-
1
-
-
0030882856
-
Alpha-synuclein in lewy bodies
-
doi:10.1038/42166
-
Spillantini MG, Schmidt ML, Lee V.M., Trojanowski JQ, Jakes R, Goedert M. (1997) Alpha-synuclein in Lewy bodies. Nature 388 (6645):839-840. doi:10.1038/42166
-
(1997)
Nature
, vol.388
, Issue.6645
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
2
-
-
34247139885
-
Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation
-
Schneider BL, Seehus CR, Capowski E.E., Aebischer P., Zhang SC, Svendsen C.N. (2007) Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation. Hum Mol Genet 16(6):651-666
-
(2007)
Hum Mol Genet
, vol.16
, Issue.6
, pp. 651-666
-
-
Schneider, B.L.1
Seehus, C.R.2
Capowski, E.E.3
Aebischer, P.4
Zhang, S.C.5
Svendsen, C.N.6
-
3
-
-
42949133399
-
Alpha-synuclein alters notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice
-
doi:10.1523/JNEUROSCI.0066-08.2008
-
Crews L, Mizuno H, Desplats P., Rockenstein E, Adame A, Patrick C., Winner B, Winkler J, Masliah E (2008) Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice. J Neurosci 28(16):4250-4260. doi:10.1523/JNEUROSCI.0066-08.2008
-
(2008)
J Neurosci
, vol.28
, Issue.16
, pp. 4250-4260
-
-
Crews, L.1
Mizuno, H.2
Desplats, P.3
Rockenstein, E.4
Adame, A.5
Patrick, C.6
Winner, B.7
Winkler, J.8
Masliah, E.9
-
4
-
-
33750117120
-
Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging
-
doi:10.1096/fj.05-5422com
-
Klucken J, Outeiro TF, Nguyen P, McLean P.J., Hyman B.T. (2006) Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging. FASEB J 20(12):2050-2057. doi:10.1096/fj.05-5422com
-
(2006)
FASEB J
, vol.20
, Issue.12
, pp. 2050-2057
-
-
Klucken, J.1
Outeiro, T.F.2
Nguyen, P.3
McLean, P.J.4
Hyman, B.T.5
-
5
-
-
3342951965
-
Lipid rafts mediate the synaptic localization of alpha-synuclein
-
doi:10.1523/JNEUROSCI.1594-04.2004
-
Fortin DL, Troyer MD, Nakamura K, Kubo S., Anthony MD, Edwards R.H. (2004) Lipid rafts mediate the synaptic localization of alpha-synuclein. J Neurosci 24(30):6715-6723. doi:10.1523/JNEUROSCI.1594-04.2004
-
(2004)
J Neurosci
, vol.24
, Issue.30
, pp. 6715-6723
-
-
Fortin, D.L.1
Troyer, M.D.2
Nakamura, K.3
Kubo, S.4
Anthony, M.D.5
Edwards, R.H.6
-
6
-
-
79551540871
-
Different sub-cellular localization of alpha-synuclein in the C57BL \6J mouse's central nervous system by two novel monoclonal antibodies
-
doi:10.1016/j.jchemneu.2010.12.003
-
Vivacqua G, Casini A, Vaccaro R., Fornai F, Yu S, D'Este L (2011) Different sub-cellular localization of alpha-synuclein in the C57BL \6J mouse's central nervous system by two novel monoclonal antibodies. J Chem Neuroanat 41(2):97-110. doi:10.1016/j.jchemneu.2010.12.003
-
(2011)
J Chem Neuroanat
, vol.41
, Issue.2
, pp. 97-110
-
-
Vivacqua, G.1
Casini, A.2
Vaccaro, R.3
Fornai, F.4
Yu, S.5
D'Este, L.6
-
7
-
-
0038456964
-
Nuclear localization of alpha-synuclein and its interaction with histones
-
doi:10.1021/bi0341152
-
Goers J, Manning-Bog AB, McCormack A.L., Millett IS, Doniach S, Di Monte DA, Uversky VN, Fink AL (2003) Nuclear localization of alpha-synuclein and its interaction with histones. Biochemistry 42(28):8465-8471. doi:10.1021/bi0341152
-
(2003)
Biochemistry
, vol.42
