메뉴 건너뛰기




Volumn 6, Issue 9, 2014, Pages

Evaluating the relationship between amyloid-β and aα-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; SERINE 129; SERINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 84927922558     PISSN: None     EISSN: 17589193     Source Type: Journal    
DOI: 10.1186/s13195-014-0077-y     Document Type: Article
Times cited : (75)

References (86)
  • 3
    • 0029981526 scopus 로고    scopus 로고
    • Neuropathology of Parkinson's disease
    • Forno LS: Neuropathology of Parkinson's disease. J Neuropathol Exp Neurol 1996, 55:259-272.
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 259-272
    • Forno, L.S.1
  • 6
    • 0024781427 scopus 로고
    • Lewy bodies in Alzheimer disease-one or two diseases?
    • Bergeron C, Pollanen M: Lewy bodies in Alzheimer disease-one or two diseases? Alzheimer Dis Assoc Disord 1989, 3:197.
    • (1989) Alzheimer Dis Assoc Disord , vol.3 , pp. 197
    • Bergeron, C.1    Pollanen, M.2
  • 9
    • 0024381241 scopus 로고
    • A pathological study of the association between Lewy body disease and Alzheimer's disease
    • Gibb W, Mountjoy C, Mann D, Lees A: A pathological study of the association between Lewy body disease and Alzheimer's disease. J Neurol Neurosurg Psychiatry 1989, 52:701-708.
    • (1989) J Neurol Neurosurg Psychiatry , vol.52 , pp. 701-708
    • Gibb, W.1    Mountjoy, C.2    Mann, D.3    Lees, A.4
  • 10
    • 0033919992 scopus 로고    scopus 로고
    • Lewy bodies in Alzheimer's disease: A neuropathological review of 145 cases using α-synuclein immunohistochemistry
    • Hamilton RL: Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using α-synuclein immunohistochemistry. Brain Pathol 2000, 10:378-384.
    • (2000) Brain Pathol , vol.10 , pp. 378-384
    • Hamilton, R.L.1
  • 11
    • 84883174947 scopus 로고    scopus 로고
    • Parkinson's disease dementia: Convergence of α-synuclein, tau and amyloid-β pathologies
    • Irwin DJ, Lee VM, Trojanowski JQ: Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies. Nat Rev Neurosci 2013, 14:626-636.
    • (2013) Nat Rev Neurosci , vol.14 , pp. 626-636
    • Irwin, D.J.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 13
    • 14844333173 scopus 로고    scopus 로고
    • Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: Evidence from the Baltimore Longitudinal Study of Aging (BLSA)
    • Mikolaenko I, Pletnikova O, Kawas CH, O'Brien R, Resnick SM, Crain B, Troncoso JC: Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA). J Neuropathol Exp Neurol 2005, 64:156-162.
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 156-162
    • Mikolaenko, I.1    Pletnikova, O.2    Kawas, C.H.3    O'Brien, R.4    Resnick, S.M.5    Crain, B.6    Troncoso, J.C.7
  • 14
    • 41149141259 scopus 로고    scopus 로고
    • Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance
    • Parkkinen L, Pirttilä T, Alafuzoff I: Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance. Acta Neuropathol 2008, 115:399-407.
    • (2008) Acta Neuropathol , vol.115 , pp. 399-407
    • Parkkinen, L.1    Pirttilä, T.2    Alafuzoff, I.3
  • 16
    • 33747821466 scopus 로고    scopus 로고
    • Alzheimer disease with amygdala Lewy bodies: A distinct form of α-synucleinopathy
    • Uchikado H, Lin WL, DeLucia MW, Dickson DW: Alzheimer disease with amygdala Lewy bodies: a distinct form of α-synucleinopathy. J Neuropathol Exp Neurol 2006, 65:685-697.
    • (2006) J Neuropathol Exp Neurol , vol.65 , pp. 685-697
    • Uchikado, H.1    Lin, W.L.2    Delucia, M.W.3    Dickson, D.W.4
  • 17
    • 33644824239 scopus 로고    scopus 로고
    • Interface between tauopathies and synucleinopathies: A tale of two proteins
    • Galpern WR, Lang AE: Interface between tauopathies and synucleinopathies: a tale of two proteins. Ann Neurol 2006, 59:449-458.
