
-
142
-
-
84888349390
-
Transmission of multiple system atrophy prions to transgenic mice
-
Watts JC, Giles K, Oehler A, Middleton L, Dexter DT, Gentleman SM, DeArmond SJ, Prusiner SB. Transmission of multiple system atrophy prions to transgenic mice. Proc Natl Acad Sci 2013; 110: 19555-60.
-
(2013)
Proc Natl Acad Sci
, vol.110
, pp. 19555-19560
-
-
Watts, J.C.1
Giles, K.2
Oehler, A.3
Middleton, L.4
Dexter, D.T.5
Gentleman, S.M.6
DeArmond, S.J.7
Prusiner, S.B.8
-
143
-
-
84924554924
-
Progressive aggregation of alpha-synuclein and selective degeneration of Lewy inclusion-bearing neurons in a mouse model of Parkinsonism
-
Osterberg VR, Spinelli KJ, Weston LJ, Luk KC, Woltjer RL, Unni VK. Progressive aggregation of alpha-synuclein and selective degeneration of Lewy inclusion-bearing neurons in a mouse model of Parkinsonism. Cell Rep 2015; 10: 1252-60.
-
(2015)
Cell Rep
, vol.10
, pp. 1252-1260
-
-
Osterberg, V.R.1
Spinelli, K.J.2
Weston, L.J.3
Luk, K.C.4
Woltjer, R.L.5
Unni, V.K.6
-
144
-
-
84934955012
-
Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration
-
Paumier KL, Luk KC, Manfredsson FP, Kanaan NM, Lipton JW, Collier TJ, Steece-Collier K, Kemp CJ, Celano S, Schulz E, Sandoval IM, Fleming S, Dirr E, Polinski NK, Trojanowski JQ, Lee VM, Sortwell CE. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiol Dis 2015; 82: 185-99.
-
(2015)
Neurobiol Dis
, vol.82
, pp. 185-199
-
-
Paumier, K.L.1
Luk, K.C.2
Manfredsson, F.P.3
Kanaan, N.M.4
Lipton, J.W.5
Collier, T.J.6
Steece-Collier, K.7
Kemp, C.J.8
Celano, S.9
Schulz, E.10
Sandoval, I.M.11
Fleming, S.12
Dirr, E.13
Polinski, N.K.14
Trojanowski, J.Q.15
Lee, V.M.16
Sortwell, C.E.17
-
145
-
-
77955366745
-
Role of post-translational modifications in modulating the structure, function and toxicity of α-synuclein
-
Ed A Björklund and MA Cenci; Academic Press, Cambridge, Massachusetts, USA
-
Oueslati A, Fournier M, Lashuel HA. Role of post-translational modifications in modulating the structure, function and toxicity of α-synuclein. In Progress in Brain Research. Ed A Björklund and MA Cenci; Academic Press, Cambridge, Massachusetts, USA, 2010; 115-45.
-
(2010)
Progress in Brain Research
, pp. 115-145
-
-
Oueslati, A.1
Fournier, M.2
Lashuel, H.A.3
-
146
-
-
0035830913
-
Synuclein Is Phosphorylated by Members of the Src Family of Protein-tyrosine Kinases
-
Ellis CE, Schwartzberg PL, Grider TL, Fink DW, Nussbaum RL. Synuclein Is Phosphorylated by Members of the Src Family of Protein-tyrosine Kinases. J Biol Chem 2001; 276: 3879-84.
-
(2001)
J Biol Chem
, vol.276
, pp. 3879-3884
-
-
Ellis, C.E.1
Schwartzberg, P.L.2
Grider, T.L.3
Fink, D.W.4
Nussbaum, R.L.5
-
147
-
-
0036174010
-
Alpha-synuclein is phosphorylated in synucleinopathy lesions
-
Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T. Alpha-synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 2002; 4: 160-4.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 160-164
-
-
Fujiwara, H.1
Hasegawa, M.2
Dohmae, N.3
Kawashima, A.4
Masliah, E.5
Goldberg, M.S.6
Shen, J.7
Takio, K.8
Iwatsubo, T.9
-
148
-
-
84904790745
-
Quantitative measurement of intact alpha-synuclein proteoforms from post-mortem control and Parkinson's disease brain tissue by intact protein mass spectrometry
-
Kellie JF, Higgs RE, Ryder JW, Major A, Beach TG, Adler CH, Merchant K, Knierman M. Quantitative measurement of intact alpha-synuclein proteoforms from post-mortem control and Parkinson's disease brain tissue by intact protein mass spectrometry. Sci Rep 2014; 4: 5797.