, Issue.28
, pp. 8465-8471
-
-
Goers, J.1
Manning-Bog, A.B.2
McCormack, A.L.3
Millett, I.S.4
Doniach, S.5
Di Monte, D.A.6
Uversky, V.N.7
Fink, A.L.8
-
8
-
-
77956289142
-
In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility
-
doi:10.1371/journal.pone.0010589
-
Unni VK, Weissman TA, Rockenstein E, Masliah E., McLean PJ, Hyman B.T. (2010) In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility. PLoS One 5(5):e10589. doi:10.1371/journal.pone.0010589
-
(2010)
PLoS One
, vol.5
, Issue.5
-
-
Unni, V.K.1
Weissman, T.A.2
Rockenstein, E.3
Masliah, E.4
McLean, P.J.5
Hyman, B.T.6
-
9
-
-
0242300619
-
Alpha-synuclein locus triplication causes parkinson's disease
-
Singleton AB, Farrer M, Johnson J., Singleton A, Hague S, Kachergus J., Hulihan M, Peuralinna T, Dutra A, Nussbaum R, Lincoln S, Crawley A, Hanson M, Maraganore D, Adler C, Cookson MR, Muenter M, Baptista M, Miller D, Blancato J, Hardy J, Gwinn-Hardy K (2003) Alpha-synuclein locus triplication causes Parkinson's disease. Science 302(5646):841
-
(2003)
Science
, vol.302
, Issue.5646
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
Lincoln, S.11
Crawley, A.12
Hanson, M.13
Maraganore, D.14
Adler, C.15
Cookson, M.R.16
Muenter, M.17
Baptista, M.18
Miller, D.19
Blancato, J.20
Hardy, J.21
Gwinn-Hardy, K.22
more..
-
10
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with parkinson's disease
-
Polymeropoulos MH, Lavedan C, Leroy E., Ide SE, Dehejia A, Dutra A, Pike B., Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276 (5321):2045-2047
-
(1997)
Science
, vol.276
, Issue.5321
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
Stenroos, E.S.11
Chandrasekharappa, S.12
Athanassiadou, A.13
Papapetropoulos, T.14
Johnson, W.G.15
Lazzarini, A.M.16
Duvoisin, R.C.17
Di Iorio, G.18
Golbe, L.I.19
Nussbaum, R.L.20
more..
-
11
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in parkinson's disease
-
Kruger R, Kuhn W, Muller T., Woitalla D, Graeber M, Kosel S., Przuntek H, Epplen JT, Schols L, Riess O (1998) Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 18(2):106-108
-
(1998)
Nat Genet
, vol.18
, Issue.2
, pp. 106-108
-
-
Kruger, R.1
Kuhn, W.2
Muller, T.3
Woitalla, D.4
Graeber, M.5
Kosel, S.6
Przuntek, H.7
Epplen, J.T.8
Schols, L.9
Riess, O.10
-
12
-
-
10744230149
-
The new mutation, E46K, of alpha-synuclein causes parkinson and lewy body dementia
-
Zarranz JJ, Alegre J, Gomez-Esteban JC, Lezcano E., Ros R, Ampuero I, Vidal L., Hoenicka J, Rodriguez O, Atares B, Llorens V, Gomez Tortosa E, del Ser T, Munoz DG, de Yebenes JG (2004) The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol 55(2):164-173
-
(2004)
Ann Neurol
, vol.55
, Issue.2
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gomez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
Vidal, L.7
Hoenicka, J.8
Rodriguez, O.9
Atares, B.10
Llorens, V.11
Gomez Tortosa, E.12
Del Ser, T.13
Munoz, D.G.14
De Yebenes, J.G.15
-
13
-
-
30044450420
-
Comparison of structure and dynamics of micelle-bound human alpha-synuclein and parkinson disease variants
-
doi:10.1074/jbc.M507624200
-
Ulmer TS, Bax A. (2005) Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants. J Biol Chem 280(52):43179-43187. doi:10.1074/jbc.M507624200