    • (2006) Ann Neurol , vol.59 , pp. 449-458
    • Galpern, W.R.1    Lang, A.E.2
  • 18
    • 41149177434 scopus 로고    scopus 로고
    • The progression of pathology in longitudinally followed patients with Parkinson's disease
    • Halliday G, Hely M, Reid W, Morris J: The progression of pathology in longitudinally followed patients with Parkinson's disease. Acta Neuropathol 2008, 115:409-415.
    • (2008) Acta Neuropathol , vol.115 , pp. 409-415
    • Halliday, G.1    Hely, M.2    Reid, W.3    Morris, J.4
  • 20
    • 0021636665 scopus 로고
    • Diffuse type of Lewy body disease - Progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree - A new disease
    • Kosaka K, Yoshimura M, Ikeda K, Budka H: Diffuse type of Lewy body disease - progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree - a new disease. Clin Neuropathol 1984, 3:185-192.
    • (1984) Clin Neuropathol , vol.3 , pp. 185-192
    • Kosaka, K.1    Yoshimura, M.2    Ikeda, K.3    Budka, H.4
  • 22
    • 0027500963 scopus 로고
    • Neurotransmitters in basal ganglia and cortex of Alzheimer's disease with and without Lewy bodies
    • Langlais PJ, Thal L, Hansen L, Galasko D, Alford M, Masliah E: Neurotransmitters in basal ganglia and cortex of Alzheimer's disease with and without Lewy bodies. Neurology 1993, 43:1927-1934.
    • (1993) Neurology , vol.43 , pp. 1927-1934
    • Langlais, P.J.1    Thal, L.2    Hansen, L.3    Galasko, D.4    Alford, M.5    Masliah, E.6
  • 24
    • 0036827419 scopus 로고    scopus 로고
    • Emerging Alzheimer's disease therapies: Focusing on the future
    • Trojanowski JQ: Emerging Alzheimer's disease therapies: focusing on the future. Neurobiol Aging 2002, 23:985-990.
    • (2002) Neurobiol Aging , vol.23 , pp. 985-990
    • Trojanowski, J.Q.1
  • 28
    • 0035834076 scopus 로고    scopus 로고
    • β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
    • Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, Mucke L: β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proc Natl Acad Sci U S A 2001, 98:12245-12250.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 12245-12250
    • Masliah, E.1    Rockenstein, E.2    Veinbergs, I.3    Sagara, Y.4    Mallory, M.5    Hashimoto, M.6    Mucke, L.7
  • 30
    • 0033520474 scopus 로고    scopus 로고
    • α-Synuclein binds to tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356
    • Jensen PH, Hager H, Nielsen MS, Højrup P, Gliemann J, Jakes R: α-Synuclein binds to tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356. J Biol Chem 1999, 274:25481-25489.
    • (1999) J Biol Chem , vol.274 , pp. 25481-25489
    • Jensen, P.H.1    Hager, H.2    Nielsen, M.S.3    Højrup, P.4    Gliemann, J.5    Jakes, R.6
  • 31
    • 70349331692 scopus 로고    scopus 로고
    • α-Synuclein contributes to GSK-3β-catalyzed tau phosphorylation in Parkinson's disease models
    • Duka T, Duka V, Joyce JN, Sidhu A: α-Synuclein contributes to GSK-3β-catalyzed tau phosphorylation in Parkinson's disease models. FASEB J 2009, 23:2820-2830.
    • (2009) FASEB J , vol.23 , pp. 2820-2830
    • Duka, T.1    Duka, V.2    Joyce, J.N.3    Sidhu, A.4
  • 36
    • 67650496503 scopus 로고    scopus 로고
    • Relationship between α synuclein phosphorylation, proteasomal inhibition and cell death: Relevance to Parkinson's disease pathogenesis
    • Chau KY, Ching HL, Schapira AH, Cooper JM: Relationship between α synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson's disease pathogenesis. J Neurochem2009, 110:1005-1013.