-
(2014)
Sci Rep
, vol.4
, pp. 5797
-
-
Kellie, J.F.1
Higgs, R.E.2
Ryder, J.W.3
Major, A.4
Beach, T.G.5
Adler, C.H.6
Merchant, K.7
Knierman, M.8
-
149
-
-
84855188545
-
α-synuclein phosphorylation and truncation are normal events in the adult human brain
-
Muntané G, Ferrer I, Martinez-Vicente M. α-synuclein phosphorylation and truncation are normal events in the adult human brain. Neuroscience 2012; 200: 106-19.
-
(2012)
Neuroscience
, vol.200
, pp. 106-119
-
-
Muntané, G.1
Ferrer, I.2
Martinez-Vicente, M.3
-
150
-
-
84867581207
-
Biochemical Increase in Phosphorylated Alpha-Synuclein Precedes Histopathology of Lewy-Type Synucleinopathies
-
Lue L-F, Walker DG, adler CH, Shill H, Tran H, Akiyama H, Sue LI, Caviness J, Sabbagh MN, Beach TG. Biochemical Increase in Phosphorylated Alpha-Synuclein Precedes Histopathology of Lewy-Type Synucleinopathies. Brain Pathol 2012; 22: 745-56.
-
(2012)
Brain Pathol
, vol.22
, pp. 745-756
-
-
Lue, L.-F.1
Walker, D.G.2
adler, C.H.3
Shill, H.4
Tran, H.5
Akiyama, H.6
Sue, L.I.7
Caviness, J.8
Sabbagh, M.N.9
Beach, T.G.10
-
152
-
-
84864150557
-
Phosphorylated α-synuclein immunoreactivity in the posterior pituitary lobe
-
Homma T, Mochizuki Y, Mizutani T. Phosphorylated α-synuclein immunoreactivity in the posterior pituitary lobe. Neuropathology 2011; 32: 385-9.
-
(2011)
Neuropathology
, vol.32
, pp. 385-389
-
-
Homma, T.1
Mochizuki, Y.2
Mizutani, T.3
-
153
-
-
0034253913
-
Widespread expression of α-synuclein and τ immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course
-
Saito Y, Kawai M, Inoue K, Sasaki R, Arai H, Nanba E, Kuzuhara S, Ihara Y, Kanazawa I, Murayama S. Widespread expression of α-synuclein and τ immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course. J Neurol Sci 2000; 177: 48-59.
-
(2000)
J Neurol Sci
, vol.177
, pp. 48-59
-
-
Saito, Y.1
Kawai, M.2
Inoue, K.3
Sasaki, R.4
Arai, H.5
Nanba, E.6
Kuzuhara, S.7
Ihara, Y.8
Kanazawa, I.9
Murayama, S.10
-
154
-
-
85018218251
-
Filamentous aggregations of phosphorylated α-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy
-
Nakamura K, Mori F, Kon T, Tanji K, Miki Y, Tomiyama M, Kurotaki H, Toyoshima Y, Kakita A, Takahashi H, Yamada M, Wakabayashi K. Filamentous aggregations of phosphorylated α-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy. Acta Neuropathol Commun 2015; 3: 29.
-
(2015)
Acta Neuropathol Commun
, vol.3
, pp. 29
-
-
Nakamura, K.1
Mori, F.2
Kon, T.3
Tanji, K.4
Miki, Y.5
Tomiyama, M.6
Kurotaki, H.7
Toyoshima, Y.8
Kakita, A.9
Takahashi, H.10
Yamada, M.11
Wakabayashi, K.12
-
155
-
-
84900827193
-
Phosphorylated α-synuclein-immunoreactive retinal neuronal elements in Parkinson's disease subjects
-
Consortium TAPD
-
Beach TG, Carew J, Serrano G, Adler CH, Shill HA, Sue LI, Sabbagh MN, Akiyama H, Cuenca N, Consortium TAPD. Phosphorylated α-synuclein-immunoreactive retinal neuronal elements in Parkinson's disease subjects. Neurosci Lett 2014; 571: 34-8.
-
(2014)
Neurosci Lett
, vol.571
, pp. 34-38
-
-
Beach, T.G.1
Carew, J.2
Serrano, G.3
Adler, C.H.4
Shill, H.A.5
Sue, L.I.6
Sabbagh, M.N.7
Akiyama, H.8
Cuenca, N.9
-
156
-
-
84940093905
-
Phosphorylated α-synuclein in skin nerve fibres differentiates Parkinson's disease from multiple system atrophy
-
Zange L, Noack C, Hahn K, Stenzel W, Lipp A. Phosphorylated α-synuclein in skin nerve fibres differentiates Parkinson's disease from multiple system atrophy. Brain 2015; 138: 2310-21.