-
(2005)
J Biol Chem
, vol.280
, Issue.52
, pp. 43179-43187
-
-
Ulmer, T.S.1
Bax, A.2
-
14
-
-
75749093356
-
Differential phospholipid binding of alpha-synuclein variants implicated in parkinson's disease revealed by solution NMR spectroscopy
-
doi:10.1021/bi901723p
-
Bodner CR, Maltsev AS, Dobson C.M., Bax A. (2010) Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy. Biochemistry 49(5):862-871. doi:10.1021/bi901723p
-
(2010)
Biochemistry
, vol.49
, Issue.5
, pp. 862-871
-
-
Bodner, C.R.1
Maltsev, A.S.2
Dobson, C.M.3
Bax, A.4
-
15
-
-
0036174010
-
Alpha-synuclein is phosphorylated in synucleinopathy lesions
-
Fujiwara H, Hasegawa M, Dohmae N., Kawashima A, Masliah E, Goldberg M.S., Shen J., Takio K, Iwatsubo T (2002) Alpha-synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 4(2):160-164
-
(2002)
Nat Cell Biol
, vol.4
, Issue.2
, pp. 160-164
-
-
Fujiwara, H.1
Hasegawa, M.2
Dohmae, N.3
Kawashima, A.4
Masliah, E.5
Goldberg, M.S.6
Shen, J.7
Takio, K.8
Iwatsubo, T.9
-
16
-
-
33749570292
-
Phosphorylation of ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic lewy body disease
-
doi:10.1074/jbc.M600933200
-
Anderson JP, Walker DE, Goldstein J.M., de Laat R, Banducci K, Caccavello R.J., Barbour R., Huang J, Kling K, Lee M, Diep L, Keim PS, Shen X, Chataway T, Schlossmacher MG, Seubert P, Schenk D, Sinha S, Gai WP, Chilcote TJ (2006) Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease. J Biol Chem 281(40):29739-29752. doi:10.1074/jbc.M600933200
-
(2006)
J Biol Chem
, vol.281
, Issue.40
, pp. 29739-29752
-
-
Anderson, J.P.1
Walker, D.E.2
Goldstein, J.M.3
De Laat, R.4
Banducci, K.5
Caccavello, R.J.6
Barbour, R.7
Huang, J.8
Kling, K.9
Lee, M.10
Diep, L.11
Keim, P.S.12
Shen, X.13
Chataway, T.14
Schlossmacher, M.G.15
Seubert, P.16
Schenk, D.17
Sinha, S.18
Gai, W.P.19
Chilcote, T.J.20
more..
-
17
-
-
0034714204
-
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
-
Pronin AN, Morris AJ, Surguchov A, Benovic J.L. (2000) Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J Biol Chem 275(34):26515-26522
-
(2000)
J Biol Chem
, vol.275
, Issue.34
, pp. 26515-26522
-
-
Pronin, A.N.1
Morris, A.J.2
Surguchov, A.3
Benovic, J.L.4
-
18
-
-
59149090357
-
Pololike kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system
-
Inglis KJ, Chereau D, Brigham E.F., Chiou SS, Schobel S, Frigon NL, Yu M, Caccavello R.J., Nelson S., Motter R, Wright S, Chian D, Santiago P, Soriano F, Ramos C, Powell K, Goldstein JM, Babcock M, Yednock T, Bard F, Basi GS, Sham H, Chilcote TJ, McConlogue L, Griswold-Prenner I, Anderson JP (2009) Pololike kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J Biol Chem 284(5):2598-2602
-
(2009)
J Biol Chem
, vol.284
, Issue.5
, pp. 2598-2602
-
-
Inglis, K.J.1
Chereau, D.2
Brigham, E.F.3
Chiou, S.S.4
Schobel, S.5
Frigon, N.L.6
Yu, M.7
Caccavello, R.J.8
Nelson, S.9
Motter, R.10
Wright, S.11
Chian, D.12
Santiago, P.13
Soriano, F.14
Ramos, C.15
Powell, K.16
Goldstein, J.M.17
Babcock, M.18
Yednock, T.19
Bard, F.20
Basi, G.S.21
Sham, H.22
Chilcote, T.J.23
McConlogue, L.24
Griswold-Prenner, I.25
Anderson, J.P.26
more..