    • (2009) J Neurochem , vol.110 , pp. 1005-1013
    • Chau, K.Y.1    Ching, H.L.2    Schapira, A.H.3    Cooper, J.M.4
  • 37
    • 17844406856 scopus 로고    scopus 로고
    • α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
    • Chen L, Feany MB: α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat Neurosci 2005, 8:657-663.
    • (2005) Nat Neurosci , vol.8 , pp. 657-663
    • Chen, L.1    Feany, M.B.2
  • 38
    • 70449347241 scopus 로고    scopus 로고
    • Tyrosine and serine phosphorylation of α-synuclein have opposing effects on neurotoxicity and soluble oligomer formation
    • Chen L, Periquet M, Wang X, Negro A, McLean PJ, Hyman BT, Feany MB: Tyrosine and serine phosphorylation of α-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. J Clin Invest 2009, 119:3257-3265.
    • (2009) J Clin Invest , vol.119 , pp. 3257-3265
    • Chen, L.1    Periquet, M.2    Wang, X.3    Negro, A.4    McLean, P.J.5    Hyman, B.T.6    Feany, M.B.7
  • 41
    • 84892623172 scopus 로고    scopus 로고
    • In vitro phosphorylation does not influence the aggregation kinetics of WT α-synuclein in contrast to its phosphorylation mutants
    • Schreurs S, Gerard M, Derua R, Waelkens E, Taymans JM, Baekelandt V, Engelborghs Y: In vitro phosphorylation does not influence the aggregation kinetics of WT α-synuclein in contrast to its phosphorylation mutants. Int J Mol Sci 2014, 15:1040-1067.
    • (2014) Int J Mol Sci , vol.15 , pp. 1040-1067
    • Schreurs, S.1    Gerard, M.2    Derua, R.3    Waelkens, E.4    Taymans, J.M.5    Baekelandt, V.6    Engelborghs, Y.7
  • 42
    • 43249108653 scopus 로고    scopus 로고
    • Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein
    • Waxman EA, Giasson BI: Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein. J Neuropathol Exp Neurol 2008, 67:402-416.
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 402-416
    • Waxman, E.A.1    Giasson, B.I.2
  • 44
    • 41149084580 scopus 로고    scopus 로고
    • Relationship of phosphorylated α-synuclein and tau accumulation to Aβ deposition in the cerebral cortex of dementia with Lewy bodies
    • Obi K, Akiyama H, Kondo H, Shimomura Y, Hasegawa M, Iwatsubo T, Mizuno Y, Mochizuki H: Relationship of phosphorylated α-synuclein and tau accumulation to Aβ deposition in the cerebral cortex of dementia with Lewy bodies. Exp Neurol 2008, 210:409-420.
    • (2008) Exp Neurol , vol.210 , pp. 409-420
    • Obi, K.1    Akiyama, H.2    Kondo, H.3    Shimomura, Y.4    Hasegawa, M.5    Iwatsubo, T.6    Mizuno, Y.7    Mochizuki, H.8
  • 45
    • 84871489685 scopus 로고    scopus 로고
    • Arizona Parkinson Disease Consortium: Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains
    • Walker DG, Lue LF, Adler CH, Shill HA, Caviness JN, Sabbagh MN, Akiyama H, Serrano GE, Sue LI, Beach TG, Arizona Parkinson Disease Consortium: Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains. Exp Neurol 2013, 240:190-204.
    • (2013) Exp Neurol , vol.240 , pp. 190-204
    • Walker, D.G.1    Lue, L.F.2    Adler, C.H.3    Shill, H.A.4    Caviness, J.N.5    Sabbagh, M.N.6    Akiyama, H.7    Serrano, G.E.8    Sue, L.I.9    Beach, T.G.10
  • 47
    • 79751480420 scopus 로고    scopus 로고
    • Oxidative balance in Alzheimer's disease: Relationship to APOE, Braak tangle stage, and the concentrations of soluble and insoluble amyloid-β
    • Tayler H, Fraser T, Miners JS, Kehoe PG, Love S: Oxidative balance in Alzheimer's disease: relationship to APOE, Braak tangle stage, and the concentrations of soluble and insoluble amyloid-β. J Alzheimers Dis 2010, 22:1363-1373.