-
(2015)
Brain
, vol.138
, pp. 2310-2321
-
-
Zange, L.1
Noack, C.2
Hahn, K.3
Stenzel, W.4
Lipp, A.5
-
157
-
-
47749139266
-
Characterization of antibodies that selectively detect α-synuclein in pathological inclusions
-
Waxman EA, Duda JE, Giasson BI. Characterization of antibodies that selectively detect α-synuclein in pathological inclusions. Acta Neuropathol 2008; 116: 37-46.
-
(2008)
Acta Neuropathol
, vol.116
, pp. 37-46
-
-
Waxman, E.A.1
Duda, J.E.2
Giasson, B.I.3
-
158
-
-
77449113371
-
Phosphorylation of Synucleins by Members of the Polo-like Kinase Family
-
Mbefo MK, Paleologou KE, Boucharaba A, Oueslati A, Schell H, Fournier M, Olschewski D, Yin G, Zweckstetter M, Masliah E, Kahle PJ, Hirling H, Lashuel HA. Phosphorylation of Synucleins by Members of the Polo-like Kinase Family. J Biol Chem 2010; 285: 2807-22.
-
(2010)
J Biol Chem
, vol.285
, pp. 2807-2822
-
-
Mbefo, M.K.1
Paleologou, K.E.2
Boucharaba, A.3
Oueslati, A.4
Schell, H.5
Fournier, M.6
Olschewski, D.7
Yin, G.8
Zweckstetter, M.9
Masliah, E.10
Kahle, P.J.11
Hirling, H.12
Lashuel, H.A.13
-
159
-
-
33749570292
-
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease
-
Anderson JP, Walker DE, Goldstein JM, de Laat R, Banducci K, Caccavello RJ, Barbour R, Huang J, Kling K, Lee M, Diep L, Keim PS, Shen X, Chataway T, Schlossmacher MG, Seubert P, Schenk D, Sinha S, Gai W-P, Chilcote TJ. Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease. J Biol Chem 2006; 281: 29739-52.
-
(2006)
J Biol Chem
, vol.281
, pp. 29739-29752
-
-
Anderson, J.P.1
Walker, D.E.2
Goldstein, J.M.3
de Laat, R.4
Banducci, K.5
Caccavello, R.J.6
Barbour, R.7
Huang, J.8
Kling, K.9
Lee, M.10
Diep, L.11
Keim, P.S.12
Shen, X.13
Chataway, T.14
Schlossmacher, M.G.15
Seubert, P.16
Schenk, D.17
Sinha, S.18
Gai, W.-P.19
Chilcote, T.J.20
more..
-
160
-
-
34249794256
-
Accumulation of phosphorylated α-synuclein in dopaminergic neurons of transgenic mice that express human α-synuclein
-
Wakamatsu M, Ishii A, Ukai Y, Sakagami J, Iwata S, Ono M, Matsumoto K, Nakamura A, Tada N, Kobayashi K, Iwatsubo T, Yoshimoto M. Accumulation of phosphorylated α-synuclein in dopaminergic neurons of transgenic mice that express human α-synuclein. J Neurosci Res 2007; 85: 1819-25.
-
(2007)
J Neurosci Res
, vol.85
, pp. 1819-1825
-
-
Wakamatsu, M.1
Ishii, A.2
Ukai, Y.3
Sakagami, J.4
Iwata, S.5
Ono, M.6
Matsumoto, K.7
Nakamura, A.8
Tada, N.9
Kobayashi, K.10
Iwatsubo, T.11
Yoshimoto, M.12
-
161
-
-
64649106275
-
Nuclear and neuritic distribution of serine-129 phosphorylated α-synuclein in transgenic mice
-
Schell H, Hasegawa T, Neumann M, Kahle PJ. Nuclear and neuritic distribution of serine-129 phosphorylated α-synuclein in transgenic mice. Neuroscience 2009; 160: 796-804.
-
(2009)
Neuroscience
, vol.160
, pp. 796-804
-
-
Schell, H.1
Hasegawa, T.2
Neumann, M.3
Kahle, P.J.4
-
162
-
-
84915763819
-
Early and persistent expression of phosphorylated α-synuclein in the enteric nervous system of A53T mutant human α-synuclein transgenic mice
-
Bencsik A, Muselli L, Leboidre M, Lakhdar L, Baron T. Early and persistent expression of phosphorylated α-synuclein in the enteric nervous system of A53T mutant human α-synuclein transgenic mice. J Neuropathol Exp Neurol 2014; 73: 1144-51.
-
(2014)
J Neuropathol Exp Neurol
, vol.73
, pp. 1144-1151
-
-
Bencsik, A.1
Muselli, L.2
Leboidre, M.3
Lakhdar, L.4
Baron, T.5
-
163
-
-
81255188869
-
Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease
-
Sato H, Arawaka S, Hara S, Fukushima S, Koga K, Koyama S, Kato T. Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease. J Neurosci 2011; 31: 16884-94.