-
19
-
-
77952915653
-
Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo
-
doi:10.1074/jbc.M110.100867
-
Lou H, Montoya SE, Alerte T.N., Wang J., Wu J, Peng X, Hong C.S., Friedrich EE, Mader SA, Pedersen CJ, Marcus BS, McCormack AL, Di Monte DA, Daubner SC, Perez RG (2010) Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo. J Biol Chem 285(23):17648-17661. doi:10.1074/jbc.M110.100867
-
(2010)
J Biol Chem
, vol.285
, Issue.23
, pp. 17648-17661
-
-
Lou, H.1
Montoya, S.E.2
Alerte, T.N.3
Wang, J.4
Wu, J.5
Peng, X.6
Hong, C.S.7
Friedrich, E.E.8
Mader, S.A.9
Pedersen, C.J.10
Marcus, B.S.11
McCormack, A.L.12
Di Monte, D.A.13
Daubner, S.C.14
Perez, R.G.15
-
20
-
-
0036468432
-
Chaperone suppression of alpha-synuclein toxicity in a drosophila model for parkinson's disease
-
doi:10.1126/science.1067389
-
Auluck PK, Chan HY, Trojanowski J.Q., Lee VM, Bonini N.M. (2002) Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science 295 (5556):865-868. doi:10.1126/science.1067389
-
(2002)
Science
, vol.295
, Issue.5556
, pp. 865-868
-
-
Auluck, P.K.1
Chan, H.Y.2
Trojanowski, J.Q.3
Lee, V.M.4
Bonini, N.M.5
-
21
-
-
23644442282
-
Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of parkinson's disease
-
doi:10.1016/j.jmb.2005.06.060
-
Flower TR, Chesnokova LS, Froelich C.A., Dixon C., Witt S.N. (2005) Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease. J Mol Biol 351(5):1081-1100. doi:10.1016/j.jmb.2005.06.060
-
(2005)
J Mol Biol
, vol.351
, Issue.5
, pp. 1081-1100
-
-
Flower, T.R.1
Chesnokova, L.S.2
Froelich, C.A.3
Dixon, C.4
Witt, S.N.5
-
22
-
-
2942620074
-
Hsp70 reduces alpha-synuclein aggregation and toxicity
-
doi:10.1074/jbc.M400255200
-
Klucken J, Shin Y, Masliah E., Hyman BT, McLean P.J. (2004) Hsp70 reduces alpha-synuclein aggregation and toxicity. J Biol Chem 279(24):25497-25502. doi:10.1074/jbc.M400255200
-
(2004)
J Biol Chem
, vol.279
, Issue.24
, pp. 25497-25502
-
-
Klucken, J.1
Shin, Y.2
Masliah, E.3
Hyman, B.T.4
McLean, P.J.5
-
23
-
-
17644383748
-
Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species
-
doi:10.1074/jbc.M413024200
-
Dedmon MM, Christodoulou J, Wilson M.R., Dobson C.M. (2005) Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species. J Biol Chem 280(15):14733-14740. doi:10.1074/jbc. M413024200
-
(2005)
J Biol Chem
, vol.280
, Issue.15
, pp. 14733-14740
-
-
Dedmon, M.M.1
Christodoulou, J.2
Wilson, M.R.3
Dobson, C.M.4
-
24
-
-
84859595997
-
A simple photoactivation and image analysis module for visualizing and analyzing axonal transport with high temporal resolution
-
doi:10.1038/nprot.2011.428
-
Roy S, Yang G, Tang Y., Scott D.A. (2012) A simple photoactivation and image analysis module for visualizing and analyzing axonal transport with high temporal resolution. Nat Protoc 7(1):62-68. doi:10.1038/nprot.2011.428
-
(2012)
Nat Protoc
, vol.7
, Issue.1
, pp. 62-68
-
-
Roy, S.1
Yang, G.2
Tang, Y.3
Scott, D.A.4
-
25
-
-
0042338695
-
Photobleaching and photoactivation: Following protein dynamics in living cells
-
Lippincott-Schwartz J., Altan-Bonnet N, Patterson G.H. (2003) Photobleaching and photoactivation: following protein dynamics in living cells. Nat Cell Biol Suppl: S7-14
-
(2003)
Nat Cell Biol
, Issue.SUPPL.
