메뉴 건너뛰기




Volumn 10, Issue 8, 2015, Pages 1252-1260

Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; GREEN FLUORESCENT PROTEIN; RECOMBINANT PROTEIN; SERINE;

EID: 84924554924     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.01.060     Document Type: Article
Times cited : (173)

References (34)
  • 5
    • 0025954066 scopus 로고
    • Ageing and Parkinson's disease: substantia nigra regional selectivity
    • Fearnley J.M., Lees A.J. Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 1991, 114:2283-2301.
    • (1991) Brain , vol.114 , pp. 2283-2301
    • Fearnley, J.M.1    Lees, A.J.2
  • 6
    • 84904497271 scopus 로고    scopus 로고
    • Prions and prion-like proteins
    • Fraser P.E. Prions and prion-like proteins. J.Biol. Chem. 2014, 289:19839-19840.
    • (2014) J.Biol. Chem. , vol.289 , pp. 19839-19840
    • Fraser, P.E.1
  • 7
    • 0028096074 scopus 로고
    • Stability of cell size and nucleolar size in Lewy body containing neurons of substantia nigra in Parkinson's disease
    • Gertz H.J., Siegers A., Kuchinke J. Stability of cell size and nucleolar size in Lewy body containing neurons of substantia nigra in Parkinson's disease. Brain Res. 1994, 637:339-341.
    • (1994) Brain Res. , vol.637 , pp. 339-341
    • Gertz, H.J.1    Siegers, A.2    Kuchinke, J.3
  • 8
    • 84877103526 scopus 로고    scopus 로고
    • Thinking laterally about neurodegenerative proteinopathies
    • Golde T.E., Borchelt D.R., Giasson B.I., Lewis J. Thinking laterally about neurodegenerative proteinopathies. J.Clin. Invest. 2013, 123:1847-1855.
    • (2013) J.Clin. Invest. , vol.123 , pp. 1847-1855
    • Golde, T.E.1    Borchelt, D.R.2    Giasson, B.I.3    Lewis, J.4
  • 9
    • 0343527226 scopus 로고    scopus 로고
    • Alpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining
    • Gómez-Tortosa E., Newell K., Irizarry M.C., Sanders J.L., Hyman B.T. alpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining. Acta Neuropathol. 2000, 99:352-357.
    • (2000) Acta Neuropathol. , vol.99 , pp. 352-357
    • Gómez-Tortosa, E.1    Newell, K.2    Irizarry, M.C.3    Sanders, J.L.4    Hyman, B.T.5
  • 10
    • 70449532484 scopus 로고    scopus 로고
    • A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death
    • Greffard S., Verny M., Bonnet A.M., Seilhean D., Hauw J.J., Duyckaerts C. A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death. Neurobiol. Aging 2010, 31:99-103.
    • (2010) Neurobiol. Aging , vol.31 , pp. 99-103
    • Greffard, S.1    Verny, M.2    Bonnet, A.M.3    Seilhean, D.4    Hauw, J.J.5    Duyckaerts, C.6
  • 11
    • 84893642253 scopus 로고    scopus 로고
    • Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases
    • Guo J.L., Lee V.M. Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases. Nat. Med. 2014, 20:130-138.
    • (2014) Nat. Med. , vol.20 , pp. 130-138
    • Guo, J.L.1    Lee, V.M.2
  • 12
    • 84883688262 scopus 로고    scopus 로고
    • Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
    • Jucker M., Walker L.C. Self-propagation of pathogenic protein aggregates in neurodegenerative diseases. Nature 2013, 501:45-51.
    • (2013) Nature , vol.501 , pp. 45-51
    • Jucker, M.1    Walker, L.C.2
  • 13
    • 47749113650 scopus 로고    scopus 로고
    • Abeta plaques lead to aberrant regulation of calcium homeostasis invivo resulting in structural and functional disruption of neuronal networks
    • Kuchibhotla K.V., Goldman S.T., Lattarulo C.R., Wu H.Y., Hyman B.T., Bacskai B.J. Abeta plaques lead to aberrant regulation of calcium homeostasis invivo resulting in structural and functional disruption of neuronal networks. Neuron 2008, 59:214-225.