-
(2011)
J Neurosci
, vol.31
, pp. 16884-16894
-
-
Sato, H.1
Arawaka, S.2
Hara, S.3
Fukushima, S.4
Koga, K.5
Koyama, S.6
Kato, T.7
-
164
-
-
84904322386
-
Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients
-
Watts JC, Condello C, Stohr J, Oehler A, Lee J, DeArmond SJ, Lannfelt L, Ingelsson M, Giles K, Prusiner SB. Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients. Proc Natl Acad Sci 2014; 111: 10323-8.
-
(2014)
Proc Natl Acad Sci
, vol.111
, pp. 10323-10328
-
-
Watts, J.C.1
Condello, C.2
Stohr, J.3
Oehler, A.4
Lee, J.5
DeArmond, S.J.6
Lannfelt, L.7
Ingelsson, M.8
Giles, K.9
Prusiner, S.B.10
-
165
-
-
0033678217
-
Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies
-
Duda JE, Giasson BI, Chen Q, Gur TL, Hurtig HI, Stern MB, Gollomp SM, Ischiropoulos H, Lee VM, Trojanowski JQ. Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies. Am J Pathol 2000; 157: 1439-45.
-
(2000)
Am J Pathol
, vol.157
, pp. 1439-1445
-
-
Duda, J.E.1
Giasson, B.I.2
Chen, Q.3
Gur, T.L.4
Hurtig, H.I.5
Stern, M.B.6
Gollomp, S.M.7
Ischiropoulos, H.8
Lee, V.M.9
Trojanowski, J.Q.10
-
167
-
-
84942499950
-
The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease
-
Xu Y, Deng Y, Qing H. The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease. J Neurochem 2015; 135: 4-18.
-
(2015)
J Neurochem
, vol.135
, pp. 4-18
-
-
Xu, Y.1
Deng, Y.2
Qing, H.3
-
168
-
-
78650356896
-
Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner
-
Machiya Y, Hara S, Arawaka S, Fukushima S, Sato H, Sakamoto M, Koyama S, Kato T. Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner. J Biol Chem 2010; 285: 40732-44.
-
(2010)
J Biol Chem
, vol.285
, pp. 40732-40744
-
-
Machiya, Y.1
Hara, S.2
Arawaka, S.3
Fukushima, S.4
Sato, H.5
Sakamoto, M.6
Koyama, S.7
Kato, T.8
-
169
-
-
79958169700
-
Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson's disease
-
Zhou J, Broe M, Huang Y, Anderson JP, Gai W-P, Milward EA, Porritt M, Howells D, Hughes AJ, Wang X, Halliday GM. Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson's disease. Acta Neuropathol 2011; 121: 695-704.
-
(2011)
Acta Neuropathol
, vol.121
, pp. 695-704
-
-
Zhou, J.1
Broe, M.2
Huang, Y.3
Anderson, J.P.4
Gai, W.-P.5
Milward, E.A.6
Porritt, M.7
Howells, D.8
Hughes, A.J.9
Wang, X.10
Halliday, G.M.11
-
170
-
-
84857938647
-
Phosphorylated α-synuclein as a potential biomarker for Parkinson's disease and related disorders
-
Foulds P, Mann DM, Allsop D. Phosphorylated α-synuclein as a potential biomarker for Parkinson's disease and related disorders. Expert Review of Molecular Diagnostics 2012; 12: 115-7.
-
(2012)
Expert Review of Molecular Diagnostics
, vol.12
, pp. 115-117
-
-
Foulds, P.1
Mann, D.M.2
Allsop, D.3
-
171
-
-
82655171636
-
Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease
-
Foulds PG, Mitchell JD, Parker A, Turner R, Green G, Diggle P, Hasegawa M, Taylor M, Mann D, Allsop D. Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease. FASEB J 2011; 25: 4127-37.
-
(2011)
FASEB J
, vol.25
, pp. 4127-4137
-
-
Foulds, P.G.1
Mitchell, J.D.2
Parker, A.3
Turner, R.4
Green, G.5
Diggle, P.6
Hasegawa, M.7
Taylor, M.8
Mann, D.9
Allsop, D.10
-
172
-
-
84863164994
-
Phosphorylated α-synuclein in Parkinson's disease
-
121ra20.
-
Wang Y, Shi M, Chung KA, Zabetian CP, Leverenz JB, Berg D, Srulijes K, Trojanowski JQ, Lee VMY, Siderowf AD, Hurtig H, Litvan I, Schiess MC, Peskind ER, Masuda M, Hasegawa M, Lin X, Pan C, Galasko D, Goldstein DS, Jensen PH, Yang H, Cain KC, Zhang J. Phosphorylated α-synuclein in Parkinson's disease. Sci Transl Med 2012; 4: 121ra20.