-
-
Lippincott-Schwartz, J.1
Altan-Bonnet, N.2
Patterson, G.H.3
-
26
-
-
0037072602
-
A photoactivatable GFP for selective photolabeling of proteins and cells
-
Patterson GH, Lippincott-Schwartz J (2002) A photoactivatable GFP for selective photolabeling of proteins and cells. Science 297 (5588):1873-1877
-
(2002)
Science
, vol.297
, Issue.5588
, pp. 1873-1877
-
-
Patterson, G.H.1
Lippincott-Schwartz, J.2
-
27
-
-
65549107985
-
The first N-terminal amino acids of alpha-synuclein are essential for alpha-helical structure formation in vitro and membrane binding in yeast
-
doi:10.1016/j.jmb.2009.03.021
-
Vamvaca K, Volles MJ, Lansbury PT Jr (2009) The first N-terminal amino acids of alpha-synuclein are essential for alpha-helical structure formation in vitro and membrane binding in yeast. J Mol Biol 389(2):413-424. doi:10.1016/j.jmb.2009.03.021
-
(2009)
J Mol Biol
, vol.389
, Issue.2
, pp. 413-424
-
-
Vamvaca, K.1
Volles, M.J.2
Lansbury Jr., P.T.3
-
28
-
-
77749239814
-
Dynamic transport and localization of alpha-synuclein in primary hippocampal neurons
-
doi:10.1186/1750-1326-5-9
-
Yang ML, Hasadsri L, Woods W.S., George J.M. (2010) Dynamic transport and localization of alpha-synuclein in primary hippocampal neurons. Mol Neurodegener 5(1):9. doi:10.1186/1750-1326-5-9
-
(2010)
Mol Neurodegener
, vol.5
, Issue.1
, pp. 9
-
-
Yang, M.L.1
Hasadsri, L.2
Woods, W.S.3
George, J.M.4
-
29
-
-
13444254033
-
Subcellular localisation of recombinant alpha-and gamma-synuclein
-
doi:10.1016/j.mcn.2004.09.017
-
Specht CG, Tigaret CM, Rast G.F., Thalhammer A., Rudhard Y, Schoepfer R. (2005) Subcellular localisation of recombinant alpha-and gamma-synuclein. Mol Cell Neurosci 28(2):326-334. doi:10.1016/j.mcn.2004.09.017
-
(2005)
Mol Cell Neurosci
, vol.28
, Issue.2
, pp. 326-334
-
-
Specht, C.G.1
Tigaret, C.M.2
Rast, G.F.3
Thalhammer, A.4
Rudhard, Y.5
Schoepfer, R.6
-
30
-
-
33749583553
-
Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotox-icity
-
Kontopoulos E, Parvin JD, Feany M.B. (2006) Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotox-icity. Hum Mol Genet 15(20):3012-3023
-
(2006)
Hum Mol Genet
, vol.15
, Issue.20
, pp. 3012-3023
-
-
Kontopoulos, E.1
Parvin, J.D.2
Feany, M.B.3
-
31
-
-
84865045728
-
Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for parkinson's disease
-
doi:10.1016/j.freeradbiomed.2012.05.024
-
Siddiqui A, Chinta SJ, Mallajosyula J.K., Rajagopolan S., Hanson I, Rane A, Andersen J.K. (2012) Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease. Free Radic Biol Med. doi:10.1016/j.freeradbiomed.2012.05.024
-
(2012)
Free Radic Biol Med.
-
-
Siddiqui, A.1
Chinta, S.J.2
Mallajosyula, J.K.3
Rajagopolan, S.4
Hanson, I.5
Rane, A.6
Andersen, J.K.7
-
32
-
-
0029904487
-
NACP, a protein implicated in alzheimer's disease and learning, is natively unfolded
-
doi:10.1021/bi961799n
-
Weinreb PH, Zhen W, Poon A.W., Conway KA, Lansbury PT Jr (1996) NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 35(43):13709-13715. doi:10.1021/bi961799n
-
(1996)
Biochemistry
, vol.35
, Issue.43
, pp. 13709-13715
-
-
Weinreb, P.H.1
Zhen, W.2
Poon, A.W.3
Conway, K.A.4
Lansbury Jr., P.T.5
-
33
-
-
80052398365
-
Alpha-synuclein occurs physiologically as a helically folded tetramer that resists aggregation
-
doi:10.1038/nature10324
-
Bartels T, Choi JG, Selkoe D.J. (2011) Alpha-synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature 477(7362):107-110. doi:10.1038/nature10324
-
(2011)
Nature
, vol.477
, Issue.7362
, pp. 107-110
-
-
Bartels, T.1
Choi, J.G.2
Selkoe, D.J.3
-
34
-
-
80055078029
-
A soluble alpha-synuclein construct forms a dynamic tetramer
-
doi:10.1073/pnas.1113260108
-
Wang W, Perovic I, Chittuluru J., Kaganovich A, Nguyen LT, Liao J, Auclair J.R., Johnson D., Landeru A, Simorellis AK, Ju S, Cookson MR, Asturias FJ, Agar JN, Webb BN, Kang C, Ringe D, Petsko GA, Pochapsky TC, Hoang QQ (2011) A soluble alpha-synuclein construct forms a dynamic tetramer. Proc Natl Acad Sci U S A 108(43):17797-17802. doi:10.1073/pnas.1113260108
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.43
, pp. 17797-17802
-
-
Wang, W.1
Perovic, I.2
Chittuluru, J.3
Kaganovich, A.4
Nguyen, L.T.5
Liao, J.6
Auclair, J.R.7
Johnson, D.8
Landeru, A.9
Simorellis, A.K.10
Ju, S.11
Cookson, M.R.12
Asturias, F.J.13
Agar, J.N.14
Webb, B.N.15
Kang, C.16
Ringe, D.17
Petsko, G.A.18
Pochapsky, T.C.19
Hoang, Q.Q.20
more..