    • (2010) J Alzheimers Dis , vol.22 , pp. 1363-1373
    • Tayler, H.1    Fraser, T.2    Miners, J.S.3    Kehoe, P.G.4    Love, S.5
  • 48
    • 77953185697 scopus 로고    scopus 로고
    • Higher soluble amyloid β concentration in frontal cortex of young adults than in normal elderly or Alzheimer's disease
    • van Helmond Z, Miners JS, Kehoe PG, Love S: Higher soluble amyloid β concentration in frontal cortex of young adults than in normal elderly or Alzheimer's disease. Brain Pathol 2010, 20:787-793.
    • (2010) Brain Pathol , vol.20 , pp. 787-793
    • Van Helmond, Z.1    Miners, J.S.2    Kehoe, P.G.3    Love, S.4
  • 49
    • 84901941810 scopus 로고    scopus 로고
    • Differential changes in Aβ42 and Aβ40 with age
    • Miners JS, Jones R, Love S: Differential changes in Aβ42 and Aβ40 with age. J Alzheimers Dis 2014, 40:727-735.
    • (2014) J Alzheimers Dis , vol.40 , pp. 727-735
    • Miners, J.S.1    Jones, R.2    Love, S.3
  • 52
    • 78651374915 scopus 로고    scopus 로고
    • Accumulation of insoluble amyloid-β in Down's syndrome is associated with increased BACE-1 and neprilysin activities
    • Miners JS, Morris S, Love S, Kehoe PG: Accumulation of insoluble amyloid-β in Down's syndrome is associated with increased BACE-1 and neprilysin activities. J Alzheimers Dis 2011, 23:101-108.
    • (2011) J Alzheimers Dis , vol.23 , pp. 101-108
    • Miners, J.S.1    Morris, S.2    Love, S.3    Kehoe, P.G.4
  • 53
    • 84902655779 scopus 로고    scopus 로고
    • Reduced vascular endothelial growth factor and capillary density in the occipital cortex in dementia with Lewy bodies
    • Miners JS, Moulding H, de Silva R, Love S: Reduced vascular endothelial growth factor and capillary density in the occipital cortex in dementia with Lewy bodies. Brain Pathol 2014, 24:334-343.
    • (2014) Brain Pathol , vol.24 , pp. 334-343
    • Miners, J.S.1    Moulding, H.2    De Silva, R.3    Love, S.4
  • 54
    • 1342325420 scopus 로고    scopus 로고
    • Casein kinase II-mediated phosphorylation regulates α-synuclein/synphilin-1 interaction and inclusion body formation
    • Lee G, Tanaka M, Park K, Lee SS, Kim YM, Junn E, Lee SH, Mouradian MM: Casein kinase II-mediated phosphorylation regulates α-synuclein/synphilin-1 interaction and inclusion body formation. J Biol Chem 2004, 279:6834-6839.
    • (2004) J Biol Chem , vol.279 , pp. 6834-6839
    • Lee, G.1    Tanaka, M.2    Park, K.3    Lee, S.S.4    Kim, Y.M.5    Junn, E.6    Lee, S.H.7    Mouradian, M.M.8
  • 57
    • 1842367306 scopus 로고    scopus 로고
    • Degradation of amyloid β-protein by a metalloprotease secreted by microglia and other neural and non-neural cells
    • Qiu WQ, Ye Z, Kholodenko D, Seubert P, Selkoe DJ: Degradation of amyloid β-protein by a metalloprotease secreted by microglia and other neural and non-neural cells. J Biol Chem 1997, 272:6641-6646.
    • (1997) J Biol Chem , vol.272 , pp. 6641-6646
    • Qiu, W.Q.1    Ye, Z.2    Kholodenko, D.3    Seubert, P.4    Selkoe, D.J.5
  • 58
    • 78149468228 scopus 로고    scopus 로고
    • Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia
    • Ashby EL, Kehoe PG, Love S: Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia. Brain Res 2010, 1363:1-10.