-
(2012)
Sci Transl Med
, vol.4
-
-
Wang, Y.1
Shi, M.2
Chung, K.A.3
Zabetian, C.P.4
Leverenz, J.B.5
Berg, D.6
Srulijes, K.7
Trojanowski, J.Q.8
Lee, V.M.Y.9
Siderowf, A.D.10
Hurtig, H.11
Litvan, I.12
Schiess, M.C.13
Peskind, E.R.14
Masuda, M.15
Hasegawa, M.16
Lin, X.17
Pan, C.18
Galasko, D.19
Goldstein, D.S.20
Jensen, P.H.21
Yang, H.22
Cain, K.C.23
Zhang, J.24
more..
-
173
-
-
85017330543
-
Phosphorylated α-synuclein in Parkinson's disease: correlation depends on disease severity
-
Stewart T. Phosphorylated α-synuclein in Parkinson's disease: correlation depends on disease severity. Acta Neuropathol Commun 2015; 3: 7.
-
(2015)
Acta Neuropathol Commun
, vol.3
, pp. 7
-
-
Stewart, T.1
-
174
-
-
84861534126
-
Increased alpha-synuclein phosphorylation and nitration in the aging primate substantia nigra
-
McCormack AL, Mak SK, Di Monte DA. Increased alpha-synuclein phosphorylation and nitration in the aging primate substantia nigra. Cell Death Dis 2012; 3: e315-9.
-
(2012)
Cell Death Dis
, vol.3
, pp. e315-e319
-
-
McCormack, A.L.1
Mak, S.K.2
Di Monte, D.A.3
-
175
-
-
84870820743
-
Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate
-
Canron M-H, Perret M, Vital A, Bézard E, Dehay B. Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate. Sci Rep 2012; 2: 910.
-
(2012)
Sci Rep
, vol.2
, pp. 910
-
-
Canron, M.-H.1
Perret, M.2
Vital, A.3
Bézard, E.4
Dehay, B.5
-
176
-
-
84902551255
-
Protective effect of telmisartan against progressive oxidative brain damage and synuclein phosphorylation in stroke-resistant spontaneously hypertensive rats
-
Fukui Y, Yamashita T, Kurata T, Sato K, Lukic V, Hishikawa N, Deguchi K, Abe K. Protective effect of telmisartan against progressive oxidative brain damage and synuclein phosphorylation in stroke-resistant spontaneously hypertensive rats. J Stroke Cerebrovasc Dis 2014; 23: 1545-53.
-
(2014)
J Stroke Cerebrovasc Dis
, vol.23
, pp. 1545-1553
-
-
Fukui, Y.1
Yamashita, T.2
Kurata, T.3
Sato, K.4
Lukic, V.5
Hishikawa, N.6
Deguchi, K.7
Abe, K.8
-
177
-
-
67650496503
-
Relationship between alpha-synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson's disease pathogenesis
-
Chau K-Y, Ching HL, Schapira AHV, Cooper JM. Relationship between alpha-synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson's disease pathogenesis. J Neurochem 2009; 110: 1005-13.
-
(2009)
J Neurochem
, vol.110
, pp. 1005-1013
-
-
Chau, K.-Y.1
Ching, H.L.2
Schapira, A.H.V.3
Cooper, J.M.4
-
179
-
-
84885363886
-
Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo
-
Oueslati A, Schneider BL, Aebischer P, Lashuel HA. Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo. Proc Natl Acad Sci U S A 2013; 110: E3945-54.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. E3945-E3954
-
-
Oueslati, A.1
Schneider, B.L.2
Aebischer, P.3
Lashuel, H.A.4
-
180
-
-
65649140858
-
Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells
-
Kragh CL, Lund LB, Febbraro F, Hansen HD, Gai W-P, El-Agnaf O, Richter-Landsberg C, Jensen PH. Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells. J Biol Chem 2009; 284: 10211-22.
-
(2009)
J Biol Chem
, vol.284
, pp. 10211-10222
-
-
Kragh, C.L.1
Lund, L.B.2
Febbraro, F.3
Hansen, H.D.4
Gai, W.-P.5
El-Agnaf, O.6
Richter-Landsberg, C.7
Jensen, P.H.8
-
181
-
-
84887273441
-
Assessing the Subcellular Dynamics of Alpha-synuclein Using Photoactivation Microscopy
-
Gonçalves S, Outeiro TF. Assessing the Subcellular Dynamics of Alpha-synuclein Using Photoactivation Microscopy. Mol Neurobiol 2013; 47: 1081-92.
-
(2013)
Mol Neurobiol
, vol.47
, pp. 1081-1092
-
-
Gonçalves, S.1
Outeiro, T.F.2
-
182
-
-
0037166267
-
Biochemical characterization of the core structure of alpha-synuclein filaments
-
Miake H, Mizusawa H, Iwatsubo T, Hasegawa M. Biochemical characterization of the core structure of alpha-synuclein filaments. J Biol Chem 2002; 277: 19213-9.