-
35
-
-
0037930855
-
Lipid binding inhibits alpha-synuclein fibril formation
-
doi:10.1074/jbc.M210136200
-
Zhu M, Fink A.L. (2003) Lipid binding inhibits alpha-synuclein fibril formation. J Biol Chem 278(19):16873-16877. doi:10.1074/jbc.M210136200
-
(2003)
J Biol Chem
, vol.278
, Issue.19
, pp. 16873-16877
-
-
Zhu, M.1
Fink, A.L.2
-
36
-
-
0038341134
-
A broken alpha-helix in folded alpha-synuclein
-
doi:10.1074/jbc.M213128200
-
Chandra S, Chen X, Rizo J., Jahn R, Sudhof T.C. (2003) A broken alpha-helix in folded alpha-synuclein. J Biol Chem 278(17):15313-15318. doi:10.1074/jbc.M213128200
-
(2003)
J Biol Chem
, vol.278
, Issue.17
, pp. 15313-15318
-
-
Chandra, S.1
Chen, X.2
Rizo, J.3
Jahn, R.4
Sudhof, T.C.5
-
37
-
-
0034602271
-
Interaction of human alpha-synuclein and parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis
-
doi:10.1074/jbc.M004851200
-
Perrin RJ, Woods WS, Clayton D.F., George J.M. (2000) Interaction of human alpha-synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis. J Biol Chem 275(44):34393-34398. doi:10.1074/jbc.M004851200
-
(2000)
J Biol Chem
, vol.275
, Issue.44
, pp. 34393-34398
-
-
Perrin, R.J.1
Woods, W.S.2
Clayton, D.F.3
George, J.M.4
-
38
-
-
15744362063
-
Structure and dynamics of micelle-bound human alpha-synuclein
-
doi:10.1074/jbc.M411805200
-
Ulmer TS, Bax A, Cole N.B., Nussbaum R.L. (2005) Structure and dynamics of micelle-bound human alpha-synuclein. J Biol Chem 280(10):9595-9603. doi:10.1074/jbc.M411805200
-
(2005)
J Biol Chem
, vol.280
, Issue.10
, pp. 9595-9603
-
-
Ulmer, T.S.1
Bax, A.2
Cole, N.B.3
Nussbaum, R.L.4
-
39
-
-
69949092913
-
{alpha}-synuclein and its A30P mutant affect actin cytoskeletal structure and dynamics
-
doi:10.1091/mbc.E08-03-0302
-
Sousa VL, Bellani S, Giannandrea M., Yousuf M, Valtorta F, Meldolesi J., Chieregatti E. (2009) {alpha}-synuclein and its A30P mutant affect actin cytoskeletal structure and dynamics. Mol Biol Cell 20(16):3725-3739. doi:10.1091/mbc.E08-03-0302
-
(2009)
Mol Biol Cell
, vol.20
, Issue.16
, pp. 3725-3739
-
-
Sousa, V.L.1
Bellani, S.2
Giannandrea, M.3
Yousuf, M.4
Valtorta, F.5
Meldolesi, J.6
Chieregatti, E.7
-
40
-
-
0036415838
-
Alpha-synuclein, especially the parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils
-
Lashuel HA, Petre BM, Wall J, Simon M., Nowak RJ, Walz T, Lansbury PT Jr (2002) Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils. J Mol Biol 322(5):1089-1102
-
(2002)
J Mol Biol
, vol.322
, Issue.5
, pp. 1089-1102
-
-
Lashuel, H.A.1
Petre, B.M.2
Wall, J.3
Simon, M.4
Nowak, R.J.5
Walz, T.6
Lansbury Jr., P.T.7
-
41
-
-
84856667162
-
Mimicking phosphorylation at serine 87 inhibits the aggregation of human alpha-synuclein and protects against its toxicity in a rat model of parkinson's disease
-
doi:10.1523/JNEUROSCI.3784-11.2012
-
Oueslati A, Paleologou KE, Schneider B.L., Aebischer P., Lashuel H.A. (2012) Mimicking phosphorylation at serine 87 inhibits the aggregation of human alpha-synuclein and protects against its toxicity in a rat model of Parkinson's disease. J Neurosci 32(5):1536-1544. doi:10.1523/JNEUROSCI.3784-11.2012