    • (2010) Brain Res , vol.1363 , pp. 1-10
    • Ashby, E.L.1    Kehoe, P.G.2    Love, S.3
  • 59
    • 0038509216 scopus 로고    scopus 로고
    • APOE ε4 influences the pathological phenotype of Alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of Aβ protein
    • Chalmers K, Wilcock GK, Love S: APOE ε4 influences the pathological phenotype of Alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of Aβ protein. Neuropathol Appl Neurobiol 2003, 29:231-238.
    • (2003) Neuropathol Appl Neurobiol , vol.29 , pp. 231-238
    • Chalmers, K.1    Wilcock, G.K.2    Love, S.3
  • 61
    • 57649171529 scopus 로고    scopus 로고
    • Characterisation of two antibodies to oligomeric Aβ and their use in ELISAs on human brain tissue homogenates
    • van Helmond Z, Heesom K, Love S: Characterisation of two antibodies to oligomeric Aβ and their use in ELISAs on human brain tissue homogenates. J Neurosci Methods 2009, 176:206-212.
    • (2009) J Neurosci Methods , vol.176 , pp. 206-212
    • Van Helmond, Z.1    Heesom, K.2    Love, S.3
  • 68
    • 0343035625 scopus 로고    scopus 로고
    • Levels of plasminogen activator inhibitor type 1 and urokinase plasminogen activator receptor in non-small cell lung cancer as measured by quantitative ELISA and semiquantitative immunohistochemistry
    • Pappot H, Skov BG, Pyke C, Grondahl-Hansen J: Levels of plasminogen activator inhibitor type 1 and urokinase plasminogen activator receptor in non-small cell lung cancer as measured by quantitative ELISA and semiquantitative immunohistochemistry. Lung Cancer 1997, 17:197-209.
    • (1997) Lung Cancer , vol.17 , pp. 197-209
    • Pappot, H.1    Skov, B.G.2    Pyke, C.3    Grondahl-Hansen, J.4
  • 71
    • 33748584602 scopus 로고    scopus 로고
    • Interaction between Aβ peptide and α synuclein: Molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease
    • A published erratum appears in Neurochem Res 2007; 32:2002
    • Mandal PK, Pettegrew JW, Masliah E, Hamilton RL, Mandal R: Interaction between Aβ peptide and α synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease. Neurochem Res 2006, 31:1153-1162. A published erratum appears in Neurochem Res 2007, 32:2002.
    • (2006) Neurochem Res , vol.31 , pp. 1153-1162
    • Mandal, P.K.1    Pettegrew, J.W.2    Masliah, E.3    Hamilton, R.L.4    Mandal, R.5
  • 72
    • 78649740289 scopus 로고    scopus 로고
    • α-Synuclein induced synapse damage is enhanced by amyloid-beta(1-42)
    • Bate C, Gentleman S, Williams A: α-Synuclein induced synapse damage is enhanced by amyloid-beta(1-42). Mol Neurodegener 2010, 5:55.
    • (2010) Mol Neurodegener , vol.5 , pp. 55
    • Bate, C.1    Gentleman, S.2    Williams, A.3
  • 73
    • 0034714204 scopus 로고    scopus 로고
    • Synucleins are a novel class of substrates for G protein-coupled receptor kinases
    • Pronin AN, Morris AJ, Surguchov A, Benovic JL: Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J Biol Chem 2000, 275:26515-26522.
    • (2000) J Biol Chem , vol.275 , pp. 26515-26522
    • Pronin, A.N.1    Morris, A.J.2    Surguchov, A.3    Benovic, J.L.4
  • 74
    • 67651008224 scopus 로고    scopus 로고
    • Lrrk2 phosphorylates α synuclein at serine 129: Parkinson disease implications
    • Qing H, Wong W, McGeer EG, McGeer PL: Lrrk2 phosphorylates α synuclein at serine 129: Parkinson disease implications. Biochem Biophys Res Commun 2009, 387:149-152.