-
(2002)
J Biol Chem
, vol.277
, pp. 19213-19219
-
-
Miake, H.1
Mizusawa, H.2
Iwatsubo, T.3
Hasegawa, M.4
-
183
-
-
0036855635
-
Misfolded proteinase K-resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies
-
Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Müller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C. Misfolded proteinase K-resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies. J. Clin. Invest. 2002; 110: 1429-39.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 1429-1439
-
-
Neumann, M.1
Kahle, P.J.2
Giasson, B.I.3
Ozmen, L.4
Borroni, E.5
Spooren, W.6
Müller, V.7
Odoy, S.8
Fujiwara, H.9
Hasegawa, M.10
Iwatsubo, T.11
Trojanowski, J.Q.12
Kretzschmar, H.A.13
Haass, C.14
-
184
-
-
84938704559
-
Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain
-
Roberts RF, Wade-Martins R, Alegre-Abarrategui J. Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain. Brain 2015; 138: 1642-57.
-
(2015)
Brain
, vol.138
, pp. 1642-1657
-
-
Roberts, R.F.1
Wade-Martins, R.2
Alegre-Abarrategui, J.3
-
185
-
-
85005846700
-
Direct detection of alpha-synuclein oligomers in vivo
-
Dimant H, Kalia SK, Kalia LV, Zhu LN, Kibuuka L, Ebrahimi-Fakhari D, et al. Direct detection of alpha-synuclein oligomers in vivo. Acta Neuropathol Commun 2013; 1: 6.
-
(2013)
Acta Neuropathol Commun
, vol.1
, pp. 6
-
-
Dimant, H.1
Kalia, S.K.2
Kalia, L.V.3
Zhu, L.N.4
Kibuuka, L.5
Ebrahimi-Fakhari, D.6
-
186
-
-
84893488562
-
Presynaptic Alpha-Synuclein Aggregation in a Mouse Model of Parkinson's Disease
-
Spinelli KJ, Taylor JK, Osterberg VR, Churchill MJ, Pollock E, Moore C, Meshul CK, Unni VK. Presynaptic Alpha-Synuclein Aggregation in a Mouse Model of Parkinson's Disease. J Neurosci 2014; 34: 2037-50.
-
(2014)
J Neurosci
, vol.34
, pp. 2037-2050
-
-
Spinelli, K.J.1
Taylor, J.K.2
Osterberg, V.R.3
Churchill, M.J.4
Pollock, E.5
Moore, C.6
Meshul, C.K.7
Unni, V.K.8
-
187
-
-
0031661141
-
Abnormal distribution of the non-Aβ component of Alzheimer's disease amyloid precursor/alpha-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment
-
Takeda A, Hashimoto M, Mallory M, Sundsumo M, Hansen L, Sisk A, Masliah E. Abnormal distribution of the non-Aβ component of Alzheimer's disease amyloid precursor/alpha-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment. Lab Invest 1998; 78: 1169-77.
-
(1998)
Lab Invest
, vol.78
, pp. 1169-1177
-
-
Takeda, A.1
Hashimoto, M.2
Mallory, M.3
Sundsumo, M.4
Hansen, L.5
Sisk, A.6
Masliah, E.7
-
188
-
-
0026602764
-
Relationships between Lewy bodies and pale bodies in Parkinson's disease
-
Dale GE, Probst A, Luthert P, Martin J, Anderton BH, Leigh PN. Relationships between Lewy bodies and pale bodies in Parkinson's disease. Acta Neuropathol 1992; 83: 525-9.
-
(1992)
Acta Neuropathol
, vol.83
, pp. 525-529
-
-
Dale, G.E.1
Probst, A.2
Luthert, P.3
Martin, J.4
Anderton, B.H.5
Leigh, P.N.6
-
189
-
-
49049114460
-
Evaluation of α-synuclein immunohistochemical methods used by invited experts
-
Beach TG, White CL, Hamilton RL, Duda JE, Iwatsubo T, Dickson DW, Leverenz JB, Roncaroli F, Buttini M, Hladik CL, Sue LI, Noorigian JV, Adler CH. Evaluation of α-synuclein immunohistochemical methods used by invited experts. Acta Neuropathol 2008; 116: 277-88.
-
(2008)
Acta Neuropathol
, vol.116
, pp. 277-288
-
-
Beach, T.G.1
White, C.L.2
Hamilton, R.L.3
Duda, J.E.4
Iwatsubo, T.5
Dickson, D.W.6
Leverenz, J.B.7
Roncaroli, F.8
Buttini, M.9
Hladik, C.L.10
Sue, L.I.11
Noorigian, J.V.12
Adler, C.H.13
-
190
-
-
0023102075
-
Perfusion-fixation of the human brain for immunohistochemistry: comparison with immersion-fixation
-
Beach TG, Tago H, Nagai T, Kimura H, McGeer PL. Perfusion-fixation of the human brain for immunohistochemistry: comparison with immersion-fixation. J Neurosci Methods 1987; 19: 183-92.