-
(2012)
J Neurosci
, vol.32
, Issue.5
, pp. 1536-1544
-
-
Oueslati, A.1
Paleologou, K.E.2
Schneider, B.L.3
Aebischer, P.4
Lashuel, H.A.5
-
42
-
-
84863349141
-
Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: Alpha-synuclein phosphor-ylation at tyrosine 125
-
doi:10.1021/ja210866j
-
Hejjaoui M, Butterfield S, Fauvet B., Vercruysse F, Cui J, Dikiy I., Prudent M, Olschewski D, Zhang Y, Eliezer D, Lashuel HA (2012) Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: alpha-synuclein phosphor-ylation at tyrosine 125. J Am Chem Soc 134(11):5196-5210. doi:10.1021/ja210866j
-
(2012)
J Am Chem Soc
, vol.134
, Issue.11
, pp. 5196-5210
-
-
Hejjaoui, M.1
Butterfield, S.2
Fauvet, B.3
Vercruysse, F.4
Cui, J.5
Dikiy, I.6
Prudent, M.7
Olschewski, D.8
Zhang, Y.9
Eliezer, D.10
Lashuel, H.A.11
-
43
-
-
0034614415
-
Constitutive phosphorylation of the parkinson's disease associated alpha-synuclein
-
Okochi M, Walter J, Koyama A., Nakajo S, Baba M, Iwatsubo T., Meijer L, Kahle PJ, Haass C (2000) Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein. J Biol Chem 275(1):390-397
-
(2000)
J Biol Chem
, vol.275
, Issue.1
, pp. 390-397
-
-
Okochi, M.1
Walter, J.2
Koyama, A.3
Nakajo, S.4
Baba, M.5
Iwatsubo, T.6
Meijer, L.7
Kahle, P.J.8
Haass, C.9
-
44
-
-
17844406856
-
Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a drosophila model of parkinson disease
-
Chen L, Feany M.B. (2005) Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat Neurosci 8(5):657-663
-
(2005)
Nat Neurosci
, vol.8
, Issue.5
, pp. 657-663
-
-
Chen, L.1
Feany, M.B.2
-
45
-
-
77449113371
-
Phosphorylation of syn-ucleins by members of the polo-like kinase family
-
doi:10.1074/jbc.M109.081950
-
Mbefo MK, Paleologou KE, Boucharaba A, Oueslati A., Schell H, Fournier M, Olschewski D., Yin G, Zweckstetter M, Masliah E, Kahle PJ, Hirling H, Lashuel HA (2010) Phosphorylation of syn-ucleins by members of the Polo-like kinase family. J Biol Chem 285(4):2807-2822. doi:10.1074/jbc.M109.081950
-
(2010)
J Biol Chem
, vol.285
, Issue.4
, pp. 2807-2822
-
-
Mbefo, M.K.1
Paleologou, K.E.2
Boucharaba, A.3
Oueslati, A.4
Schell, H.5
Fournier, M.6
Olschewski, D.7
Yin, G.8
Zweckstetter, M.9
Masliah, E.10
Kahle, P.J.11
Hirling, H.12
Lashuel, H.A.13
-
46
-
-
80052722040
-
Contribution of alanine-76 and serine phosphorylation in alpha-synuclein membrane association and aggregation in yeasts
-
doi:10.4061/2011/392180
-
Fiske M, Valtierra S, Solvang K., Zorniak M, White M, Herrera S., Konnikova A, Brezinsky R, Debburman S (2011) Contribution of alanine-76 and serine phosphorylation in alpha-synuclein membrane association and aggregation in yeasts. Park Dis 2011: 392180. doi:10.4061/2011/392180
-
(2011)
Park Dis
, vol.2011
, pp. 392180
-
-
Fiske, M.1
Valtierra, S.2
Solvang, K.3
Zorniak, M.4
White, M.5
Herrera, S.6
Konnikova, A.7
Brezinsky, R.8
Debburman, S.9
-
47
-
-
75149142186
-
Hsp70 molecular chaperones and parkinson's disease
-
doi:10.1002/bip.21302
-
Witt SN (2010) Hsp70 molecular chaperones and Parkinson's disease. Biopolymers 93(3):218-228. doi:10.1002/bip.21302