    • (2008) Neuron , vol.59 , pp. 214-225
    • Kuchibhotla, K.V.1    Goldman, S.T.2    Lattarulo, C.R.3    Wu, H.Y.4    Hyman, B.T.5    Bacskai, B.J.6
  • 15
    • 80051694263 scopus 로고    scopus 로고
    • Alpha-synuclein functions in the nucleus to protect against hydroxyurea-induced replication stress in yeast
    • Liu X., Lee Y.J., Liou L.C., Ren Q., Zhang Z., Wang S., Witt S.N. Alpha-synuclein functions in the nucleus to protect against hydroxyurea-induced replication stress in yeast. Hum. Mol. Genet. 2011, 20:3401-3414.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 3401-3414
    • Liu, X.1    Lee, Y.J.2    Liou, L.C.3    Ren, Q.4    Zhang, Z.5    Wang, S.6    Witt, S.N.7
  • 17
    • 84862609075 scopus 로고    scopus 로고
    • Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
    • Luk K.C., Kehm V.M., Zhang B., O'Brien P., Trojanowski J.Q., Lee V.M. Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. J.Exp. Med. 2012, 209:975-986.
    • (2012) J.Exp. Med. , vol.209 , pp. 975-986
    • Luk, K.C.1    Kehm, V.M.2    Zhang, B.3    O'Brien, P.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 18
    • 84869109864 scopus 로고    scopus 로고
    • Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
    • Luk K.C., Kehm V., Carroll J., Zhang B., O'Brien P., Trojanowski J.Q., Lee V.M. Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 2012, 338:949-953.
    • (2012) Science , vol.338 , pp. 949-953
    • Luk, K.C.1    Kehm, V.2    Carroll, J.3    Zhang, B.4    O'Brien, P.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 20
    • 0023722437 scopus 로고
    • Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal
    • Maroteaux L., Campanelli J.T., Scheller R.H. Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J.Neurosci. 1988, 8:2804-2815.
    • (1988) J.Neurosci. , vol.8 , pp. 2804-2815
    • Maroteaux, L.1    Campanelli, J.T.2    Scheller, R.H.3
  • 26
    • 84907015989 scopus 로고    scopus 로고
    • Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker
    • Sacino A.N., Brooks M., McKinney A.B., Thomas M.A., Shaw G., Golde T.E., Giasson B.I. Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker. J.Neurosci. 2014, 34:12368-12378.
    • (2014) J.Neurosci. , vol.34 , pp. 12368-12378
    • Sacino, A.N.1    Brooks, M.2    McKinney, A.B.3    Thomas, M.A.4    Shaw, G.5    Golde, T.E.6    Giasson, B.I.7
  • 29
    • 0033857342 scopus 로고    scopus 로고
    • X-34, a fluorescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology
    • Styren S.D., Hamilton R.L., Styren G.C., Klunk W.E. X-34, a fluorescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology. J.Histochem. Cytochem. 2000, 48:1223-1232.
    • (2000) J.Histochem. Cytochem. , vol.48 , pp. 1223-1232
    • Styren, S.D.1    Hamilton, R.L.2    Styren, G.C.3    Klunk, W.E.4
  • 30
  • 31
    • 77956289142 scopus 로고    scopus 로고
    • Invivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility
    • Unni V.K., Weissman T.A., Rockenstein E., Masliah E., McLean P.J., Hyman B.T. Invivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility. PLoS ONE 2010, 5:e10589.
    • (2010) PLoS ONE , vol.5 , pp. e10589
    • Unni, V.K.1    Weissman, T.A.2    Rockenstein, E.3    Masliah, E.4    McLean, P.J.5    Hyman, B.T.6
  • 34
    • 43249108653 scopus 로고    scopus 로고
    • Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein
    • Waxman E.A., Giasson B.I. Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein. J.Neuropathol. Exp. Neurol. 2008, 67:402-416.
    • (2008) J.Neuropathol. Exp. Neurol. , vol.67 , pp. 402-416
    • Waxman, E.A.1    Giasson, B.I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.