-
(1987)
J Neurosci Methods
, vol.19
, pp. 183-192
-
-
Beach, T.G.1
Tago, H.2
Nagai, T.3
Kimura, H.4
McGeer, P.L.5
-
191
-
-
84927922558
-
Evaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson's disease
-
Swirski M, Miners JS, de Silva R, Lashley T, Ling H, Holton J, Revesz T, Love S. Evaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson's disease. Alzheimers Res Ther 2014; 6: 77.
-
(2014)
Alzheimers Res Ther
, vol.6
, pp. 77
-
-
Swirski, M.1
Miners, J.S.2
de Silva, R.3
Lashley, T.4
Ling, H.5
Holton, J.6
Revesz, T.7
Love, S.8
-
192
-
-
0034602442
-
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions
-
Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurtig HI, Ischiropoulos H, Trojanowski JQ, Lee VM. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science 2000; 290: 985-9.
-
(2000)
Science
, vol.290
, pp. 985-989
-
-
Giasson, B.I.1
Duda, J.E.2
Murray, I.V.3
Chen, Q.4
Souza, J.M.5
Hurtig, H.I.6
Ischiropoulos, H.7
Trojanowski, J.Q.8
Lee, V.M.9
-
193
-
-
0036322266
-
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
-
Duda JE, Giasson BI, Mabon ME, Lee VMY, Trojanowski JQ. Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Ann Neurol 2002; 52: 205-10.
-
(2002)
Ann Neurol
, vol.52
, pp. 205-210
-
-
Duda, J.E.1
Giasson, B.I.2
Mabon, M.E.3
Lee, V.M.Y.4
Trojanowski, J.Q.5
-
194
-
-
67449123313
-
Edwin Chan HY, Chung KKK. The role of ubiquitin linkages on α-synuclein induced-toxicity in a Drosophila model of Parkinson's disease
-
Lee FKM, Wong AKY, Lee YW, Wan OW. Edwin Chan HY, Chung KKK. The role of ubiquitin linkages on α-synuclein induced-toxicity in a Drosophila model of Parkinson's disease. J Neurochem 2009; 110: 208-19.
-
(2009)
J Neurochem
, vol.110
, pp. 208-219
-
-
Lee, F.K.M.1
Wong, A.K.Y.2
Lee, Y.W.3
Wan, O.W.4
-
195
-
-
0038307156
-
Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies
-
Sampathu DM, Giasson BI, Pawlyk AC, Trojanowski JQ, Lee VMY. Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies. Am J Pathol 2003; 163: 91-100.
-
(2003)
Am J Pathol
, vol.163
, pp. 91-100
-
-
Sampathu, D.M.1
Giasson, B.I.2
Pawlyk, A.C.3
Trojanowski, J.Q.4
Lee, V.M.Y.5
-
196
-
-
0343527226
-
Alpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining
-
Gomez-Tortosa E, Newell K, Irizarri MC, Sanders JL, Hyman BT. Alpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining. Acta Neuropathol 2000; 99: 352-7.
-
(2000)
Acta Neuropathol
, vol.99
, pp. 352-357
-
-
Gomez-Tortosa, E.1
Newell, K.2
Irizarri, M.C.3
Sanders, J.L.4
Hyman, B.T.5
-
197
-
-
0344305371
-
Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62
-
Kuusisto E, Parkkinen L, Alafuzoff I. Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62. J Neuropathol Exp Neurol 2003; 62: 1241-53.
-
(2003)
J Neuropathol Exp Neurol
, vol.62
, pp. 1241-1253
-
-
Kuusisto, E.1
Parkkinen, L.2
Alafuzoff, I.3
-
198
-
-
84871742997
-
p62/SQSTM1-Dependent Autophagy of Lewy Body-Like α-Synuclein Inclusions
-
Watanabe Y, Tatebe H, Taguchi K, Endo Y, Tokuda T, Mizuno T, Nakagawa M, Tanaka M. p62/SQSTM1-Dependent Autophagy of Lewy Body-Like α-Synuclein Inclusions. PLoS One 2012; 7: e52868.
-
(2012)
PLoS One
, vol.7
, pp. e52868
-
-
Watanabe, Y.1
Tatebe, H.2
Taguchi, K.3
Endo, Y.4
Tokuda, T.5
Mizuno, T.6
Nakagawa, M.7
Tanaka, M.8
-
199
-
-
79956221317
-
Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases
-
Braak H, Thal DR, del Tredici K. Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases. J Neural Transm 2010; 118: 809-19.