-
(2010)
Biopolymers
, vol.93
, Issue.3
, pp. 218-228
-
-
Witt, S.N.1
-
48
-
-
4644291645
-
Analysis of alpha-synuclein-associated proteins by quantitative proteomics
-
doi:10.1074/jbc.M405456200
-
Zhou Y, Gu G, Goodlett D.R., Zhang T., Pan C, Montine TJ, Montine K.S., Aebersold RH, Zhang J (2004) Analysis of alpha-synuclein-associated proteins by quantitative proteomics. J Biol Chem 279(37):39155-39164. doi:10.1074/jbc. M405456200
-
(2004)
J Biol Chem
, vol.279
, Issue.37
, pp. 39155-39164
-
-
Zhou, Y.1
Gu, G.2
Goodlett, D.R.3
Zhang, T.4
Pan, C.5
Montine, T.J.6
Montine, K.S.7
Aebersold, R.H.8
Zhang, J.9
-
49
-
-
0038116620
-
Role of alpha-synuclein carboxy-terminus on fibril formation in vitro
-
doi:10.1021/bi027363r
-
Murray IV, Giasson BI, Quinn S.M., Koppaka V., Axelsen PH, Ischiropoulos H, Trojanowski JQ, Lee V.M. (2003) Role of alpha-synuclein carboxy-terminus on fibril formation in vitro. Biochemistry 42(28):8530-8540. doi:10.1021/bi027363r
-
(2003)
Biochemistry
, vol.42
, Issue.28
, pp. 8530-8540
-
-
Murray, I.V.1
Giasson, B.I.2
Quinn, S.M.3
Koppaka, V.4
Axelsen, P.H.5
Ischiropoulos, H.6
Trojanowski, J.Q.7
Lee, V.M.8
-
50
-
-
9344230362
-
Alpha-synuclein structures from fluorescence energy-transfer kinetics: Implications for the role of the protein in parkinson's disease
-
Lee JC, Langen R, Hummel P.A., Gray HB, Winkler J.R. (2004) Alpha-synuclein structures from fluorescence energy-transfer kinetics: implications for the role of the protein in Parkinson's disease. Proc Natl Acad Sci U S A 101(47): 16466-16471
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.47
, pp. 16466-16471
-
-
Lee, J.C.1
Langen, R.2
Hummel, P.A.3
Gray, H.B.4
Winkler, J.R.5
-
51
-
-
44849125207
-
Formation of toxic oligomeric alpha-synuclein species in living cells
-
doi:10.1371/journal.pone.0001867
-
Outeiro TF, Putcha P, Tetzlaff J.E., Spoelgen R., Koker M, Carvalho F, Hyman B.T., McLean P.J. (2008) Formation of toxic oligomeric alpha-synuclein species in living cells. PLoS One 3(4):e1867. doi:10.1371/journal.pone.0001867
-
(2008)
PLoS One
, vol.3
, Issue.4
-
-
Outeiro, T.F.1
Putcha, P.2
Tetzlaff, J.E.3
Spoelgen, R.4
Koker, M.5
Carvalho, F.6
Hyman, B.T.7
McLean, P.J.8
-
52
-
-
0035859226
-
Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons
-
McLean PJ, Kawamata H, Hyman B.T. (2001) Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons. Neuroscience 104(3):901-912
-
(2001)
Neuroscience
, vol.104
, Issue.3
, pp. 901-912
-
-
McLean, P.J.1
Kawamata, H.2
Hyman, B.T.3
-
53
-
-
70249123134
-
Dopamine-induced conformational changes in alpha-synuclein
-
doi:10.1371/journal.pone.0006906
-
Outeiro TF, Klucken J, Bercury K., Tetzlaff J, Putcha P, Oliveira L.M., Quintas A., McLean PJ, Hyman BT (2009) Dopamine-induced conformational changes in alpha-synuclein. PLoS One 4(9):e6906. doi:10.1371/journal.pone.0006906
-
(2009)
PLoS One
, vol.4
, Issue.9
-
-
Outeiro, T.F.1
Klucken, J.2
Bercury, K.3
Tetzlaff, J.4
Putcha, P.5
Oliveira, L.M.6
Quintas, A.7
McLean, P.J.8
Hyman, B.T.9
|