    • (2009) Biochem Biophys Res Commun , vol.387 , pp. 149-152
    • Qing, H.1    Wong, W.2    McGeer, E.G.3    McGeer, P.L.4
  • 77
    • 0034685703 scopus 로고    scopus 로고
    • Casein kinase 1 delta mRNA is upregulated in Alzheimer disease brain
    • Yasojima K, Kuret J, DeMaggio AJ, McGeer E, McGeer PL: Casein kinase 1 delta mRNA is upregulated in Alzheimer disease brain. Brain Res 2000, 865:116-120.
    • (2000) Brain Res , vol.865 , pp. 116-120
    • Yasojima, K.1    Kuret, J.2    Demaggio, A.J.3    McGeer, E.4    McGeer, P.L.5
  • 78
    • 69449098018 scopus 로고    scopus 로고
    • Tau hyperphosphorylation affects Smad 2/3 translocation
    • Baig S, van Helmond Z, Love S: Tau hyperphosphorylation affects Smad 2/3 translocation. Neuroscience 2009, 163:561-570.
    • (2009) Neuroscience , vol.163 , pp. 561-570
    • Baig, S.1    Van Helmond, Z.2    Love, S.3
  • 79
    • 0035943436 scopus 로고    scopus 로고
    • Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils
    • Götz J, Chen F, Van Dorpe J, Nitsch R: Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils. Science 2001, 293:1491-1495.
    • (2001) Science , vol.293 , pp. 1491-1495
    • Götz, J.1    Chen, F.2    Van Dorpe, J.3    Nitsch, R.4
  • 82
    • 77958449984 scopus 로고    scopus 로고
    • α-Synuclein: Membrane interactions and toxicity in Parkinson's disease
    • Auluck PK, Caraveo G, Lindquist S: α-Synuclein: membrane interactions and toxicity in Parkinson's disease. Annu Rev Cell Dev Biol 2010, 26:211-233.
    • (2010) Annu Rev Cell Dev Biol , vol.26 , pp. 211-233
    • Auluck, P.K.1    Caraveo, G.2    Lindquist, S.3
  • 83
    • 77958482255 scopus 로고    scopus 로고
    • The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding
    • Bartels T, Ahlstrom LS, Leftin A, Kamp F, Haass C, Brown MF, Beyer K: The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding. Biophys J 2010, 99:2116-2124.
    • (2010) Biophys J , vol.99 , pp. 2116-2124
    • Bartels, T.1    Ahlstrom, L.S.2    Leftin, A.3    Kamp, F.4    Haass, C.5    Brown, M.F.6    Beyer, K.7
  • 84
    • 0035941201 scopus 로고    scopus 로고
    • Metal-triggered structural transformations, aggregation, and fibrillation of human α-synuclein - A possible molecular link between Parkinson's disease and heavy metal exposure
    • Uversky VN, Li J, Fink AL: Metal-triggered structural transformations, aggregation, and fibrillation of human α-synuclein - a possible molecular link between Parkinson's disease and heavy metal exposure. J Biol Chem 2001, 276:44284-44296.
    • (2001) J Biol Chem , vol.276 , pp. 44284-44296
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 85
    • 81255188869 scopus 로고    scopus 로고
    • Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease
    • Sato H, Arawaka S, Hara S, Fukushima S, Koga K, Koyama S, Kato T: Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease. J Neurosci 2011, 31:16884-16894.
    • (2011) J Neurosci , vol.31 , pp. 16884-16894
    • Sato, H.1    Arawaka, S.2    Hara, S.3    Fukushima, S.4    Koga, K.5    Koyama, S.6    Kato, T.7
  • 86
    • 77952915653 scopus 로고    scopus 로고
    • Serine 129 phosphorylation reduces the ability of α-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo
    • Lou H, Montoya SE, Alerte TN, Wang J, Wu J, Peng X, Hong CS, Friedrich EE, Mader SA, Pedersen CJ: Serine 129 phosphorylation reduces the ability of α-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo. J Biol Chem 2010, 285:17648-17661.
    • (2010) J Biol Chem , vol.285 , pp. 17648-17661
    • Lou, H.1    Montoya, S.E.2    Alerte, T.N.3    Wang, J.4    Wu, J.5    Peng, X.6    Hong, C.S.7    Friedrich, E.E.8    Mader, S.A.9    Pedersen, C.J.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.