-
(2010)
J Neural Transm
, vol.118
, pp. 809-819
-
-
Braak, H.1
Thal, D.R.2
del Tredici, K.3
-
200
-
-
84881018218
-
Behavioral Characterization of A53T Mice Reveals Early and Late Stage Deficits Related to Parkinson's Disease
-
Paumier KL, Sukoff Rizzo SJ, Berger Z, Chen Y, Gonzales C, Kaftan E, Li L, Lotarski S, Monaghan M, Shen W, Stolyar P, Vasilyev D, Zaleska M, D Hirst W, Dunlop J. Behavioral Characterization of A53T Mice Reveals Early and Late Stage Deficits Related to Parkinson's Disease. PLoS One 2013; 8: e70274.
-
(2013)
PLoS One
, vol.8
, pp. e70274
-
-
Paumier, K.L.1
Sukoff Rizzo, S.J.2
Berger, Z.3
Chen, Y.4
Gonzales, C.5
Kaftan, E.6
Li, L.7
Lotarski, S.8
Monaghan, M.9
Shen, W.10
Stolyar, P.11
Vasilyev, D.12
Zaleska, M.D.13
Hirst, W.14
Dunlop, J.15
-
201
-
-
0029981197
-
Alternative conformations of amyloidogenic proteins govern their behavior
-
Kelly JW. Alternative conformations of amyloidogenic proteins govern their behavior. Curr Opin Struct Biol 1996; 6: 11-7.
-
(1996)
Curr Opin Struct Biol
, vol.6
, pp. 11-17
-
-
Kelly, J.W.1
-
203
-
-
84863425120
-
α-Synuclein in human cerebrospinal fluid is principally derived from neurons of the central nervous system
-
Mollenhauer B, Trautmann E, Otte B, Ng J, Spreer A, Lange P, Sixel-Döring F, Hakimi M, VonSattel J-P, Nussbaum R, Trenkwalder C, Schlossmacher MG. α-Synuclein in human cerebrospinal fluid is principally derived from neurons of the central nervous system. J Neural Transm 2012; 119: 739-46.
-
(2012)
J Neural Transm
, vol.119
, pp. 739-746
-
-
Mollenhauer, B.1
Trautmann, E.2
Otte, B.3
Ng, J.4
Spreer, A.5
Lange, P.6
Sixel-Döring, F.7
Hakimi, M.8
VonSattel, J.-P.9
Nussbaum, R.10
Trenkwalder, C.11
Schlossmacher, M.G.12
-
204
-
-
33645833848
-
Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease
-
El-Agnaf OMA, Salem SA, Paleologou KE, Curran MD, Gibson MJ, Court JA, Schlossmacher MG, Allsop D. Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease. FASEB J 2006; 20: 419-25.
-
(2006)
FASEB J
, vol.20
, pp. 419-425
-
-
El-Agnaf, O.M.A.1
Salem, S.A.2
Paleologou, K.E.3
Curran, M.D.4
Gibson, M.J.5
Court, J.A.6
Schlossmacher, M.G.7
Allsop, D.8
-
205
-
-
78649990079
-
Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease
-
Tokuda T, Qureshi MM, Ardah MT, Varghese S, Shehab SAS, Kasai T, Ishigami N, Tamaoka A, Nakagawa M, El-Agnaf OMA. Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease. Neurology 2010; 75: 1766-72.
-
(2010)
Neurology
, vol.75
, pp. 1766-1772
-
-
Tokuda, T.1
Qureshi, M.M.2
Ardah, M.T.3
Varghese, S.4
Shehab, S.A.S.5
Kasai, T.6
Ishigami, N.7
Tamaoka, A.8
Nakagawa, M.9
El-Agnaf, O.M.A.10
-
206
-
-
84929996447
-
Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology
-
Vaikath NN, Majbour NK, Paleologou KE, Ardah MT, van Dam E, van de Berg WDJ, Forrest SL, Parkkinen L, Gai W-P, Hattori N, Takanashi M, Lee S-J, Mann DMA, Imai Y, Halliday GM, Li J-Y, El-Agnaf OMA. Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology. Neurobiol Dis 2015; 79: 81-99.
-
(2015)
Neurobiol Dis
, vol.79
, pp. 81-99
-
-
Vaikath, N.N.1
Majbour, N.K.2
Paleologou, K.E.3
Ardah, M.T.4
van Dam, E.5
van de Berg, W.D.J.6
Forrest, S.L.7
Parkkinen, L.8
Gai, W.-P.9
Hattori, N.10
Takanashi, M.11
Lee, S.-J.12
Mann, D.M.A.13
Imai, Y.14
Halliday, G.M.15
Li, J.-Y.16
El-Agnaf, O.M.A.17
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